Harringtonine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.206924
CXCL3 chemokine (C-X-C motif) ligand 3 0.190791
EGR1 early growth response 1 0.127152
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.10498
KLF10 Kruppel-like factor 10 0.0787798
CXCL2 chemokine (C-X-C motif) ligand 2 0.0763023
ZBTB10 zinc finger and BTB domain containing 10 0.0660595
CD83 CD83 molecule 0.0619948
SQSTM1 sequestosome 1 0.0498626
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0434947
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0427018
PLAU plasminogen activator, urokinase 0.0335271
JUN jun proto-oncogene 0.0325393
SDC4 syndecan 4 0.0319911
LOC102724023 ES1 protein homolog, mitochondrial 0.0318916
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0318067
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0316997
CENPF centromere protein F, 350/400kDa 0.0286182
BIRC3 baculoviral IAP repeat containing 3 0.0283034
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0278951
SPAG9 sperm associated antigen 9 0.0268323
FTL ferritin, light polypeptide 0.0243458
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0242566
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0240344
TFPI2 tissue factor pathway inhibitor 2 0.0232994
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0229993
BRD2 bromodomain containing 2 0.0224535
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0218673
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0218133
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0214982
ZFP36 ZFP36 ring finger protein 0.0206633
IRF1 interferon regulatory factor 1 0.0199863
GADD45B growth arrest and DNA-damage-inducible, beta 0.0198533
ATF3 activating transcription factor 3 0.0197735
CCNL1 cyclin L1 0.0196275
CENPE centromere protein E, 312kDa 0.0187114
HMGB2 high mobility group box 2 0.0184657
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0183672
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0179491
PRRC2C proline-rich coiled-coil 2C 0.0178637
SMC4 structural maintenance of chromosomes 4 0.0178599
DENND4A DENN/MADD domain containing 4A 0.017673
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0171134
CHD4 chromodomain helicase DNA binding protein 4 0.0167349
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0165721
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0159268
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0158627
RIPK2 receptor-interacting serine-threonine kinase 2 0.0156809
OXTR oxytocin receptor 0.0155018
IER2 immediate early response 2 0.0154516
IL6ST interleukin 6 signal transducer 0.0152098
MCL1 myeloid cell leukemia 1 0.0150228
RSRC2 arginine/serine-rich coiled-coil 2 0.0149425
RPS3 ribosomal protein S3 0.0144313
INSIG1 insulin induced gene 1 0.014008
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0136927
TRA2B transformer 2 beta homolog (Drosophila) 0.013691
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0135132
B2M beta-2-microglobulin 0.0135031
EPS8 epidermal growth factor receptor pathway substrate 8 0.0131673
RAD21 RAD21 homolog (S. pombe) 0.0127035
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0126017
MKI67 marker of proliferation Ki-67 0.0124871
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.0122869
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0122627
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0122521
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0122438
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0122362
GPBP1 GC-rich promoter binding protein 1 0.0120082
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0119701
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0118731
MIDEAS mitotic deacetylase associated SANT domain protein 0.0117861
PTMA prothymosin, alpha 0.0116695
NOCT nocturnin 0.0114956
RYBP RING1 and YY1 binding protein 0.0113122
FOSL1 FOS-like antigen 1 0.0112119
SFPQ splicing factor proline/glutamine-rich 0.0110128
ZNF292 zinc finger protein 292 0.0109656
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.0108476
AZIN1 antizyme inhibitor 1 0.0108413
GAS2L3 growth arrest-specific 2 like 3 0.0108109
PER1 period circadian clock 1 0.010675
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.0105124
CSF1 colony stimulating factor 1 (macrophage) 0.0104954
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0103675
FSCN1 fascin actin-bundling protein 1 0.0103136
KDM6B lysine (K)-specific demethylase 6B 0.0103088
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.00984852
IFRD1 interferon-related developmental regulator 1 0.00974476
POTEF POTE ankyrin domain family, member F 0.00973922
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.00970735
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00962996
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00940398
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00937362
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.00926741
TEX14 testis expressed 14 0.00907266
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.00906651
CYLD cylindromatosis (turban tumor syndrome) 0.0088727
BCL9L B-cell CLL/lymphoma 9-like 0.00881404
APLP2 amyloid beta (A4) precursor-like protein 2 0.00861875

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.0722071
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0452085
LPP LIM domain containing preferred translocation partner in lipoma -0.0446074
UBC ubiquitin C -0.0426158
LIMCH1 LIM and calponin homology domains 1 -0.039753
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0389815
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0389204
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0366205
BHLHE40 basic helix-loop-helix family, member e40 -0.0355871
TXNRD1 thioredoxin reductase 1 -0.0355197
NDRG1 N-myc downstream regulated 1 -0.0354106
TRIO trio Rho guanine nucleotide exchange factor -0.0329622
AHNAK AHNAK nucleoprotein -0.0326105
SAMD4A sterile alpha motif domain containing 4A -0.0318489
FBXO32 F-box protein 32 -0.0316043
EFNA5 ephrin-A5 -0.0293982
FNDC3B fibronectin type III domain containing 3B -0.029275
IGFBP3 insulin-like growth factor binding protein 3 -0.0274142
EXT1 exostosin glycosyltransferase 1 -0.0252892
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0249639
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0248658
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0243644
FAM13A family with sequence similarity 13, member A -0.0240501
PTK2 protein tyrosine kinase 2 -0.0237454
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0231762
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0227079
GRB10 growth factor receptor-bound protein 10 -0.0218957
NPEPPS aminopeptidase puromycin sensitive -0.0208079
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0201017
DTNA dystrobrevin, alpha -0.0200595
ARRDC3 arrestin domain containing 3 -0.0198832
RNF213 ring finger protein 213 -0.0197224
LDHA lactate dehydrogenase A -0.0195396
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0194125
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0191687
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0189854
LMO7 LIM domain 7 -0.0188014
MYO6 myosin VI -0.0187871
RCOR1 REST corepressor 1 -0.018755
FTH1 ferritin, heavy polypeptide 1 -0.018617
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0186057
SBF2 SET binding factor 2 -0.018132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0180164
ERBIN erbb2 interacting protein -0.0177455
ITCH itchy E3 ubiquitin protein ligase -0.0176256
PLSCR1 phospholipid scramblase 1 -0.0175886
MAP4 microtubule-associated protein 4 -0.0175521
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0172733
DST dystonin -0.0170614
RAI14 retinoic acid induced 14 -0.0163971
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0160736
DSPP dentin sialophosphoprotein -0.0157629
IFI16 interferon, gamma-inducible protein 16 -0.0157361
CD2AP CD2-associated protein -0.0155451
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0155375
TMEM165 transmembrane protein 165 -0.0154905
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0153152
MX1 MX dynamin-like GTPase 1 -0.0152432
TMSB4X thymosin beta 4, X-linked -0.0151287
SEC31A SEC31 homolog A (S. cerevisiae) -0.0150895
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0149216
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0148894
ENO1 enolase 1, (alpha) -0.0147801
MAP1B microtubule-associated protein 1B -0.0146464
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0146044
ETV6 ets variant 6 -0.0145342
UBE2H ubiquitin-conjugating enzyme E2H -0.0144031
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0143166
ZBTB20 zinc finger and BTB domain containing 20 -0.0140825
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.013947
VEGFA vascular endothelial growth factor A -0.0138783
TPT1 tumor protein, translationally-controlled 1 -0.0137848
CD47 CD47 molecule -0.013779
PDLIM5 PDZ and LIM domain 5 -0.0137288
NF1 neurofibromin 1 -0.0136694
PGK1 phosphoglycerate kinase 1 -0.0136456
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0134663
CD44 CD44 molecule (Indian blood group) -0.0134075
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.013251
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0131408
SAMD9 sterile alpha motif domain containing 9 -0.0130264
SOX4 SRY (sex determining region Y)-box 4 -0.0129657
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0128788
WSB1 WD repeat and SOCS box containing 1 -0.0128463
IFIH1 interferon induced with helicase C domain 1 -0.0127673
MYO1E myosin IE -0.0127402
FBXO34 F-box protein 34 -0.0127312
APOL6 apolipoprotein L, 6 -0.0127285
ATXN1 ataxin 1 -0.0127164
FAM3C family with sequence similarity 3, member C -0.0126791
BBX bobby sox homolog (Drosophila) -0.0125554
STRN3 striatin, calmodulin binding protein 3 -0.0124923
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0124804
SMAD3 SMAD family member 3 -0.0124619
YEATS2 YEATS domain containing 2 -0.0124616
RAB6A RAB6A, member RAS oncogene family -0.0124504
COPA coatomer protein complex, subunit alpha -0.0124431
NRIP1 nuclear receptor interacting protein 1 -0.0124217
RUNX1 runt-related transcription factor 1 -0.0123387
PATJ PATJ crumbs cell polarity complex component -0.012321