Hemochromatosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A metal metabolism disorder characterized by the accumulation of iron in various organs of the body. (Human Disease Ontology, DOID_2352)
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Genes

683 genes co-occuring with the disease Hemochromatosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HFE hemochromatosis 4.0
HAMP hepcidin antimicrobial peptide 3.927
HJV hemojuvelin BMP co-receptor 3.883
TFR2 transferrin receptor 2 3.844
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 3.528
TFRC transferrin receptor 3.366
TMPRSS6 transmembrane protease, serine 6 3.311
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 3.253
BMP6 bone morphogenetic protein 6 3.045
CYBRD1 cytochrome b reductase 1 3.041
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.85
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.76
IREB2 iron-responsive element binding protein 2 2.752
CP ceruloplasmin (ferroxidase) 2.735
ACO1 aconitase 1, soluble 2.711
UROD uroporphyrinogen decarboxylase 2.612
FTH1 ferritin, heavy polypeptide 1 2.611
FTL ferritin, light polypeptide 2.609
HEPH hephaestin 2.6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.588
EPO erythropoietin 2.535
ALB albumin 2.533
AFP alpha-fetoprotein 2.517
INS insulin 2.5
PNPLA3 patatin-like phospholipase domain containing 3 2.446
ERFE erythroferrone 2.437
IL6 interleukin 6 2.405
STEAP3 STEAP family member 3, metalloreductase 2.355
F2 coagulation factor II (thrombin) 2.319
MB myoglobin 2.319
HLA-A major histocompatibility complex, class I, A 2.287
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.25
HP haptoglobin 2.241
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.239
HMOX1 heme oxygenase 1 2.237
SLC46A1 solute carrier family 46 (folate transporter), member 1 2.224
GPX4 glutathione peroxidase 4 2.22
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.206
CRP C-reactive protein, pentraxin-related 2.192
NEO1 neogenin 1 2.177
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 2.175
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.173
ALAS2 5'-aminolevulinate synthase 2 2.168
TNF tumor necrosis factor 2.151
FBXL5 F-box and leucine-rich repeat protein 5 2.149
TM6SF2 transmembrane 6 superfamily member 2 2.149
FXN frataxin 2.134
HPX hemopexin 2.125
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.115
LTF lactotransferrin 2.109
RGMB repulsive guidance molecule family member b 2.108
SMAD4 SMAD family member 4 2.105
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2.099
B2M beta-2-microglobulin 2.097
NCOA4 nuclear receptor coactivator 4 2.086
GNPAT glyceronephosphate O-acyltransferase 2.086
ACVR1 activin A receptor, type I 2.077
IL1B interleukin 1, beta 2.07
BMPR1A bone morphogenetic protein receptor, type IA 2.068
TGFB1 transforming growth factor, beta 1 2.063
EPAS1 endothelial PAS domain protein 1 2.045
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.042
ALAD aminolevulinate dehydratase 2.037
TP53 tumor protein p53 2.017
GDF15 growth differentiation factor 15 2.007
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.003
LCN2 lipocalin 2 1.992
FECH ferrochelatase 1.979
PCBP1 poly(rC) binding protein 1 1.971
RGMA repulsive guidance molecule family member a 1.957
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 1.949
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.949
APOE apolipoprotein E 1.939
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.921
MBOAT7 membrane bound O-acyltransferase domain containing 7 1.918
CD8A CD8a molecule 1.909
ACSL4 acyl-CoA synthetase long-chain family member 4 1.902
CD4 CD4 molecule 1.89
ACO2 aconitase 2, mitochondrial 1.889
ADIPOQ adiponectin, C1Q and collagen domain containing 1.863
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.859
HBB hemoglobin, beta 1.849
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.845
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.84
CREB3L3 cAMP responsive element binding protein 3-like 3 1.839
JAK2 Janus kinase 2 1.837
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.833
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 1.825
IFNG interferon, gamma 1.824
EPOR erythropoietin receptor 1.823
HLA-F major histocompatibility complex, class I, F 1.821
BMP2 bone morphogenetic protein 2 1.819
NFE2L2 nuclear factor, erythroid 2-like 2 1.808
STEAP2 STEAP family member 2, metalloreductase 1.806
IL1A interleukin 1, alpha 1.783
GCG glucagon 1.779
TLR4 toll-like receptor 4 1.778
ALAS1 5'-aminolevulinate synthase 1 1.772
ACVR2A activin A receptor, type IIA 1.772
LEP leptin 1.766
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.758
MT1E metallothionein 1E 1.75
CDAN1 codanin 1 1.737
ISCU iron-sulfur cluster assembly enzyme 1.737
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.734
SEC23B Sec23 homolog B (S. cerevisiae) 1.729
SCARA5 scavenger receptor class A, member 5 1.728
ACE angiotensin I converting enzyme 1.728
IGF1 insulin-like growth factor 1 (somatomedin C) 1.722
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.721
A2M alpha-2-macroglobulin 1.719
TWSG1 twisted gastrulation BMP signaling modulator 1 1.714
ACTB actin, beta 1.713
GPX2 glutathione peroxidase 2 1.712
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.71
KRT18 keratin 18, type I 1.71
PXDN peroxidasin 1.71
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 1.709
PXDNL peroxidasin-like 1.706
GPX3 glutathione peroxidase 3 1.706
GPX8 glutathione peroxidase 8 (putative) 1.703
SMAD5 SMAD family member 5 1.703
IFNL3 interferon, lambda 3 1.703
PTH parathyroid hormone 1.702
TTR transthyretin 1.698
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.697
APOB apolipoprotein B 1.696
GPX7 glutathione peroxidase 7 1.694
IL10 interleukin 10 1.693
GPX6 glutathione peroxidase 6 1.693
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.688
GPX5 glutathione peroxidase 5 1.686
SUGP2 SURP and G patch domain containing 2 1.68
DNAH8 dynein, axonemal, heavy chain 8 1.679
TERT telomerase reverse transcriptase 1.678
MYBPC3 myosin binding protein C, cardiac 1.671
FURIN furin (paired basic amino acid cleaving enzyme) 1.671
GPC3 glypican 3 1.67
ACTA1 actin, alpha 1, skeletal muscle 1.658
PCBP2 poly(rC) binding protein 2 1.656
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.65
PPARA peroxisome proliferator-activated receptor alpha 1.648
CD163 CD163 molecule 1.647
LPCAT3 lysophosphatidylcholine acyltransferase 3 1.645
BMP4 bone morphogenetic protein 4 1.643
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.637
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.629
HBE1 hemoglobin, epsilon 1 1.628
GLRX5 glutaredoxin 5 1.623
HLA-B major histocompatibility complex, class I, B 1.622
UBE2D1 ubiquitin-conjugating enzyme E2D 1 1.618
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.616
CISD1 CDGSH iron sulfur domain 1 1.611
PPARG peroxisome proliferator-activated receptor gamma 1.599
CBR3 carbonyl reductase 3 1.598
DGUOK deoxyguanosine kinase 1.598
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.595
IFNA1 interferon, alpha 1 1.595
PCSK7 proprotein convertase subtilisin/kexin type 7 1.593
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.59
ATOX1 antioxidant 1 copper chaperone 1.576
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.573
GLUL glutamate-ammonia ligase 1.571
FGF19 fibroblast growth factor 19 1.567
EIF5B eukaryotic translation initiation factor 5B 1.565
NFS1 NFS1 cysteine desulfurase 1.559
CCL2 chemokine (C-C motif) ligand 2 1.558
CYCS cytochrome c, somatic 1.554
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.554
ANKH ANKH inorganic pyrophosphate transport regulator 1.552
PPOX protoporphyrinogen oxidase 1.549
BMP5 bone morphogenetic protein 5 1.537
TNNT2 troponin T type 2 (cardiac) 1.536
KEAP1 kelch-like ECH-associated protein 1 1.536
EGF epidermal growth factor 1.535
SREBF1 sterol regulatory element binding transcription factor 1 1.534
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.533
SFXN1 sideroflexin 1 1.531
EGLN1 egl-9 family hypoxia-inducible factor 1 1.527
KRT19 keratin 19, type I 1.526
SMAD7 SMAD family member 7 1.523
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.522
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.522
INSR insulin receptor 1.519
APOA1 apolipoprotein A-I 1.516
BDH2 3-hydroxybutyrate dehydrogenase, type 2 1.511
PKM pyruvate kinase, muscle 1.51
LDLR low density lipoprotein receptor 1.509
GSTM1 glutathione S-transferase mu 1 1.506
HMOX2 heme oxygenase 2 1.501
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.501
RNF217 ring finger protein 217 1.5
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 1.499
HNF4A hepatocyte nuclear factor 4, alpha 1.494
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.493
AXIN1 axin 1 1.493
GSTP1 glutathione S-transferase pi 1 1.49
EPCAM epithelial cell adhesion molecule 1.488
SMAD9 SMAD family member 9 1.487
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.486
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.485
REN renin 1.485
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.484
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1.477
TIMP1 TIMP metallopeptidase inhibitor 1 1.476
GGTLC3 gamma-glutamyltransferase light chain 3 1.475
SPP1 secreted phosphoprotein 1 1.474
GGT1 gamma-glutamyltransferase 1 1.474
LOX lysyl oxidase 1.472
APP amyloid beta (A4) precursor protein 1.471
TMC4 transmembrane channel-like 4 1.468
SLC22A17 solute carrier family 22, member 17 1.467
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.464
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.464
NPPB natriuretic peptide B 1.463
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.463
USF2 upstream transcription factor 2, c-fos interacting 1.463
IFNA2 interferon, alpha 2 1.46
CDKN2A cyclin-dependent kinase inhibitor 2A 1.46
JUN jun proto-oncogene 1.459
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 1.457
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.457
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.457
SLC30A10 solute carrier family 30, member 10 1.457
POMC proopiomelanocortin 1.456
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.454
G6PD glucose-6-phosphate dehydrogenase 1.453
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.452
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.451
SHBG sex hormone-binding globulin 1.45
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.45
HNF1A HNF1 homeobox A 1.446
CXCL8 chemokine (C-X-C motif) ligand 8 1.445
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.444
BRCA1 breast cancer 1, early onset 1.434
F3 coagulation factor III (thromboplastin, tissue factor) 1.433
LRP1 low density lipoprotein receptor-related protein 1 1.432
DPP4 dipeptidyl-peptidase 4 1.43
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.429
IL22 interleukin 22 1.425
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.425
DENND3 DENN/MADD domain containing 3 1.424
TTN titin 1.423
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.422
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 1.421
SOD1 superoxide dismutase 1, soluble 1.417
SMAD6 SMAD family member 6 1.415
SLC25A38 solute carrier family 25, member 38 1.415
CD34 CD34 molecule 1.413
CPOX coproporphyrinogen oxidase 1.412
IL2 interleukin 2 1.406
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.402
PRL prolactin 1.394
SPTA1 spectrin, alpha, erythrocytic 1 1.393
GSR glutathione reductase 1.392
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.392
ICAM1 intercellular adhesion molecule 1 1.391
CYB561 cytochrome b561 1.39
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 1.389
ZSCAN9 zinc finger and SCAN domain containing 9 1.386
SLC39A1 solute carrier family 39 (zinc transporter), member 1 1.384
CCND1 cyclin D1 1.383
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.381
PKLR pyruvate kinase, liver and RBC 1.38
GCK glucokinase (hexokinase 4) 1.379
MMP9 matrix metallopeptidase 9 1.379
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.379
TGM2 transglutaminase 2 1.377
FGF21 fibroblast growth factor 21 1.374
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.374
IL4 interleukin 4 1.373
SCN5A sodium channel, voltage gated, type V alpha subunit 1.373
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 1.373
HBS1L HBS1-like translational GTPase 1.372
SCARB1 scavenger receptor class B, member 1 1.371
MPO myeloperoxidase 1.37
SOD2 superoxide dismutase 2, mitochondrial 1.368
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 1.365
ARNT aryl hydrocarbon receptor nuclear translocator 1.365
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.363
HMBS hydroxymethylbilane synthase 1.362
LRP2 low density lipoprotein receptor-related protein 2 1.358
PANK2 pantothenate kinase 2 1.35
MAPK3 mitogen-activated protein kinase 3 1.349
EGFR epidermal growth factor receptor 1.349
ACTC1 actin, alpha, cardiac muscle 1 1.349
FOXO1 forkhead box O1 1.347
ASGR1 asialoglycoprotein receptor 1 1.346
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.345
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.343
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 1.343
UROS uroporphyrinogen III synthase 1.342
BGLAP bone gamma-carboxyglutamate (gla) protein 1.339
IRS1 insulin receptor substrate 1 1.339
BCL2 B-cell CLL/lymphoma 2 1.339
LMNA lamin A/C 1.338
IL17A interleukin 17A 1.337
NOX4 NADPH oxidase 4 1.337
DNAL1 dynein, axonemal, light chain 1 1.331
PTEN phosphatase and tensin homolog 1.329
MYH14 myosin, heavy chain 14, non-muscle 1.327
NQO1 NAD(P)H dehydrogenase, quinone 1 1.326
BMP7 bone morphogenetic protein 7 1.323
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.322
LIPC lipase, hepatic 1.319
SMAD2 SMAD family member 2 1.318
SMAD3 SMAD family member 3 1.317
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.316
STEAP4 STEAP family member 4 1.314
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.314
NFE2 nuclear factor, erythroid 2 1.311
SIRT1 sirtuin 1 1.311
MET MET proto-oncogene, receptor tyrosine kinase 1.31
OR4A5 olfactory receptor, family 4, subfamily A, member 5 1.31
IFNA17 interferon, alpha 17 1.309
TXNDC9 thioredoxin domain containing 9 1.308
IFNA21 interferon, alpha 21 1.307
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.307
PON1 paraoxonase 1 1.307
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.305
TLR2 toll-like receptor 2 1.305
CD68 CD68 molecule 1.305
IFNA8 interferon, alpha 8 1.301
IFNA14 interferon, alpha 14 1.301
IFNA16 interferon, alpha 16 1.296
IFNA7 interferon, alpha 7 1.295
IFNA10 interferon, alpha 10 1.295
XDH xanthine dehydrogenase 1.295
CKM creatine kinase, muscle 1.295
SLC39A6 solute carrier family 39 (zinc transporter), member 6 1.295
IFNA6 interferon, alpha 6 1.294
IFNA5 interferon, alpha 5 1.293
TXN thioredoxin 1.293
IFNA13 interferon, alpha 13 1.292
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.291
IFNA4 interferon, alpha 4 1.29
ARG1 arginase 1 1.29
HLA-E major histocompatibility complex, class I, E 1.289
FN1 fibronectin 1 1.289
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.287
MON1A MON1 secretory trafficking family member A 1.286
CD44 CD44 molecule (Indian blood group) 1.286
ATP13A2 ATPase type 13A2 1.285
TNNI3 troponin I type 3 (cardiac) 1.285
FLNC filamin C, gamma 1.283
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.281
GJB2 gap junction protein, beta 2, 26kDa 1.281
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 1.281
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.281
RBM20 RNA binding motif protein 20 1.281
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.279
GDF2 growth differentiation factor 2 1.279
FTMT ferritin mitochondrial 1.278
PTPRC protein tyrosine phosphatase, receptor type, C 1.277
BRCA2 breast cancer 2, early onset 1.277
TRIM38 tripartite motif containing 38 1.273
SLC39A5 solute carrier family 39 (zinc transporter), member 5 1.272
EGLN2 egl-9 family hypoxia-inducible factor 2 1.271
MMP2 matrix metallopeptidase 2 1.27
MTTP microsomal triglyceride transfer protein 1.27
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.269
GLP1R glucagon-like peptide 1 receptor 1.268
BLVRA biliverdin reductase A 1.268
CKB creatine kinase, brain 1.265
VCAM1 vascular cell adhesion molecule 1 1.264
LYRM4 LYR motif containing 4 1.264
RETN resistin 1.263
CKMT1B creatine kinase, mitochondrial 1B 1.263
COL1A1 collagen, type I, alpha 1 1.262
CYGB cytoglobin 1.261
CD36 CD36 molecule (thrombospondin receptor) 1.26
GCLC glutamate-cysteine ligase, catalytic subunit 1.26
MELTF melanotransferrin 1.258
CD80 CD80 molecule 1.258
RETNLB resistin like beta 1.257
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.257
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.256
CSF3 colony stimulating factor 3 (granulocyte) 1.256
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.255
FGF4 fibroblast growth factor 4 1.255
SLC30A3 solute carrier family 30 (zinc transporter), member 3 1.255
CD274 CD274 molecule 1.254
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.252
ELN elastin 1.252
BMPER BMP binding endothelial regulator 1.25
FGF8 fibroblast growth factor 8 (androgen-induced) 1.25
IGF2 insulin-like growth factor 2 1.25
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.25
FGF3 fibroblast growth factor 3 1.247
HBA2 hemoglobin, alpha 2 1.247
EXOC6 exocyst complex component 6 1.246
SCARB2 scavenger receptor class B, member 2 1.243
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.241
IL18 interleukin 18 1.24
G6PC2 glucose-6-phosphatase, catalytic, 2 1.24
TGFA transforming growth factor, alpha 1.237
BCHE butyrylcholinesterase 1.237
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.235
LIX1 Lix1 homolog (chicken) 1.233
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.231
EDN1 endothelin 1 1.23
LYPLAL1 lysophospholipase-like 1 1.229
HBA1 hemoglobin, alpha 1 1.229
VWF von Willebrand factor 1.228
AVP arginine vasopressin 1.227
FGF7 fibroblast growth factor 7 1.227
SLC31A1 solute carrier family 31 (copper transporter), member 1 1.226
THPO thrombopoietin 1.226
GTPBP1 GTP binding protein 1 1.225
PKP2 plakophilin 2 1.223
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.223
FGF6 fibroblast growth factor 6 1.223
HLA-C major histocompatibility complex, class I, C 1.222
ALPL alkaline phosphatase, liver/bone/kidney 1.221
DHODH dihydroorotate dehydrogenase (quinone) 1.22
FGF17 fibroblast growth factor 17 1.218
TPM1 tropomyosin 1 (alpha) 1.217
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.213
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.213
TH tyrosine hydroxylase 1.213
SOCS3 suppressor of cytokine signaling 3 1.213
ARID1A AT rich interactive domain 1A (SWI-like) 1.213
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.21
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.208
SLC39A4 solute carrier family 39 (zinc transporter), member 4 1.207
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.206
AKR1D1 aldo-keto reductase family 1, member D1 1.205
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.203
XPR1 xenotropic and polytropic retrovirus receptor 1 1.202
FGF10 fibroblast growth factor 10 1.201
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.201
FGF20 fibroblast growth factor 20 1.2
PGRMC1 progesterone receptor membrane component 1 1.199
FGGY FGGY carbohydrate kinase domain containing 1.198
BMPR1B bone morphogenetic protein receptor, type IB 1.198
NDFIP1 Nedd4 family interacting protein 1 1.198
SREBF2 sterol regulatory element binding transcription factor 2 1.198
SH2B3 SH2B adaptor protein 3 1.197
BAX BCL2-associated X protein 1.194
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.194
FGF18 fibroblast growth factor 18 1.194
GLRX3 glutaredoxin 3 1.192
SUCNR1 succinate receptor 1 1.192
FGF9 fibroblast growth factor 9 1.192
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.19
GLA galactosidase, alpha 1.188
FGF5 fibroblast growth factor 5 1.187
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.186
OR4C12 olfactory receptor, family 4, subfamily C, member 12 1.185
ALOX15 arachidonate 15-lipoxygenase 1.183
FGF23 fibroblast growth factor 23 1.183
FGF22 fibroblast growth factor 22 1.183
C3 complement component 3 1.183
FGF16 fibroblast growth factor 16 1.182
OPTN optineurin 1.181
ORM1 orosomucoid 1 1.178
PPY pancreatic polypeptide 1.178
HIF3A hypoxia inducible factor 3, alpha subunit 1.176
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.176
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.176
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.174
EGLN3 egl-9 family hypoxia-inducible factor 3 1.174
ISCA1 iron-sulfur cluster assembly 1 1.17
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.168
CCN2 cellular communication network factor 2 1.168
ACVR2B activin A receptor, type IIB 1.167
PGBD1 piggyBac transposable element derived 1 1.167
KLF1 Kruppel-like factor 1 (erythroid) 1.166
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.165
MTF1 metal-regulatory transcription factor 1 1.162
LPL lipoprotein lipase 1.162
ATG7 autophagy related 7 1.161
NOS3 nitric oxide synthase 3 (endothelial cell) 1.156
FASLG Fas ligand (TNF superfamily, member 6) 1.156
CYBB cytochrome b-245, beta polypeptide 1.156
SLC17A4 solute carrier family 17, member 4 1.154
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.154
SLCO1B1 solute carrier organic anion transporter family, member 1B1 1.153
SLC35F1 solute carrier family 35, member F1 1.151
TUBGCP3 tubulin, gamma complex associated protein 3 1.149
RYR2 ryanodine receptor 2 (cardiac) 1.147
RPL19 ribosomal protein L19 1.146
ZNF165 zinc finger protein 165 1.145
BAG3 BCL2-associated athanogene 3 1.145
LAMP2 lysosomal-associated membrane protein 2 1.145
TXNRD1 thioredoxin reductase 1 1.145
TBL1X transducin (beta)-like 1X-linked 1.144
PROM1 prominin 1 1.143
ESR1 estrogen receptor 1 1.141
ANKAR ankyrin and armadillo repeat containing 1.14
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.139
KRT7 keratin 7, type II 1.139
ANOS1 anosmin 1 1.138
PEBP1 phosphatidylethanolamine binding protein 1 1.138
G6PC3 glucose 6 phosphatase, catalytic, 3 1.134
ALOX12 arachidonate 12-lipoxygenase 1.134
HDDC3 HD domain containing 3 1.134
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 1.133
CFLAR CASP8 and FADD-like apoptosis regulator 1.131
KDR kinase insert domain receptor 1.131
KRAS Kirsten rat sarcoma viral oncogene homolog 1.13
SPINK1 serine peptidase inhibitor, Kazal type 1 1.129
KLF6 Kruppel-like factor 6 1.128
CALR calreticulin 1.127
CCL5 chemokine (C-C motif) ligand 5 1.127
SLC39A10 solute carrier family 39 (zinc transporter), member 10 1.126
JAK1 Janus kinase 1 1.126
DUOX2 dual oxidase 2 1.124
LPIN1 lipin 1 1.124
MMP3 matrix metallopeptidase 3 1.124
ALDOB aldolase B, fructose-bisphosphate 1.123
NCAM1 neural cell adhesion molecule 1 1.123
APOC3 apolipoprotein C-III 1.123
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.121
IL13 interleukin 13 1.118
ARG2 arginase 2 1.118
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.117
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.116
ATOH8 atonal homolog 8 (Drosophila) 1.113
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.113
MAPK8 mitogen-activated protein kinase 8 1.113
ATG5 autophagy related 5 1.113
NLRP3 NLR family, pyrin domain containing 3 1.113
FOS FBJ murine osteosarcoma viral oncogene homolog 1.111
ASPG asparaginase 1.108
FBL fibrillarin 1.108
ZBTB43 zinc finger and BTB domain containing 43 1.108
HEBP1 heme binding protein 1 1.107
GLS2 glutaminase 2 (liver, mitochondrial) 1.107
HSPA4 heat shock 70kDa protein 4 1.106
MCOLN1 mucolipin 1 1.106
TGFBR1 transforming growth factor, beta receptor 1 1.106
SLC15A5 solute carrier family 15, member 5 1.106
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.104
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 1.104
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 1.104
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.103
AHSG alpha-2-HS-glycoprotein 1.103
BECN1 beclin 1, autophagy related 1.103
IL6R interleukin 6 receptor 1.101
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.1
FASN fatty acid synthase 1.099
ACP5 acid phosphatase 5, tartrate resistant 1.099
CD28 CD28 molecule 1.099
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.099
MMP1 matrix metallopeptidase 1 1.097
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 1.094
TMBIM4 transmembrane BAX inhibitor motif containing 4 1.091
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.091
SLC39A13 solute carrier family 39 (zinc transporter), member 13 1.09
CYBA cytochrome b-245, alpha polypeptide 1.09
STK11 serine/threonine kinase 11 1.089
RET ret proto-oncogene 1.089
LGALS3 lectin, galactoside-binding, soluble, 3 1.089
CXCL10 chemokine (C-X-C motif) ligand 10 1.088
LOXL2 lysyl oxidase-like 2 1.087
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.085
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.085
HLA-G major histocompatibility complex, class I, G 1.084
STAT5A signal transducer and activator of transcription 5A 1.084
MYD88 myeloid differentiation primary response 88 1.084
SOX9 SRY (sex determining region Y)-box 9 1.082
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.081
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.081
GSK3B glycogen synthase kinase 3 beta 1.081
ORM2 orosomucoid 2 1.08
NOS2 nitric oxide synthase 2, inducible 1.079
CCR2 chemokine (C-C motif) receptor 2 1.079
PON3 paraoxonase 3 1.078
GCKR glucokinase (hexokinase 4) regulator 1.078
PROM2 prominin 2 1.077
SLC25A39 solute carrier family 25, member 39 1.077
NUP210 nucleoporin 210kDa 1.077
SFXN5 sideroflexin 5 1.076
PON2 paraoxonase 2 1.076
CXCR4 chemokine (C-X-C motif) receptor 4 1.076
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.074
SLC30A5 solute carrier family 30 (zinc transporter), member 5 1.073
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.073
DSG2 desmoglein 2 1.072
CETP cholesteryl ester transfer protein, plasma 1.072
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.071
ATXN2 ataxin 2 1.071
TOR1A torsin family 1, member A (torsin A) 1.071
PRF1 perforin 1 (pore forming protein) 1.07
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.07
BAMBI BMP and activin membrane-bound inhibitor 1.069
STAT5B signal transducer and activator of transcription 5B 1.069
MYPN myopalladin 1.068
POR P450 (cytochrome) oxidoreductase 1.068
OTC ornithine carbamoyltransferase 1.066
FN3K fructosamine 3 kinase 1.062
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.062
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.061
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 1.06
KRT38 keratin 38, type I 1.058
CBS cystathionine-beta-synthase 1.057
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.056
GNMT glycine N-methyltransferase 1.055
ELANE elastase, neutrophil expressed 1.055
FADS2 fatty acid desaturase 2 1.055
LAMP1 lysosomal-associated membrane protein 1 1.054
SST somatostatin 1.054
GDF11 growth differentiation factor 11 1.051
MT1G metallothionein 1G 1.051
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.051
CREB1 cAMP responsive element binding protein 1 1.05
CIAO1 cytosolic iron-sulfur assembly component 1 1.049
JAG1 jagged 1 1.049
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.048
STAT1 signal transducer and activator of transcription 1, 91kDa 1.048
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.048
NEMP2 nuclear envelope integral membrane protein 2 1.048
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.047
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.046
COMMD1 copper metabolism (Murr1) domain containing 1 1.046
MLKL mixed lineage kinase domain-like 1.046
PCSK9 proprotein convertase subtilisin/kexin type 9 1.041
PAH phenylalanine hydroxylase 1.041
CDC14A cell division cycle 14A 1.041
CCL3 chemokine (C-C motif) ligand 3 1.038
SLC31A2 solute carrier family 31 (copper transporter), member 2 1.037
MYB v-myb avian myeloblastosis viral oncogene homolog 1.037
EPB42 erythrocyte membrane protein band 4.2 1.037
DUOX1 dual oxidase 1 1.036
MME membrane metallo-endopeptidase 1.036
PNLIP pancreatic lipase 1.036
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.035
CCL4 chemokine (C-C motif) ligand 4 1.034
TPMT thiopurine S-methyltransferase 1.034
IL6ST interleukin 6 signal transducer 1.033
CD19 CD19 molecule 1.033
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.032
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.032
RYR1 ryanodine receptor 1 (skeletal) 1.032
IRF2 interferon regulatory factor 2 1.031
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.031
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.031
GYPA glycophorin A (MNS blood group) 1.029
AGTR1 angiotensin II receptor, type 1 1.028
NOX1 NADPH oxidase 1 1.027
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.027
SLC35B1 solute carrier family 35, member B1 1.027
TYR tyrosinase 1.026
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.026
ANK1 ankyrin 1, erythrocytic 1.025
PDCD1 programmed cell death 1 1.025
GCLM glutamate-cysteine ligase, modifier subunit 1.025
RUNX2 runt-related transcription factor 2 1.024
AR androgen receptor 1.024
XBP1 X-box binding protein 1 1.022
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.022
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.022
MAOB monoamine oxidase B 1.018
ANXA5 annexin A5 1.018
FDXR ferredoxin reductase 1.017
MUTYH mutY homolog 1.017
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.017
ACSL3 acyl-CoA synthetase long-chain family member 3 1.015
MMP13 matrix metallopeptidase 13 1.015
DSC2 desmocollin 2 1.014
DOHH deoxyhypusine hydroxylase/monooxygenase 1.014
MTNR1B melatonin receptor 1B 1.013
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 1.013
KRT8 keratin 8, type II 1.013
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.012
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.012
ACLY ATP citrate lyase 1.011
ERBB2 erb-b2 receptor tyrosine kinase 2 1.011
DICER1 dicer 1, ribonuclease type III 1.011
SIRT3 sirtuin 3 1.01
STAB2 stabilin 2 1.01
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.007
AHSP alpha hemoglobin stabilizing protein 1.007
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.006
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.004
ACOX1 acyl-CoA oxidase 1, palmitoyl 1.001
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.001
DCAF17 DDB1 and CUL4 associated factor 17 1.001
IL15 interleukin 15 1.001
CCDC115 coiled-coil domain containing 115 1.0
CLU clusterin 1.0
H3C12 H3 clustered histone 12 1.0