Hesperidin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0855261
ATP13A3 ATPase type 13A3 0.0777551
FNDC3B fibronectin type III domain containing 3B 0.0530968
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0460272
ARRDC3 arrestin domain containing 3 0.0440333
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0438642
ZNF292 zinc finger protein 292 0.0422889
NAMPT nicotinamide phosphoribosyltransferase 0.0412803
TFG TRK-fused gene 0.0398902
SOD2 superoxide dismutase 2, mitochondrial 0.036632
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0345845
RASA2 RAS p21 protein activator 2 0.0340826
TNIP1 TNFAIP3 interacting protein 1 0.0334128
IL6ST interleukin 6 signal transducer 0.0327144
SPAG9 sperm associated antigen 9 0.0326912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313638
ZFAND3 zinc finger, AN1-type domain 3 0.0301596
ADAM17 ADAM metallopeptidase domain 17 0.0289721
FXR1 fragile X mental retardation, autosomal homolog 1 0.0287512
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0280614
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0279014
TRIO trio Rho guanine nucleotide exchange factor 0.0274886
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0265718
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0263737
MRTFA myocardin related transcription factor A 0.0263036
UBA6 ubiquitin-like modifier activating enzyme 6 0.0259412
USP3 ubiquitin specific peptidase 3 0.0259388
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0256797
ADAM9 ADAM metallopeptidase domain 9 0.0253218
QKI QKI, KH domain containing, RNA binding 0.0250483
PDIA6 protein disulfide isomerase family A, member 6 0.0249284
RNF145 ring finger protein 145 0.0248221
TSC22D2 TSC22 domain family, member 2 0.0243333
YBX1 Y box binding protein 1 0.0241069
ALCAM activated leukocyte cell adhesion molecule 0.0240753
TRAM1 translocation associated membrane protein 1 0.0236408
RYBP RING1 and YY1 binding protein 0.0235633
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0235389
FTH1 ferritin, heavy polypeptide 1 0.0230262
ICAM1 intercellular adhesion molecule 1 0.0228947
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0224511
CCNL1 cyclin L1 0.0222345
CADM1 cell adhesion molecule 1 0.0221876
PKM pyruvate kinase, muscle 0.0220094
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0219998
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0216953
AZIN1 antizyme inhibitor 1 0.021595
HELZ helicase with zinc finger 0.0214572
CXCL3 chemokine (C-X-C motif) ligand 3 0.0213917
CSF1 colony stimulating factor 1 (macrophage) 0.021341
EEF2 eukaryotic translation elongation factor 2 0.0211268
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0208703
POTEF POTE ankyrin domain family, member F 0.020649
UGCG UDP-glucose ceramide glucosyltransferase 0.0204147
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0202531
RLF rearranged L-myc fusion 0.0200007
PCBP2 poly(rC) binding protein 2 0.0198562
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0194762
EPS8 epidermal growth factor receptor pathway substrate 8 0.0194278
PERP PERP, TP53 apoptosis effector 0.0193258
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0191043
RYK receptor-like tyrosine kinase 0.0186738
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0186344
KDM6A lysine (K)-specific demethylase 6A 0.0186159
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0185202
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0184868
DSTN destrin (actin depolymerizing factor) 0.0183563
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.018054
MSN moesin 0.0177794
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177771
GLS2 glutaminase 2 (liver, mitochondrial) 0.0177263
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0177227
CXCL8 chemokine (C-X-C motif) ligand 8 0.0176475
AXL AXL receptor tyrosine kinase 0.017632
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0174114
SMAD3 SMAD family member 3 0.0171366
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0171089
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0170572
SQLE squalene epoxidase 0.0170167
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0170138
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0169643
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0168295
KMT2E lysine (K)-specific methyltransferase 2E 0.0166964
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0166694
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0163831
FOXJ3 forkhead box J3 0.0163053
ECT2 epithelial cell transforming 2 0.0162055
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0160885
CLIC4 chloride intracellular channel 4 0.0160092
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.015897
SCARB2 scavenger receptor class B, member 2 0.0157601
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0157219
XPO1 exportin 1 0.0156763
NCKAP1 NCK-associated protein 1 0.015663
MTF2 metal response element binding transcription factor 2 0.0153761
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0153669
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0151482
NUP58 nucleoporin 58 0.0150127
ANLN anillin, actin binding protein 0.0150099
FOSL1 FOS-like antigen 1 0.014725

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.389416
VIM vimentin -0.187158
TIMP3 TIMP metallopeptidase inhibitor 3 -0.168866
COL1A1 collagen, type I, alpha 1 -0.161091
FN1 fibronectin 1 -0.157558
COL6A3 collagen, type VI, alpha 3 -0.157098
NDRG1 N-myc downstream regulated 1 -0.119707
CDH13 cadherin 13 -0.114886
LOXL2 lysyl oxidase-like 2 -0.100422
TGFBI transforming growth factor, beta-induced, 68kDa -0.100221
PSD3 pleckstrin and Sec7 domain containing 3 -0.0994877
COL1A2 collagen, type I, alpha 2 -0.0986263
COL5A1 collagen, type V, alpha 1 -0.0931423
TMSB10 thymosin beta 10 -0.0884885
ZBTB20 zinc finger and BTB domain containing 20 -0.0824357
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0819552
FBN1 fibrillin 1 -0.0796279
STC1 stanniocalcin 1 -0.0701298
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0687971
IER3 immediate early response 3 -0.0683244
EXT1 exostosin glycosyltransferase 1 -0.0612648
GLIS3 GLIS family zinc finger 3 -0.0607795
ASPH aspartate beta-hydroxylase -0.0605301
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.05948
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0574121
HLA-B major histocompatibility complex, class I, B -0.0570575
F3 coagulation factor III (thromboplastin, tissue factor) -0.0552502
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0551489
CAVIN1 caveolae associated protein 1 -0.054983
RRBP1 ribosome binding protein 1 -0.0548576
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0537616
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0527922
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0507365
TPM4 tropomyosin 4 -0.0494995
NAV1 neuron navigator 1 -0.0482728
AHNAK AHNAK nucleoprotein -0.0481689
TRPS1 trichorhinophalangeal syndrome I -0.0469437
TM4SF1 transmembrane 4 L six family member 1 -0.0468552
HMGA2 high mobility group AT-hook 2 -0.0431858
COL6A2 collagen, type VI, alpha 2 -0.0431644
DPYD dihydropyrimidine dehydrogenase -0.0431176
JARID2 jumonji, AT rich interactive domain 2 -0.0421065
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0416433
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0415257
CLMP CXADR-like membrane protein -0.0404288
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.040306
OSMR oncostatin M receptor -0.0401456
TPT1 tumor protein, translationally-controlled 1 -0.0401254
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0399806
GOLGB1 golgin B1 -0.038158
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0380949
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.037148
COL7A1 collagen, type VII, alpha 1 -0.0366825
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0362942
ACTG1 actin gamma 1 -0.0351328
LOX lysyl oxidase -0.0348012
CD44 CD44 molecule (Indian blood group) -0.0346962
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0346931
RPL35A ribosomal protein L35a -0.0341541
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0331714
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0327618
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0323497
EIF1 eukaryotic translation initiation factor 1 -0.0318602
CMIP c-Maf inducing protein -0.0314917
FTL ferritin, light polypeptide -0.0310999
DOCK5 dedicator of cytokinesis 5 -0.030702
SDC2 syndecan 2 -0.0302591
RUNX1 runt-related transcription factor 1 -0.0300317
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0287541
PDE10A phosphodiesterase 10A -0.0285906
IFI6 interferon, alpha-inducible protein 6 -0.0282143
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0278928
LMAN1 lectin, mannose-binding, 1 -0.027256
TTC3 tetratricopeptide repeat domain 3 -0.0271833
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0271798
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0267014
FKBP10 FK506 binding protein 10, 65 kDa -0.0265296
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0265075
OXR1 oxidation resistance 1 -0.0262125
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0258719
COL6A1 collagen, type VI, alpha 1 -0.0257472
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0256771
NRP1 neuropilin 1 -0.0252812
MT2A metallothionein 2A -0.0250022
VCL vinculin -0.0242032
PRELID2 PRELI domain containing 2 -0.024021
ARL4C ADP-ribosylation factor-like 4C -0.0239681
S100A6 S100 calcium binding protein A6 -0.0239657
RPS8 ribosomal protein S8 -0.0239238
CUX1 cut-like homeobox 1 -0.0238961
GNAS GNAS complex locus -0.0238448
HM13 histocompatibility (minor) 13 -0.0238386
MTDH metadherin -0.023773
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.02374
LTBP1 latent transforming growth factor beta binding protein 1 -0.0235133
CALR calreticulin -0.0227988
EGFR epidermal growth factor receptor -0.0227337
CTSB cathepsin B -0.0226168
ABI3BP ABI family, member 3 (NESH) binding protein -0.0225545
ARHGAP22 Rho GTPase activating protein 22 -0.0224596