Hemangioblastoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

362 genes co-occuring with the disease Hemangioblastoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 3.332
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 3.035
EPAS1 endothelial PAS domain protein 1 3.018
MEN1 multiple endocrine neoplasia I 2.943
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.939
NF1 neurofibromin 1 2.934
ELOC elongin C 2.909
TMEM127 transmembrane protein 127 2.902
ELOB elongin B 2.837
CUL2 cullin 2 2.787
SDHAF2 succinate dehydrogenase complex assembly factor 2 2.693
RET ret proto-oncogene 2.692
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.658
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.567
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.538
EGLN1 egl-9 family hypoxia-inducible factor 1 2.515
EIF5B eukaryotic translation initiation factor 5B 2.487
CHGA chromogranin A 2.48
ENO2 enolase 2 (gamma, neuronal) 2.451
VHLL von Hippel-Lindau tumor suppressor-like 2.402
CA9 carbonic anhydrase IX 2.398
SYP synaptophysin 2.392
ARNT aryl hydrocarbon receptor nuclear translocator 2.376
TSC2 tuberous sclerosis 2 2.365
FLCN folliculin 2.329
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.324
SST somatostatin 2.321
FH fumarate hydratase 2.32
EPO erythropoietin 2.309
EGLN2 egl-9 family hypoxia-inducible factor 2 2.26
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.22
EGLN3 egl-9 family hypoxia-inducible factor 3 2.198
TP53 tumor protein p53 2.145
NF2 neurofibromin 2 (merlin) 2.121
PBRM1 polybromo 1 2.118
CD34 CD34 molecule 2.112
ATRX alpha thalassemia/mental retardation syndrome X-linked 2.109
PAX8 paired box 8 2.101
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.097
HIF3A hypoxia inducible factor 3, alpha subunit 2.089
GAST gastrin 2.073
KIF1B kinesin family member 1B 2.07
TCHP trichoplein, keratin filament binding 2.059
MAX MYC associated factor X 2.058
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 2.042
PTEN phosphatase and tensin homolog 2.014
PPY pancreatic polypeptide 2.013
DAXX death-domain associated protein 2.012
SETD2 SET domain containing 2 2.007
VIP vasoactive intestinal peptide 2.001
PECAM1 platelet/endothelial cell adhesion molecule 1 1.998
PNMT phenylethanolamine N-methyltransferase 1.995
TGFA transforming growth factor, alpha 1.98
MME membrane metallo-endopeptidase 1.975
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 1.931
JADE1 jade family PHD finger 1 1.923
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1.911
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.896
SSTR2 somatostatin receptor 2 1.89
TFE3 transcription factor binding to IGHM enhancer 3 1.879
KDR kinase insert domain receptor 1.866
KRT7 keratin 7, type II 1.864
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.861
PAX2 paired box 2 1.858
TSC1 tuberous sclerosis 1 1.855
GCG glucagon 1.849
CDKN2A cyclin-dependent kinase inhibitor 2A 1.847
BRCA1 breast cancer 1, early onset 1.837
PDPN podoplanin 1.836
GFAP glial fibrillary acidic protein 1.827
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.827
SLC49A4 solute carrier family 49 member 4 1.827
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 1.819
EGFR epidermal growth factor receptor 1.815
EPOR erythropoietin receptor 1.806
BRCA2 breast cancer 2, early onset 1.795
FLT1 fms-related tyrosine kinase 1 1.792
CSDE1 cold shock domain containing E1, RNA-binding 1.767
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.767
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.764
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.755
USP33 ubiquitin specific peptidase 33 1.749
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.734
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.728
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.725
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.724
MUTYH mutY homolog 1.722
POMC proopiomelanocortin 1.721
KDM5C lysine (K)-specific demethylase 5C 1.705
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.691
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.675
HRAS Harvey rat sarcoma viral oncogene homolog 1.67
NCAM1 neural cell adhesion molecule 1 1.665
FNIP1 folliculin interacting protein 1 1.662
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 1.661
AQP1 aquaporin 1 (Colton blood group) 1.648
INS insulin 1.635
KRAS Kirsten rat sarcoma viral oncogene homolog 1.633
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.629
CHEK2 checkpoint kinase 2 1.628
STK11 serine/threonine kinase 11 1.604
MET MET proto-oncogene, receptor tyrosine kinase 1.598
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.587
AMACR alpha-methylacyl-CoA racemase 1.584
SDHAF1 succinate dehydrogenase complex assembly factor 1 1.582
SSTR5 somatostatin receptor 5 1.58
VBP1 von Hippel-Lindau binding protein 1 1.57
MLH1 mutL homolog 1 1.57
CCND1 cyclin D1 1.553
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.551
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 1.547
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 1.539
MSH2 mutS homolog 2 1.532
CA12 carbonic anhydrase XII 1.525
MGMT O-6-methylguanine-DNA methyltransferase 1.523
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.522
USP20 ubiquitin specific peptidase 20 1.52
FNIP2 folliculin interacting protein 2 1.516
NEK8 NIMA-related kinase 8 1.512
ATM ATM serine/threonine kinase 1.51
IFNA17 interferon, alpha 17 1.496
KIAA1549 KIAA1549 1.493
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.485
MAML3 mastermind-like 3 (Drosophila) 1.483
IFNA1 interferon, alpha 1 1.483
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.482
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.474
EP300 E1A binding protein p300 1.468
IFNA10 interferon, alpha 10 1.465
IFNA7 interferon, alpha 7 1.465
IFNA14 interferon, alpha 14 1.465
IFNA16 interferon, alpha 16 1.465
IFNA8 interferon, alpha 8 1.464
IFNA6 interferon, alpha 6 1.464
IFNA21 interferon, alpha 21 1.464
IFNA2 interferon, alpha 2 1.463
IFNA5 interferon, alpha 5 1.463
IFNA13 interferon, alpha 13 1.462
FN1 fibronectin 1 1.462
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.46
IFNA4 interferon, alpha 4 1.459
TERT telomerase reverse transcriptase 1.458
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.457
SCT secretin 1.45
MSH6 mutS homolog 6 1.447
OFD1 oral-facial-digital syndrome 1 1.444
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.436
SMAD4 SMAD family member 4 1.431
GNAS GNAS complex locus 1.43
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.43
PGF placental growth factor 1.428
FGFR1 fibroblast growth factor receptor 1 1.426
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.422
H3-3B H3.3 histone B 1.412
CXCR4 chemokine (C-X-C motif) receptor 4 1.411
KRT8 keratin 8, type II 1.411
RWDD3 RWD domain containing 3 1.41
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.406
GHRH growth hormone releasing hormone 1.406
SHH sonic hedgehog 1.402
WT1 Wilms tumor 1 1.396
FLT4 fms-related tyrosine kinase 4 1.395
TBXT T-box transcription factor T 1.389
SSTR1 somatostatin receptor 1 1.386
CD99 CD99 molecule 1.386
OLIG2 oligodendrocyte lineage transcription factor 2 1.384
IL2 interleukin 2 1.381
PDGFB platelet-derived growth factor beta polypeptide 1.381
KRT20 keratin 20, type I 1.38
PKD1 polycystic kidney disease 1 (autosomal dominant) 1.376
KDM6A lysine (K)-specific demethylase 6A 1.373
PALB2 partner and localizer of BRCA2 1.372
TGFB1 transforming growth factor, beta 1 1.368
ERBB2 erb-b2 receptor tyrosine kinase 2 1.365
ELOA2 elongin A2 1.363
BPGM 2,3-bisphosphoglycerate mutase 1.361
CD99L2 CD99 molecule-like 2 1.359
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.342
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.341
PKD2 polycystic kidney disease 2 (autosomal dominant) 1.338
REN renin 1.334
NEK9 NIMA-related kinase 9 1.333
CDK4 cyclin-dependent kinase 4 1.333
EGF epidermal growth factor 1.329
IGF2 insulin-like growth factor 2 1.328
KIF3A kinesin family member 3A 1.327
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.326
SKP1 S-phase kinase-associated protein 1 1.321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.32
CUL1 cullin 1 1.32
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.318
CD274 CD274 molecule 1.316
ZNF814 zinc finger protein 814 1.316
SSTR3 somatostatin receptor 3 1.316
FHIT fragile histidine triad 1.315
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.311
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.31
H3-3A H3.3 histone A 1.31
PTCH1 patched 1 1.309
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.302
TFEB transcription factor EB 1.298
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.297
NPHP1 nephronophthisis 1 (juvenile) 1.293
PGR progesterone receptor 1.292
IGF1 insulin-like growth factor 1 (somatomedin C) 1.282
FGF2 fibroblast growth factor 2 (basic) 1.282
MITF microphthalmia-associated transcription factor 1.279
CA14 carbonic anhydrase XIV 1.278
CDC73 cell division cycle 73 1.273
ZHX2 zinc fingers and homeoboxes 2 1.269
TEK TEK tyrosine kinase, endothelial 1.268
CUL5 cullin 5 1.262
JAK2 Janus kinase 2 1.262
LDHA lactate dehydrogenase A 1.26
PXDN peroxidasin 1.258
BCL2 B-cell CLL/lymphoma 2 1.257
PXDNL peroxidasin-like 1.254
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.253
TH tyrosine hydroxylase 1.253
PGK1 phosphoglycerate kinase 1 1.249
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.247
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.245
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.241
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.24
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.239
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.236
INVS inversin 1.233
MAPKBP1 mitogen-activated protein kinase binding protein 1 1.233
EPHB4 EPH receptor B4 1.232
PTH parathyroid hormone 1.231
H3C12 H3 clustered histone 12 1.23
AXL AXL receptor tyrosine kinase 1.229
SOX10 SRY (sex determining region Y)-box 10 1.226
RHEB Ras homolog enriched in brain 1.224
KRT19 keratin 19, type I 1.224
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 1.219
USP8 ubiquitin specific peptidase 8 1.218
ACTB actin, beta 1.211
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.202
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.201
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.201
UBE2S ubiquitin-conjugating enzyme E2S 1.201
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 1.194
DICER1 dicer 1, ribonuclease type III 1.194
ALB albumin 1.193
CD68 CD68 molecule 1.193
ELOA elongin A 1.19
CALB2 calbindin 2 1.189
CEP68 centrosomal protein 68kDa 1.189
CHGB chromogranin B 1.188
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 1.185
SSTR4 somatostatin receptor 4 1.181
GCGR glucagon receptor 1.18
CCM2 cerebral cavernous malformation 2 1.175
FLT3 fms-related tyrosine kinase 3 1.175
CDK6 cyclin-dependent kinase 6 1.171
HNF1B HNF1 homeobox B 1.17
H3-5 H3.5 histone 1.169
EWSR1 EWS RNA-binding protein 1 1.168
CUL3 cullin 3 1.168
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.167
CA5A carbonic anhydrase VA, mitochondrial 1.166
RPTOR regulatory associated protein of MTOR, complex 1 1.163
H3C13 H3 clustered histone 13 1.161
PKM pyruvate kinase, muscle 1.16
H3-4 H3.4 histone, cluster member 1.16
PRL prolactin 1.158
KMT2C lysine (K)-specific methyltransferase 2C 1.157
EFNB2 ephrin-B2 1.156
PARP1 poly (ADP-ribose) polymerase 1 1.153
ADRB2 adrenoceptor beta 2, surface 1.151
KMT2D lysine (K)-specific methyltransferase 2D 1.15
CA7 carbonic anhydrase VII 1.145
FGF4 fibroblast growth factor 4 1.141
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1.14
POU5F1 POU class 5 homeobox 1 1.138
LOX lysyl oxidase 1.136
INSM1 insulinoma-associated 1 1.133
SFMBT1 Scm-like with four mbt domains 1 1.132
FGFR3 fibroblast growth factor receptor 3 1.132
FGF6 fibroblast growth factor 6 1.132
FGF17 fibroblast growth factor 17 1.127
FGF18 fibroblast growth factor 18 1.124
FGF5 fibroblast growth factor 5 1.124
UMOD uromodulin 1.122
CDKN3 cyclin-dependent kinase inhibitor 3 1.121
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.12
FGF3 fibroblast growth factor 3 1.119
PDCD10 programmed cell death 10 1.118
FGF20 fibroblast growth factor 20 1.118
NPHP3 nephronophthisis 3 (adolescent) 1.117
FGF10 fibroblast growth factor 10 1.115
THRB thyroid hormone receptor, beta 1.114
FGF22 fibroblast growth factor 22 1.111
FGF16 fibroblast growth factor 16 1.11
HOXD11 homeobox D11 1.109
BARD1 BRCA1 associated RING domain 1 1.108
GATA3 GATA binding protein 3 1.108
ALK anaplastic lymphoma receptor tyrosine kinase 1.108
SUFU suppressor of fused homolog (Drosophila) 1.101
FANCD2 Fanconi anemia, complementation group D2 1.101
BBS4 Bardet-Biedl syndrome 4 1.1
DAPK1 death-associated protein kinase 1 1.099
FGF8 fibroblast growth factor 8 (androgen-induced) 1.098
MXD1 MAX dimerization protein 1 1.096
ESR1 estrogen receptor 1 1.095
JUN jun proto-oncogene 1.092
KRIT1 KRIT1, ankyrin repeat containing 1.092
FGF9 fibroblast growth factor 9 1.092
DEPDC5 DEP domain containing 5 1.091
FGF7 fibroblast growth factor 7 1.091
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.09
DDB1 damage-specific DNA binding protein 1, 127kDa 1.089
RARB retinoic acid receptor, beta 1.087
AFP alpha-fetoprotein 1.085
PTHLH parathyroid hormone-like hormone 1.083
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.08
NKX2-1 NK2 homeobox 1 1.079
CD44 CD44 molecule (Indian blood group) 1.079
ARID1A AT rich interactive domain 1A (SWI-like) 1.077
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.076
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.075
VIM vimentin 1.071
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 1.069
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.065
CXCL12 chemokine (C-X-C motif) ligand 12 1.064
PROM1 prominin 1 1.062
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 1.062
NES nestin 1.06
UBE3A ubiquitin protein ligase E3A 1.057
EZR ezrin 1.057
GPR101 G protein-coupled receptor 101 1.052
TMEM67 transmembrane protein 67 1.051
MN1 meningioma (disrupted in balanced translocation) 1 1.051
AIP aryl hydrocarbon receptor interacting protein 1.048
CA2 carbonic anhydrase II 1.047
RNF139 ring finger protein 139 1.045
CDH13 cadherin 13 1.043
NDRG3 NDRG family member 3 1.042
GLI1 GLI family zinc finger 1 1.042
CLN5 ceroid-lipofuscinosis, neuronal 5 1.041
SLC16A4 solute carrier family 16, member 4 1.04
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.036
UBR1 ubiquitin protein ligase E3 component n-recognin 1 1.036
NTS neurotensin 1.036
CDX2 caudal type homeobox 2 1.033
MARCHF6 membrane associated ring-CH-type finger 6 1.033
CUL7 cullin 7 1.029
MAPK3 mitogen-activated protein kinase 3 1.023
RB1 retinoblastoma 1 1.021
GANAB glucosidase, alpha; neutral AB 1.02
CA5B carbonic anhydrase VB, mitochondrial 1.02
IL6 interleukin 6 1.018
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.016
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.015
CISH cytokine inducible SH2-containing protein 1.013
ZUP1 zinc finger containing ubiquitin peptidase 1 1.006
MMP9 matrix metallopeptidase 9 1.005
CDK2 cyclin-dependent kinase 2 1.004
EPCAM epithelial cell adhesion molecule 1.001
MUC1 mucin 1, cell surface associated 1.0
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 1.0