Hesperidin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0971499
B2M beta-2-microglobulin 0.082966
ENO1 enolase 1, (alpha) 0.0766824
CLU clusterin 0.0720323
NAMPT nicotinamide phosphoribosyltransferase 0.0704477
PTMA prothymosin, alpha 0.0673808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0643558
GOLGA4 golgin A4 0.0605989
PGK1 phosphoglycerate kinase 1 0.0604526
MYOF myoferlin 0.0578451
CANX calnexin 0.0546878
ANXA1 annexin A1 0.0544977
KRT17 keratin 17, type I 0.0540684
SQLE squalene epoxidase 0.0515421
RBM39 RNA binding motif protein 39 0.0505642
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0501
ITCH itchy E3 ubiquitin protein ligase 0.0485568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0478813
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0473828
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0463804
MEF2A myocyte enhancer factor 2A 0.0459256
DSTN destrin (actin depolymerizing factor) 0.0457545
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0454068
KDM6A lysine (K)-specific demethylase 6A 0.0415557
RICTOR RPTOR independent companion of MTOR, complex 2 0.0415047
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0401676
FLNB filamin B, beta 0.038568
KDM3A lysine (K)-specific demethylase 3A 0.0382536
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.037798
POTEF POTE ankyrin domain family, member F 0.0372961
GARS1 glycyl-tRNA synthetase 1 0.0367466
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0351654
S100A10 S100 calcium binding protein A10 0.0345176
EZR ezrin 0.0344091
RAB6A RAB6A, member RAS oncogene family 0.0338443
ARRDC3 arrestin domain containing 3 0.033631
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0335348
OGA O-GlcNAcase 0.0332827
CALU calumenin 0.0329799
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0329279
YBX1 Y box binding protein 1 0.0327759
LDHA lactate dehydrogenase A 0.0325717
ANLN anillin, actin binding protein 0.0325534
APLP2 amyloid beta (A4) precursor-like protein 2 0.0324018
SUCO SUN domain containing ossification factor 0.0321521
PDIA3 protein disulfide isomerase family A, member 3 0.0319835
KRT6A keratin 6A, type II 0.03153
MATR3 matrin 3 0.0313448
MORF4L2 mortality factor 4 like 2 0.0309257
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0307419
COG5 component of oligomeric golgi complex 5 0.0304934
NUP58 nucleoporin 58 0.0297344
COPB1 coatomer protein complex, subunit beta 1 0.0294146
KTN1 kinectin 1 (kinesin receptor) 0.0290518
PRRC2C proline-rich coiled-coil 2C 0.0285609
MT2A metallothionein 2A 0.0282753
EIF1 eukaryotic translation initiation factor 1 0.0282576
HELZ helicase with zinc finger 0.0282301
RLF rearranged L-myc fusion 0.0281679
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0276962
RPS8 ribosomal protein S8 0.0276834
TMSB10 thymosin beta 10 0.0276574
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0276408
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0275095
TOP2A topoisomerase (DNA) II alpha 170kDa 0.027389
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.027225
SRP54 signal recognition particle 54kDa 0.0271699
RNF145 ring finger protein 145 0.0268934
CSDE1 cold shock domain containing E1, RNA-binding 0.0268363
QKI QKI, KH domain containing, RNA binding 0.0266624
ACBD3 acyl-CoA binding domain containing 3 0.0265182
SERINC3 serine incorporator 3 0.0263103
TFG TRK-fused gene 0.0262363
RPS13 ribosomal protein S13 0.0261119
ESYT2 extended synaptotagmin-like protein 2 0.0260953
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0258571
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0257819
RPS6 ribosomal protein S6 0.0257804
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255159
LMAN1 lectin, mannose-binding, 1 0.0254797
SFTPA2 surfactant protein A2 0.0254657
ADAM9 ADAM metallopeptidase domain 9 0.0250511
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0249401
NPEPPS aminopeptidase puromycin sensitive 0.0247822
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0244188
COPA coatomer protein complex, subunit alpha 0.0241777
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0241369
RPLP1 ribosomal protein, large, P1 0.0241084
FTL ferritin, light polypeptide 0.0239506
ITGA6 integrin, alpha 6 0.0238654
PCBP2 poly(rC) binding protein 2 0.0238432
NDRG1 N-myc downstream regulated 1 0.0238267
S100A6 S100 calcium binding protein A6 0.0238198
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0237142
RIOK3 RIO kinase 3 0.0235131
CD99 CD99 molecule 0.0234937
RPLP0 ribosomal protein, large, P0 0.0233674
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0233309
PKM pyruvate kinase, muscle 0.0233188
TPM3 tropomyosin 3 0.0232901

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.197306
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.085728
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0836216
SLC35F3 solute carrier family 35, member F3 -0.0742104
DPYD dihydropyrimidine dehydrogenase -0.0673734
LMO7 LIM domain 7 -0.0672209
PDLIM5 PDZ and LIM domain 5 -0.0652258
PDE4D phosphodiesterase 4D, cAMP-specific -0.0631004
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0592928
RIGI RNA sensor RIG-I -0.0497607
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0494686
HMGA2 high mobility group AT-hook 2 -0.0427097
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0409639
RABGAP1L RAB GTPase activating protein 1-like -0.0409317
INTS6 integrator complex subunit 6 -0.0398561
RAD51B RAD51 paralog B -0.0372374
RASAL2 RAS protein activator like 2 -0.0364163
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0343476
PRSS23 protease, serine, 23 -0.0333993
MTSS1 metastasis suppressor 1 -0.0326354
CDK6 cyclin-dependent kinase 6 -0.0314153
SMYD3 SET and MYND domain containing 3 -0.0313038
MECOM MDS1 and EVI1 complex locus -0.031258
LAMC2 laminin, gamma 2 -0.0310831
ALCAM activated leukocyte cell adhesion molecule -0.0298231
PALLD palladin, cytoskeletal associated protein -0.0291035
FN1 fibronectin 1 -0.0290984
MACF1 microtubule-actin crosslinking factor 1 -0.0282925
ANO1 anoctamin 1, calcium activated chloride channel -0.0280626
EFNA5 ephrin-A5 -0.0277953
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0276457
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0276189
DOK5 docking protein 5 -0.0275973
SULF1 sulfatase 1 -0.0271733
HSPG2 heparan sulfate proteoglycan 2 -0.0271584
CSMD2 CUB and Sushi multiple domains 2 -0.0270546
RAI14 retinoic acid induced 14 -0.0270289
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0269532
OSMR oncostatin M receptor -0.0265344
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0263141
ABI3BP ABI family, member 3 (NESH) binding protein -0.0242836
TENM4 teneurin transmembrane protein 4 -0.0241502
MTAP methylthioadenosine phosphorylase -0.0239318
VCL vinculin -0.0237868
PLXNA2 plexin A2 -0.0235303
AMOTL1 angiomotin like 1 -0.0234241
EXT1 exostosin glycosyltransferase 1 -0.0233695
ZEB1 zinc finger E-box binding homeobox 1 -0.023297
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0229507
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0227086
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0223635
C4BPB complement component 4 binding protein, beta -0.022324
BCAR3 breast cancer anti-estrogen resistance 3 -0.0222192
AOPEP aminopeptidase O (putative) -0.0220351
MAML2 mastermind-like 2 (Drosophila) -0.0217618
SAMD9 sterile alpha motif domain containing 9 -0.0217228
KIAA1671 KIAA1671 -0.0214478
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0213773
THSD4 thrombospondin, type I, domain containing 4 -0.0211004
KLF5 Kruppel-like factor 5 (intestinal) -0.0206353
PSD3 pleckstrin and Sec7 domain containing 3 -0.0204007
ACTN4 actinin, alpha 4 -0.0200781
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0198464
AHNAK AHNAK nucleoprotein -0.0198367
SULF2 sulfatase 2 -0.0195058
PODXL podocalyxin-like -0.0192544
EXOC4 exocyst complex component 4 -0.0192139
RNF217 ring finger protein 217 -0.0191505
DST dystonin -0.0190489
KIAA0040 KIAA0040 -0.018828
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0186203
BMAL2 basic helix-loop-helix ARNT like 2 -0.0185539
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0184836
SVIL supervillin -0.0183625
PLEC plectin -0.0181372
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0179838
HDAC9 histone deacetylase 9 -0.0179148
ACTN1 actinin, alpha 1 -0.0178668
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.017844
TNS3 tensin 3 -0.0175855
CNTNAP3 contactin associated protein-like 3 -0.0175357
SDCCAG8 serologically defined colon cancer antigen 8 -0.0174974
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.017292
AKAP13 A kinase (PRKA) anchor protein 13 -0.017124
LRRC8A leucine rich repeat containing 8 family, member A -0.0169142
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0169059
NAV2 neuron navigator 2 -0.0167723
EGFR epidermal growth factor receptor -0.0167482
FRMD4B FERM domain containing 4B -0.0166436
UTRN utrophin -0.0165838
PRELID2 PRELI domain containing 2 -0.0160924
LUZP1 leucine zipper protein 1 -0.0160816
PLS3 plastin 3 -0.0159985
TBC1D22A TBC1 domain family, member 22A -0.0159052
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0158837
CRACDL CRACD like -0.0157419
FOXO1 forkhead box O1 -0.0156989
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0156292
ABLIM3 actin binding LIM protein family, member 3 -0.0154614
LAMA4 laminin, alpha 4 -0.0154503