Hesperidin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0719367
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0662562
SSBP2 single-stranded DNA binding protein 2 0.0615833
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0604266
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0512221
EML4 echinoderm microtubule associated protein like 4 0.0497632
PCBP2 poly(rC) binding protein 2 0.0419602
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.04072
TFG TRK-fused gene 0.039897
ECT2 epithelial cell transforming 2 0.0392042
SRP54 signal recognition particle 54kDa 0.0391817
QKI QKI, KH domain containing, RNA binding 0.0388133
NUP58 nucleoporin 58 0.0387643
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380561
BIRC6 baculoviral IAP repeat containing 6 0.0373617
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0368516
GOLGA4 golgin A4 0.0356148
TXNIP thioredoxin interacting protein 0.0355524
KMT2E lysine (K)-specific methyltransferase 2E 0.0348186
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347486
MATR3 matrin 3 0.0341372
DSTN destrin (actin depolymerizing factor) 0.0335028
ELOVL5 ELOVL fatty acid elongase 5 0.0330267
NCKAP1 NCK-associated protein 1 0.0320356
VMP1 vacuole membrane protein 1 0.0317781
LCORL ligand dependent nuclear receptor corepressor-like 0.0317735
WAC WW domain containing adaptor with coiled-coil 0.0317131
B2M beta-2-microglobulin 0.03156
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0309845
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0305848
RAB6A RAB6A, member RAS oncogene family 0.0304638
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0303274
AKAP9 A kinase (PRKA) anchor protein 9 0.0302123
RNF145 ring finger protein 145 0.0300379
HELZ helicase with zinc finger 0.0297241
ADAM10 ADAM metallopeptidase domain 10 0.0296937
KDM6A lysine (K)-specific demethylase 6A 0.0296542
ZMYM2 zinc finger, MYM-type 2 0.0291246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0287411
XPO1 exportin 1 0.0285296
DENND4A DENN/MADD domain containing 4A 0.028388
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0283462
RLF rearranged L-myc fusion 0.0281869
RBM25 RNA binding motif protein 25 0.0278674
TRA2A transformer 2 alpha homolog (Drosophila) 0.0278319
CCNL1 cyclin L1 0.0277913
NAMPT nicotinamide phosphoribosyltransferase 0.0276067
USP3 ubiquitin specific peptidase 3 0.0272645
NEK7 NIMA-related kinase 7 0.0272592
PDIA6 protein disulfide isomerase family A, member 6 0.0271375
SMC3 structural maintenance of chromosomes 3 0.0265948
NPEPPS aminopeptidase puromycin sensitive 0.0264239
SRPK2 SRSF protein kinase 2 0.0261975
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0259332
RIOK3 RIO kinase 3 0.025932
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0258056
STAG2 stromal antigen 2 0.0257164
PDS5B PDS5 cohesin associated factor B 0.025493
FXR1 fragile X mental retardation, autosomal homolog 1 0.0247533
COPA coatomer protein complex, subunit alpha 0.0243727
KIF5B kinesin family member 5B 0.0242166
ANXA1 annexin A1 0.0241799
PCM1 pericentriolar material 1 0.0241639
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0236276
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0234498
DSCAM Down syndrome cell adhesion molecule 0.0232021
PUM2 pumilio RNA-binding family member 2 0.0231749
SKIC3 SKI3 subunit of superkiller complex 0.023099
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0228945
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0228089
NBAS neuroblastoma amplified sequence 0.0228052
UBA6 ubiquitin-like modifier activating enzyme 6 0.022769
RYBP RING1 and YY1 binding protein 0.0227429
PRRC1 proline-rich coiled-coil 1 0.0227269
PIAS1 protein inhibitor of activated STAT, 1 0.0226569
FNDC3B fibronectin type III domain containing 3B 0.0224136
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0223424
NCOR1 nuclear receptor corepressor 1 0.0223381
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0221598
ZFAND3 zinc finger, AN1-type domain 3 0.0220756
KPNB1 karyopherin (importin) beta 1 0.0219295
RAD21 RAD21 homolog (S. pombe) 0.0218933
TOP2B topoisomerase (DNA) II beta 180kDa 0.0217788
RAD23B RAD23 homolog B (S. cerevisiae) 0.0217734
INSIG2 insulin induced gene 2 0.0213531
CENPF centromere protein F, 350/400kDa 0.0210182
CCDC88A coiled-coil domain containing 88A 0.0208566
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0208347
SCAF11 SR-related CTD-associated factor 11 0.0208207
STRN3 striatin, calmodulin binding protein 3 0.0207084
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0204216
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0204193
WSB1 WD repeat and SOCS box containing 1 0.020269
HILPDA hypoxia inducible lipid droplet-associated 0.0201958
PFN1 profilin 1 0.0201365
NKTR natural killer cell triggering receptor 0.0200334
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0199936
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0199553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0199474
KMT2C lysine (K)-specific methyltransferase 2C 0.0199242

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137726
PDE4D phosphodiesterase 4D, cAMP-specific -0.123306
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0866712
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0705997
FLNB filamin B, beta -0.0678152
AHNAK AHNAK nucleoprotein -0.0660209
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0587082
PYGB phosphorylase, glycogen; brain -0.0576629
GLI2 GLI family zinc finger 2 -0.0560259
TPT1 tumor protein, translationally-controlled 1 -0.0509935
ARL4C ADP-ribosylation factor-like 4C -0.0488122
EZR ezrin -0.0488102
BMP10 bone morphogenetic protein 10 -0.0412973
LOC112694756 uncharaterized LOC112694756 -0.0410068
EGFR epidermal growth factor receptor -0.0396015
TXNRD1 thioredoxin reductase 1 -0.0390499
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0382115
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0381891
CCND1 cyclin D1 -0.0381163
ATP9B ATPase, class II, type 9B -0.0380272
DUSP4 dual specificity phosphatase 4 -0.0377026
RPS27A ribosomal protein S27a -0.0365024
EEF2 eukaryotic translation elongation factor 2 -0.0356339
EFNA5 ephrin-A5 -0.0351943
TMSB4X thymosin beta 4, X-linked -0.0342169
RPL35A ribosomal protein L35a -0.0339166
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0330341
ACTG1 actin gamma 1 -0.0325691
FOXP1 forkhead box P1 -0.0322293
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0318795
LDHA lactate dehydrogenase A -0.03161
RPS8 ribosomal protein S8 -0.0308968
RPL34 ribosomal protein L34 -0.0308567
NPAS2 neuronal PAS domain protein 2 -0.0307569
VCL vinculin -0.0305189
RPL26 ribosomal protein L26 -0.0301382
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0299034
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0298041
HDAC9 histone deacetylase 9 -0.0289957
GLI3 GLI family zinc finger 3 -0.028325
UBC ubiquitin C -0.0281748
ZBTB20 zinc finger and BTB domain containing 20 -0.0281232
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0278777
RPL31 ribosomal protein L31 -0.0273041
PKM pyruvate kinase, muscle -0.0272135
RPL4 ribosomal protein L4 -0.0266496
TAS2R14 taste receptor, type 2, member 14 -0.0265439
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0264569
TMSB10 thymosin beta 10 -0.0251886
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0248748
PTMA prothymosin, alpha -0.0248283
TM4SF1 transmembrane 4 L six family member 1 -0.0248177
HEG1 heart development protein with EGF-like domains 1 -0.0245874
ZEB1 zinc finger E-box binding homeobox 1 -0.0241742
RHOA ras homolog family member A -0.0241532
S100A4 S100 calcium binding protein A4 -0.0241433
MAPK8 mitogen-activated protein kinase 8 -0.023742
RPS6 ribosomal protein S6 -0.0236598
RPL37A ribosomal protein L37a -0.023638
RRBP1 ribosome binding protein 1 -0.0232672
NCEH1 neutral cholesterol ester hydrolase 1 -0.0230302
SMYD3 SET and MYND domain containing 3 -0.0227449
PRRC2B proline-rich coiled-coil 2B -0.0226057
APP amyloid beta (A4) precursor protein -0.0225793
HDLBP high density lipoprotein binding protein -0.0220036
SAMD4A sterile alpha motif domain containing 4A -0.0218476
MYO5A myosin VA (heavy chain 12, myoxin) -0.0216171
RPL12 ribosomal protein L12 -0.0215518
GNAS GNAS complex locus -0.0211253
BMP2K BMP2 inducible kinase -0.0210267
NBEA neurobeachin -0.0209495
RPL19 ribosomal protein L19 -0.0207935
MYO5C myosin VC -0.0203941
SDK1 sidekick cell adhesion molecule 1 -0.0199881
ZMYND8 zinc finger, MYND-type containing 8 -0.0198904
DOCK3 dedicator of cytokinesis 3 -0.0197511
R3HDM2 R3H domain containing 2 -0.0196069
FBLN2 fibulin 2 -0.019596
ONECUT2 one cut homeobox 2 -0.0193578
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0192878
S100A6 S100 calcium binding protein A6 -0.0190997
IGF2R insulin-like growth factor 2 receptor -0.0189199
RACK1 receptor for activated C kinase 1 -0.0188243
IFI16 interferon, gamma-inducible protein 16 -0.0187684
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0187647
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0187234
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0184806
RPL35 ribosomal protein L35 -0.0183205
SPRY4 sprouty homolog 4 (Drosophila) -0.0182158
RPL9 ribosomal protein L9 -0.0181673
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0180753
RPLP2 ribosomal protein, large, P2 -0.0179005
RPL32 ribosomal protein L32 -0.017734
PDGFC platelet derived growth factor C -0.0176623
RPS24 ribosomal protein S24 -0.0176469
RPS13 ribosomal protein S13 -0.0176372
PHF3 PHD finger protein 3 -0.017564
KANK1 KN motif and ankyrin repeat domains 1 -0.017495
ATRN attractin -0.0174522
EXT1 exostosin glycosyltransferase 1 -0.0172855