Hesperidin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.122054
TXNRD1 thioredoxin reductase 1 0.0996243
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0897523
PM20D1 peptidase M20 domain containing 1 0.0829469
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0729964
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0648344
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0594788
POTEF POTE ankyrin domain family, member F 0.0535562
TPM3 tropomyosin 3 0.0517828
FGB fibrinogen beta chain 0.0480075
FTH1 ferritin, heavy polypeptide 1 0.0474401
PCBP2 poly(rC) binding protein 2 0.0462329
RTN4 reticulon 4 0.0437538
PDE4D phosphodiesterase 4D, cAMP-specific 0.0428869
TFPI2 tissue factor pathway inhibitor 2 0.0417789
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0416585
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0411288
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0398788
TM4SF1 transmembrane 4 L six family member 1 0.0394556
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0388095
WDR43 WD repeat domain 43 0.0371402
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0364391
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0361685
TFG TRK-fused gene 0.0355952
BIRC3 baculoviral IAP repeat containing 3 0.0352915
ZFAND3 zinc finger, AN1-type domain 3 0.0352447
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0351516
PDIA6 protein disulfide isomerase family A, member 6 0.0350062
CXCL8 chemokine (C-X-C motif) ligand 8 0.0345478
NUP58 nucleoporin 58 0.0336208
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0334319
FAM168A family with sequence similarity 168, member A 0.0331788
YBX3 Y box binding protein 3 0.0327221
NAMPT nicotinamide phosphoribosyltransferase 0.0319028
YBX1 Y box binding protein 1 0.0318891
CCNL1 cyclin L1 0.030251
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0300804
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.029569
DENND4A DENN/MADD domain containing 4A 0.028892
SPAG9 sperm associated antigen 9 0.0286663
B2M beta-2-microglobulin 0.0284498
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0284237
ENO1 enolase 1, (alpha) 0.0280838
LDHB lactate dehydrogenase B 0.0280573
CAMTA1 calmodulin binding transcription activator 1 0.0279699
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0278413
ECT2 epithelial cell transforming 2 0.0277358
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0275604
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273675
PKM pyruvate kinase, muscle 0.0271145
PFN1 profilin 1 0.0270477
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0268765
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0268445
ADAM9 ADAM metallopeptidase domain 9 0.026504
CSDE1 cold shock domain containing E1, RNA-binding 0.026353
NAP1L1 nucleosome assembly protein 1-like 1 0.0261508
RRM2 ribonucleotide reductase M2 0.0258789
WWOX WW domain containing oxidoreductase 0.0256678
USP3 ubiquitin specific peptidase 3 0.0255866
RPS12 ribosomal protein S12 0.0253555
BCLAF1 BCL2-associated transcription factor 1 0.0250284
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.024714
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0245318
PTK2 protein tyrosine kinase 2 0.0244669
MATR3 matrin 3 0.0240076
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0237002
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0236665
XPO1 exportin 1 0.0235494
KTN1 kinectin 1 (kinesin receptor) 0.0235127
TRA2A transformer 2 alpha homolog (Drosophila) 0.0234178
FXR1 fragile X mental retardation, autosomal homolog 1 0.0231626
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0228349
ZNF207 zinc finger protein 207 0.0224863
TNPO1 transportin 1 0.0223602
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0223346
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0220628
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0217871
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0216776
IPO7 importin 7 0.0215784
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0214956
MIS18BP1 MIS18 binding protein 1 0.0213693
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0211385
ANLN anillin, actin binding protein 0.0211065
NOL10 nucleolar protein 10 0.0210383
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0206775
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0204722
ZNF292 zinc finger protein 292 0.0203893
OSBPL9 oxysterol binding protein-like 9 0.0203246
QKI QKI, KH domain containing, RNA binding 0.0203197
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.020299
RPLP0 ribosomal protein, large, P0 0.0202908
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0201678
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0201662
AHR aryl hydrocarbon receptor 0.0201379
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0201288
PA2G4 proliferation-associated 2G4, 38kDa 0.0200926
RAD21 RAD21 homolog (S. pombe) 0.0200899
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0200459
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0199
MORF4L1 mortality factor 4 like 1 0.0197251

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0825283
TMSB10 thymosin beta 10 -0.0685227
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0604478
THSD4 thrombospondin, type I, domain containing 4 -0.0563532
DOCK4 dedicator of cytokinesis 4 -0.0550069
IGFBP3 insulin-like growth factor binding protein 3 -0.0527261
PYGL phosphorylase, glycogen, liver -0.0431993
CMIP c-Maf inducing protein -0.0407495
CAVIN1 caveolae associated protein 1 -0.0377426
SAMD4A sterile alpha motif domain containing 4A -0.0371599
SVIL supervillin -0.0366546
FLNB filamin B, beta -0.0348816
BICC1 BicC family RNA binding protein 1 -0.0323686
GRAMD1B GRAM domain containing 1B -0.0323312
IER3 immediate early response 3 -0.0300414
EGFR epidermal growth factor receptor -0.0297093
TRIO trio Rho guanine nucleotide exchange factor -0.0296037
FMNL2 formin-like 2 -0.0288675
STC1 stanniocalcin 1 -0.0279329
DOCK5 dedicator of cytokinesis 5 -0.0276791
ZFHX3 zinc finger homeobox 3 -0.0266661
NEBL nebulette -0.0265733
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0258589
ACTG1 actin gamma 1 -0.0255269
HDAC9 histone deacetylase 9 -0.0251646
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.024744
LOC102724023 ES1 protein homolog, mitochondrial -0.0242267
ZMYND8 zinc finger, MYND-type containing 8 -0.0239447
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0235551
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0228147
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0222447
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0217566
HLA-B major histocompatibility complex, class I, B -0.021701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0216375
HLA-E major histocompatibility complex, class I, E -0.0211953
NUMB numb homolog (Drosophila) -0.0207759
ARHGAP26 Rho GTPase activating protein 26 -0.0206078
RPL35A ribosomal protein L35a -0.0203727
EHBP1 EH domain binding protein 1 -0.0200435
PTPRM protein tyrosine phosphatase, receptor type, M -0.0197465
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0194442
RPS6 ribosomal protein S6 -0.0183631
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0180995
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0179602
EXT1 exostosin glycosyltransferase 1 -0.0178325
CFLAR CASP8 and FADD-like apoptosis regulator -0.0177248
AKAP12 A kinase (PRKA) anchor protein 12 -0.0176772
JUN jun proto-oncogene -0.0175996
BASP1 brain abundant, membrane attached signal protein 1 -0.0175957
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0173057
OSMR oncostatin M receptor -0.0171325
CFDP1 craniofacial development protein 1 -0.0169267
CUX1 cut-like homeobox 1 -0.016367
CHD9 chromodomain helicase DNA binding protein 9 -0.0159999
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0154823
NDRG1 N-myc downstream regulated 1 -0.0151623
IGF2 insulin-like growth factor 2 -0.0150919
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0150725
UBASH3B ubiquitin associated and SH3 domain containing B -0.0150179
CYTH1 cytohesin 1 -0.0149875
PTPRF protein tyrosine phosphatase, receptor type, F -0.0149482
NPAS2 neuronal PAS domain protein 2 -0.0149361
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0149218
RPL36 ribosomal protein L36 -0.0149147
ERBIN erbb2 interacting protein -0.0148976
PATJ PATJ crumbs cell polarity complex component -0.0148723
FOXP1 forkhead box P1 -0.0148423
NIPBL Nipped-B homolog (Drosophila) -0.0146329
MAML3 mastermind-like 3 (Drosophila) -0.0145623
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0143131
LASP1 LIM and SH3 protein 1 -0.0142821
CDK13 cyclin-dependent kinase 13 -0.0140001
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0138547
VIM vimentin -0.0134297
EPAS1 endothelial PAS domain protein 1 -0.0134085
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0132695
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0132491
NF1 neurofibromin 1 -0.0132101
DOCK1 dedicator of cytokinesis 1 -0.0132016
BCAR3 breast cancer anti-estrogen resistance 3 -0.0131634
PARD3 par-3 family cell polarity regulator -0.0130837
BTBD9 BTB (POZ) domain containing 9 -0.0130231
AHNAK AHNAK nucleoprotein -0.0127801
ZBTB38 zinc finger and BTB domain containing 38 -0.0127761
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0126753
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0126491
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0123385
ITSN2 intersectin 2 -0.0123379
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0122046
HLA-A major histocompatibility complex, class I, A -0.0121883
KAT6B K(lysine) acetyltransferase 6B -0.0120906
TNRC6B trinucleotide repeat containing 6B -0.0120074
EP300 E1A binding protein p300 -0.0119991
DENND5B DENN/MADD domain containing 5B -0.0119144
STC2 stanniocalcin 2 -0.0118179
CLIP1 CAP-GLY domain containing linker protein 1 -0.0117303
HMGA2 high mobility group AT-hook 2 -0.0115965
PRKCE protein kinase C, epsilon -0.0115218
LOXL2 lysyl oxidase-like 2 -0.0114574
AGO2 argonaute RISC catalytic component 2 -0.0113953