Hesperidin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.209879
CXCL8 chemokine (C-X-C motif) ligand 8 0.123978
SPAG9 sperm associated antigen 9 0.0811815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0764876
FN1 fibronectin 1 0.0716411
NAMPT nicotinamide phosphoribosyltransferase 0.065181
SOD2 superoxide dismutase 2, mitochondrial 0.0618153
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0550551
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0523208
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0491411
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0478122
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474777
NUP58 nucleoporin 58 0.0444595
FTH1 ferritin, heavy polypeptide 1 0.0444369
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.043296
PGK1 phosphoglycerate kinase 1 0.0425463
KDM6A lysine (K)-specific demethylase 6A 0.0411114
BIRC6 baculoviral IAP repeat containing 6 0.0409299
CDH13 cadherin 13 0.0405904
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0398912
FNDC3B fibronectin type III domain containing 3B 0.0392916
KMT2C lysine (K)-specific methyltransferase 2C 0.0388071
CANX calnexin 0.0383889
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0372694
PCBP2 poly(rC) binding protein 2 0.0362528
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0361755
ATP13A3 ATPase type 13A3 0.0359635
PDIA6 protein disulfide isomerase family A, member 6 0.0359223
ANXA1 annexin A1 0.0353432
WDR43 WD repeat domain 43 0.0353398
USP3 ubiquitin specific peptidase 3 0.0350574
TRA2A transformer 2 alpha homolog (Drosophila) 0.0350541
ENO1 enolase 1, (alpha) 0.034381
GRB10 growth factor receptor-bound protein 10 0.033268
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0329423
WAC WW domain containing adaptor with coiled-coil 0.0318147
GLS2 glutaminase 2 (liver, mitochondrial) 0.0317611
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0316004
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0315036
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.031112
NAP1L1 nucleosome assembly protein 1-like 1 0.031072
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0304708
WDR45B WD repeat domain 45B 0.0301331
TENT5A terminal nucleotidyltransferase 5A 0.0297339
PDIA3 protein disulfide isomerase family A, member 3 0.0297122
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0292566
RTN4 reticulon 4 0.0291023
NCKAP1 NCK-associated protein 1 0.029035
MATR3 matrin 3 0.0288325
TRIO trio Rho guanine nucleotide exchange factor 0.0282655
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.02814
HELZ helicase with zinc finger 0.0279052
ZFAND3 zinc finger, AN1-type domain 3 0.027874
TFG TRK-fused gene 0.0278389
ECPAS Ecm29 proteasome adaptor and scaffold 0.0278381
UBA6 ubiquitin-like modifier activating enzyme 6 0.027277
RBM39 RNA binding motif protein 39 0.0272503
RNF145 ring finger protein 145 0.0267988
BZW1 basic leucine zipper and W2 domains 1 0.0265897
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0265667
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.026554
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0262132
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0261305
KDM3A lysine (K)-specific demethylase 3A 0.0260597
GARS1 glycyl-tRNA synthetase 1 0.0259974
RLF rearranged L-myc fusion 0.0259576
RICTOR RPTOR independent companion of MTOR, complex 2 0.0258619
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0254074
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0250254
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0244341
HILPDA hypoxia inducible lipid droplet-associated 0.0243646
ADAM17 ADAM metallopeptidase domain 17 0.024082
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0238036
AGFG1 ArfGAP with FG repeats 1 0.0234325
OGA O-GlcNAcase 0.0234109
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0233891
OLA1 Obg-like ATPase 1 0.0233684
RAD23B RAD23 homolog B (S. cerevisiae) 0.0232107
COPA coatomer protein complex, subunit alpha 0.0231658
FMNL2 formin-like 2 0.0229937
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229141
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0228712
USP9X ubiquitin specific peptidase 9, X-linked 0.0228139
CHD1 chromodomain helicase DNA binding protein 1 0.0227993
SSBP2 single-stranded DNA binding protein 2 0.0227856
RAP1B RAP1B, member of RAS oncogene family 0.0226624
ELL2 elongation factor, RNA polymerase II, 2 0.02266
ARRDC3 arrestin domain containing 3 0.0224268
KMT2E lysine (K)-specific methyltransferase 2E 0.0223506
TSC22D2 TSC22 domain family, member 2 0.0223234
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0221904
WTAP Wilms tumor 1 associated protein 0.0221608
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0220015
DNER delta/notch-like EGF repeat containing 0.0220011
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0215667
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0215189
NBAS neuroblastoma amplified sequence 0.0215137
CAMTA1 calmodulin binding transcription activator 1 0.0214779
ANKRD11 ankyrin repeat domain 11 0.0210806
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0210356

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.106529
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.103851
PDE4D phosphodiesterase 4D, cAMP-specific -0.0780073
TFPI2 tissue factor pathway inhibitor 2 -0.0705164
MT2A metallothionein 2A -0.0697894
GDA guanine deaminase -0.069548
PDE10A phosphodiesterase 10A -0.0692844
EFNA5 ephrin-A5 -0.0675675
RPS6 ribosomal protein S6 -0.0662708
COL8A1 collagen, type VIII, alpha 1 -0.0639672
BASP1 brain abundant, membrane attached signal protein 1 -0.0565183
COL4A5 collagen, type IV, alpha 5 -0.0549901
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0538295
RGS2 regulator of G-protein signaling 2 -0.0488776
TGFBI transforming growth factor, beta-induced, 68kDa -0.046458
TM4SF1 transmembrane 4 L six family member 1 -0.0452921
PDLIM5 PDZ and LIM domain 5 -0.0419429
PSD3 pleckstrin and Sec7 domain containing 3 -0.0413752
RPL26 ribosomal protein L26 -0.0407857
RPS2 ribosomal protein S2 -0.0390736
DST dystonin -0.0389479
NRCAM neuronal cell adhesion molecule -0.037307
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0372781
TMSB10 thymosin beta 10 -0.0363583
CENPF centromere protein F, 350/400kDa -0.0362163
RPL37A ribosomal protein L37a -0.0354169
DOCK5 dedicator of cytokinesis 5 -0.035251
SAMD4A sterile alpha motif domain containing 4A -0.0352036
MFF mitochondrial fission factor -0.0351284
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0350623
ASPH aspartate beta-hydroxylase -0.0314184
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.031065
KYNU kynureninase -0.0296566
RPS12 ribosomal protein S12 -0.0295118
RPS19 ribosomal protein S19 -0.0286118
RPL12 ribosomal protein L12 -0.0285206
MKI67 marker of proliferation Ki-67 -0.0268947
RPLP1 ribosomal protein, large, P1 -0.0267115
DGKD diacylglycerol kinase, delta 130kDa -0.026511
RAB3B RAB3B, member RAS oncogene family -0.0264347
PALLD palladin, cytoskeletal associated protein -0.0262279
ESYT2 extended synaptotagmin-like protein 2 -0.0260478
RPL19 ribosomal protein L19 -0.0259741
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0257568
RPL38 ribosomal protein L38 -0.0254113
BCAR3 breast cancer anti-estrogen resistance 3 -0.0251545
SLF1 SMC5-SMC6 complex localization factor 1 -0.0247538
RPL9 ribosomal protein L9 -0.02475
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0243596
CTSL cathepsin L -0.0242906
RPL35A ribosomal protein L35a -0.0235524
GREM2 gremlin 2, DAN family BMP antagonist -0.0233841
RPS8 ribosomal protein S8 -0.0233768
TMX4 thioredoxin-related transmembrane protein 4 -0.0228587
MAML3 mastermind-like 3 (Drosophila) -0.0225365
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.022267
KRT19 keratin 19, type I -0.0219526
ANTXR1 anthrax toxin receptor 1 -0.0217785
RPL7 ribosomal protein L7 -0.0216974
CTSC cathepsin C -0.0216238
RPS29 ribosomal protein S29 -0.0215979
SRGN serglycin -0.021591
TBXT T-box transcription factor T -0.0215079
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0214155
BPTF bromodomain PHD finger transcription factor -0.0212425
PM20D1 peptidase M20 domain containing 1 -0.0211925
CTIF CBP80/20-dependent translation initiation factor -0.0209703
RPH3AL rabphilin 3A-like (without C2 domains) -0.0204747
VIM vimentin -0.0204349
CFLAR CASP8 and FADD-like apoptosis regulator -0.0204202
PYGL phosphorylase, glycogen, liver -0.0203553
SORBS2 sorbin and SH3 domain containing 2 -0.0202607
DOCK4 dedicator of cytokinesis 4 -0.020151
ARHGAP29 Rho GTPase activating protein 29 -0.0200155
RPS13 ribosomal protein S13 -0.0199966
ZBTB38 zinc finger and BTB domain containing 38 -0.0199675
GLIS3 GLIS family zinc finger 3 -0.0199399
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0198567
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0198129
BDNF brain-derived neurotrophic factor -0.0197588
NCOA7 nuclear receptor coactivator 7 -0.0195086
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0194836
DISP1 dispatched homolog 1 (Drosophila) -0.0192847
BCAS3 breast carcinoma amplified sequence 3 -0.0192532
TUSC3 tumor suppressor candidate 3 -0.0191711
NPAS2 neuronal PAS domain protein 2 -0.0188956
ZEB2 zinc finger E-box binding homeobox 2 -0.018749
RPL36 ribosomal protein L36 -0.0187127
PCBP3 poly(rC) binding protein 3 -0.0186329
SH3KBP1 SH3-domain kinase binding protein 1 -0.0185136
MT1X metallothionein 1X -0.0180123
RPS3 ribosomal protein S3 -0.0180096
RPS21 ribosomal protein S21 -0.0178725
MYOF myoferlin -0.0178594
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0177205
GNAS GNAS complex locus -0.0175787
ANKRD28 ankyrin repeat domain 28 -0.0175776
EXT1 exostosin glycosyltransferase 1 -0.0173919
WWTR1 WW domain containing transcription regulator 1 -0.0173464
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0172946