Hesperidin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.110301
PTMA prothymosin, alpha 0.0735742
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0587365
S100A10 S100 calcium binding protein A10 0.051794
TPT1 tumor protein, translationally-controlled 1 0.0508576
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0504231
ABI3BP ABI family, member 3 (NESH) binding protein 0.0502118
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0474165
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0445111
PLAT plasminogen activator, tissue 0.0431067
ZEB1 zinc finger E-box binding homeobox 1 0.0417759
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0415328
SLC39A11 solute carrier family 39, member 11 0.0409842
TPM4 tropomyosin 4 0.0404137
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0369589
MSI2 musashi RNA-binding protein 2 0.0364557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362273
RPS24 ribosomal protein S24 0.0337304
TRIO trio Rho guanine nucleotide exchange factor 0.0336321
FN1 fibronectin 1 0.0333796
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0328294
RPL35A ribosomal protein L35a 0.0328072
CCND1 cyclin D1 0.0317423
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.031708
ASPH aspartate beta-hydroxylase 0.0315191
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0309671
SEPTIN7 septin 7 0.0306205
GOLGA4 golgin A4 0.0304426
INSIG1 insulin induced gene 1 0.0303948
MXI1 MAX interactor 1, dimerization protein 0.0300291
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0299164
POTEF POTE ankyrin domain family, member F 0.0296483
DDIT4 DNA-damage-inducible transcript 4 0.0293774
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0289191
MACF1 microtubule-actin crosslinking factor 1 0.0286793
HELZ helicase with zinc finger 0.0286049
CENPF centromere protein F, 350/400kDa 0.0285781
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0280929
NDRG1 N-myc downstream regulated 1 0.0277293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0277174
SUCNR1 succinate receptor 1 0.0276367
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0275422
PGK1 phosphoglycerate kinase 1 0.027266
ACTG1 actin gamma 1 0.0270292
RPL37A ribosomal protein L37a 0.0268654
DTNA dystrobrevin, alpha 0.0267558
KRT81 keratin 81, type II 0.0266809
BHLHE40 basic helix-loop-helix family, member e40 0.0266308
FMNL2 formin-like 2 0.026133
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0259618
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0257898
FCHSD2 FCH and double SH3 domains 2 0.0256401
DENND1A DENN/MADD domain containing 1A 0.0255211
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0252659
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0250025
SQSTM1 sequestosome 1 0.0249297
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0248719
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0248184
INSIG2 insulin induced gene 2 0.0247224
RPS8 ribosomal protein S8 0.0245738
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0242701
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0241549
ANKRD11 ankyrin repeat domain 11 0.0241544
DGKG diacylglycerol kinase, gamma 90kDa 0.0241427
ENO1 enolase 1, (alpha) 0.023987
RPLP1 ribosomal protein, large, P1 0.0239624
CYLD cylindromatosis (turban tumor syndrome) 0.0237066
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.023674
NUP58 nucleoporin 58 0.0230388
NAMPT nicotinamide phosphoribosyltransferase 0.0228487
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0228019
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0227216
RPS23 ribosomal protein S23 0.0226942
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225019
NT5C2 5'-nucleotidase, cytosolic II 0.0223796
PICALM phosphatidylinositol binding clathrin assembly protein 0.0218959
ZFP36L1 ZFP36 ring finger protein-like 1 0.0215784
GADD45B growth arrest and DNA-damage-inducible, beta 0.021567
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0214848
PBX3 pre-B-cell leukemia homeobox 3 0.0214786
RPS6 ribosomal protein S6 0.0214305
LRRC17 leucine rich repeat containing 17 0.0210454
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0210447
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.020964
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0209604
CSTB cystatin B (stefin B) 0.0209471
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0208405
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0204713
ATP13A3 ATPase type 13A3 0.0202045
FAM107B family with sequence similarity 107, member B 0.0201319
RPS14 ribosomal protein S14 0.0201304
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0199978
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0196549
UPP1 uridine phosphorylase 1 0.01965
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0196156
SPIRE1 spire-type actin nucleation factor 1 0.0193026
CTBP2 C-terminal binding protein 2 0.0192456
SORBS2 sorbin and SH3 domain containing 2 0.0191701
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0191371
RPL31 ribosomal protein L31 0.0191019

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.234035
LOX lysyl oxidase -0.170217
TMSB10 thymosin beta 10 -0.113794
FBN1 fibrillin 1 -0.112523
CD44 CD44 molecule (Indian blood group) -0.0893393
MT2A metallothionein 2A -0.0832762
IGFBP3 insulin-like growth factor binding protein 3 -0.0824871
GLIS3 GLIS family zinc finger 3 -0.0815893
AKAP12 A kinase (PRKA) anchor protein 12 -0.0801744
COL8A1 collagen, type VIII, alpha 1 -0.0774282
COL1A2 collagen, type I, alpha 2 -0.0737156
COL3A1 collagen, type III, alpha 1 -0.0716268
UBC ubiquitin C -0.0705019
NAV1 neuron navigator 1 -0.0684645
ANXA2 annexin A2 -0.0605702
ZBTB20 zinc finger and BTB domain containing 20 -0.0573246
THBS2 thrombospondin 2 -0.0568391
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0562138
LOXL2 lysyl oxidase-like 2 -0.0520342
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0518304
COL5A2 collagen, type V, alpha 2 -0.0497955
MAP1B microtubule-associated protein 1B -0.049132
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0488416
AHNAK AHNAK nucleoprotein -0.0468
LOC112694756 uncharaterized LOC112694756 -0.042674
STC1 stanniocalcin 1 -0.0405041
RAI14 retinoic acid induced 14 -0.0399852
PSD3 pleckstrin and Sec7 domain containing 3 -0.0391766
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.038891
MYADM myeloid-associated differentiation marker -0.035747
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0348221
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0344391
DST dystonin -0.0331952
TXNIP thioredoxin interacting protein -0.0328301
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0326798
IFITM1 interferon induced transmembrane protein 1 -0.0314908
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0314348
WWTR1 WW domain containing transcription regulator 1 -0.0312731
RBM25 RNA binding motif protein 25 -0.0293729
MEIS2 Meis homeobox 2 -0.0285135
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0283718
OSMR oncostatin M receptor -0.0283258
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0280637
IFITM3 interferon induced transmembrane protein 3 -0.0276583
VEGFC vascular endothelial growth factor C -0.0274779
AKAP9 A kinase (PRKA) anchor protein 9 -0.0274225
EHBP1 EH domain binding protein 1 -0.0273336
FBXL7 F-box and leucine-rich repeat protein 7 -0.0269974
HDLBP high density lipoprotein binding protein -0.0266492
LDHA lactate dehydrogenase A -0.0266248
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0266235
C1D C1D nuclear receptor corepressor -0.0260948
HLA-C major histocompatibility complex, class I, C -0.0258679
MB21D2 Mab-21 domain containing 2 -0.0255206
VCL vinculin -0.0254356
MX2 MX dynamin-like GTPase 2 -0.0253459
FLNB filamin B, beta -0.0251224
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0249543
RNF213 ring finger protein 213 -0.024341
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0242097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0237222
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0236832
ACTN4 actinin, alpha 4 -0.0236597
IGF2R insulin-like growth factor 2 receptor -0.0234806
DOCK5 dedicator of cytokinesis 5 -0.0234171
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0231347
MT1X metallothionein 1X -0.0229571
HLA-B major histocompatibility complex, class I, B -0.0228184
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.022623
TUT7 terminal uridylyl transferase 7 -0.0223254
IFI6 interferon, alpha-inducible protein 6 -0.0221181
ARHGAP5 Rho GTPase activating protein 5 -0.0221135
SVIL supervillin -0.0216835
ADAR adenosine deaminase, RNA-specific -0.0213992
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0213391
PRELID2 PRELI domain containing 2 -0.0212642
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0212405
COL4A2 collagen, type IV, alpha 2 -0.0211935
TDRD7 tudor domain containing 7 -0.020998
RABGAP1L RAB GTPase activating protein 1-like -0.020883
APP amyloid beta (A4) precursor protein -0.0206439
TMOD1 tropomodulin 1 -0.0204136
SMC5 structural maintenance of chromosomes 5 -0.020398
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0202572
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0202421
NF1 neurofibromin 1 -0.0200611
CLU clusterin -0.0200197
CALU calumenin -0.0200033
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0199076
MYO9A myosin IXA -0.0196994
MBD5 methyl-CpG binding domain protein 5 -0.0196208
CAPN2 calpain 2, (m/II) large subunit -0.0195513
FLNA filamin A, alpha -0.019515
ANKRD36 ankyrin repeat domain 36 -0.0194859
ITPRID2 ITPR interacting domain containing 2 -0.0194142
PXDN peroxidasin -0.0192252
SON SON DNA binding protein -0.0192159
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0191598
LAMB1 laminin, beta 1 -0.0190884
NID1 nidogen 1 -0.0184853