Hellp Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count. (Human Disease Ontology, DOID_13133)
External Link https://www.disgenet.org/browser/0/1/0/C0162739
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Genes

75 genes associated with the disease Hellp Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTB actin, beta
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AHSP alpha hemoglobin stabilizing protein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
APC adenomatous polyposis coli
CA9 carbonic anhydrase IX
CD40LG CD40 ligand
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFH complement factor H
CFI complement factor I
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
EBI3 Epstein-Barr virus induced 3
ENG endoglin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERVW-1 endogenous retrovirus group W, member 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FLT1 fms-related tyrosine kinase 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAP2 GRB2-related adaptor protein 2
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HPGDS hematopoietic prostaglandin D synthase
HSPA4 heat shock 70kDa protein 4
HSPG2 heparan sulfate proteoglycan 2
IFNG interferon, gamma
IL10 interleukin 10
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
LEP leptin
LEPR leptin receptor
LGALS13 lectin, galactoside-binding, soluble, 13
LNPEP leucyl/cystinyl aminopeptidase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAEP progestagen-associated endometrial protein
PAH phenylalanine hydroxylase
PGF placental growth factor
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POTEF POTE ankyrin domain family, member F
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT4 sirtuin 4
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
TFPI2 tissue factor pathway inhibitor 2
TGFB3 transforming growth factor, beta 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TPBG trophoblast glycoprotein
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor