Heavy Metal Toxicity Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:C535854
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Genes

193 genes/proteins associated with the disease Heavy Metal Toxicity from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KDM3B lysine (K)-specific demethylase 3B 2.88009
CAT catalase 1.86991
GSR glutathione reductase 1.86907
APP amyloid beta (A4) precursor protein 1.82011
HMOX1 heme oxygenase 1 1.78033
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.68889
NOS2 nitric oxide synthase 2, inducible 1.67029
ZFP36 ZFP36 ring finger protein 1.61318
ALAD aminolevulinate dehydratase 1.60105
HSPA1A heat shock 70kDa protein 1A 1.57688
TP53 tumor protein p53 1.57498
TNF tumor necrosis factor 1.55353
GSTM3 glutathione S-transferase mu 3 (brain) 1.53159
SOD1 superoxide dismutase 1, soluble 1.51708
CXCL2 chemokine (C-X-C motif) ligand 2 1.51683
CCL2 chemokine (C-C motif) ligand 2 1.50751
IL1B interleukin 1, beta 1.5065
ICAM1 intercellular adhesion molecule 1 1.50448
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.49457
DUSP1 dual specificity phosphatase 1 1.45089
BAX BCL2-associated X protein 1.45036
IGF1 insulin-like growth factor 1 (somatomedin C) 1.44982
DDIT3 DNA-damage-inducible transcript 3 1.44409
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.44273
ADM adrenomedullin 1.42562
IFNG interferon, gamma 1.41202
BCL2 B-cell CLL/lymphoma 2 1.4098
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.4026
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.3998
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.39451
PTX3 pentraxin 3, long 1.38946
MAPK3 mitogen-activated protein kinase 3 1.37475
GADD45A growth arrest and DNA-damage-inducible, alpha 1.36876
NFE2L2 nuclear factor, erythroid 2-like 2 1.36848
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.3556
MT2A metallothionein 2A 1.35213
LTF lactotransferrin 1.34459
RAD18 RAD18 E3 ubiquitin protein ligase 1.33523
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.33464
CD36 CD36 molecule (thrombospondin receptor) 1.32876
MPO myeloperoxidase 1.31596
TFRC transferrin receptor 1.31536
SOD2 superoxide dismutase 2, mitochondrial 1.30881
GSTA1 glutathione S-transferase alpha 1 1.29626
LOX lysyl oxidase 1.28919
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 1.28241
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.28027
TXNRD1 thioredoxin reductase 1 1.27502
GAS1 growth arrest-specific 1 1.26917
GPX2 glutathione peroxidase 2 1.26856
FOS FBJ murine osteosarcoma viral oncogene homolog 1.26669
GADD45B growth arrest and DNA-damage-inducible, beta 1.2599
FTH1 ferritin, heavy polypeptide 1 1.2599
CXCL8 chemokine (C-X-C motif) ligand 8 1.25682
GPX1 glutathione peroxidase 1 1.25369
ANXA1 annexin A1 1.25121
IL10 interleukin 10 1.2509
MAPK1 mitogen-activated protein kinase 1 1.24655
IL6 interleukin 6 1.24338
MAOA monoamine oxidase A 1.2415
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.24024
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.23743
SCD5 stearoyl-CoA desaturase 5 1.2368
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.23616
HSPA1L heat shock 70kDa protein 1-like 1.22916
SLPI secretory leukocyte peptidase inhibitor 1.22853
LCN2 lipocalin 2 1.22821
TF transferrin 1.22048
CD44 CD44 molecule (Indian blood group) 1.21919
ALB albumin 1.21887
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.21663
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 1.21239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.21206
SYT7 synaptotagmin VII 1.21206
NQO1 NAD(P)H dehydrogenase, quinone 1 1.21173
VCAM1 vascular cell adhesion molecule 1 1.20784
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.20687
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.19246
SPHK1 sphingosine kinase 1 1.18554
FAS Fas cell surface death receptor 1.18521
JUN jun proto-oncogene 1.18159
HAMP hepcidin antimicrobial peptide 1.18126
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.17926
BHMT betaine--homocysteine S-methyltransferase 1.17728
ACO1 aconitase 1, soluble 1.1753
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.17497
HSPA8 heat shock 70kDa protein 8 1.17431
PTH parathyroid hormone 1.173
NFIL3 nuclear factor, interleukin 3 regulated 1.173
HADH hydroxyacyl-CoA dehydrogenase 1.17101
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.169
CDC42 cell division cycle 42 1.169
PON1 paraoxonase 1 1.16799
G6PD glucose-6-phosphate dehydrogenase 1.167
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.16533
ACO2 aconitase 2, mitochondrial 1.16137
CLU clusterin 1.1607
IL4 interleukin 4 1.15122
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.1485
ACHE acetylcholinesterase (Yt blood group) 1.14575
CRYAA crystallin, alpha A 1.14336
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.14234
FTL ferritin, light polypeptide 1.13929
B2M beta-2-microglobulin 1.13895
ARG2 arginase 2 1.13862
PRDX6 peroxiredoxin 6 1.13689
RBM25 RNA binding motif protein 25 1.13552
CCNE1 cyclin E1 1.13109
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.12703
CCNA2 cyclin A2 1.12391
PDIA3 protein disulfide isomerase family A, member 3 1.12323
CTH cystathionine gamma-lyase 1.12151
GCLM glutamate-cysteine ligase, modifier subunit 1.11877
HJURP Holliday junction recognition protein 1.11466
PRNP prion protein 1.1129
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.11186
UBE2D2 ubiquitin-conjugating enzyme E2D 2 1.11151
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.10838
DTYMK deoxythymidylate kinase (thymidylate kinase) 1.10769
RSRP1 arginine/serine-rich protein 1 1.10353
CALR calreticulin 1.10282
HSPH1 heat shock 105kDa/110kDa protein 1 1.1014
FGF1 fibroblast growth factor 1 (acidic) 1.10104
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.09751
S100A8 S100 calcium binding protein A8 1.09681
CCL5 chemokine (C-C motif) ligand 5 1.09436
STEAP4 STEAP family member 4 1.09119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.08868
DUSP6 dual specificity phosphatase 6 1.08655
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.08372
COX2 1.08337
IER3 immediate early response 3 1.08055
DMBT1 deleted in malignant brain tumors 1 1.07983
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.07947
SPP1 secreted phosphoprotein 1 1.07875
SRXN1 sulfiredoxin 1 1.07804
MMP9 matrix metallopeptidase 9 1.07768
BOK BCL2-related ovarian killer 1.0734
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.07128
HSPA1B heat shock 70kDa protein 1B 1.07022
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.06734
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.06188
CRYAB crystallin, alpha B 1.06152
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 1.05828
RBM3 RNA binding motif (RNP1, RRM) protein 3 1.05685
E2F1 E2F transcription factor 1 1.05685
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.05386
SP1 Sp1 transcription factor 1.05312
ITGB5 integrin, beta 5 1.04831
CD14 CD14 molecule 1.04684
KRT5 keratin 5, type II 1.04538
SULF2 sulfatase 2 1.04501
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.04352
FABP4 fatty acid binding protein 4, adipocyte 1.04314
GSTM1 glutathione S-transferase mu 1 1.04276
RSAD2 radical S-adenosyl methionine domain containing 2 1.04201
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.04163
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 1.04163
SQSTM1 sequestosome 1 1.03939
GEM GTP binding protein overexpressed in skeletal muscle 1.03939
VEGFA vascular endothelial growth factor A 1.03901
NLRC4 NLR family, CARD domain containing 4 1.03789
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.03678
INHBB inhibin, beta B 1.03641
PNP purine nucleoside phosphorylase 1.03641
GCLC glutamate-cysteine ligase, catalytic subunit 1.0353
CCND1 cyclin D1 1.03456
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.03456
TPX2 TPX2, microtubule-associated 1.03419
CP ceruloplasmin (ferroxidase) 1.03382
TACC3 transforming, acidic coiled-coil containing protein 3 1.03345
CDC14A cell division cycle 14A 1.03159
MGST2 microsomal glutathione S-transferase 2 1.03159
HIST1H1C histone cluster 1, H1c 1.03159
EGR1 early growth response 1 1.03046
F2 coagulation factor II (thrombin) 1.02783
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.02708
IL1A interleukin 1, alpha 1.02671
LRP1 low density lipoprotein receptor-related protein 1 1.02634
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.02596
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.02262
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.02077
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 1.02003
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.02003
EDN1 endothelin 1 1.01966
ECI1 enoyl-CoA delta isomerase 1 1.0189
CCL4 chemokine (C-C motif) ligand 4 1.01776
EXO1 exonuclease 1 1.01663
POU5F1 POU class 5 homeobox 1 1.01286
CANX calnexin 1.01286
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 1.01249
MEF2C myocyte enhancer factor 2C 1.01249
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.01025