Harringtonine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.162268
MT2A metallothionein 2A 0.113079
ERRFI1 ERBB receptor feedback inhibitor 1 0.112703
EGR1 early growth response 1 0.106703
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0982659
JUN jun proto-oncogene 0.0949533
PTMA prothymosin, alpha 0.0688094
HDAC9 histone deacetylase 9 0.0683875
SQSTM1 sequestosome 1 0.0681801
PLK2 polo-like kinase 2 0.0604817
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0591998
KLF6 Kruppel-like factor 6 0.0581173
BIRC3 baculoviral IAP repeat containing 3 0.0572997
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0525446
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0522231
BRD2 bromodomain containing 2 0.0521493
FOSL1 FOS-like antigen 1 0.0511373
PRRC2C proline-rich coiled-coil 2C 0.048047
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0468015
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0466652
H1-0 H1.0 linker histone 0.0453761
KLF10 Kruppel-like factor 10 0.0450733
ZFP36 ZFP36 ring finger protein 0.0443851
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.043785
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0426602
SPAG9 sperm associated antigen 9 0.0425334
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0419242
CXCL3 chemokine (C-X-C motif) ligand 3 0.0411226
CREB5 cAMP responsive element binding protein 5 0.0371996
TMSB10 thymosin beta 10 0.0364366
PLAU plasminogen activator, urokinase 0.0363199
KTN1 kinectin 1 (kinesin receptor) 0.0358175
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0348034
PER1 period circadian clock 1 0.0343545
FAT1 FAT atypical cadherin 1 0.0336076
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0335216
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.031675
TSC22D2 TSC22 domain family, member 2 0.0313432
AHNAK AHNAK nucleoprotein 0.0309682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297165
RSRC2 arginine/serine-rich coiled-coil 2 0.0291224
ZBTB10 zinc finger and BTB domain containing 10 0.0290423
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0289152
SON SON DNA binding protein 0.028522
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282703
RBM25 RNA binding motif protein 25 0.0272814
IER2 immediate early response 2 0.0269324
SET SET nuclear proto-oncogene 0.0265187
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0260335
EZR ezrin 0.0258073
VIM vimentin 0.0257575
CD83 CD83 molecule 0.0257126
CAVIN1 caveolae associated protein 1 0.0253748
RPL23 ribosomal protein L23 0.0250008
JMJD1C jumonji domain containing 1C 0.0244286
RPS3 ribosomal protein S3 0.0241158
EIF5B eukaryotic translation initiation factor 5B 0.0238998
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.023326
CHD1 chromodomain helicase DNA binding protein 1 0.0231235
IRF1 interferon regulatory factor 1 0.022892
KDM6B lysine (K)-specific demethylase 6B 0.0228673
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0227574
TMSB4X thymosin beta 4, X-linked 0.0227264
MCL1 myeloid cell leukemia 1 0.0224825
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0223689
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0220987
FTL ferritin, light polypeptide 0.0220226
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0219721
LOC102724023 ES1 protein homolog, mitochondrial 0.0216631
NIPBL Nipped-B homolog (Drosophila) 0.0214451
TOP1 topoisomerase (DNA) I 0.0213169
CXCL2 chemokine (C-X-C motif) ligand 2 0.0211434
AFF4 AF4/FMR2 family, member 4 0.0209455
SFPQ splicing factor proline/glutamine-rich 0.0208764
SMC4 structural maintenance of chromosomes 4 0.020789
CENPF centromere protein F, 350/400kDa 0.0207605
EEF2 eukaryotic translation elongation factor 2 0.0206628
SETX senataxin 0.020619
ENO1 enolase 1, (alpha) 0.0205393
TUBB4B tubulin, beta 4B class IVb 0.0203811
RPL37A ribosomal protein L37a 0.0202441
ZFP36L1 ZFP36 ring finger protein-like 1 0.020149
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0201117
BHLHE40 basic helix-loop-helix family, member e40 0.0199706
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0199379
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0199024
KMT2C lysine (K)-specific methyltransferase 2C 0.019822
RAB7A RAB7A, member RAS oncogene family 0.0198036
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0197023
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0195411
CCNL1 cyclin L1 0.0192956
OGA O-GlcNAcase 0.0192101
GPBP1 GC-rich promoter binding protein 1 0.0190804
MED13 mediator complex subunit 13 0.0188456
RPS12 ribosomal protein S12 0.0185515
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0185104
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0184984
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0182688
LIMA1 LIM domain and actin binding 1 0.0182617
RPS19 ribosomal protein S19 0.0181316

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0951927
PSD3 pleckstrin and Sec7 domain containing 3 -0.058763
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0376013
TXNRD1 thioredoxin reductase 1 -0.0370929
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0364051
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0355694
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0349422
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0302948
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.029409
SLC38A2 solute carrier family 38, member 2 -0.0287143
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0269113
WWTR1 WW domain containing transcription regulator 1 -0.0241693
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0212951
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0210814
TSC22D1 TSC22 domain family, member 1 -0.0182381
CD44 CD44 molecule (Indian blood group) -0.0181361
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0177741
EHBP1 EH domain binding protein 1 -0.017394
TMEM41B transmembrane protein 41B -0.0171373
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0162317
ZMYND8 zinc finger, MYND-type containing 8 -0.0161344
WARS1 tryptophanyl-tRNA synthetase 1 -0.0151124
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.014709
TM4SF1 transmembrane 4 L six family member 1 -0.0138582
BCAR3 breast cancer anti-estrogen resistance 3 -0.0137675
DLG1 discs, large homolog 1 (Drosophila) -0.0133285
GCLM glutamate-cysteine ligase, modifier subunit -0.012925
ADAM17 ADAM metallopeptidase domain 17 -0.0128166
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0127002
TTC3 tetratricopeptide repeat domain 3 -0.0125731
KDM4C lysine (K)-specific demethylase 4C -0.012348
RERE arginine-glutamic acid dipeptide (RE) repeats -0.012317
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0122891
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0121903
COG5 component of oligomeric golgi complex 5 -0.0118402
BMERB1 bMERB domain containing 1 -0.0115204
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0114648
USP34 ubiquitin specific peptidase 34 -0.0113819
EXOC4 exocyst complex component 4 -0.0113735
BABAM2 BRISC and BRCA1 A complex member 2 -0.0113075
TMEM123 transmembrane protein 123 -0.01096
LOXL2 lysyl oxidase-like 2 -0.0108697
ADAM10 ADAM metallopeptidase domain 10 -0.0108433
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0106747
YEATS2 YEATS domain containing 2 -0.0106561
NPAS2 neuronal PAS domain protein 2 -0.0105885
GARS1 glycyl-tRNA synthetase 1 -0.0103793
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0103484
NBAS neuroblastoma amplified sequence -0.0103337
PYGB phosphorylase, glycogen; brain -0.0103179
CSMD3 CUB and Sushi multiple domains 3 -0.0102284
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.010049
PDIA3 protein disulfide isomerase family A, member 3 -0.0100474
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00999331
TAS2R14 taste receptor, type 2, member 14 -0.00998911
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00997261
DNER delta/notch-like EGF repeat containing -0.00990973
SBF2 SET binding factor 2 -0.00985164
KIAA1958 KIAA1958 -0.00966783
MBNL2 muscleblind-like splicing regulator 2 -0.00947226
DOCK11 dedicator of cytokinesis 11 -0.00929946
SPATS2L spermatogenesis associated, serine-rich 2-like -0.00920128
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.00918722
MBD5 methyl-CpG binding domain protein 5 -0.00918456
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.00910867
THSD4 thrombospondin, type I, domain containing 4 -0.00909957
POM121 POM121 transmembrane nucleoporin -0.00903307
PDE10A phosphodiesterase 10A -0.00899773
EXOC6B exocyst complex component 6B -0.00893292
DYM dymeclin -0.00890033
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.00882695
PDIA6 protein disulfide isomerase family A, member 6 -0.00879551
FTH1 ferritin, heavy polypeptide 1 -0.00853106
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.00846169
COPA coatomer protein complex, subunit alpha -0.00843187
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0083325
FBXO11 F-box protein 11 -0.00820119
TBC1D22A TBC1 domain family, member 22A -0.00818409
RTTN rotatin -0.00813326
TBC1D5 TBC1 domain family, member 5 -0.00811335
ANTXR2 anthrax toxin receptor 2 -0.00806283
CAPN2 calpain 2, (m/II) large subunit -0.00799409
LPP LIM domain containing preferred translocation partner in lipoma -0.00799149
CALU calumenin -0.00796608
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.00795608
HOOK2 hook microtubule-tethering protein 2 -0.0079546
ANK2 ankyrin 2, neuronal -0.0078447
SMYD3 SET and MYND domain containing 3 -0.00773735
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.00769643
OSMR oncostatin M receptor -0.00752785
PYGL phosphorylase, glycogen, liver -0.00751517
HM13 histocompatibility (minor) 13 -0.00749879
DNAAF9 dynein axonemal assembly factor 9 -0.00749765
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00745381
IARS1 isoleucyl-tRNA synthetase 1 -0.00742262
PTK2 protein tyrosine kinase 2 -0.00739061
HPCAL1 hippocalcin-like 1 -0.00737501
RAB6A RAB6A, member RAS oncogene family -0.00735802
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00734326
VMP1 vacuole membrane protein 1 -0.00731624