| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Harringtonine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Harringtonine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.205203 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0768739 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0725402 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0671261 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0662027 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0489869 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0487041 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0455223 |
| SQSTM1 | sequestosome 1 | 0.0401503 |
| IL6 | interleukin 6 | 0.0372375 |
| EGR1 | early growth response 1 | 0.0359003 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0343144 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0335356 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0315783 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0312205 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0311038 |
| H1-0 | H1.0 linker histone | 0.031018 |
| JUN | jun proto-oncogene | 0.0294499 |
| KLF10 | Kruppel-like factor 10 | 0.027206 |
| UBC | ubiquitin C | 0.0271732 |
| KLF6 | Kruppel-like factor 6 | 0.0244302 |
| SDC4 | syndecan 4 | 0.0238164 |
| H3-3B | H3.3 histone B | 0.0233022 |
| MCL1 | myeloid cell leukemia 1 | 0.0224945 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0211003 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0204108 |
| ZFP36 | ZFP36 ring finger protein | 0.0201223 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0191904 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0191603 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0180605 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.017575 |
| AHR | aryl hydrocarbon receptor | 0.0175025 |
| SIRT1 | sirtuin 1 | 0.0172174 |
| IRF1 | interferon regulatory factor 1 | 0.0167208 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0158088 |
| FOSL1 | FOS-like antigen 1 | 0.0155595 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0154569 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0152387 |
| NOCT | nocturnin | 0.0146555 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0142108 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0141017 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.014051 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0136921 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0136415 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0134107 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0132652 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0131028 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0129959 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0129168 |
| DENND4A | DENN/MADD domain containing 4A | 0.0127965 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.0125642 |
| RASAL2 | RAS protein activator like 2 | 0.0124756 |
| PLK2 | polo-like kinase 2 | 0.0122963 |
| CCNL1 | cyclin L1 | 0.0122435 |
| SETX | senataxin | 0.0122244 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0120137 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0120082 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0119965 |
| BRD2 | bromodomain containing 2 | 0.0118996 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0118852 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0118205 |
| WTAP | Wilms tumor 1 associated protein | 0.0115091 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0113339 |
| PER1 | period circadian clock 1 | 0.0108732 |
| H1-2 | H1.2 linker histone, cluster member | 0.0108305 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0108038 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0107495 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0107454 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.0107397 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0105945 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0105939 |
| IER2 | immediate early response 2 | 0.0104795 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0103875 |
| CD83 | CD83 molecule | 0.0101627 |
| LIF | leukemia inhibitory factor | 0.0101364 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00994153 |
| H1-10 | H1.10 linker histone | 0.00988494 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.00985931 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.00985729 |
| HLA-A | major histocompatibility complex, class I, A | 0.00983555 |
| TES | testin LIM domain protein | 0.00968023 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.00966016 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00958829 |
| AFF4 | AF4/FMR2 family, member 4 | 0.00947015 |
| JAK1 | Janus kinase 1 | 0.00944301 |
| LMNA | lamin A/C | 0.00929356 |
| B2M | beta-2-microglobulin | 0.00919802 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.00919282 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00898725 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.00898271 |
| TPX2 | TPX2, microtubule-associated | 0.00897586 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.00879695 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00865182 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00864207 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00862658 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00854538 |
| HMOX1 | heme oxygenase 1 | 0.00849523 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00846258 |
| SON | SON DNA binding protein | 0.00843411 |
| RYBP | RING1 and YY1 binding protein | 0.00839811 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0999836 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0974599 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0679049 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.065218 |
| TMSB10 | thymosin beta 10 | -0.0649341 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0505462 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0485071 |
| GRAMD1B | GRAM domain containing 1B | -0.0484368 |
| FTL | ferritin, light polypeptide | -0.0375337 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0372543 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0334694 |
| PM20D1 | peptidase M20 domain containing 1 | -0.031321 |
| VIM | vimentin | -0.0309979 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0297225 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0295162 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0294921 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0268785 |
| ASPH | aspartate beta-hydroxylase | -0.0260403 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0251987 |
| CMIP | c-Maf inducing protein | -0.02417 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0220182 |
| PTMA | prothymosin, alpha | -0.0217786 |
| RPL19 | ribosomal protein L19 | -0.0214902 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0212841 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0203609 |
| STC1 | stanniocalcin 1 | -0.0199631 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0184215 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0175567 |
| RPLP1 | ribosomal protein, large, P1 | -0.017171 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.016178 |
| WWOX | WW domain containing oxidoreductase | -0.0159747 |
| RPS21 | ribosomal protein S21 | -0.0157975 |
| TPD52 | tumor protein D52 | -0.0155442 |
| RPS8 | ribosomal protein S8 | -0.015473 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0151424 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0148543 |
| BICC1 | BicC family RNA binding protein 1 | -0.0148358 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0144199 |
| GLG1 | golgi glycoprotein 1 | -0.014298 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0142755 |
| RAD51B | RAD51 paralog B | -0.0142657 |
| EFNA5 | ephrin-A5 | -0.0138451 |
| COG5 | component of oligomeric golgi complex 5 | -0.0137007 |
| FMNL2 | formin-like 2 | -0.0135956 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0131073 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0129041 |
| RPLP0 | ribosomal protein, large, P0 | -0.012875 |
| RPL35A | ribosomal protein L35a | -0.0128281 |
| GLIS3 | GLIS family zinc finger 3 | -0.0125735 |
| RPL23 | ribosomal protein L23 | -0.0125027 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0123317 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0122403 |
| CALU | calumenin | -0.0121749 |
| RPS19 | ribosomal protein S19 | -0.0121437 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0121407 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0121296 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0120524 |
| RPS6 | ribosomal protein S6 | -0.0119379 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0119149 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0118888 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0117402 |
| ACTG1 | actin gamma 1 | -0.011599 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0115907 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0115485 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0114316 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.011178 |
| RPL36 | ribosomal protein L36 | -0.0111496 |
| CFDP1 | craniofacial development protein 1 | -0.0111072 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0110988 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0110878 |
| RPS25 | ribosomal protein S25 | -0.0110868 |
| PDE8A | phosphodiesterase 8A | -0.0110662 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0110486 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0109256 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0108378 |
| OSMR | oncostatin M receptor | -0.0108274 |
| FGB | fibrinogen beta chain | -0.0107777 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0107308 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0105853 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0104736 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.010473 |
| RPS29 | ribosomal protein S29 | -0.0103962 |
| FLNB | filamin B, beta | -0.0103712 |
| NEGR1 | neuronal growth regulator 1 | -0.0102107 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0101677 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0101649 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0101321 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0101281 |
| NEBL | nebulette | -0.0101195 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0101151 |
| ERBIN | erbb2 interacting protein | -0.0100849 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.00999255 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0099878 |
| TBC1D5 | TBC1 domain family, member 5 | -0.00995099 |
| PYGL | phosphorylase, glycogen, liver | -0.00985831 |
| UTRN | utrophin | -0.0097552 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.00972894 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.00930131 |
| AK1 | adenylate kinase 1 | -0.00929566 |
| RPL37A | ribosomal protein L37a | -0.00928142 |
