Hesperidin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Hesperidin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.102936
EXT1 exostosin glycosyltransferase 1 0.0881242
HELZ helicase with zinc finger 0.0823669
NALF1 NALCN channel auxiliary factor 1 0.0684145
NRG1 neuregulin 1 0.0678314
ZFAND3 zinc finger, AN1-type domain 3 0.063825
CEMIP cell migration inducing protein, hyaluronan binding 0.0638211
CADM1 cell adhesion molecule 1 0.0511277
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0488876
MACF1 microtubule-actin crosslinking factor 1 0.0488761
MYH9 myosin, heavy chain 9, non-muscle 0.0486028
THSD4 thrombospondin, type I, domain containing 4 0.0477845
TOP1 topoisomerase (DNA) I 0.0475565
TRIO trio Rho guanine nucleotide exchange factor 0.0441753
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0435254
WDR43 WD repeat domain 43 0.0430433
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0406524
VMP1 vacuole membrane protein 1 0.0405193
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0393521
PCBP2 poly(rC) binding protein 2 0.0390453
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.037207
ZC3H11A zinc finger CCCH-type containing 11A 0.0368376
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0365137
LPP LIM domain containing preferred translocation partner in lipoma 0.036303
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0362844
NBAS neuroblastoma amplified sequence 0.035909
CCNL1 cyclin L1 0.0358842
ZCCHC7 zinc finger, CCHC domain containing 7 0.0353258
RNF213 ring finger protein 213 0.0350967
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0349176
PICALM phosphatidylinositol binding clathrin assembly protein 0.0348488
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0346895
TLK2 tousled-like kinase 2 0.0342619
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0341136
MSI2 musashi RNA-binding protein 2 0.0338513
BBX bobby sox homolog (Drosophila) 0.0333966
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0329079
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0328348
PLAT plasminogen activator, tissue 0.0327503
RAD23B RAD23 homolog B (S. cerevisiae) 0.0327489
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0326237
CCNY cyclin Y 0.0325255
RAD51B RAD51 paralog B 0.0322686
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0321938
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0321173
ANKRD17 ankyrin repeat domain 17 0.0319273
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0311498
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0305651
TM9SF3 transmembrane 9 superfamily member 3 0.0296773
NCOR2 nuclear receptor corepressor 2 0.029661
ITGAV integrin, alpha V 0.0294676
GLS2 glutaminase 2 (liver, mitochondrial) 0.0294303
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0290787
SLITRK6 SLIT and NTRK-like family, member 6 0.0290287
LSAMP limbic system-associated membrane protein 0.0289537
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0288921
PUM1 pumilio RNA-binding family member 1 0.0286457
PTPRM protein tyrosine phosphatase, receptor type, M 0.0282768
SMAD3 SMAD family member 3 0.0282106
DNM3 dynamin 3 0.0281692
USP9X ubiquitin specific peptidase 9, X-linked 0.0276518
GPC5 glypican 5 0.0275544
CDH13 cadherin 13 0.0269198
USP34 ubiquitin specific peptidase 34 0.0268486
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0268077
PRKCA protein kinase C, alpha 0.0267742
TTC3 tetratricopeptide repeat domain 3 0.0266282
SEPTIN9 septin 9 0.0266165
KMT2E lysine (K)-specific methyltransferase 2E 0.0266159
SLMAP sarcolemma associated protein 0.0265442
LPIN1 lipin 1 0.0263177
TBC1D5 TBC1 domain family, member 5 0.0262972
FMN1 formin 1 0.0260503
GOLGB1 golgin B1 0.025824
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0257766
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0256762
KDM6A lysine (K)-specific demethylase 6A 0.0256076
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0253785
WAC WW domain containing adaptor with coiled-coil 0.0252998
CANX calnexin 0.0252108
ANTXR1 anthrax toxin receptor 1 0.0251999
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0250364
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0248451
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0248348
LRP1B low density lipoprotein receptor-related protein 1B 0.024754
AHR aryl hydrocarbon receptor 0.0247051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0246019
SETD2 SET domain containing 2 0.0244817
EGFR epidermal growth factor receptor 0.0244625
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0244272
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0241914
RPTOR regulatory associated protein of MTOR, complex 1 0.0241315
DYM dymeclin 0.0240649
CLTC clathrin, heavy chain (Hc) 0.0238644
THBS1 thrombospondin 1 0.0237594
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0237239
CUL3 cullin 3 0.0235419
XPO1 exportin 1 0.0233936
STAU1 staufen double-stranded RNA binding protein 1 0.023289
FAM107B family with sequence similarity 107, member B 0.0231211

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.248503
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.19054
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.105185
RPS6 ribosomal protein S6 -0.084003
SYT1 synaptotagmin I -0.076169
RPL35A ribosomal protein L35a -0.0699139
RPL38 ribosomal protein L38 -0.0640105
RPLP1 ribosomal protein, large, P1 -0.0612749
RPL23 ribosomal protein L23 -0.0610829
RPL19 ribosomal protein L19 -0.0586637
VIM vimentin -0.0583151
TPT1 tumor protein, translationally-controlled 1 -0.05501
RPL34 ribosomal protein L34 -0.054098
HAND2 heart and neural crest derivatives expressed 2 -0.0513719
DCAF7 DDB1 and CUL4 associated factor 7 -0.0488225
CD36 CD36 molecule (thrombospondin receptor) -0.0485936
RPL31 ribosomal protein L31 -0.0464825
PRRC2C proline-rich coiled-coil 2C -0.0431244
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0428056
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0422157
EIF1 eukaryotic translation initiation factor 1 -0.0419867
RPS24 ribosomal protein S24 -0.0417033
SOS1 son of sevenless homolog 1 (Drosophila) -0.0403611
UBE2O ubiquitin-conjugating enzyme E2O -0.0390904
GNAS GNAS complex locus -0.0388914
SCAF11 SR-related CTD-associated factor 11 -0.0381964
PCDH9 protocadherin 9 -0.0375519
TOP2A topoisomerase (DNA) II alpha 170kDa -0.036674
RPS19 ribosomal protein S19 -0.0355683
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0353332
RPL27 ribosomal protein L27 -0.0346863
RPL26 ribosomal protein L26 -0.0341457
ZBTB20 zinc finger and BTB domain containing 20 -0.0332131
PTPRD protein tyrosine phosphatase, receptor type, D -0.0331677
RPL13A ribosomal protein L13a -0.0329105
CENPF centromere protein F, 350/400kDa -0.0328714
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0318394
RPS2 ribosomal protein S2 -0.0317496
TBX2 T-box 2 -0.0317182
WDR45B WD repeat domain 45B -0.0317144
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0313882
TMSB10 thymosin beta 10 -0.0311564
FOXP1 forkhead box P1 -0.0302253
RPL37A ribosomal protein L37a -0.0301501
PTMA prothymosin, alpha -0.0299911
CCAR1 cell division cycle and apoptosis regulator 1 -0.028836
MAP1B microtubule-associated protein 1B -0.0282724
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0278654
KIF21A kinesin family member 21A -0.027275
RPS3 ribosomal protein S3 -0.0269434
RPL7 ribosomal protein L7 -0.0267934
S100A9 S100 calcium binding protein A9 -0.0267745
TRIB2 tribbles pseudokinase 2 -0.0267038
AMOTL1 angiomotin like 1 -0.0266868
SEC23A Sec23 homolog A (S. cerevisiae) -0.0264812
RPL12 ribosomal protein L12 -0.0262982
S100A6 S100 calcium binding protein A6 -0.0262913
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0261619
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.026153
EIF5B eukaryotic translation initiation factor 5B -0.026047
ARHGAP5 Rho GTPase activating protein 5 -0.0257006
GCC2 GRIP and coiled-coil domain containing 2 -0.0256816
RPS11 ribosomal protein S11 -0.0254372
THOC2 THO complex 2 -0.0251607
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0250585
NSD3 nuclear receptor binding SET domain protein 3 -0.0249548
RALYL RALY RNA binding protein-like -0.0249101
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0248524
FTL ferritin, light polypeptide -0.0248278
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0247369
PNISR PNN-interacting serine/arginine-rich protein -0.0247128
RPL28 ribosomal protein L28 -0.0243523
PDE4D phosphodiesterase 4D, cAMP-specific -0.0243271
RPL30 ribosomal protein L30 -0.024146
RACK1 receptor for activated C kinase 1 -0.0241207
FAM13A family with sequence similarity 13, member A -0.0239873
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0239613
ARF1 ADP-ribosylation factor 1 -0.0239207
XRN1 5'-3' exoribonuclease 1 -0.0238721
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0236146
PHIP pleckstrin homology domain interacting protein -0.0235314
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0232057
RPL11 ribosomal protein L11 -0.023102
RPL36A ribosomal protein L36a -0.0231007
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0228967
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.022785
FNBP1 formin binding protein 1 -0.0227821
LMNA lamin A/C -0.0227207
YEATS2 YEATS domain containing 2 -0.0225528
RPLP2 ribosomal protein, large, P2 -0.0224335
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0222566
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.022223
RPL36AL ribosomal protein L36a-like -0.0221364
RPS20 ribosomal protein S20 -0.0218965
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0218943
RPL37 ribosomal protein L37 -0.0218044
TBCK TBC1 domain containing kinase -0.0213243
CCNI cyclin I -0.0213183
IER3 immediate early response 3 -0.0213153
RPL4 ribosomal protein L4 -0.0210988