Hesperidin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0880833
ASPH aspartate beta-hydroxylase 0.0565653
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0453228
FNDC3B fibronectin type III domain containing 3B 0.0411864
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0385819
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0373594
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0360598
TOP2A topoisomerase (DNA) II alpha 170kDa 0.030633
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0288915
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.028771
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0285111
FXR1 fragile X mental retardation, autosomal homolog 1 0.0267062
TXNRD1 thioredoxin reductase 1 0.0256372
CENPF centromere protein F, 350/400kDa 0.0230758
NCKAP1 NCK-associated protein 1 0.0229109
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0227103
TFG TRK-fused gene 0.0224237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0216719
HMGB2 high mobility group box 2 0.0210301
NUP58 nucleoporin 58 0.0199613
RAD21 RAD21 homolog (S. pombe) 0.0199215
ECT2 epithelial cell transforming 2 0.0192363
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0192008
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187203
SET SET nuclear proto-oncogene 0.0185563
PEG10 paternally expressed 10 0.0185434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0178985
GLS2 glutaminase 2 (liver, mitochondrial) 0.0178574
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0172452
TPM3 tropomyosin 3 0.0170977
ARRDC3 arrestin domain containing 3 0.0170203
CCNL1 cyclin L1 0.0168678
MATR3 matrin 3 0.0166577
IPO7 importin 7 0.0164279
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0163886
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0161122
SMC4 structural maintenance of chromosomes 4 0.0159715
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0156489
PCBP2 poly(rC) binding protein 2 0.0152946
AZIN1 antizyme inhibitor 1 0.0151145
MSMO1 methylsterol monooxygenase 1 0.0150918
KRT7 keratin 7, type II 0.0150571
BIRC3 baculoviral IAP repeat containing 3 0.0148992
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.014735
UBQLN1 ubiquilin 1 0.014594
SFPQ splicing factor proline/glutamine-rich 0.0145784
CCNB1 cyclin B1 0.0145121
NAMPT nicotinamide phosphoribosyltransferase 0.0143056
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0142716
TNIP1 TNFAIP3 interacting protein 1 0.014213
DST dystonin 0.0141703
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0140167
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0139168
USP9X ubiquitin specific peptidase 9, X-linked 0.013669
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0136297
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0136218
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0134712
ATP13A3 ATPase type 13A3 0.0134144
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0133634
RPS3A ribosomal protein S3A 0.0132543
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0132287
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0132196
TOP2B topoisomerase (DNA) II beta 180kDa 0.012998
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0128134
RYK receptor-like tyrosine kinase 0.0127041
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0126779
OSBPL9 oxysterol binding protein-like 9 0.0124011
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.012396
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0122606
EREG epiregulin 0.0122559
LDHB lactate dehydrogenase B 0.0122366
MRPL3 mitochondrial ribosomal protein L3 0.0121737
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0121057
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0120869
RPS18 ribosomal protein S18 0.0120316
ELOVL5 ELOVL fatty acid elongase 5 0.0119674
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0119597
RAD23B RAD23 homolog B (S. cerevisiae) 0.011947
TMEM131L transmembrane 131 like 0.0117996
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0116429
CD83 CD83 molecule 0.0116213
TNPO1 transportin 1 0.0116026
TRIO trio Rho guanine nucleotide exchange factor 0.0115843
SCEL sciellin 0.011552
ANXA5 annexin A5 0.0114848
APLP2 amyloid beta (A4) precursor-like protein 2 0.0114324
PAPOLA poly(A) polymerase alpha 0.0114213
ZBTB10 zinc finger and BTB domain containing 10 0.0113261
TMEM39A transmembrane protein 39A 0.0112912
NAP1L1 nucleosome assembly protein 1-like 1 0.0111958
KDM6A lysine (K)-specific demethylase 6A 0.0111241
TSPAN15 tetraspanin 15 0.0110414
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0107792
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0105694
HELZ helicase with zinc finger 0.0102973
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0102
CLINT1 clathrin interactor 1 0.0101785
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0100693
STK24 serine/threonine kinase 24 0.0100513
TFRC transferrin receptor 0.0100471

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.343393
TMSB10 thymosin beta 10 -0.224535
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215629
PTMA prothymosin, alpha -0.215471
ACTG1 actin gamma 1 -0.161896
NDRG1 N-myc downstream regulated 1 -0.13013
IFI27 interferon, alpha-inducible protein 27 -0.118852
IGFBP3 insulin-like growth factor binding protein 3 -0.0896593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0886646
LAMB3 laminin, beta 3 -0.0853503
RPL35A ribosomal protein L35a -0.0852841
EIF1 eukaryotic translation initiation factor 1 -0.084249
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0838934
IFI6 interferon, alpha-inducible protein 6 -0.0829181
MT2A metallothionein 2A -0.0822163
ISG15 ISG15 ubiquitin-like modifier -0.0767155
SOX4 SRY (sex determining region Y)-box 4 -0.0752879
FBXO32 F-box protein 32 -0.072383
RPS19 ribosomal protein S19 -0.0717478
RPLP2 ribosomal protein, large, P2 -0.0712732
IFITM3 interferon induced transmembrane protein 3 -0.0703904
CSTB cystatin B (stefin B) -0.0691159
TPT1 tumor protein, translationally-controlled 1 -0.0685691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0665916
RPLP1 ribosomal protein, large, P1 -0.0656349
HLA-B major histocompatibility complex, class I, B -0.0639202
IFITM1 interferon induced transmembrane protein 1 -0.0631557
WSB1 WD repeat and SOCS box containing 1 -0.0626151
S100A6 S100 calcium binding protein A6 -0.0617612
RPS29 ribosomal protein S29 -0.0613806
S100A10 S100 calcium binding protein A10 -0.0604326
LIMCH1 LIM and calponin homology domains 1 -0.0581416
RPS6 ribosomal protein S6 -0.0573146
BASP1 brain abundant, membrane attached signal protein 1 -0.0562479
RPL8 ribosomal protein L8 -0.055887
S100A9 S100 calcium binding protein A9 -0.0554407
RPL34 ribosomal protein L34 -0.054049
RPS8 ribosomal protein S8 -0.0535367
HLA-A major histocompatibility complex, class I, A -0.051972
RPS13 ribosomal protein S13 -0.0465311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0462172
GNAS GNAS complex locus -0.0451365
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0444068
UBC ubiquitin C -0.0440041
VIM vimentin -0.0433516
NPEPPS aminopeptidase puromycin sensitive -0.0433316
IFI16 interferon, gamma-inducible protein 16 -0.043283
RPS27 ribosomal protein S27 -0.043106
RPL23 ribosomal protein L23 -0.0418108
LY6E lymphocyte antigen 6 complex, locus E -0.0417286
ENO2 enolase 2 (gamma, neuronal) -0.0411519
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0405836
MDK midkine (neurite growth-promoting factor 2) -0.0399875
RPS21 ribosomal protein S21 -0.0381611
SAMD4A sterile alpha motif domain containing 4A -0.0374197
TM4SF1 transmembrane 4 L six family member 1 -0.0372482
RPL36 ribosomal protein L36 -0.0372052
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0370593
RPL19 ribosomal protein L19 -0.0368366
HMGA1 high mobility group AT-hook 1 -0.0367768
TXNIP thioredoxin interacting protein -0.0366309
RPS23 ribosomal protein S23 -0.0366164
TPI1 triosephosphate isomerase 1 -0.0365337
HSPB1 heat shock 27kDa protein 1 -0.0364407
RPS14 ribosomal protein S14 -0.0363395
TMSB4X thymosin beta 4, X-linked -0.0363362
POTEF POTE ankyrin domain family, member F -0.0362606
RPL32 ribosomal protein L32 -0.0362529
RPL28 ribosomal protein L28 -0.0362325
LMNA lamin A/C -0.0361907
RPL37A ribosomal protein L37a -0.0356828
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0353651
RPL12 ribosomal protein L12 -0.0352175
LOC112694756 uncharaterized LOC112694756 -0.0350427
VEGFA vascular endothelial growth factor A -0.034354
TMEM165 transmembrane protein 165 -0.0342593
LPP LIM domain containing preferred translocation partner in lipoma -0.0336674
C15ORF48 chromosome 15 open reading frame 48 -0.0332708
YY1 YY1 transcription factor -0.0329265
TPM4 tropomyosin 4 -0.0329214
RPS3 ribosomal protein S3 -0.0328947
RBM25 RNA binding motif protein 25 -0.0327764
LMO7 LIM domain 7 -0.0327599
EXT1 exostosin glycosyltransferase 1 -0.031711
EFNA5 ephrin-A5 -0.0308854
H1-0 H1.0 linker histone -0.0307716
RPS27A ribosomal protein S27a -0.0303567
FTH1 ferritin, heavy polypeptide 1 -0.0303395
RRBP1 ribosome binding protein 1 -0.0300563
PKM pyruvate kinase, muscle -0.0295296
WASF2 WAS protein family, member 2 -0.0295216
PLAUR plasminogen activator, urokinase receptor -0.0294529
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0291252
KDM5B lysine (K)-specific demethylase 5B -0.028952
CD2AP CD2-associated protein -0.028417
GOLGA4 golgin A4 -0.0283793
MAP1B microtubule-associated protein 1B -0.0283615
RPL31 ribosomal protein L31 -0.0283468
RPS10 ribosomal protein S10 -0.0280633
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0279676