Hematopoietic stem cell differentiation Gene Set

Dataset WikiPathways Pathways 2024
Category structural or functional annotations
Type pathway
Description The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. (Gene Ontology, GO_0060218)
External Link https://www.wikipathways.org/pathways/WP2849.html
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Genes

55 proteins participating in the Hematopoietic stem cell differentiation pathway from the WikiPathways Pathways 2024 dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACVR1B activin A receptor, type IB
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CD34 CD34 molecule
CIITA class II, major histocompatibility complex, transactivator
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CXCR4 chemokine (C-X-C motif) receptor 4
EPO erythropoietin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GP9 glycoprotein IX (platelet)
GYPA glycophorin A (MNS blood group)
HES6 hes family bHLH transcription factor 6
HMGN5 high mobility group nucleosome binding domain 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL3 interleukin 3
IL5 interleukin 5
IL6 interleukin 6
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KITLG KIT ligand
KLF1 Kruppel-like factor 1 (erythroid)
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NCKAP1L NCK-associated protein 1-like
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2 nuclear factor, erythroid 2
NOTCH1 notch 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
RHOH ras homolog family member H
RIOK3 RIO kinase 3
RUNX1 runt-related transcription factor 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SPI1 Spi-1 proto-oncogene
STAT5A signal transducer and activator of transcription 5A
THRB thyroid hormone receptor, beta
TNXB tenascin XB
TPO thyroid peroxidase
TRAF3IP3 TRAF3 interacting protein 3
TRIM29 tripartite motif containing 29
VAV1 vav 1 guanine nucleotide exchange factor
ZNF835 zinc finger protein 835