Hesperidin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129532
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0781508
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.073263
DST dystonin 0.0684793
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0666853
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0629114
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.05528
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0536678
PEG10 paternally expressed 10 0.0519945
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0476104
MKI67 marker of proliferation Ki-67 0.0465017
CENPF centromere protein F, 350/400kDa 0.0430554
THBS1 thrombospondin 1 0.0402836
TMSB4X thymosin beta 4, X-linked 0.0401145
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376383
TPX2 TPX2, microtubule-associated 0.0342612
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0317019
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0307921
NAMPT nicotinamide phosphoribosyltransferase 0.0301859
NCKAP1 NCK-associated protein 1 0.0298511
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0293911
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0293716
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0288408
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0278021
CKAP2 cytoskeleton associated protein 2 0.0277631
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0276891
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0263507
SSB Sjogren syndrome antigen B (autoantigen La) 0.0261605
TPM3 tropomyosin 3 0.0259729
CDK6 cyclin-dependent kinase 6 0.0258099
CLTC clathrin, heavy chain (Hc) 0.0257711
KMT2C lysine (K)-specific methyltransferase 2C 0.0257608
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0239278
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0236848
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0234415
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0233679
ARHGAP15 Rho GTPase activating protein 15 0.0233288
SMC4 structural maintenance of chromosomes 4 0.0232645
ANXA5 annexin A5 0.0229447
RANBP2 RAN binding protein 2 0.0228838
ADAM9 ADAM metallopeptidase domain 9 0.0227655
FAM171B family with sequence similarity 171, member B 0.0227307
RAD23B RAD23 homolog B (S. cerevisiae) 0.0226925
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0224137
CSDE1 cold shock domain containing E1, RNA-binding 0.0223531
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.022152
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0220962
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0220836
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0220554
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0219419
USP3 ubiquitin specific peptidase 3 0.021418
MATR3 matrin 3 0.0212238
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0210236
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0209681
GPC3 glypican 3 0.0209098
TXNRD1 thioredoxin reductase 1 0.0208789
SGO2 shugoshin 2 0.0208101
SLC38A2 solute carrier family 38, member 2 0.0206964
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0203701
SFPQ splicing factor proline/glutamine-rich 0.0203507
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.020151
DIAPH3 diaphanous-related formin 3 0.0199063
KPNB1 karyopherin (importin) beta 1 0.0198248
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0196497
ECT2 epithelial cell transforming 2 0.0194899
TEX11 testis expressed 11 0.0194569
ZFR zinc finger RNA binding protein 0.0194165
TRIO trio Rho guanine nucleotide exchange factor 0.0191832
NUSAP1 nucleolar and spindle associated protein 1 0.0189706
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0189679
PRRC2C proline-rich coiled-coil 2C 0.0189665
TMEM123 transmembrane protein 123 0.0189194
KDM1A lysine (K)-specific demethylase 1A 0.018672
IQGAP1 IQ motif containing GTPase activating protein 1 0.018392
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0182468
TNPO1 transportin 1 0.018034
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0180228
METAP2 methionyl aminopeptidase 2 0.0178385
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0178267
UBQLN1 ubiquilin 1 0.0177257
OLA1 Obg-like ATPase 1 0.0176508
FUBP1 far upstream element (FUSE) binding protein 1 0.0176322
PCBP2 poly(rC) binding protein 2 0.0175472
RTN4 reticulon 4 0.0174972
CYRIB CYFIP related Rac1 interactor B 0.0174547
U2SURP U2 snRNP-associated SURP domain containing 0.0173853
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0173689
RDX radixin 0.0173566
NOP58 NOP58 ribonucleoprotein 0.0170726
POTEF POTE ankyrin domain family, member F 0.017067
FAT1 FAT atypical cadherin 1 0.0170261
CLSPN claspin 0.0170062
CCNL1 cyclin L1 0.0169835
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0169496
LAMP2 lysosomal-associated membrane protein 2 0.0169133
IPO5 importin 5 0.0168985
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0168813
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0168666
FXR1 fragile X mental retardation, autosomal homolog 1 0.0167553
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0165499

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.116947
CDH10 cadherin 10, type 2 (T2-cadherin) -0.101607
PTMA prothymosin, alpha -0.091038
RPS16 ribosomal protein S16 -0.0833453
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0754208
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.072172
RPS6 ribosomal protein S6 -0.070887
COL11A1 collagen, type XI, alpha 1 -0.0693653
RPS8 ribosomal protein S8 -0.0641738
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0634237
PHIP pleckstrin homology domain interacting protein -0.05981
WSB1 WD repeat and SOCS box containing 1 -0.0529701
RPL35A ribosomal protein L35a -0.0522516
RPL37 ribosomal protein L37 -0.0518561
RPL37A ribosomal protein L37a -0.0514574
RPS12 ribosomal protein S12 -0.0493064
FTL ferritin, light polypeptide -0.0458861
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0439598
VIM vimentin -0.0438447
RPL9 ribosomal protein L9 -0.0418937
RPS19 ribosomal protein S19 -0.0418092
RPS13 ribosomal protein S13 -0.0414688
LDHA lactate dehydrogenase A -0.0404898
MDK midkine (neurite growth-promoting factor 2) -0.0394396
HDAC9 histone deacetylase 9 -0.0393909
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0385594
RPL23 ribosomal protein L23 -0.0380759
LOC102724023 ES1 protein homolog, mitochondrial -0.0375477
CNRIP1 cannabinoid receptor interacting protein 1 -0.0366741
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0364272
GNAS GNAS complex locus -0.0362549
RPLP1 ribosomal protein, large, P1 -0.0359463
ATXN2 ataxin 2 -0.0351703
RPL30 ribosomal protein L30 -0.034913
RPS3 ribosomal protein S3 -0.0348938
RPS27A ribosomal protein S27a -0.0339371
RPLP2 ribosomal protein, large, P2 -0.0330722
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0325712
RPL31 ribosomal protein L31 -0.0324374
PDIA3 protein disulfide isomerase family A, member 3 -0.031987
TPT1 tumor protein, translationally-controlled 1 -0.0319178
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0313836
PARD3B par-3 family cell polarity regulator beta -0.0313311
RPL12 ribosomal protein L12 -0.031289
SOX2 SRY (sex determining region Y)-box 2 -0.0309359
SETD5 SET domain containing 5 -0.0307791
ANKRD33B ankyrin repeat domain 33B -0.0305984
RPL26 ribosomal protein L26 -0.0304786
ANKRD12 ankyrin repeat domain 12 -0.0295541
CALR calreticulin -0.0294574
PLPP1 phospholipid phosphatase 1 -0.0291725
EIF1 eukaryotic translation initiation factor 1 -0.028111
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0278009
SREBF2 sterol regulatory element binding transcription factor 2 -0.0277596
RPL5 ribosomal protein L5 -0.0276396
RPL28 ribosomal protein L28 -0.0274803
PGK1 phosphoglycerate kinase 1 -0.0271458
RPL7A ribosomal protein L7a -0.0269736
CUX1 cut-like homeobox 1 -0.0265971
RBM20 RNA binding motif protein 20 -0.0264282
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0256118
RPL36 ribosomal protein L36 -0.0254343
NACA nascent polypeptide-associated complex alpha subunit -0.0253258
RPS10 ribosomal protein S10 -0.024746
RPL34 ribosomal protein L34 -0.0240092
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0240071
DDIT4 DNA-damage-inducible transcript 4 -0.0239622
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0238426
FAM177A1 family with sequence similarity 177, member A1 -0.0236826
ADGRL2 adhesion G protein-coupled receptor L2 -0.0235859
NEBL nebulette -0.0235794
MYO10 myosin X -0.0235753
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0235331
NCOR2 nuclear receptor corepressor 2 -0.0235079
NHSL1 NHS-like 1 -0.0234697
ISG15 ISG15 ubiquitin-like modifier -0.023169
RPS25 ribosomal protein S25 -0.0229506
PCDH9 protocadherin 9 -0.0219455
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0216108
APOE apolipoprotein E -0.0215686
DSTN destrin (actin depolymerizing factor) -0.021467
RACK1 receptor for activated C kinase 1 -0.021429
SNX6 sorting nexin 6 -0.0213693
RPL19 ribosomal protein L19 -0.0213544
DOCK5 dedicator of cytokinesis 5 -0.0212686
BBX bobby sox homolog (Drosophila) -0.0212447
RPL11 ribosomal protein L11 -0.02123
RPS17 ribosomal protein S17 -0.0211179
PRKD1 protein kinase D1 -0.0208851
MRPS6 mitochondrial ribosomal protein S6 -0.0207184
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0206934
TRPS1 trichorhinophalangeal syndrome I -0.0204147
MED13L mediator complex subunit 13-like -0.020368
RPS27 ribosomal protein S27 -0.0203424
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0198165
PGAP1 post-GPI attachment to proteins 1 -0.0197498
FOXG1 forkhead box G1 -0.0196168
BRWD1 bromodomain and WD repeat domain containing 1 -0.0194732
LOC112694756 uncharaterized LOC112694756 -0.0193599
FST follistatin -0.0191861