Hemosiderosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload. (Human Disease Ontology, DOID_12119)
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Genes

135 genes co-occuring with the disease Hemosiderosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HAMP hepcidin antimicrobial peptide 2.574
HFE hemochromatosis 2.445
TFR2 transferrin receptor 2 2.108
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.049
HJV hemojuvelin BMP co-receptor 1.989
HP haptoglobin 1.963
EPO erythropoietin 1.923
ALB albumin 1.92
PRTN3 proteinase 3 1.894
TFRC transferrin receptor 1.835
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.821
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.768
CRP C-reactive protein, pentraxin-related 1.727
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.711
MPO myeloperoxidase 1.698
COPA coatomer protein complex, subunit alpha 1.672
HBE1 hemoglobin, epsilon 1 1.646
MB myoglobin 1.635
F2 coagulation factor II (thrombin) 1.63
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 1.615
SLC25A38 solute carrier family 25, member 38 1.606
IL6 interleukin 6 1.585
INS insulin 1.583
IREB2 iron-responsive element binding protein 2 1.531
CD68 CD68 molecule 1.503
TNF tumor necrosis factor 1.495
IL1B interleukin 1, beta 1.484
SFTPB surfactant protein B 1.482
CD34 CD34 molecule 1.47
APOE apolipoprotein E 1.457
ERFE erythroferrone 1.442
PTH parathyroid hormone 1.441
CYBRD1 cytochrome b reductase 1 1.436
CP ceruloplasmin (ferroxidase) 1.435
SFTPC surfactant protein C 1.43
ALAS2 5'-aminolevulinate synthase 2 1.425
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.42
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.384
TGM2 transglutaminase 2 1.375
IGF1 insulin-like growth factor 1 (somatomedin C) 1.365
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.362
IL1A interleukin 1, alpha 1.361
TMPRSS6 transmembrane protease, serine 6 1.355
OR2T3 olfactory receptor, family 2, subfamily T, member 3 1.349
F3 coagulation factor III (thromboplastin, tissue factor) 1.348
ACO1 aconitase 1, soluble 1.346
FTL ferritin, light polypeptide 1.342
CD163 CD163 molecule 1.342
CDAN1 codanin 1 1.323
CD4 CD4 molecule 1.323
UROD uroporphyrinogen decarboxylase 1.313
HMOX1 heme oxygenase 1 1.313
TBX4 T-box 4 1.311
CD59 CD59 molecule, complement regulatory protein 1.309
HPX hemopexin 1.309
APP amyloid beta (A4) precursor protein 1.3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.294
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 1.285
BMP10 bone morphogenetic protein 10 1.276
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.276
FTH1 ferritin, heavy polypeptide 1 1.274
HBB hemoglobin, beta 1.266
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.258
LTF lactotransferrin 1.252
CD8A CD8a molecule 1.252
PXDNL peroxidasin-like 1.245
PXDN peroxidasin 1.243
BMP6 bone morphogenetic protein 6 1.241
SEC23B Sec23 homolog B (S. cerevisiae) 1.235
NPPB natriuretic peptide B 1.23
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.216
ACE angiotensin I converting enzyme 1.206
GLRX5 glutaredoxin 5 1.206
FXN frataxin 1.198
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.196
SPTA1 spectrin, alpha, erythrocytic 1 1.192
TGFB1 transforming growth factor, beta 1 1.186
IFNA1 interferon, alpha 1 1.177
NKX2-1 NK2 homeobox 1 1.173
LRP2 low density lipoprotein receptor-related protein 2 1.172
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.168
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.168
CKMT1B creatine kinase, mitochondrial 1B 1.167
CKB creatine kinase, brain 1.164
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.163
CKM creatine kinase, muscle 1.163
SPTB spectrin, beta, erythrocytic 1.157
IFNG interferon, gamma 1.148
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 1.139
B2M beta-2-microglobulin 1.138
GYPA glycophorin A (MNS blood group) 1.13
OGA O-GlcNAcase 1.128
PKLR pyruvate kinase, liver and RBC 1.126
EPB42 erythrocyte membrane protein band 4.2 1.124
PKM pyruvate kinase, muscle 1.12
MME membrane metallo-endopeptidase 1.104
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.104
GET1 guided entry of tail-anchored proteins factor 1 1.096
CD1A CD1a molecule 1.084
IL10 interleukin 10 1.084
IFNA16 interferon, alpha 16 1.066
IFNA7 interferon, alpha 7 1.066
IFNA14 interferon, alpha 14 1.065
IFNA8 interferon, alpha 8 1.065
IFNA21 interferon, alpha 21 1.065
IFNA10 interferon, alpha 10 1.065
IFNA6 interferon, alpha 6 1.065
GPX6 glutathione peroxidase 6 1.064
IFNA5 interferon, alpha 5 1.064
GPX8 glutathione peroxidase 8 (putative) 1.063
GPX5 glutathione peroxidase 5 1.063
IFNA17 interferon, alpha 17 1.062
IFNA13 interferon, alpha 13 1.062
IFNA4 interferon, alpha 4 1.06
GPX7 glutathione peroxidase 7 1.06
CD1E CD1e molecule 1.058
HEPH hephaestin 1.057
GPX2 glutathione peroxidase 2 1.05
AFP alpha-fetoprotein 1.05
LCN2 lipocalin 2 1.045
GPX3 glutathione peroxidase 3 1.041
ACR acrosin 1.04
CD1B CD1b molecule 1.04
C3 complement component 3 1.033
TRH thyrotropin-releasing hormone 1.031
TALDO1 transaldolase 1 1.029
SORD sorbitol dehydrogenase 1.025
RPS19 ribosomal protein S19 1.024
GHRH growth hormone releasing hormone 1.024
POMC proopiomelanocortin 1.021
HMOX2 heme oxygenase 2 1.011
IFNA2 interferon, alpha 2 1.01
GCG glucagon 1.009
GDF2 growth differentiation factor 2 1.009
GDF15 growth differentiation factor 15 1.0