Hesperidin_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.293371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105757
NPSR1 neuropeptide S receptor 1 0.0676008
MAML2 mastermind-like 2 (Drosophila) 0.0573733
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0549669
MBNL2 muscleblind-like splicing regulator 2 0.0476226
IARS1 isoleucyl-tRNA synthetase 1 0.0438338
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0411465
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0392902
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0389493
KDM3A lysine (K)-specific demethylase 3A 0.0383855
PTMA prothymosin, alpha 0.0361331
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345257
CANX calnexin 0.0328245
ERRFI1 ERBB receptor feedback inhibitor 1 0.0322882
FNDC3B fibronectin type III domain containing 3B 0.0322366
ARHGAP32 Rho GTPase activating protein 32 0.0309055
SEC31A SEC31 homolog A (S. cerevisiae) 0.0307602
GARS1 glycyl-tRNA synthetase 1 0.0289869
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0289249
HM13 histocompatibility (minor) 13 0.0285969
ENO1 enolase 1, (alpha) 0.0279791
MORF4L2 mortality factor 4 like 2 0.0277813
ATXN1 ataxin 1 0.0275496
ANLN anillin, actin binding protein 0.0269138
ZCCHC7 zinc finger, CCHC domain containing 7 0.026655
ANXA1 annexin A1 0.0266457
PGK1 phosphoglycerate kinase 1 0.0262558
GOLGA4 golgin A4 0.0250028
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0249791
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.024901
ANKRD11 ankyrin repeat domain 11 0.0248522
EHBP1 EH domain binding protein 1 0.0245789
KLHL29 kelch-like family member 29 0.0241667
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.024138
AHNAK AHNAK nucleoprotein 0.0241267
RAD21 RAD21 homolog (S. pombe) 0.0235102
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0233283
WDR45B WD repeat domain 45B 0.0231607
KLF5 Kruppel-like factor 5 (intestinal) 0.0231027
RBM39 RNA binding motif protein 39 0.022957
FAM13A family with sequence similarity 13, member A 0.0226996
SET SET nuclear proto-oncogene 0.0226776
TES testin LIM domain protein 0.0224768
TMEM123 transmembrane protein 123 0.0224594
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0223916
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0223142
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0221944
COG5 component of oligomeric golgi complex 5 0.0220393
ESYT2 extended synaptotagmin-like protein 2 0.0220238
FNIP1 folliculin interacting protein 1 0.0216543
ESRP1 epithelial splicing regulatory protein 1 0.0214427
PDIA6 protein disulfide isomerase family A, member 6 0.0205707
ZFAND3 zinc finger, AN1-type domain 3 0.020548
GRB10 growth factor receptor-bound protein 10 0.0205311
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0204583
HKDC1 hexokinase domain containing 1 0.0203179
ANO1 anoctamin 1, calcium activated chloride channel 0.0202261
BIRC6 baculoviral IAP repeat containing 6 0.0200061
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0198718
TRA2A transformer 2 alpha homolog (Drosophila) 0.0194615
ITGA6 integrin, alpha 6 0.0191319
TRPS1 trichorhinophalangeal syndrome I 0.0190454
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0190082
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0188028
EIF4A2 eukaryotic translation initiation factor 4A2 0.0186665
NUPR1 nuclear protein, transcriptional regulator, 1 0.0186417
RAB6A RAB6A, member RAS oncogene family 0.0185557
CCNY cyclin Y 0.0185372
RAB1A RAB1A, member RAS oncogene family 0.0184571
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0184536
NUP58 nucleoporin 58 0.0183585
TAS2R14 taste receptor, type 2, member 14 0.018235
SRP54 signal recognition particle 54kDa 0.0181758
CLTC clathrin, heavy chain (Hc) 0.0181019
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0180414
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0180135
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0179259
ARF4 ADP-ribosylation factor 4 0.0178906
SETD5 SET domain containing 5 0.0177748
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0177335
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0175121
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.017438
BTBD9 BTB (POZ) domain containing 9 0.0170245
AREG amphiregulin 0.0169401
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0168327
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0168002
PDIA3 protein disulfide isomerase family A, member 3 0.0166187
EGLN3 egl-9 family hypoxia-inducible factor 3 0.016282
PMM2 phosphomannomutase 2 0.0160566
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0160355
TM9SF3 transmembrane 9 superfamily member 3 0.0160007
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0158198
ZNF292 zinc finger protein 292 0.0158151
CXCL5 chemokine (C-X-C motif) ligand 5 0.015814
PICALM phosphatidylinositol binding clathrin assembly protein 0.0156595
WARS1 tryptophanyl-tRNA synthetase 1 0.0156021
MATR3 matrin 3 0.0155772
CADPS2 Ca++-dependent secretion activator 2 0.0151108
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0150659

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112976
TMSB10 thymosin beta 10 -0.0916608
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0632049
B2M beta-2-microglobulin -0.0515811
CLDN4 claudin 4 -0.0514381
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0486452
IFI27 interferon, alpha-inducible protein 27 -0.048537
RPS19 ribosomal protein S19 -0.047799
ACTN4 actinin, alpha 4 -0.047027
LOC102724023 ES1 protein homolog, mitochondrial -0.0461754
RPL23 ribosomal protein L23 -0.0452497
MUC1 mucin 1, cell surface associated -0.0417509
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0409346
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.040118
ANXA2 annexin A2 -0.0390073
FTL ferritin, light polypeptide -0.0387431
EIF1 eukaryotic translation initiation factor 1 -0.0384285
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0357053
S100A10 S100 calcium binding protein A10 -0.0354423
TMC5 transmembrane channel-like 5 -0.034544
RNF213 ring finger protein 213 -0.0339883
RPS21 ribosomal protein S21 -0.033329
RPL35A ribosomal protein L35a -0.0331926
LOC112694756 uncharaterized LOC112694756 -0.0324185
RPLP1 ribosomal protein, large, P1 -0.0320111
GPX2 glutathione peroxidase 2 -0.0318527
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0313693
ACTG1 actin gamma 1 -0.0311607
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0307035
EGR1 early growth response 1 -0.0302461
C6ORF132 chromosome 6 open reading frame 132 -0.0299523
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0294604
RPS6 ribosomal protein S6 -0.0293205
S100P S100 calcium binding protein P -0.0291663
INSIG1 insulin induced gene 1 -0.0281338
KRT19 keratin 19, type I -0.0278328
SEPTIN9 septin 9 -0.0277993
CLDN7 claudin 7 -0.0274811
POTEF POTE ankyrin domain family, member F -0.0272912
TUBB4B tubulin, beta 4B class IVb -0.0270034
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0268973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0268015
TMEM45B transmembrane protein 45B -0.0256117
BCL2L1 BCL2-like 1 -0.0254056
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0250707
SHB Src homology 2 domain containing adaptor protein B -0.024574
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.02457
RPL32 ribosomal protein L32 -0.0244525
MDK midkine (neurite growth-promoting factor 2) -0.0240158
MACC1 metastasis associated in colon cancer 1 -0.0238696
RPLP2 ribosomal protein, large, P2 -0.0236177
PRSS3 protease, serine, 3 -0.0235543
RBM47 RNA binding motif protein 47 -0.0234383
TXNRD1 thioredoxin reductase 1 -0.0229482
WWC1 WW and C2 domain containing 1 -0.0228113
JUP junction plakoglobin -0.0227094
HLA-B major histocompatibility complex, class I, B -0.0218837
RPL19 ribosomal protein L19 -0.0215687
S100A9 S100 calcium binding protein A9 -0.0215069
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0214634
STK24 serine/threonine kinase 24 -0.0214455
BPTF bromodomain PHD finger transcription factor -0.0213924
PKM pyruvate kinase, muscle -0.0213825
KRT8 keratin 8, type II -0.0212426
ITGB4 integrin, beta 4 -0.021232
NDUFA4 NDUFA4, mitochondrial complex associated -0.0211475
RPL11 ribosomal protein L11 -0.0209184
RPL28 ribosomal protein L28 -0.0205871
RPL35 ribosomal protein L35 -0.0203416
CST3 cystatin C -0.0201594
S100A11 S100 calcium binding protein A11 -0.0200193
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0199859
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0199494
AKAP9 A kinase (PRKA) anchor protein 9 -0.0198917
PLSCR1 phospholipid scramblase 1 -0.0198878
GSTP1 glutathione S-transferase pi 1 -0.019708
EZR ezrin -0.0196471
MYOF myoferlin -0.0192763
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.019237
LIMA1 LIM domain and actin binding 1 -0.0192231
RRBP1 ribosome binding protein 1 -0.0191136
IFI6 interferon, alpha-inducible protein 6 -0.0189292
LMO7 LIM domain 7 -0.0185616
RPS8 ribosomal protein S8 -0.0184902
H1-0 H1.0 linker histone -0.0184324
LPIN1 lipin 1 -0.0183984
TJP1 tight junction protein 1 -0.0180939
TNRC18 trinucleotide repeat containing 18 -0.0180531
TFF2 trefoil factor 2 -0.0180298
MUC17 mucin 17, cell surface associated -0.0178888
SH3RF1 SH3 domain containing ring finger 1 -0.0177896
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0176213
RPS5 ribosomal protein S5 -0.0176109
UGCG UDP-glucose ceramide glucosyltransferase -0.0175272
NCEH1 neutral cholesterol ester hydrolase 1 -0.017372
BCAS3 breast carcinoma amplified sequence 3 -0.0173026
BSG basigin (Ok blood group) -0.0172752
RPL34 ribosomal protein L34 -0.0172447
RPL12 ribosomal protein L12 -0.0171932
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0170728