Harringtonine_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.136366
SQSTM1 sequestosome 1 0.109159
HDAC9 histone deacetylase 9 0.107267
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.10198
BIRC3 baculoviral IAP repeat containing 3 0.0998738
H1-0 H1.0 linker histone 0.0886229
KLF10 Kruppel-like factor 10 0.0824476
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0758554
PTMA prothymosin, alpha 0.0740382
EGR1 early growth response 1 0.0725251
TMSB10 thymosin beta 10 0.0714379
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0700556
B2M beta-2-microglobulin 0.067992
TXNIP thioredoxin interacting protein 0.0671906
DSPP dentin sialophosphoprotein 0.0656365
ZNF292 zinc finger protein 292 0.0650177
KRT17 keratin 17, type I 0.0637139
TPT1 tumor protein, translationally-controlled 1 0.0632797
LOC102724023 ES1 protein homolog, mitochondrial 0.0629471
DST dystonin 0.0572506
EZR ezrin 0.0562455
PLEC plectin 0.0522741
JUN jun proto-oncogene 0.0515722
DSCAM Down syndrome cell adhesion molecule 0.0504462
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0496967
SKIL SKI-like proto-oncogene 0.0490901
RPL23 ribosomal protein L23 0.0483407
KRT8 keratin 8, type II 0.0477198
RPS6 ribosomal protein S6 0.0453791
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0431479
EMP1 epithelial membrane protein 1 0.0431468
EIF1 eukaryotic translation initiation factor 1 0.0428075
MYH9 myosin, heavy chain 9, non-muscle 0.0426037
H3-3B H3.3 histone B 0.0417294
RPL35A ribosomal protein L35a 0.0412504
FOSL1 FOS-like antigen 1 0.0409555
BRD2 bromodomain containing 2 0.0408727
LMNA lamin A/C 0.0407395
KLF5 Kruppel-like factor 5 (intestinal) 0.0406646
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.040374
RPS3 ribosomal protein S3 0.0397114
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0396422
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.0394216
KRT18 keratin 18, type I 0.0393631
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0390534
RSRC2 arginine/serine-rich coiled-coil 2 0.0388135
RBM39 RNA binding motif protein 39 0.0387373
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0386983
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0382975
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0378698
PRRC2C proline-rich coiled-coil 2C 0.0373743
HMGA1 high mobility group AT-hook 1 0.0355825
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0354736
ACTG1 actin gamma 1 0.0353029
SMC4 structural maintenance of chromosomes 4 0.0351473
FTL ferritin, light polypeptide 0.0347072
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.03464
RPS8 ribosomal protein S8 0.0334713
CENPF centromere protein F, 350/400kDa 0.032961
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0329184
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0326431
LPP LIM domain containing preferred translocation partner in lipoma 0.0326055
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0322655
RPS19 ribosomal protein S19 0.0322134
PTPRK protein tyrosine phosphatase, receptor type, K 0.0320789
BCL3 B-cell CLL/lymphoma 3 0.0312037
SPAG9 sperm associated antigen 9 0.0310007
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0308773
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0306198
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0303866
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0303418
RPL19 ribosomal protein L19 0.0303183
KMT2C lysine (K)-specific methyltransferase 2C 0.0301643
HLA-A major histocompatibility complex, class I, A 0.0301167
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0300539
RPL26 ribosomal protein L26 0.0298916
KDM6B lysine (K)-specific demethylase 6B 0.0295197
CREB5 cAMP responsive element binding protein 5 0.0292876
TMSB4X thymosin beta 4, X-linked 0.0289976
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0286965
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0286221
TRA2B transformer 2 beta homolog (Drosophila) 0.0284432
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0281572
ANKRD12 ankyrin repeat domain 12 0.0279693
JMJD1C jumonji domain containing 1C 0.0278525
RPL37A ribosomal protein L37a 0.0276888
LIMA1 LIM domain and actin binding 1 0.0276045
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.027488
RPLP1 ribosomal protein, large, P1 0.0270989
BHLHE41 basic helix-loop-helix family, member e41 0.0267811
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.026773
TUBB4B tubulin, beta 4B class IVb 0.0265441
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.026476
LCN2 lipocalin 2 0.0259598
KLF6 Kruppel-like factor 6 0.0258998
HMGB2 high mobility group box 2 0.0256687
LAMB3 laminin, beta 3 0.0253012
GSTP1 glutathione S-transferase pi 1 0.0251353
AHR aryl hydrocarbon receptor 0.0250835
SOX4 SRY (sex determining region Y)-box 4 0.0250442

decreased expression

Symbol Name Standardized Value
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0766773
GMDS GDP-mannose 4,6-dehydratase -0.0657222
FGFR2 fibroblast growth factor receptor 2 -0.0515549
NPSR1 neuropeptide S receptor 1 -0.0407652
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0405733
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0401
PDIA3 protein disulfide isomerase family A, member 3 -0.039461
PRSS3 protease, serine, 3 -0.0355767
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0351397
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0329251
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0328122
CEMIP cell migration inducing protein, hyaluronan binding -0.0324106
FTH1 ferritin, heavy polypeptide 1 -0.0310354
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0276572
IARS1 isoleucyl-tRNA synthetase 1 -0.0265815
LMO7 LIM domain 7 -0.0261378
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0249751
COG5 component of oligomeric golgi complex 5 -0.0245893
HYOU1 hypoxia up-regulated 1 -0.0241964
TMC5 transmembrane channel-like 5 -0.0238776
MUC17 mucin 17, cell surface associated -0.0237364
TMEM45B transmembrane protein 45B -0.023233
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0231462
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0229415
BCL2L1 BCL2-like 1 -0.0229399
SH3RF1 SH3 domain containing ring finger 1 -0.0226173
COG6 component of oligomeric golgi complex 6 -0.0226095
MON2 MON2 homolog (S. cerevisiae) -0.0220076
VEGFA vascular endothelial growth factor A -0.0219014
TNRC18 trinucleotide repeat containing 18 -0.0214608
STK24 serine/threonine kinase 24 -0.0203523
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0202363
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0198117
EHBP1 EH domain binding protein 1 -0.0193726
MGAM2 maltase-glucoamylase 2 (putative) -0.0190031
GARS1 glycyl-tRNA synthetase 1 -0.018599
ATM ATM serine/threonine kinase -0.0180448
SRP54 signal recognition particle 54kDa -0.0177999
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0177569
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0176947
AOPEP aminopeptidase O (putative) -0.017454
PMM2 phosphomannomutase 2 -0.0173802
MBNL2 muscleblind-like splicing regulator 2 -0.0173493
ESRP1 epithelial splicing regulatory protein 1 -0.0172123
COPA coatomer protein complex, subunit alpha -0.0165663
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0163829
TNIK TRAF2 and NCK interacting kinase -0.0163522
TFG TRK-fused gene -0.0161033
VMP1 vacuole membrane protein 1 -0.0155532
SAMD12 sterile alpha motif domain containing 12 -0.0154651
TRIM2 tripartite motif containing 2 -0.015411
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0153275
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0150787
NBAS neuroblastoma amplified sequence -0.0150598
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0146558
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0144297
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0143912
SEC24D SEC24 family member D -0.0142881
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0142213
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0140181
CLINT1 clathrin interactor 1 -0.0139174
FLNB filamin B, beta -0.0138856
MCU mitochondrial calcium uniporter -0.0136873
TRAM1 translocation associated membrane protein 1 -0.0131179
CD46 CD46 molecule, complement regulatory protein -0.0129637
ANXA11 annexin A11 -0.012834
PTEN phosphatase and tensin homolog -0.0128066
ABHD17C abhydrolase domain containing 17C -0.0128052
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0127546
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0126932
BTBD9 BTB (POZ) domain containing 9 -0.0126475
ARFGEF3 ARFGEF family member 3 -0.0126104
FAM13A family with sequence similarity 13, member A -0.0124852
UBAC2 UBA domain containing 2 -0.0123958
TBC1D23 TBC1 domain family, member 23 -0.0123872
GPX2 glutathione peroxidase 2 -0.0123517
NEK7 NIMA-related kinase 7 -0.0123002
ADAM10 ADAM metallopeptidase domain 10 -0.0122601
LMAN1 lectin, mannose-binding, 1 -0.0121916
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0120988
GDA guanine deaminase -0.012094
CDK13 cyclin-dependent kinase 13 -0.0120725
POTEF POTE ankyrin domain family, member F -0.0120144
GOLGA4 golgin A4 -0.0119671
RARS1 arginyl-tRNA synthetase 1 -0.0118813
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.011839
AVL9 AVL9 homolog (S. cerevisiase) -0.0117834
ZNF75D zinc finger protein 75D -0.0117741
UBE4A ubiquitination factor E4A -0.0117553
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0117451
PLSCR1 phospholipid scramblase 1 -0.011743
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0116453
PGM3 phosphoglucomutase 3 -0.0115735
SEC31A SEC31 homolog A (S. cerevisiae) -0.0114945
ITGA6 integrin, alpha 6 -0.011468
TM9SF3 transmembrane 9 superfamily member 3 -0.0114412
CLMN calmin (calponin-like, transmembrane) -0.0114168
OSBPL10 oxysterol binding protein-like 10 -0.0114157
BIRC6 baculoviral IAP repeat containing 6 -0.0113194
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -0.0113175