Hesperidin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.376091
FNDC3B fibronectin type III domain containing 3B 0.117005
GPC6 glypican 6 0.100554
ERRFI1 ERBB receptor feedback inhibitor 1 0.0920641
ITGAV integrin, alpha V 0.0743407
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0685074
IGFBP1 insulin-like growth factor binding protein 1 0.064535
SVIL supervillin 0.0621433
DSPP dentin sialophosphoprotein 0.059943
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0587837
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0527213
ATXN1 ataxin 1 0.0508493
ELL2 elongation factor, RNA polymerase II, 2 0.0494413
LRMDA leucine rich melanocyte differentiation associated 0.0487237
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0484955
EXT1 exostosin glycosyltransferase 1 0.0479675
ASPH aspartate beta-hydroxylase 0.046559
DTNA dystrobrevin, alpha 0.0459894
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0453283
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0450217
FAT1 FAT atypical cadherin 1 0.0439662
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0438474
SAMD4A sterile alpha motif domain containing 4A 0.0437202
VMP1 vacuole membrane protein 1 0.0433342
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0429748
SOD2 superoxide dismutase 2, mitochondrial 0.0409462
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0379072
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0378724
SKIL SKI-like proto-oncogene 0.0370871
CEMIP2 cell migration inducing hyaluronidase 2 0.0367301
GOLGA4 golgin A4 0.0364806
CCL20 chemokine (C-C motif) ligand 20 0.0363017
USP34 ubiquitin specific peptidase 34 0.0352754
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0351851
CSNK1A1 casein kinase 1, alpha 1 0.0351023
APOB apolipoprotein B 0.0343307
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0334008
JMJD1C jumonji domain containing 1C 0.0333015
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0330076
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321646
SOX5 SRY (sex determining region Y)-box 5 0.031672
RUNX1 runt-related transcription factor 1 0.0306554
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0302795
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298192
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0294305
BIRC6 baculoviral IAP repeat containing 6 0.0292474
SBF2 SET binding factor 2 0.0284936
FTH1 ferritin, heavy polypeptide 1 0.0283701
FRMD5 FERM domain containing 5 0.0283043
NPAS2 neuronal PAS domain protein 2 0.0280105
SOS1 son of sevenless homolog 1 (Drosophila) 0.0279134
MBNL1 muscleblind-like splicing regulator 1 0.027885
TXNRD1 thioredoxin reductase 1 0.0277234
CRLS1 cardiolipin synthase 1 0.027635
RTN4 reticulon 4 0.0275007
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0272184
MYH9 myosin, heavy chain 9, non-muscle 0.0270942
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0268553
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.026732
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.026661
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0263516
MACF1 microtubule-actin crosslinking factor 1 0.0263397
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0262811
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259065
VCL vinculin 0.0258824
FRK fyn-related Src family tyrosine kinase 0.0258701
NIPBL Nipped-B homolog (Drosophila) 0.0258676
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0256921
MYO1B myosin IB 0.0256029
TTC28 tetratricopeptide repeat domain 28 0.0250304
LPP LIM domain containing preferred translocation partner in lipoma 0.0249955
USP47 ubiquitin specific peptidase 47 0.0248581
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0246787
PTEN phosphatase and tensin homolog 0.0244167
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0244139
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024263
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0241069
TNS1 tensin 1 0.0240736
EXOC6B exocyst complex component 6B 0.0240275
RSRC2 arginine/serine-rich coiled-coil 2 0.023785
BIRC3 baculoviral IAP repeat containing 3 0.023733
ZFAND3 zinc finger, AN1-type domain 3 0.0235581
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0234467
FNIP1 folliculin interacting protein 1 0.0233867
PCBP2 poly(rC) binding protein 2 0.0233235
ANKRD17 ankyrin repeat domain 17 0.0230876
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0229919
BHLHE40 basic helix-loop-helix family, member e40 0.0228127
MAML2 mastermind-like 2 (Drosophila) 0.0226096
KDM4C lysine (K)-specific demethylase 4C 0.0225739
TIMP1 TIMP metallopeptidase inhibitor 1 0.0225639
DARS1 aspartyl-tRNA synthetase 1 0.0225256
YAP1 Yes-associated protein 1 0.0224716
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0223782
PDE4D phosphodiesterase 4D, cAMP-specific 0.0221259
ANKRD12 ankyrin repeat domain 12 0.0220645
KMT2C lysine (K)-specific methyltransferase 2C 0.0220606
FAM107B family with sequence similarity 107, member B 0.0219734
ZBTB20 zinc finger and BTB domain containing 20 0.0219483
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0219071

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.0819118
MT2A metallothionein 2A -0.0654898
AKAP12 A kinase (PRKA) anchor protein 12 -0.0634116
RPL37A ribosomal protein L37a -0.0617328
RPS6 ribosomal protein S6 -0.0610719
FBF1 Fas (TNFRSF6) binding factor 1 -0.0608657
RPS12 ribosomal protein S12 -0.0543694
APOA2 apolipoprotein A-II -0.0498742
RPS8 ribosomal protein S8 -0.0471734
RPS27A ribosomal protein S27a -0.0462073
RPL11 ribosomal protein L11 -0.0441663
AHSG alpha-2-HS-glycoprotein -0.0413344
RPL35A ribosomal protein L35a -0.0411914
TRIM26 tripartite motif containing 26 -0.04068
FTL ferritin, light polypeptide -0.0403772
DLC1 DLC1 Rho GTPase activating protein -0.0397906
RBM39 RNA binding motif protein 39 -0.0396516
TMSB10 thymosin beta 10 -0.0374592
AMBP alpha-1-microglobulin/bikunin precursor -0.0365432
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0359764
EML4 echinoderm microtubule associated protein like 4 -0.0350955
TPT1 tumor protein, translationally-controlled 1 -0.0347691
RPLP1 ribosomal protein, large, P1 -0.0335555
APOE apolipoprotein E -0.0322292
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0316711
RPS29 ribosomal protein S29 -0.0304257
RPS21 ribosomal protein S21 -0.0297797
RPS3 ribosomal protein S3 -0.029684
A2M alpha-2-macroglobulin -0.0293211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0292473
RPS19 ribosomal protein S19 -0.0292094
GPC3 glypican 3 -0.0285718
APOA1 apolipoprotein A-I -0.0284732
RPS13 ribosomal protein S13 -0.027781
RPL19 ribosomal protein L19 -0.0276363
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0274757
SLC38A1 solute carrier family 38, member 1 -0.0272719
RPL26 ribosomal protein L26 -0.0268833
RPL34 ribosomal protein L34 -0.0267751
CTSB cathepsin B -0.0260825
PLIN2 perilipin 2 -0.0258869
TF transferrin -0.0258427
TM4SF1 transmembrane 4 L six family member 1 -0.0258103
NPR2 natriuretic peptide receptor 2 -0.0256879
RPS17 ribosomal protein S17 -0.0246739
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0245483
RPL5 ribosomal protein L5 -0.0244709
PEG10 paternally expressed 10 -0.0238671
H1-0 H1.0 linker histone -0.0235048
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0225691
SEPTIN7 septin 7 -0.0222586
RPL31 ribosomal protein L31 -0.0216402
S100A9 S100 calcium binding protein A9 -0.021334
CALD1 caldesmon 1 -0.0211515
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0210467
RPL27 ribosomal protein L27 -0.0209888
SELENOP selenoprotein P -0.020597
UBASH3B ubiquitin associated and SH3 domain containing B -0.0205844
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0204089
TMEM123 transmembrane protein 123 -0.0203476
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0203451
GCC2 GRIP and coiled-coil domain containing 2 -0.020056
RPL9 ribosomal protein L9 -0.0200556
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0199216
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0197985
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0197427
RPS27 ribosomal protein S27 -0.0195875
HMGA1 high mobility group AT-hook 1 -0.0194364
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0193636
RPL36 ribosomal protein L36 -0.0193381
RPL18 ribosomal protein L18 -0.0188975
PDIA6 protein disulfide isomerase family A, member 6 -0.018894
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0187576
ZMYND8 zinc finger, MYND-type containing 8 -0.0187015
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0185389
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0183942
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0182305
CPE carboxypeptidase E -0.0180501
LYZ lysozyme -0.0180291
MAPK8 mitogen-activated protein kinase 8 -0.0178667
PTPRM protein tyrosine phosphatase, receptor type, M -0.0176165
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.017396
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0170311
RPL38 ribosomal protein L38 -0.0169735
RPL7 ribosomal protein L7 -0.0169454
RPS14 ribosomal protein S14 -0.0166849
B2M beta-2-microglobulin -0.0164947
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0160249
ACYP2 acylphosphatase 2, muscle type -0.0158156
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0157848
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0156896
RPL23 ribosomal protein L23 -0.0156025
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0155818
RPL37 ribosomal protein L37 -0.0154719
PTCHD4 patched domain containing 4 -0.0154264
AHNAK AHNAK nucleoprotein -0.0153642
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0153455
F11R F11 receptor -0.0153309
RPLP2 ribosomal protein, large, P2 -0.0153216
PDGFB platelet-derived growth factor beta polypeptide -0.015316