Hesperidin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.136705
TXNRD1 thioredoxin reductase 1 0.128537
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0729536
PABPC1 poly(A) binding protein, cytoplasmic 1 0.066353
XPO1 exportin 1 0.0643561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0586663
TFPI2 tissue factor pathway inhibitor 2 0.0570455
ZCCHC7 zinc finger, CCHC domain containing 7 0.053528
CSDE1 cold shock domain containing E1, RNA-binding 0.0530417
NAP1L1 nucleosome assembly protein 1-like 1 0.0521455
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0468908
IPO7 importin 7 0.0457695
KDM3A lysine (K)-specific demethylase 3A 0.0457167
ERRFI1 ERBB receptor feedback inhibitor 1 0.045546
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0422871
PHIP pleckstrin homology domain interacting protein 0.0410368
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0385962
TRIO trio Rho guanine nucleotide exchange factor 0.0382828
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0376364
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0369504
MATR3 matrin 3 0.0361819
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0361174
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0360496
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0359401
JMJD1C jumonji domain containing 1C 0.0358067
ZFAND3 zinc finger, AN1-type domain 3 0.0356972
MARCHF4 membrane associated ring-CH-type finger 4 0.0348299
PRRC2C proline-rich coiled-coil 2C 0.0347197
RBM39 RNA binding motif protein 39 0.034536
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0342963
KDM2A lysine (K)-specific demethylase 2A 0.0342528
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0339224
RTN4 reticulon 4 0.0338933
CAMKMT calmodulin-lysine N-methyltransferase 0.0331177
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0331144
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0330743
PCBP2 poly(rC) binding protein 2 0.0324506
OGA O-GlcNAcase 0.0323079
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322709
SPAG9 sperm associated antigen 9 0.0315163
NIPBL Nipped-B homolog (Drosophila) 0.0313962
COG5 component of oligomeric golgi complex 5 0.0313169
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0312884
COPA coatomer protein complex, subunit alpha 0.0312772
GPHN gephyrin 0.0310047
WNK1 WNK lysine deficient protein kinase 1 0.0309903
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.030818
BIRC6 baculoviral IAP repeat containing 6 0.0305371
MED13L mediator complex subunit 13-like 0.030022
MED13 mediator complex subunit 13 0.0298869
RPLP0 ribosomal protein, large, P0 0.0290944
ZNF292 zinc finger protein 292 0.0290794
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0289524
GOLGA4 golgin A4 0.0288169
KMT2E lysine (K)-specific methyltransferase 2E 0.0287804
PUM2 pumilio RNA-binding family member 2 0.0286451
RAD51B RAD51 paralog B 0.0285559
TPM3 tropomyosin 3 0.0285259
PREPL prolyl endopeptidase-like 0.0283595
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0281947
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0280972
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0280722
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0279634
SRP54 signal recognition particle 54kDa 0.0279063
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0275919
MORF4L2 mortality factor 4 like 2 0.0275036
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0274791
CAMTA1 calmodulin binding transcription activator 1 0.0274102
UBE2H ubiquitin-conjugating enzyme E2H 0.0270819
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0269379
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0265035
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0262629
ATAD2 ATPase family, AAA domain containing 2 0.0259873
SEC31A SEC31 homolog A (S. cerevisiae) 0.0259283
TFG TRK-fused gene 0.0258831
TRIM33 tripartite motif containing 33 0.0256497
PCNX1 pecanex 1 0.0255584
CSNK1A1 casein kinase 1, alpha 1 0.0251599
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0250092
NUP153 nucleoporin 153kDa 0.0248496
NOP58 NOP58 ribonucleoprotein 0.0246983
PGK1 phosphoglycerate kinase 1 0.0246833
TOP2B topoisomerase (DNA) II beta 180kDa 0.0243892
NCKAP1 NCK-associated protein 1 0.0241005
SBF2 SET binding factor 2 0.0237886
FXR1 fragile X mental retardation, autosomal homolog 1 0.0237447
NCAPG2 non-SMC condensin II complex, subunit G2 0.0237276
ZMYM2 zinc finger, MYM-type 2 0.0237071
SUCO SUN domain containing ossification factor 0.0235163
ERBIN erbb2 interacting protein 0.0233339
CHD1 chromodomain helicase DNA binding protein 1 0.0232391
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0231573
ADAM17 ADAM metallopeptidase domain 17 0.0231475
RAB6A RAB6A, member RAS oncogene family 0.0227713
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0226942
RB1CC1 RB1-inducible coiled-coil 1 0.022575
NF1 neurofibromin 1 0.0225694
PDIA6 protein disulfide isomerase family A, member 6 0.0225573
ATF6 activating transcription factor 6 0.0225288
WAC WW domain containing adaptor with coiled-coil 0.0225022

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.164464
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.101963
EGR1 early growth response 1 -0.058601
TMSB10 thymosin beta 10 -0.05809
VIM vimentin -0.0443788
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0424864
OSMR oncostatin M receptor -0.0413372
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0393672
THSD4 thrombospondin, type I, domain containing 4 -0.0388977
IFI6 interferon, alpha-inducible protein 6 -0.0381757
POTEF POTE ankyrin domain family, member F -0.0366269
AFF3 AF4/FMR2 family, member 3 -0.0360082
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0351853
PDE10A phosphodiesterase 10A -0.0351734
HLA-B major histocompatibility complex, class I, B -0.0347637
HMGA2 high mobility group AT-hook 2 -0.0344451
TPM4 tropomyosin 4 -0.0316182
MT2A metallothionein 2A -0.0314305
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0312776
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0312026
RYR3 ryanodine receptor 3 -0.027272
ACTG1 actin gamma 1 -0.0271818
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0270874
WWOX WW domain containing oxidoreductase -0.0269572
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0264395
PRH1 proline-rich protein HaeIII subfamily 1 -0.0263684
RPS6 ribosomal protein S6 -0.0253453
MCL1 myeloid cell leukemia 1 -0.0240476
PRKCE protein kinase C, epsilon -0.0230224
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0228205
PFN1 profilin 1 -0.0227456
RIMS2 regulating synaptic membrane exocytosis 2 -0.0227369
IER3 immediate early response 3 -0.0221096
RPS8 ribosomal protein S8 -0.0219533
PYGL phosphorylase, glycogen, liver -0.0219494
RPL35A ribosomal protein L35a -0.0218396
NCOA7 nuclear receptor coactivator 7 -0.021631
LOC102724023 ES1 protein homolog, mitochondrial -0.0214268
ACTN1 actinin, alpha 1 -0.0212485
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.021167
TPM2 tropomyosin 2 (beta) -0.020999
ATG7 autophagy related 7 -0.0209482
RPS10 ribosomal protein S10 -0.0209232
GNAS GNAS complex locus -0.0207859
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0204334
RNF213 ring finger protein 213 -0.0201474
EGFR epidermal growth factor receptor -0.0200922
IGF2 insulin-like growth factor 2 -0.0200719
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.019576
TAPBP TAP binding protein (tapasin) -0.0179592
EPAS1 endothelial PAS domain protein 1 -0.0178349
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0177755
RPL9 ribosomal protein L9 -0.017666
HDGF hepatoma-derived growth factor -0.0176575
RPL36 ribosomal protein L36 -0.0176391
FTH1 ferritin, heavy polypeptide 1 -0.0175454
MCTP1 multiple C2 domains, transmembrane 1 -0.0173602
STC1 stanniocalcin 1 -0.0173123
ETV6 ets variant 6 -0.0171223
PDLIM5 PDZ and LIM domain 5 -0.0170552
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0169826
SVIL supervillin -0.0168334
ATXN1 ataxin 1 -0.0166282
RPL28 ribosomal protein L28 -0.0163667
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0162686
BASP1 brain abundant, membrane attached signal protein 1 -0.0161613
NTSR1 neurotensin receptor 1 (high affinity) -0.0159312
PLSCR1 phospholipid scramblase 1 -0.015863
RPS19 ribosomal protein S19 -0.0156194
EHBP1 EH domain binding protein 1 -0.0154723
RPS3 ribosomal protein S3 -0.015346
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0151648
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0145869
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0145193
SMAD3 SMAD family member 3 -0.0144431
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0141592
MMP12 matrix metallopeptidase 12 -0.0138369
MYADM myeloid-associated differentiation marker -0.0136859
PCNX4 pecanex 4 -0.0135845
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0134373
HLA-A major histocompatibility complex, class I, A -0.0133598
ITSN1 intersectin 1 (SH3 domain protein) -0.013346
PTPRF protein tyrosine phosphatase, receptor type, F -0.0130039
DOCK1 dedicator of cytokinesis 1 -0.0129915
FTL ferritin, light polypeptide -0.0128837
BNC2 basonuclin 2 -0.0125669
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.012523
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0124614
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0124543
CUX1 cut-like homeobox 1 -0.0124428
CCDC91 coiled-coil domain containing 91 -0.0123796
TRIM9 tripartite motif containing 9 -0.0121719
PMP22 peripheral myelin protein 22 -0.0120541
NEBL nebulette -0.0119809
RPL35 ribosomal protein L35 -0.0119566
STEAP3 STEAP family member 3, metalloreductase -0.0119059
SDK1 sidekick cell adhesion molecule 1 -0.0117608
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0117344
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.011665
PTMS parathymosin -0.0115466