Harringtonine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.173629
CXCL8 chemokine (C-X-C motif) ligand 8 0.119937
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0945926
MT2A metallothionein 2A 0.0919505
TMSB10 thymosin beta 10 0.0837804
ASPH aspartate beta-hydroxylase 0.0733113
LAMC2 laminin, gamma 2 0.0620565
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0495942
CAV1 caveolin 1, caveolae protein, 22kDa 0.0490575
RPS3 ribosomal protein S3 0.0489034
EGFR epidermal growth factor receptor 0.0470887
ACTG1 actin gamma 1 0.0437202
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0434516
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0406924
THSD4 thrombospondin, type I, domain containing 4 0.0406222
SEC61G Sec61 gamma subunit 0.0354823
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352429
LAMA4 laminin, alpha 4 0.0328243
PKM pyruvate kinase, muscle 0.0324983
OSMR oncostatin M receptor 0.0319621
LDHA lactate dehydrogenase A 0.0318288
PTPRM protein tyrosine phosphatase, receptor type, M 0.0313172
RPL37A ribosomal protein L37a 0.0312678
CST3 cystatin C 0.030925
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0307542
FAT1 FAT atypical cadherin 1 0.0303991
FTL ferritin, light polypeptide 0.0301976
LMO7 LIM domain 7 0.0297634
PTMA prothymosin, alpha 0.0296247
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0293147
ERRFI1 ERBB receptor feedback inhibitor 1 0.0291192
STC1 stanniocalcin 1 0.028721
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0281597
KRT18 keratin 18, type I 0.0281025
S100A10 S100 calcium binding protein A10 0.0280984
PDLIM5 PDZ and LIM domain 5 0.0280563
JUN jun proto-oncogene 0.0269804
VCL vinculin 0.0265653
IFI6 interferon, alpha-inducible protein 6 0.0262679
ENO1 enolase 1, (alpha) 0.0262507
GRAMD1B GRAM domain containing 1B 0.0259816
ZFP36 ZFP36 ring finger protein 0.0256754
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0249696
KLF10 Kruppel-like factor 10 0.0240993
PDE4D phosphodiesterase 4D, cAMP-specific 0.0239327
AREG amphiregulin 0.0237847
KRT7 keratin 7, type II 0.0236723
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0226307
H1-0 H1.0 linker histone 0.0223327
ELL2 elongation factor, RNA polymerase II, 2 0.0221805
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0221223
LOC112694756 uncharaterized LOC112694756 0.0219629
SLTM SAFB-like, transcription modulator 0.0218589
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0218087
EFNA5 ephrin-A5 0.0214796
ANXA2 annexin A2 0.0213831
IGFBP5 insulin-like growth factor binding protein 5 0.0211548
TES testin LIM domain protein 0.0207822
UBC ubiquitin C 0.0206834
KDM6B lysine (K)-specific demethylase 6B 0.0206349
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0204049
MYOF myoferlin 0.0202444
RPS24 ribosomal protein S24 0.0202163
CPE carboxypeptidase E 0.020126
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0201259
SLC38A2 solute carrier family 38, member 2 0.0199576
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.019775
IER2 immediate early response 2 0.019754
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0196204
B2M beta-2-microglobulin 0.0195194
RPL31 ribosomal protein L31 0.0194891
RPL12 ribosomal protein L12 0.0193965
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0193464
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.019261
DSCAM Down syndrome cell adhesion molecule 0.0191635
LOC102724023 ES1 protein homolog, mitochondrial 0.0191339
PRRC2C proline-rich coiled-coil 2C 0.0189853
PGK1 phosphoglycerate kinase 1 0.0188664
BZW1 basic leucine zipper and W2 domains 1 0.0187649
RPLP1 ribosomal protein, large, P1 0.0187029
RPL34 ribosomal protein L34 0.0186416
RPL11 ribosomal protein L11 0.0185006
CCND1 cyclin D1 0.0184682
TPT1 tumor protein, translationally-controlled 1 0.0179927
SETX senataxin 0.0179214
KRT8 keratin 8, type II 0.0178086
RPL23 ribosomal protein L23 0.0177538
ATG12 autophagy related 12 0.0175233
DENND4A DENN/MADD domain containing 4A 0.0174651
S100A11 S100 calcium binding protein A11 0.0172046
TPI1 triosephosphate isomerase 1 0.0171785
SCEL sciellin 0.0171192
RPL19 ribosomal protein L19 0.0170489
SQSTM1 sequestosome 1 0.0169917
C15ORF48 chromosome 15 open reading frame 48 0.0168894
AHNAK AHNAK nucleoprotein 0.0168288
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0167497
DOCK5 dedicator of cytokinesis 5 0.0167485
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0167356
RPS8 ribosomal protein S8 0.0165659

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0567038
FAM13A family with sequence similarity 13, member A -0.0419852
NDRG1 N-myc downstream regulated 1 -0.04102
SEC31A SEC31 homolog A (S. cerevisiae) -0.0290964
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0279965
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0275701
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0229835
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0223261
TMEM165 transmembrane protein 165 -0.0221679
SRP54 signal recognition particle 54kDa -0.0205767
PDE8A phosphodiesterase 8A -0.0196383
KCMF1 potassium channel modulatory factor 1 -0.0160796
SMAD3 SMAD family member 3 -0.015628
MON2 MON2 homolog (S. cerevisiae) -0.0150821
ARRDC3 arrestin domain containing 3 -0.0147552
FNIP1 folliculin interacting protein 1 -0.0144269
GRB10 growth factor receptor-bound protein 10 -0.0143712
SUCO SUN domain containing ossification factor -0.0143555
FTH1 ferritin, heavy polypeptide 1 -0.0142642
KDM5B lysine (K)-specific demethylase 5B -0.0142011
SEC24A SEC24 family member A -0.0136002
RNMT RNA (guanine-7-) methyltransferase -0.0135006
PDIA3 protein disulfide isomerase family A, member 3 -0.0132669
ESYT2 extended synaptotagmin-like protein 2 -0.0131631
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.013155
SEC24D SEC24 family member D -0.0130651
NGLY1 N-glycanase 1 -0.0127637
TTC3 tetratricopeptide repeat domain 3 -0.0126599
GOLGA4 golgin A4 -0.0125952
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0118263
PTEN phosphatase and tensin homolog -0.0117079
HOOK2 hook microtubule-tethering protein 2 -0.0115664
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0114384
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0114168
GOLGB1 golgin B1 -0.0113945
COPA coatomer protein complex, subunit alpha -0.0112111
ARF4 ADP-ribosylation factor 4 -0.0109997
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0108546
ZNF638 zinc finger protein 638 -0.0106563
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0104104
HELZ helicase with zinc finger -0.0103828
SPIRE1 spire-type actin nucleation factor 1 -0.010028
PTPRJ protein tyrosine phosphatase, receptor type, J -0.00997596
KLHL24 kelch-like family member 24 -0.00993875
TPD52 tumor protein D52 -0.00986054
AFF1 AF4/FMR2 family, member 1 -0.00965036
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00950236
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.00949377
CCNY cyclin Y -0.00947411
KDM2A lysine (K)-specific demethylase 2A -0.00937281
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00930553
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00926743
TXNDC11 thioredoxin domain containing 11 -0.00925201
MLF1 myeloid leukemia factor 1 -0.009188
BIRC6 baculoviral IAP repeat containing 6 -0.00913151
RICTOR RPTOR independent companion of MTOR, complex 2 -0.00902091
RAB1A RAB1A, member RAS oncogene family -0.00900119
KDM4C lysine (K)-specific demethylase 4C -0.00896845
USP3 ubiquitin specific peptidase 3 -0.00875498
YEATS2 YEATS domain containing 2 -0.00866891
ACBD3 acyl-CoA binding domain containing 3 -0.00860846
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0081842
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0081822
GK glycerol kinase -0.00806747
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.00794767
RIC1 RAB6A GEF complex partner 1 -0.00789653
WASF2 WAS protein family, member 2 -0.00780324
HBP1 HMG-box transcription factor 1 -0.00779625
UBE4B ubiquitination factor E4B -0.00775134
ADAM17 ADAM metallopeptidase domain 17 -0.00773339
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.00769991
SREBF2 sterol regulatory element binding transcription factor 2 -0.00769243
ATOSA atos homolog A -0.00766753
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.00766517
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.00764272
SEPTIN2 septin 2 -0.00763453
CAMTA1 calmodulin binding transcription activator 1 -0.00759702
HILPDA hypoxia inducible lipid droplet-associated -0.0075341
TMF1 TATA element modulatory factor 1 -0.00753269
OGA O-GlcNAcase -0.00752702
KMT2E lysine (K)-specific methyltransferase 2E -0.00751201
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.00750308
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00749777
EPB41 erythrocyte membrane protein band 4.1 -0.00749387
GLS2 glutaminase 2 (liver, mitochondrial) -0.00746436
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00740773
VEGFA vascular endothelial growth factor A -0.00734259
PER2 period circadian clock 2 -0.00723496
TFG TRK-fused gene -0.0072001
ANXA5 annexin A5 -0.00719549
ZNF292 zinc finger protein 292 -0.0071478
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.00714534
ESRP1 epithelial splicing regulatory protein 1 -0.00711933
KDM6A lysine (K)-specific demethylase 6A -0.00707189
ZNF207 zinc finger protein 207 -0.00701192
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.00689443
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -0.00686609
LMAN1 lectin, mannose-binding, 1 -0.00684995
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.00681318
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.00680915