Harringtonine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.117033
TXNRD1 thioredoxin reductase 1 0.106525
H1-0 H1.0 linker histone 0.0674342
TFPI2 tissue factor pathway inhibitor 2 0.0563017
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0553775
PRRC2C proline-rich coiled-coil 2C 0.0535914
GPHN gephyrin 0.0520606
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0515721
NIPBL Nipped-B homolog (Drosophila) 0.0502275
TRIO trio Rho guanine nucleotide exchange factor 0.0494549
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0480052
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0474466
SQSTM1 sequestosome 1 0.0470033
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0451548
ZFR zinc finger RNA binding protein 0.0449575
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0439335
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0433426
UBC ubiquitin C 0.0421505
OGA O-GlcNAcase 0.0407303
AHNAK AHNAK nucleoprotein 0.0398931
CREB5 cAMP responsive element binding protein 5 0.039658
EEF2 eukaryotic translation elongation factor 2 0.0390769
VIM vimentin 0.0386959
KDM3A lysine (K)-specific demethylase 3A 0.0386169
KLF6 Kruppel-like factor 6 0.035257
KLF10 Kruppel-like factor 10 0.0346473
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0342366
CAVIN1 caveolae associated protein 1 0.0342019
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0340843
CLTC clathrin, heavy chain (Hc) 0.0340442
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0339741
MKI67 marker of proliferation Ki-67 0.033389
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0326191
CENPF centromere protein F, 350/400kDa 0.0321544
SDC4 syndecan 4 0.03191
RSRC2 arginine/serine-rich coiled-coil 2 0.0312001
SPAG9 sperm associated antigen 9 0.0311667
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0311326
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0310234
LMNA lamin A/C 0.0309535
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0303116
BZW1 basic leucine zipper and W2 domains 1 0.030184
H3-3B H3.3 histone B 0.030011
SCAF11 SR-related CTD-associated factor 11 0.0299484
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0292696
JUN jun proto-oncogene 0.0288073
RSF1 remodeling and spacing factor 1 0.0286079
ANXA2 annexin A2 0.0285209
PPME1 protein phosphatase methylesterase 1 0.0283464
ANLN anillin, actin binding protein 0.0278497
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0278416
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0276815
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0274598
CAMTA1 calmodulin binding transcription activator 1 0.027388
PCLO piccolo presynaptic cytomatrix protein 0.0272368
LDHA lactate dehydrogenase A 0.0267671
AFF4 AF4/FMR2 family, member 4 0.026651
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.026437
EIF5B eukaryotic translation initiation factor 5B 0.026277
COL12A1 collagen, type XII, alpha 1 0.0262507
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0262054
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0261975
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0259882
BRIX1 BRX1, biogenesis of ribosomes 0.0258721
DST dystonin 0.0256748
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0255801
HDAC9 histone deacetylase 9 0.0255797
PCNX1 pecanex 1 0.0255583
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.025433
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0251239
IER3 immediate early response 3 0.0247228
IPO7 importin 7 0.0245266
KTN1 kinectin 1 (kinesin receptor) 0.0244219
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0244128
ZNF292 zinc finger protein 292 0.0242705
CCND2 cyclin D2 0.0242375
PHIP pleckstrin homology domain interacting protein 0.0241228
TASOR2 transcription activation suppressor family member 2 0.0238007
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0237843
GOLGA4 golgin A4 0.0236864
H1-10 H1.10 linker histone 0.0233054
RBM25 RNA binding motif protein 25 0.0230512
ARHGAP5 Rho GTPase activating protein 5 0.0228742
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0226811
ANXA5 annexin A5 0.0226572
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0226161
TNPO1 transportin 1 0.022165
ENO1 enolase 1, (alpha) 0.0220374
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0220155
RSL1D1 ribosomal L1 domain containing 1 0.0220095
TPX2 TPX2, microtubule-associated 0.0218319
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0216513
PREPL prolyl endopeptidase-like 0.0215852
MATR3 matrin 3 0.0215559
PLCB4 phospholipase C, beta 4 0.0214199
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0211435
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0210956
IL6ST interleukin 6 signal transducer 0.0210416
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0209983
TOP1 topoisomerase (DNA) I 0.0209832

decreased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0820285
THSD4 thrombospondin, type I, domain containing 4 -0.0774546
RAD51B RAD51 paralog B -0.0683291
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0576308
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0570731
GRAMD1B GRAM domain containing 1B -0.0554231
AKAP12 A kinase (PRKA) anchor protein 12 -0.0525601
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.041962
ZBTB20 zinc finger and BTB domain containing 20 -0.0416436
ATXN1 ataxin 1 -0.040084
AFF3 AF4/FMR2 family, member 3 -0.0400262
YBX3 Y box binding protein 3 -0.0350134
MCL1 myeloid cell leukemia 1 -0.0316139
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0315236
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0312924
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0311077
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0307498
VCL vinculin -0.0307102
HMGA2 high mobility group AT-hook 2 -0.0306762
DOCK5 dedicator of cytokinesis 5 -0.0303547
INTS6 integrator complex subunit 6 -0.0299826
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0297745
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.028584
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.028563
POTEF POTE ankyrin domain family, member F -0.0283677
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0279412
EXOC4 exocyst complex component 4 -0.0277607
TBC1D5 TBC1 domain family, member 5 -0.0273444
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0266933
SLC38A2 solute carrier family 38, member 2 -0.0265446
WNT2B wingless-type MMTV integration site family, member 2B -0.0262953
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0262518
BABAM2 BRISC and BRCA1 A complex member 2 -0.0261829
WWOX WW domain containing oxidoreductase -0.0259435
MBD5 methyl-CpG binding domain protein 5 -0.0257441
NABP1 nucleic acid binding protein 1 -0.0255007
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0246615
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0245679
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0238639
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0238108
NTSR1 neurotensin receptor 1 (high affinity) -0.0235751
PDE10A phosphodiesterase 10A -0.0231156
RABGAP1L RAB GTPase activating protein 1-like -0.0230475
EGFR epidermal growth factor receptor -0.0228219
TMSB10 thymosin beta 10 -0.0224086
RIMS2 regulating synaptic membrane exocytosis 2 -0.0223805
BCAS3 breast carcinoma amplified sequence 3 -0.0223356
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0217661
IGF1R insulin-like growth factor 1 receptor -0.021691
ATP11A ATPase, class VI, type 11A -0.0214593
VMP1 vacuole membrane protein 1 -0.02129
OSMR oncostatin M receptor -0.0205172
PYGL phosphorylase, glycogen, liver -0.0205142
RNF213 ring finger protein 213 -0.0203465
EXOC6B exocyst complex component 6B -0.020057
PRH1 proline-rich protein HaeIII subfamily 1 -0.0199577
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0198632
PDLIM5 PDZ and LIM domain 5 -0.0198235
SMYD3 SET and MYND domain containing 3 -0.0197309
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0191363
SPIDR scaffolding protein involved in DNA repair -0.0189604
TAPBP TAP binding protein (tapasin) -0.0188983
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0188476
ACTN1 actinin, alpha 1 -0.0184512
EHBP1 EH domain binding protein 1 -0.0183738
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0179682
SDK1 sidekick cell adhesion molecule 1 -0.0179024
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0178394
USP34 ubiquitin specific peptidase 34 -0.017761
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.017729
LPP LIM domain containing preferred translocation partner in lipoma -0.01757
ATG7 autophagy related 7 -0.0174859
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0171483
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0170512
KIAA1328 KIAA1328 -0.0168968
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.01684
BBS9 Bardet-Biedl syndrome 9 -0.0166828
ARB2A ARB2 cotranscriptional regulator A -0.0166482
RRM2 ribonucleotide reductase M2 -0.0166464
WWTR1 WW domain containing transcription regulator 1 -0.016634
PARD3 par-3 family cell polarity regulator -0.0166159
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0165241
CDK13 cyclin-dependent kinase 13 -0.0164925
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0164915
COPA coatomer protein complex, subunit alpha -0.0164422
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0162729
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0162447
PATJ PATJ crumbs cell polarity complex component -0.0162315
PRELID2 PRELI domain containing 2 -0.0162169
PTPRF protein tyrosine phosphatase, receptor type, F -0.0162074
TBC1D22A TBC1 domain family, member 22A -0.0162068
TNRC6B trinucleotide repeat containing 6B -0.0160557
RSU1 Ras suppressor protein 1 -0.0160286
AEBP2 AE binding protein 2 -0.0159845
FMNL2 formin-like 2 -0.0159117
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0155651
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0148782
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0148231
NEK10 NIMA-related kinase 10 -0.0148121
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0142604