Heroin Dependence Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An opiate dependence that involves the continued use of heroin despite problems related to use of the substance. (Human Disease Ontology, DOID_9976)
External Link https://www.disgenet.org/browser/0/1/0/C0019337
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Genes

96 genes associated with the disease Heroin Dependence in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGBL4 ATP/GTP binding protein-like 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKK1 ankyrin repeat and kinase domain containing 1
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
ANTXR2 anthrax toxin receptor 2
AUTS2 autism susceptibility candidate 2
BDNF brain-derived neurotrophic factor
BRSK2 BR serine/threonine kinase 2
CCDC42 coiled-coil domain containing 42
CDK5 cyclin-dependent kinase 5
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSNK1E casein kinase 1, epsilon
CTNNA2 catenin (cadherin-associated protein), alpha 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DLG4 discs, large homolog 4 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO2 enolase 2 (gamma, neuronal)
EPHB1 EPH receptor B1
F2R coagulation factor II (thrombin) receptor
FAAH fatty acid amide hydrolase
FAS Fas cell surface death receptor
FKBP5 FK506 binding protein 5
FLAD1 flavin adenine dinucleotide synthetase 1
FOXO1 forkhead box O1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALR1 galanin receptor 1
GDNF glial cell derived neurotrophic factor
GLRA1 glycine receptor, alpha 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRK5 G protein-coupled receptor kinase 5
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
LEP leptin
LOC400927-CSNK1E LOC400927-CSNK1E readthrough
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAOA monoamine oxidase A
MAPK8 mitogen-activated protein kinase 8
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MPDZ multiple PDZ domain protein
MUSK muscle, skeletal, receptor tyrosine kinase
NCAM1 neural cell adhesion molecule 1
NGF nerve growth factor (beta polypeptide)
NPY1R neuropeptide Y receptor Y1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene)
PDYN prodynorphin
PENK proenkephalin
PER3 period circadian clock 3
POMC proopiomelanocortin
RAPSN receptor-associated protein of the synapse
RETN resistin
RGS9 regulator of G-protein signaling 9
SAGE1 sarcoma antigen 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIRT1 sirtuin 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
ZNF611 zinc finger protein 611
ZNF804A zinc finger protein 804A