Hesperidin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Hesperidin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0717604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0656058
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0458489
MBNL2 muscleblind-like splicing regulator 2 0.0386519
SEC24D SEC24 family member D 0.0346044
INTS6 integrator complex subunit 6 0.03376
SEC31A SEC31 homolog A (S. cerevisiae) 0.0310845
ERRFI1 ERBB receptor feedback inhibitor 1 0.0304502
CANX calnexin 0.0271989
COG6 component of oligomeric golgi complex 6 0.0269052
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0267872
FNIP1 folliculin interacting protein 1 0.0265522
DSCAM Down syndrome cell adhesion molecule 0.0240664
GOLGA4 golgin A4 0.0231998
AHI1 Abelson helper integration site 1 0.0227727
FNDC3A fibronectin type III domain containing 3A 0.0224828
ZMYM2 zinc finger, MYM-type 2 0.0223608
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0214687
IFNGR1 interferon gamma receptor 1 0.0207573
KDM6A lysine (K)-specific demethylase 6A 0.0200319
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0197759
TTC3 tetratricopeptide repeat domain 3 0.0197233
ARRDC3 arrestin domain containing 3 0.0195974
COPB1 coatomer protein complex, subunit beta 1 0.0195271
SUCO SUN domain containing ossification factor 0.0186356
SSR1 signal sequence receptor, alpha 0.0174145
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.017199
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0171598
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0171578
HBS1L HBS1-like translational GTPase 0.0168123
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0167792
USP3 ubiquitin specific peptidase 3 0.0166922
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.016118
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0159317
TM9SF2 transmembrane 9 superfamily member 2 0.0157813
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0157249
PLSCR2 phospholipid scramblase 2 0.0156445
PDIA3 protein disulfide isomerase family A, member 3 0.0155962
MCTP2 multiple C2 domains, transmembrane 2 0.0154298
PRRC1 proline-rich coiled-coil 1 0.0153932
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0150772
TSC22D2 TSC22 domain family, member 2 0.014995
HELZ helicase with zinc finger 0.0149401
BCLAF1 BCL2-associated transcription factor 1 0.0147112
BIRC6 baculoviral IAP repeat containing 6 0.0146519
HDLBP high density lipoprotein binding protein 0.0144378
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0143462
TMEM263 transmembrane protein 263 0.0142809
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0141951
UBL3 ubiquitin-like 3 0.0139471
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0136719
PUM2 pumilio RNA-binding family member 2 0.0135467
MORF4L2 mortality factor 4 like 2 0.0134089
HYOU1 hypoxia up-regulated 1 0.0133123
KIZ kizuna centrosomal protein 0.0132321
SCFD1 sec1 family domain containing 1 0.0130529
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0128006
SEC24A SEC24 family member A 0.0126912
PGM3 phosphoglucomutase 3 0.0125908
TMED2 transmembrane emp24 domain trafficking protein 2 0.0125004
PRELID2 PRELI domain containing 2 0.0124473
WDR26 WD repeat domain 26 0.0124466
TENT2 terminal nucleotidyltransferase 2 0.0122456
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0122151
TBC1D23 TBC1 domain family, member 23 0.0121749
ESYT2 extended synaptotagmin-like protein 2 0.012159
CADPS2 Ca++-dependent secretion activator 2 0.0121239
TMEM39A transmembrane protein 39A 0.0121212
DIAPH3 diaphanous-related formin 3 0.0120732
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0119108
FAT1 FAT atypical cadherin 1 0.011909
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0118857
KLHL24 kelch-like family member 24 0.0118778
SRP54 signal recognition particle 54kDa 0.0117289
ZNF451 zinc finger protein 451 0.0115952
LNX2 ligand of numb-protein X 2 0.0115437
SEC23B Sec23 homolog B (S. cerevisiae) 0.0115007
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0114918
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.0114704
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0114456
SMAD3 SMAD family member 3 0.0114413
CEP350 centrosomal protein 350kDa 0.0113312
RAB2A RAB2A, member RAS oncogene family 0.0113196
TXNDC11 thioredoxin domain containing 11 0.0113164
CALU calumenin 0.0113039
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0112371
PTEN phosphatase and tensin homolog 0.0112206
USPL1 ubiquitin specific peptidase like 1 0.011204
COPA coatomer protein complex, subunit alpha 0.0110488
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0109162
FANCI Fanconi anemia, complementation group I 0.0109157
DMXL2 Dmx-like 2 0.0108082
CAMTA1 calmodulin binding transcription activator 1 0.0106677
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0106632
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0106122
RNF149 ring finger protein 149 0.0105992
TRIP11 thyroid hormone receptor interactor 11 0.0105906
PIBF1 progesterone immunomodulatory binding factor 1 0.0105623
SFXN1 sideroflexin 1 0.0105272
RBM33 RNA binding motif protein 33 0.010517

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.177486
EPSTI1 epithelial stromal interaction 1 (breast) -0.166226
LYZ lysozyme -0.113571
LCN2 lipocalin 2 -0.10896
ZMYND8 zinc finger, MYND-type containing 8 -0.105581
IFI6 interferon, alpha-inducible protein 6 -0.0994721
HLA-B major histocompatibility complex, class I, B -0.0951278
C6ORF132 chromosome 6 open reading frame 132 -0.0891895
TPT1 tumor protein, translationally-controlled 1 -0.0852689
MX2 MX dynamin-like GTPase 2 -0.0849711
PTMA prothymosin, alpha -0.0848912
LOC102724023 ES1 protein homolog, mitochondrial -0.0818179
GMDS GDP-mannose 4,6-dehydratase -0.0724899
RABGAP1L RAB GTPase activating protein 1-like -0.0721534
RNF213 ring finger protein 213 -0.0718107
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0711186
IFI27 interferon, alpha-inducible protein 27 -0.0704375
TMC5 transmembrane channel-like 5 -0.0701438
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0696047
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0688128
RIGI RNA sensor RIG-I -0.0683021
MX1 MX dynamin-like GTPase 1 -0.0681851
ITGA6 integrin, alpha 6 -0.0667833
SP100 SP100 nuclear antigen -0.0630204
XAF1 XIAP associated factor 1 -0.062174
TMSB10 thymosin beta 10 -0.0608595
STS steroid sulfatase (microsomal), isozyme S -0.0607733
TSHZ2 teashirt zinc finger homeobox 2 -0.0604442
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0593839
SPATA13 spermatogenesis associated 13 -0.0592753
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0573396
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0547304
SLC38A1 solute carrier family 38, member 1 -0.0538571
EPHB2 EPH receptor B2 -0.0538333
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0507092
PLSCR1 phospholipid scramblase 1 -0.0482906
MAML2 mastermind-like 2 (Drosophila) -0.0477059
MT2A metallothionein 2A -0.0472425
ARHGAP26 Rho GTPase activating protein 26 -0.0469747
PKM pyruvate kinase, muscle -0.0456093
SSH2 slingshot protein phosphatase 2 -0.0453173
NPSR1 neuropeptide S receptor 1 -0.0452759
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0451896
EGR1 early growth response 1 -0.0450078
JUN jun proto-oncogene -0.043983
RPL35A ribosomal protein L35a -0.0432862
EXT1 exostosin glycosyltransferase 1 -0.0424959
PRKCA protein kinase C, alpha -0.0424366
ATP11A ATPase, class VI, type 11A -0.0422966
NCKAP5 NCK-associated protein 5 -0.0416372
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0411492
RAB7A RAB7A, member RAS oncogene family -0.0406833
ERBIN erbb2 interacting protein -0.0405267
GCLC glutamate-cysteine ligase, catalytic subunit -0.0399302
FTL ferritin, light polypeptide -0.0398391
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0390539
H1-0 H1.0 linker histone -0.0382601
PTGR1 prostaglandin reductase 1 -0.0366889
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0366505
HLA-A major histocompatibility complex, class I, A -0.0361473
GCC2 GRIP and coiled-coil domain containing 2 -0.0354754
IFITM3 interferon induced transmembrane protein 3 -0.0354456
ETV6 ets variant 6 -0.0354129
RPL23 ribosomal protein L23 -0.0351001
PMP22 peripheral myelin protein 22 -0.0347792
RAD51B RAD51 paralog B -0.034518
KRT19 keratin 19, type I -0.0342966
MSI2 musashi RNA-binding protein 2 -0.0339174
TRIO trio Rho guanine nucleotide exchange factor -0.0336497
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0336189
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0332662
PERP PERP, TP53 apoptosis effector -0.0332577
SQSTM1 sequestosome 1 -0.0329853
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0327741
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0324297
RBM47 RNA binding motif protein 47 -0.0321392
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.031681
MACC1 metastasis associated in colon cancer 1 -0.0311624
TRIM56 tripartite motif containing 56 -0.0310288
RPS19 ribosomal protein S19 -0.0309267
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0308717
MAP7 microtubule-associated protein 7 -0.0308397
HLA-E major histocompatibility complex, class I, E -0.0307319
HLA-C major histocompatibility complex, class I, C -0.0306713
MPHOSPH8 M-phase phosphoprotein 8 -0.0305338
MUC20 mucin 20, cell surface associated -0.0305052
PATJ PATJ crumbs cell polarity complex component -0.0299458
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0296855
IGFBP3 insulin-like growth factor binding protein 3 -0.0294433
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0294239
NKD1 naked cuticle homolog 1 (Drosophila) -0.0290795
TM4SF1 transmembrane 4 L six family member 1 -0.029004
PGK1 phosphoglycerate kinase 1 -0.0289075
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0288401
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0285575
MECOM MDS1 and EVI1 complex locus -0.0284781
ASPH aspartate beta-hydroxylase -0.0284551
ATP10B ATPase, class V, type 10B -0.0284323
CST3 cystatin C -0.0283279
MUC13 mucin 13, cell surface associated -0.0282188