Hemoglobinuria Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

383 genes co-occuring with the disease Hemoglobinuria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 3.91
CD59 CD59 molecule, complement regulatory protein 3.8
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.708
HP haptoglobin 3.084
C5 complement component 5 3.071
C3 complement component 3 3.023
C5AR1 complement component 5a receptor 1 2.754
CD46 CD46 molecule, complement regulatory protein 2.702
CFP complement factor properdin 2.701
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.659
C1S complement component 1, s subcomponent 2.629
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.547
CFH complement factor H 2.489
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.481
C4A complement component 4A (Rodgers blood group) 2.44
MASP2 mannan-binding lectin serine peptidase 2 2.433
C1R complement component 1, r subcomponent 2.406
MBL2 mannose-binding lectin (protein C) 2, soluble 2.397
F2 coagulation factor II (thrombin) 2.391
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 2.385
F3 coagulation factor III (thromboplastin, tissue factor) 2.372
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.362
C3AR1 complement component 3a receptor 1 2.336
G6PD glucose-6-phosphate dehydrogenase 2.335
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.333
C4B complement component 4B (Chido blood group) 2.312
CFHR1 complement factor H-related 1 2.286
CFB complement factor B 2.263
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.241
CD34 CD34 molecule 2.236
C5AR2 complement component 5a receptor 2 2.232
GYPA glycophorin A (MNS blood group) 2.225
CFI complement factor I 2.215
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 2.205
BST1 bone marrow stromal cell antigen 1 2.179
HPX hemopexin 2.163
JAK2 Janus kinase 2 2.162
EPO erythropoietin 2.162
MB myoglobin 2.159
CSF3 colony stimulating factor 3 (granulocyte) 2.153
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2.153
VWF von Willebrand factor 2.136
ASXL1 additional sex combs like transcriptional regulator 1 2.131
ALB albumin 2.126
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.125
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.116
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.115
MPL MPL proto-oncogene, thrombopoietin receptor 2.108
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.106
CFHR3 complement factor H-related 3 2.09
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.074
THBD thrombomodulin 2.072
CFHR5 complement factor H-related 5 2.031
CD24 CD24 molecule 1.984
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.981
DGKE diacylglycerol kinase, epsilon 64kDa 1.981
THPO thrombopoietin 1.967
CD52 CD52 molecule 1.96
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 1.954
IL6 interleukin 6 1.95
CRP C-reactive protein, pentraxin-related 1.929
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 1.925
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 1.918
CD4 CD4 molecule 1.915
TNF tumor necrosis factor 1.915
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.91
IFNG interferon, gamma 1.906
CFD complement factor D (adipsin) 1.903
VSIG4 V-set and immunoglobulin domain containing 4 1.901
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 1.898
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 1.895
CD8A CD8a molecule 1.886
CD48 CD48 molecule 1.867
TET2 tet methylcytosine dioxygenase 2 1.853
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.848
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.829
C2 complement component 2 1.826
VTN vitronectin 1.812
PIGY phosphatidylinositol glycan anchor biosynthesis, class Y 1.809
PTPRC protein tyrosine phosphatase, receptor type, C 1.809
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.807
CD58 CD58 molecule 1.805
BCORL1 BCL6 corepressor-like 1 1.802
U2AF1 U2 small nuclear RNA auxiliary factor 1 1.796
COLEC11 collectin sub-family member 11 1.793
PF4 platelet factor 4 1.782
IL1B interleukin 1, beta 1.778
C8B complement component 8, beta polypeptide 1.771
SAA2 serum amyloid A2 1.764
CD19 CD19 molecule 1.758
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 1.75
SAA1 serum amyloid A1 1.736
FCN3 ficolin (collagen/fibrinogen domain containing) 3 1.735
PGAP1 post-GPI attachment to proteins 1 1.726
CD33 CD33 molecule 1.716
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.702
HLA-A major histocompatibility complex, class I, A 1.7
GATA2 GATA binding protein 2 1.697
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 1.691
CFHR4 complement factor H-related 4 1.69
PLG plasminogen 1.68
IL10 interleukin 10 1.678
F10 coagulation factor X 1.674
CD38 CD38 molecule 1.671
TFRC transferrin receptor 1.665
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.663
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.657
FCN1 ficolin (collagen/fibrinogen domain containing) 1 1.651
CALR calreticulin 1.648
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 1.642
PRSS2 protease, serine, 2 (trypsin 2) 1.642
CLU clusterin 1.636
RUNX1 runt-related transcription factor 1 1.632
APOH apolipoprotein H (beta-2-glycoprotein I) 1.629
SRSF2 serine/arginine-rich splicing factor 2 1.627
PGAP2 post-GPI attachment to proteins 2 1.623
PLAT plasminogen activator, tissue 1.622
GPAA1 glycosylphosphatidylinositol anchor attachment 1 1.621
RHD Rh blood group, D antigen 1.619
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 1.616
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 1.607
MPO myeloperoxidase 1.6
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.592
CKMT1B creatine kinase, mitochondrial 1B 1.591
CKB creatine kinase, brain 1.588
CKM creatine kinase, muscle 1.587
SBDS Shwachman-Bodian-Diamond syndrome 1.587
PLAUR plasminogen activator, urokinase receptor 1.586
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.584
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 1.576
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.574
PRTN3 proteinase 3 1.566
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.565
KNG1 kininogen 1 1.563
ACHE acetylcholinesterase (Yt blood group) 1.56
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.554
IL2 interleukin 2 1.554
HAMP hepcidin antimicrobial peptide 1.552
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.547
IL1A interleukin 1, alpha 1.54
PKM pyruvate kinase, muscle 1.53
DKC1 dyskeratosis congenita 1, dyskerin 1.528
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.526
HMOX1 heme oxygenase 1 1.514
VCAM1 vascular cell adhesion molecule 1 1.513
CD2 CD2 molecule 1.511
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.511
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.51
B3GAT1 beta-1,3-glucuronyltransferase 1 1.506
ERV3-1 endogenous retrovirus group 3, member 1 1.505
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.504
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.499
SETBP1 SET binding protein 1 1.499
NCAM1 neural cell adhesion molecule 1 1.494
FYB1 FYN binding protein 1 1.484
CFHR2 complement factor H-related 2 1.478
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.477
NOP10 NOP10 ribonucleoprotein 1.469
EPB41 erythrocyte membrane protein band 4.1 1.468
CPB2 carboxypeptidase B2 (plasma) 1.462
CXCL8 chemokine (C-X-C motif) ligand 8 1.462
PLAU plasminogen activator, urokinase 1.458
C9 complement component 9 1.454
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.452
CSF3R colony stimulating factor 3 receptor (granulocyte) 1.451
NHP2 NHP2 ribonucleoprotein 1.45
STX2 syntaxin 2 1.445
ERVW-1 endogenous retrovirus group W, member 1 1.445
CD163 CD163 molecule 1.44
PF4V1 platelet factor 4 variant 1 1.44
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.438
F8 coagulation factor VIII, procoagulant component 1.436
IL17A interleukin 17A 1.435
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 1.434
TLR4 toll-like receptor 4 1.433
ICAM1 intercellular adhesion molecule 1 1.433
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.427
TGFB1 transforming growth factor, beta 1 1.422
IL4 interleukin 4 1.421
CCL2 chemokine (C-C motif) ligand 2 1.414
C19ORF67 chromosome 19 open reading frame 67 1.404
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.403
ACE angiotensin I converting enzyme 1.399
PRF1 perforin 1 (pore forming protein) 1.398
CD40LG CD40 ligand 1.395
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.388
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.387
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.383
SELE selectin E 1.381
ANPEP alanyl (membrane) aminopeptidase 1.373
WT1 Wilms tumor 1 1.373
STAG2 stromal antigen 2 1.369
ANAPC5 anaphase promoting complex subunit 5 1.367
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.367
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.364
SAMD9 sterile alpha motif domain containing 9 1.36
PGAP3 post-GPI attachment to proteins 3 1.356
CD5 CD5 molecule 1.355
HAVCR1 hepatitis A virus cellular receptor 1 1.354
F11 coagulation factor XI 1.35
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.347
SYK spleen tyrosine kinase 1.346
IL18 interleukin 18 1.341
SELPLG selectin P ligand 1.34
CD27 CD27 molecule 1.339
LCN2 lipocalin 2 1.336
CP ceruloplasmin (ferroxidase) 1.332
C1QBP complement component 1, q subcomponent binding protein 1.332
C6 complement component 6 1.328
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.326
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.324
IFNA1 interferon, alpha 1 1.323
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.321
MUSK muscle, skeletal, receptor tyrosine kinase 1.32
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.319
HLA-B major histocompatibility complex, class I, B 1.319
ELANE elastase, neutrophil expressed 1.317
HBE1 hemoglobin, epsilon 1 1.311
B2M beta-2-microglobulin 1.308
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.305
KITLG KIT ligand 1.305
ZNF619 zinc finger protein 619 1.301
CD28 CD28 molecule 1.3
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.299
APOL1 apolipoprotein L, 1 1.295
HBA2 hemoglobin, alpha 2 1.292
IL3 interleukin 3 1.29
HBB hemoglobin, beta 1.288
ECI2 enoyl-CoA delta isomerase 2 1.285
PKLR pyruvate kinase, liver and RBC 1.283
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 1.281
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.279
ADA adenosine deaminase 1.274
MPDU1 mannose-P-dolichol utilization defect 1 1.272
TP53 tumor protein p53 1.268
MME membrane metallo-endopeptidase 1.264
ADGRE5 adhesion G protein-coupled receptor E5 1.259
ADGRE2 adhesion G protein-coupled receptor E2 1.257
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.256
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 1.255
CXCR4 chemokine (C-X-C motif) receptor 4 1.254
CD40 CD40 molecule, TNF receptor superfamily member 5 1.252
ULBP1 UL16 binding protein 1 1.252
CD80 CD80 molecule 1.25
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.249
PHF6 PHD finger protein 6 1.248
THY1 Thy-1 cell surface antigen 1.246
FANCG Fanconi anemia, complementation group G 1.245
FLT3 fms-related tyrosine kinase 3 1.243
HMOX2 heme oxygenase 2 1.239
MYD88 myeloid differentiation primary response 88 1.233
LRP2 low density lipoprotein receptor-related protein 2 1.229
ADI1 acireductone dioxygenase 1 1.227
CD14 CD14 molecule 1.227
FASLG Fas ligand (TNF superfamily, member 6) 1.227
TERT telomerase reverse transcriptase 1.226
ETV6 ets variant 6 1.226
F2R coagulation factor II (thrombin) receptor 1.225
RPS19 ribosomal protein S19 1.224
SEC23B Sec23 homolog B (S. cerevisiae) 1.224
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 1.222
ANK1 ankyrin 1, erythrocytic 1.222
AMBP alpha-1-microglobulin/bikunin precursor 1.218
EPB42 erythrocyte membrane protein band 4.2 1.216
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 1.214
HBA1 hemoglobin, alpha 1 1.211
KLF1 Kruppel-like factor 1 (erythroid) 1.211
FANCA Fanconi anemia, complementation group A 1.206
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 1.205
ANXA5 annexin A5 1.205
CD1D CD1d molecule 1.202
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.201
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.199
CD7 CD7 molecule 1.195
REN renin 1.195
PROCR protein C receptor, endothelial 1.194
XTBD1 XRN2 binding domain containing 1 1.191
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 1.19
KEL Kell blood group, metallo-endopeptidase 1.187
NLRP3 NLR family, pyrin domain containing 3 1.183
CXCL12 chemokine (C-X-C motif) ligand 12 1.173
CD109 CD109 molecule 1.168
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.168
CTC1 CTS telomere maintenance complex component 1 1.164
INS insulin 1.164
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.162
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 1.162
PXDN peroxidasin 1.162
AGBL4 ATP/GTP binding protein-like 4 1.16
RBMS2 RNA binding motif, single stranded interacting protein 2 1.16
ACE2 angiotensin I converting enzyme 2 1.157
FOXP3 forkhead box P3 1.156
ARG2 arginase 2 1.154
SPTB spectrin, beta, erythrocytic 1.152
PXDNL peroxidasin-like 1.152
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.149
JAK1 Janus kinase 1 1.149
CSMD1 CUB and Sushi multiple domains 1 1.147
BTK Bruton agammaglobulinemia tyrosine kinase 1.147
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.144
SLURP2 secreted LY6/PLAUR domain containing 2 1.139
C1QA complement component 1, q subcomponent, A chain 1.138
AGBL3 ATP/GTP binding protein-like 3 1.137
ARG1 arginase 1 1.136
ARMS2 age-related maculopathy susceptibility 2 1.136
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.134
TLR2 toll-like receptor 2 1.133
CD22 CD22 molecule 1.133
ULBP2 UL16 binding protein 2 1.131
HMGA2 high mobility group AT-hook 2 1.125
A2M alpha-2-macroglobulin 1.123
CCL5 chemokine (C-C motif) ligand 5 1.121
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.12
STAT5B signal transducer and activator of transcription 5B 1.12
FOLR1 folate receptor 1 (adult) 1.119
RHCE Rh blood group, CcEe antigens 1.118
CD86 CD86 molecule 1.116
SPACA4 sperm acrosome associated 4 1.116
CDAN1 codanin 1 1.11
CD47 CD47 molecule 1.11
IFNB1 interferon, beta 1, fibroblast 1.106
STX1A syntaxin 1A (brain) 1.106
IL3RA interleukin 3 receptor, alpha (low affinity) 1.106
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.104
ALAS1 5'-aminolevulinate synthase 1 1.1
CCL3 chemokine (C-C motif) ligand 3 1.1
IL15 interleukin 15 1.098
IL5 interleukin 5 1.098
MECOM MDS1 and EVI1 complex locus 1.097
WRAP53 WD repeat containing, antisense to TP53 1.092
SELL selectin L 1.092
ANGPT2 angiopoietin 2 1.09
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.089
SH2B3 SH2B adaptor protein 3 1.088
CD177 CD177 molecule 1.088
RTEL1 regulator of telomere elongation helicase 1 1.087
FANCB Fanconi anemia, complementation group B 1.085
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.084
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.084
AGBL2 ATP/GTP binding protein-like 2 1.083
PTX3 pentraxin 3, long 1.082
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 1.08
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.077
IFNA2 interferon, alpha 2 1.076
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.074
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.073
CXCL10 chemokine (C-X-C motif) ligand 10 1.072
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.066
SAMD9L sterile alpha motif domain containing 9-like 1.063
CD36 CD36 molecule (thrombospondin receptor) 1.061
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.054
UBA1 ubiquitin-like modifier activating enzyme 1 1.05
GET1 guided entry of tail-anchored proteins factor 1 1.049
NPPB natriuretic peptide B 1.046
MAPRE2 microtubule-associated protein, RP/EB family, member 2 1.046
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.046
FN1 fibronectin 1 1.045
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.043
ANXA7 annexin A7 1.04
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.034
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.033
COLEC10 collectin sub-family member 10 (C-type lectin) 1.032
CD274 CD274 molecule 1.031
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.03
SPTA1 spectrin, alpha, erythrocytic 1 1.028
CTSL cathepsin L 1.027
SCARB2 scavenger receptor class B, member 2 1.023
LY6G6D lymphocyte antigen 6 complex, locus G6D 1.022
MYOM2 myomesin 2 1.021
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.019
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 1.013
JAK3 Janus kinase 3 1.012
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.011
PRNP prion protein 1.011
IZUMO1R IZUMO1 receptor, JUNO 1.009
FOLR3 folate receptor 3 (gamma) 1.008
PECAM1 platelet/endothelial cell adhesion molecule 1 1.007
CTSG cathepsin G 1.007
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 1.006
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.003
IL13 interleukin 13 1.002
XK X-linked Kx blood group 1.001
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.0