Hesperidin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

176 genes differentially expressed following the Hesperidin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.139504
EFNA5 ephrin-A5 0.124949
MATR3 matrin 3 0.115372
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.114048
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.108464
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0969238
GLS2 glutaminase 2 (liver, mitochondrial) 0.0950027
OGA O-GlcNAcase 0.0947023
YAP1 Yes-associated protein 1 0.0924947
IGF2 insulin-like growth factor 2 0.0882984
TPST1 tyrosylprotein sulfotransferase 1 0.0879587
NAMPT nicotinamide phosphoribosyltransferase 0.0869256
VMP1 vacuole membrane protein 1 0.085581
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0844927
DST dystonin 0.0844067
ATXN1 ataxin 1 0.0790917
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0747795
PTK2 protein tyrosine kinase 2 0.074105
MBNL1 muscleblind-like splicing regulator 1 0.0736193
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0730925
ASPH aspartate beta-hydroxylase 0.0722361
IGFBP3 insulin-like growth factor binding protein 3 0.0713471
LAMB3 laminin, beta 3 0.0629107
SPTBN1 spectrin, beta, non-erythrocytic 1 0.062789
RERE arginine-glutamic acid dipeptide (RE) repeats 0.061148
RORA RAR-related orphan receptor A 0.0593911
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0569066
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0547179
NAP1L1 nucleosome assembly protein 1-like 1 0.0524617
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0510645
ERRFI1 ERBB receptor feedback inhibitor 1 0.050365
BIRC6 baculoviral IAP repeat containing 6 0.0501091
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0492909
EXT1 exostosin glycosyltransferase 1 0.0440987
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0436407
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0415742
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0383951
POTEF POTE ankyrin domain family, member F 0.0381443
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0368062
LCORL ligand dependent nuclear receptor corepressor-like 0.0356215
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.032419
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0320787
VCL vinculin 0.0317679
RPL31 ribosomal protein L31 0.0315172
PDE10A phosphodiesterase 10A 0.0308286
MED13L mediator complex subunit 13-like 0.0295375
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0292077
PGK1 phosphoglycerate kinase 1 0.0288398
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0280873
ZSWIM6 zinc finger, SWIM-type containing 6 0.0269004
TXNRD1 thioredoxin reductase 1 0.0262552
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0256132
AKAP9 A kinase (PRKA) anchor protein 9 0.0253149
RICTOR RPTOR independent companion of MTOR, complex 2 0.0249753
YBX3 Y box binding protein 3 0.024403
NDRG1 N-myc downstream regulated 1 0.0242641
FNDC3B fibronectin type III domain containing 3B 0.0241161
NF1 neurofibromin 1 0.0240815
ARB2A ARB2 cotranscriptional regulator A 0.0220287
USP34 ubiquitin specific peptidase 34 0.0220251
PDE4D phosphodiesterase 4D, cAMP-specific 0.0213029
ELL2 elongation factor, RNA polymerase II, 2 0.0211064
ARRDC3 arrestin domain containing 3 0.0202375
AHNAK AHNAK nucleoprotein 0.0201047
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.019382
MYO6 myosin VI 0.0186835
SND1 staphylococcal nuclease and tudor domain containing 1 0.0184687
NKD1 naked cuticle homolog 1 (Drosophila) 0.0165223
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0159005
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0156315
RAB7A RAB7A, member RAS oncogene family 0.0152741
TOP1 topoisomerase (DNA) I 0.0151911
SQSTM1 sequestosome 1 0.0131613
SLC38A1 solute carrier family 38, member 1 0.0129715
GPC6 glypican 6 0.0116119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0110138
SMYD3 SET and MYND domain containing 3 0.0104196
RBM39 RNA binding motif protein 39 0.0102485
RPL35A ribosomal protein L35a 0.0100018
TNRC6B trinucleotide repeat containing 6B 0.00999297
NCOA3 nuclear receptor coactivator 3 0.00997962
ASCC3 activating signal cointegrator 1 complex subunit 3 0.00863829
TRIO trio Rho guanine nucleotide exchange factor 0.00656591
DLG1 discs, large homolog 1 (Drosophila) 0.00656378
RPL11 ribosomal protein L11 0.0061501
RUNX1 runt-related transcription factor 1 0.00600438
MAP4 microtubule-associated protein 4 0.00594916
ZFAND3 zinc finger, AN1-type domain 3 0.0048678
PRRC2C proline-rich coiled-coil 2C 0.00262067
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 6.84607E-4
ARHGAP5 Rho GTPase activating protein 5 5.63543E-4

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.19715
PTMA prothymosin, alpha -0.163952
EGFR epidermal growth factor receptor -0.145185
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111018
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.110759
TTC3 tetratricopeptide repeat domain 3 -0.108889
MYO1E myosin IE -0.107621
RPS6 ribosomal protein S6 -0.104974
DSCAM Down syndrome cell adhesion molecule -0.103407
RPL37A ribosomal protein L37a -0.0911297
RPS12 ribosomal protein S12 -0.0901668
HLA-B major histocompatibility complex, class I, B -0.0886506
SLTM SAFB-like, transcription modulator -0.0884453
RPLP1 ribosomal protein, large, P1 -0.0839717
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.081184
MYO10 myosin X -0.0811342
PRKCA protein kinase C, alpha -0.0810897
TPT1 tumor protein, translationally-controlled 1 -0.0783134
THSD4 thrombospondin, type I, domain containing 4 -0.0759206
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0757203
B2M beta-2-microglobulin -0.0750904
SBF2 SET binding factor 2 -0.0714249
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0712382
RPS16 ribosomal protein S16 -0.0688463
RPL26 ribosomal protein L26 -0.0674933
ANKRD12 ankyrin repeat domain 12 -0.0666992
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0645106
RPS3 ribosomal protein S3 -0.0637688
H3-3B H3.3 histone B -0.0628408
KTN1 kinectin 1 (kinesin receptor) -0.0600273
MT2A metallothionein 2A -0.0572093
ANKHD1 ankyrin repeat and KH domain containing 1 -0.055627
ANXA2 annexin A2 -0.0553677
ITGA6 integrin, alpha 6 -0.0552991
PKM pyruvate kinase, muscle -0.0551886
VIM vimentin -0.0543096
FTH1 ferritin, heavy polypeptide 1 -0.0535406
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0520748
KDM2A lysine (K)-specific demethylase 2A -0.0516201
CD44 CD44 molecule (Indian blood group) -0.0502865
FTL ferritin, light polypeptide -0.0459365
RPS27 ribosomal protein S27 -0.0452504
KMT2E lysine (K)-specific methyltransferase 2E -0.0446317
RPL19 ribosomal protein L19 -0.0427594
RPS19 ribosomal protein S19 -0.0423419
PIAS1 protein inhibitor of activated STAT, 1 -0.0420892
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0412157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0397899
MACF1 microtubule-actin crosslinking factor 1 -0.0390229
AKAP12 A kinase (PRKA) anchor protein 12 -0.0385362
HDAC9 histone deacetylase 9 -0.0372948
MCL1 myeloid cell leukemia 1 -0.0360663
MYOF myoferlin -0.0344648
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0337512
RPL15 ribosomal protein L15 -0.0331512
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0320735
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0310907
RPL23 ribosomal protein L23 -0.0302657
RPL12 ribosomal protein L12 -0.0301506
LDHA lactate dehydrogenase A -0.0284044
FN1 fibronectin 1 -0.0277383
PDE8A phosphodiesterase 8A -0.0272516
TPM4 tropomyosin 4 -0.0244426
LPP LIM domain containing preferred translocation partner in lipoma -0.0208401
PCBP2 poly(rC) binding protein 2 -0.0205019
ZNF292 zinc finger protein 292 -0.0201463
FMNL2 formin-like 2 -0.0192936
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0190489
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0190066
RPS8 ribosomal protein S8 -0.017686
NIPBL Nipped-B homolog (Drosophila) -0.0168599
EIF1 eukaryotic translation initiation factor 1 -0.0163682
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0161421
LOC102724023 ES1 protein homolog, mitochondrial -0.0129312
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.012588
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0122076
GOLGA4 golgin A4 -0.011835
JMJD1C jumonji domain containing 1C -0.0112519
EEF2 eukaryotic translation elongation factor 2 -0.00982768
THOC2 THO complex 2 -0.00956036
PSD3 pleckstrin and Sec7 domain containing 3 -0.00733785
RTN4 reticulon 4 -0.00594646
LMO7 LIM domain 7 -0.00585068
ACTG1 actin gamma 1 -0.0039684
ENO1 enolase 1, (alpha) -0.00128383