Harringtonine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Harringtonine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.317151
VIM vimentin 0.107308
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0577034
AKAP12 A kinase (PRKA) anchor protein 12 0.0548423
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0545953
MT2A metallothionein 2A 0.0525984
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0497985
SQSTM1 sequestosome 1 0.0487989
TMSB10 thymosin beta 10 0.0481432
PKM pyruvate kinase, muscle 0.0473476
TXNRD1 thioredoxin reductase 1 0.0472792
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0467945
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0458363
PRRC2C proline-rich coiled-coil 2C 0.0449808
BIRC3 baculoviral IAP repeat containing 3 0.0449691
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0447282
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0426026
FTL ferritin, light polypeptide 0.0421883
ENO1 enolase 1, (alpha) 0.0419958
PTMA prothymosin, alpha 0.0407818
BHLHE40 basic helix-loop-helix family, member e40 0.0381713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0372548
KLF10 Kruppel-like factor 10 0.0371474
LDHA lactate dehydrogenase A 0.0370778
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0365562
TXNIP thioredoxin interacting protein 0.0358507
RPLP1 ribosomal protein, large, P1 0.0344243
JUN jun proto-oncogene 0.0336815
RSRC2 arginine/serine-rich coiled-coil 2 0.0334194
INSIG1 insulin induced gene 1 0.0309669
B2M beta-2-microglobulin 0.0306857
DDIT4 DNA-damage-inducible transcript 4 0.0296815
EEF2 eukaryotic translation elongation factor 2 0.0295216
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0293212
EIF1 eukaryotic translation initiation factor 1 0.0289611
IER3 immediate early response 3 0.0284555
MYH9 myosin, heavy chain 9, non-muscle 0.0282168
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0277454
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0275731
FOSL1 FOS-like antigen 1 0.0274324
EIF5B eukaryotic translation initiation factor 5B 0.0273972
RPS19 ribosomal protein S19 0.0271263
NAP1L1 nucleosome assembly protein 1-like 1 0.027058
EGR1 early growth response 1 0.0267331
ADM adrenomedullin 0.0258943
ANGPTL4 angiopoietin-like 4 0.025862
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252488
RPL23 ribosomal protein L23 0.0248393
CXCL3 chemokine (C-X-C motif) ligand 3 0.0245531
NAV3 neuron navigator 3 0.0245202
AHNAK AHNAK nucleoprotein 0.0243605
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0242136
RPS6 ribosomal protein S6 0.0239872
HDAC9 histone deacetylase 9 0.0231952
UBC ubiquitin C 0.0226117
RPS8 ribosomal protein S8 0.0224595
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0220477
KDM3A lysine (K)-specific demethylase 3A 0.0218694
RPL37A ribosomal protein L37a 0.0218239
STC1 stanniocalcin 1 0.0212906
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0211384
RPS12 ribosomal protein S12 0.0211083
RPS3 ribosomal protein S3 0.0210277
PDGFA platelet-derived growth factor alpha polypeptide 0.020586
RPL36 ribosomal protein L36 0.0205347
RPL31 ribosomal protein L31 0.0204917
KLF6 Kruppel-like factor 6 0.0197534
RPL35A ribosomal protein L35a 0.0196775
H3-3B H3.3 histone B 0.0195921
BTG1 B-cell translocation gene 1, anti-proliferative 0.0195401
KTN1 kinectin 1 (kinesin receptor) 0.0194383
ZBTB10 zinc finger and BTB domain containing 10 0.0193378
RPL32 ribosomal protein L32 0.0192296
ACTG1 actin gamma 1 0.0191779
RLF rearranged L-myc fusion 0.0190431
TMSB4X thymosin beta 4, X-linked 0.0190304
RPL11 ribosomal protein L11 0.0188537
TFPI2 tissue factor pathway inhibitor 2 0.0187459
RIOK3 RIO kinase 3 0.0186347
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0185897
HMGA1 high mobility group AT-hook 1 0.018444
POTEF POTE ankyrin domain family, member F 0.0184292
RPL5 ribosomal protein L5 0.018035
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0180331
RBM25 RNA binding motif protein 25 0.0180252
RPLP2 ribosomal protein, large, P2 0.0173708
H1-0 H1.0 linker histone 0.0172242
RPS29 ribosomal protein S29 0.0170688
LOC112694756 uncharaterized LOC112694756 0.0170125
ZFP36 ZFP36 ring finger protein 0.0168947
SAMD9 sterile alpha motif domain containing 9 0.0168562
RPL19 ribosomal protein L19 0.0166624
RPL34 ribosomal protein L34 0.0166439
PNRC1 proline-rich nuclear receptor coactivator 1 0.0165037
RPL37 ribosomal protein L37 0.0162033
ANKRD33B ankyrin repeat domain 33B 0.0161403
ALCAM activated leukocyte cell adhesion molecule 0.0161313
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.015952
RPS17 ribosomal protein S17 0.0158531
BRD2 bromodomain containing 2 0.0158186

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.0905056
FNDC3B fibronectin type III domain containing 3B -0.0653298
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0534478
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0466473
IGFBP3 insulin-like growth factor binding protein 3 -0.0407874
GLCCI1 glucocorticoid induced 1 -0.0371483
EFNA5 ephrin-A5 -0.0336241
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0328863
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0315162
SDK1 sidekick cell adhesion molecule 1 -0.0306013
OSMR oncostatin M receptor -0.0294574
LOX lysyl oxidase -0.0288222
GPC6 glypican 6 -0.0285473
VMP1 vacuole membrane protein 1 -0.027861
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0277597
CD44 CD44 molecule (Indian blood group) -0.0272916
DOCK5 dedicator of cytokinesis 5 -0.0256637
PSD3 pleckstrin and Sec7 domain containing 3 -0.0246879
GRB10 growth factor receptor-bound protein 10 -0.0238633
ETV6 ets variant 6 -0.023439
DPYD dihydropyrimidine dehydrogenase -0.0229353
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0225375
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0214146
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0209468
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0205252
NRP1 neuropilin 1 -0.0204791
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0203667
SEC31A SEC31 homolog A (S. cerevisiae) -0.0201506
RAD51B RAD51 paralog B -0.020117
FAM20C family with sequence similarity 20, member C -0.0191208
COPA coatomer protein complex, subunit alpha -0.0190938
TTC3 tetratricopeptide repeat domain 3 -0.0185586
NTN4 netrin 4 -0.0183838
ANKRD28 ankyrin repeat domain 28 -0.0180248
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0178122
HMGA2 high mobility group AT-hook 2 -0.0174529
NPC1 Niemann-Pick disease, type C1 -0.016528
RUNX2 runt-related transcription factor 2 -0.0163569
PID1 phosphotyrosine interaction domain containing 1 -0.0163402
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.016196
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0161855
ZEB2 zinc finger E-box binding homeobox 2 -0.0161538
MON2 MON2 homolog (S. cerevisiae) -0.0161037
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0159089
EXOC6B exocyst complex component 6B -0.0157481
RAB27B RAB27B, member RAS oncogene family -0.0155316
EHBP1 EH domain binding protein 1 -0.015508
VRK2 vaccinia related kinase 2 -0.015443
ARHGAP5 Rho GTPase activating protein 5 -0.0152419
FBXL13 F-box and leucine-rich repeat protein 13 -0.01521
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0150226
AOPEP aminopeptidase O (putative) -0.0149244
NPAS2 neuronal PAS domain protein 2 -0.0147806
CDH13 cadherin 13 -0.0146749
SIK3 SIK family kinase 3 -0.014623
ITCH itchy E3 ubiquitin protein ligase -0.0142414
STRN3 striatin, calmodulin binding protein 3 -0.0140786
COG5 component of oligomeric golgi complex 5 -0.0138173
NRG1 neuregulin 1 -0.013805
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0137326
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0136205
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0135665
ADD3 adducin 3 (gamma) -0.013472
TNNC1 troponin C type 1 (slow) -0.0133902
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0133317
SOD2 superoxide dismutase 2, mitochondrial -0.0132162
STK38L serine/threonine kinase 38 like -0.0132053
MBD5 methyl-CpG binding domain protein 5 -0.0130471
MEF2A myocyte enhancer factor 2A -0.0129673
KSR1 kinase suppressor of ras 1 -0.0128914
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0128823
EXT1 exostosin glycosyltransferase 1 -0.0128418
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0128389
GLIS3 GLIS family zinc finger 3 -0.0128371
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0127673
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0126636
RNF24 ring finger protein 24 -0.012586
CD109 CD109 molecule -0.0125518
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0125422
SOS2 son of sevenless homolog 2 (Drosophila) -0.0122056
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0120906
PDLIM5 PDZ and LIM domain 5 -0.0120792
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0120501
NF1 neurofibromin 1 -0.0117209
GREB1L growth regulation by estrogen in breast cancer-like -0.0116769
USP34 ubiquitin specific peptidase 34 -0.011667
EGFR epidermal growth factor receptor -0.011641
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0115734
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0114926
RAB1A RAB1A, member RAS oncogene family -0.0114918
MAML2 mastermind-like 2 (Drosophila) -0.0114396
SEC23A Sec23 homolog A (S. cerevisiae) -0.0112827
CALU calumenin -0.011169
UBE2H ubiquitin-conjugating enzyme E2H -0.0110242
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.011015
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0109427
TGM2 transglutaminase 2 -0.0109181
LRRC49 leucine rich repeat containing 49 -0.0108843
KIAA1328 KIAA1328 -0.0106852
IL1R1 interleukin 1 receptor, type I -0.0106601