Head and neck squamous cell carcinoma Gene Set

Dataset WikiPathways Pathways 2024
Category structural or functional annotations
Type pathway
Description A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands.|A carcinoma of any tissue within the head and neck region. (Experimental Factor Ontology, EFO_0000181)
External Link https://www.wikipathways.org/pathways/WP4674.html
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Genes

73 proteins participating in the Head and neck squamous cell carcinoma pathway from the WikiPathways Pathways 2024 dataset.

Symbol Name
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
BIRC2 baculoviral IAP repeat containing 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CSMD3 CUB and Sushi multiple domains 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
DDIT4 DNA-damage-inducible transcript 4
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FADD Fas (TNFRSF6)-associated via death domain
FAT1 FAT atypical cadherin 1
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
GAB1 GRB2-associated binding protein 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1R insulin-like growth factor 1 receptor
IRF6 interferon regulatory factor 6
KEAP1 kelch-like ECH-associated protein 1
KRAS Kirsten rat sarcoma viral oncogene homolog
MAML1 mastermind-like 1 (Drosophila)
MAPKAP1 mitogen-activated protein kinase associated protein 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOTCH1 notch 1
NOTCH2 notch 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUMB numb homolog (Drosophila)
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6 ribosomal protein S6
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
SESN1 sestrin 1
SESN2 sestrin 2
SMAD4 SMAD family member 4
STK11 serine/threonine kinase 11
TERT telomerase reverse transcriptase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TP53 tumor protein p53
TP63 tumor protein p63
TRAF3 TNF receptor-associated factor 3
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
VEGFA vascular endothelial growth factor A