Hesperidin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.147905
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.126848
SPAG9 sperm associated antigen 9 0.0906854
FTH1 ferritin, heavy polypeptide 1 0.0812829
UGCG UDP-glucose ceramide glucosyltransferase 0.0743076
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0710845
CADM1 cell adhesion molecule 1 0.0675167
TSC22D2 TSC22 domain family, member 2 0.0591552
FNDC3B fibronectin type III domain containing 3B 0.0576636
ZNF292 zinc finger protein 292 0.0570328
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0554262
ATP13A3 ATPase type 13A3 0.0517649
HELZ helicase with zinc finger 0.0504084
QKI QKI, KH domain containing, RNA binding 0.0495348
MYH9 myosin, heavy chain 9, non-muscle 0.0456286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045103
NT5C2 5'-nucleotidase, cytosolic II 0.0448302
FN1 fibronectin 1 0.0444564
ELL2 elongation factor, RNA polymerase II, 2 0.0444108
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0430798
RYBP RING1 and YY1 binding protein 0.0427433
EPS8 epidermal growth factor receptor pathway substrate 8 0.0415829
EEF2 eukaryotic translation elongation factor 2 0.0410023
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0403815
ZFAND3 zinc finger, AN1-type domain 3 0.0391078
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0388084
POTEF POTE ankyrin domain family, member F 0.0387195
WTAP Wilms tumor 1 associated protein 0.0385812
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0384735
UBA6 ubiquitin-like modifier activating enzyme 6 0.0374731
CCNL1 cyclin L1 0.0361082
USP9X ubiquitin specific peptidase 9, X-linked 0.036018
PICALM phosphatidylinositol binding clathrin assembly protein 0.0357873
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0355603
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354832
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0353766
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0352649
MSN moesin 0.0348568
YBX1 Y box binding protein 1 0.0347566
OGA O-GlcNAcase 0.0337227
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0331392
TFG TRK-fused gene 0.0330879
PCBP2 poly(rC) binding protein 2 0.0330466
LAMP2 lysosomal-associated membrane protein 2 0.0321635
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0321479
CRY1 cryptochrome circadian clock 1 0.0316997
MATR3 matrin 3 0.0310583
DENND5A DENN/MADD domain containing 5A 0.0310034
ANXA2 annexin A2 0.0300215
IPO7 importin 7 0.0297158
GPBP1 GC-rich promoter binding protein 1 0.0294763
NAMPT nicotinamide phosphoribosyltransferase 0.0293693
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0286227
MXI1 MAX interactor 1, dimerization protein 0.0285545
ICAM1 intercellular adhesion molecule 1 0.0284133
WAC WW domain containing adaptor with coiled-coil 0.0283695
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0281607
KDM6A lysine (K)-specific demethylase 6A 0.0280711
BIRC3 baculoviral IAP repeat containing 3 0.0275759
FXR1 fragile X mental retardation, autosomal homolog 1 0.0275566
UBC ubiquitin C 0.0271368
USP12 ubiquitin specific peptidase 12 0.0271173
ZNF207 zinc finger protein 207 0.0268159
NCKAP1 NCK-associated protein 1 0.0266383
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0264444
GLS2 glutaminase 2 (liver, mitochondrial) 0.0263382
CHD1 chromodomain helicase DNA binding protein 1 0.0261265
RNF145 ring finger protein 145 0.0260681
SRGN serglycin 0.0258293
RAB1A RAB1A, member RAS oncogene family 0.025526
UVRAG UV radiation resistance associated 0.0253977
WDR43 WD repeat domain 43 0.0250936
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0249053
ADAM17 ADAM metallopeptidase domain 17 0.0248828
TBC1D12 TBC1 domain family, member 12 0.0245849
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0242857
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0242463
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0242027
MARCHF6 membrane associated ring-CH-type finger 6 0.024124
DSTN destrin (actin depolymerizing factor) 0.0240399
PTBP3 polypyrimidine tract binding protein 3 0.0239682
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0239028
ABI1 abl-interactor 1 0.023869
RPLP0 ribosomal protein, large, P0 0.0238643
UBE2H ubiquitin-conjugating enzyme E2H 0.0237587
CKAP5 cytoskeleton associated protein 5 0.02321
AKAP13 A kinase (PRKA) anchor protein 13 0.023201
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0231405
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0230732
NUP58 nucleoporin 58 0.0230232
NEK7 NIMA-related kinase 7 0.0229894
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0228973
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0228087
NAV2 neuron navigator 2 0.0227913
ANLN anillin, actin binding protein 0.0227637
SNX9 sorting nexin 9 0.0226607
HILPDA hypoxia inducible lipid droplet-associated 0.0224618
RLF rearranged L-myc fusion 0.0223391
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0223282
PDIA3 protein disulfide isomerase family A, member 3 0.0223257

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.176921
TMSB10 thymosin beta 10 -0.107109
HLA-B major histocompatibility complex, class I, B -0.10329
MT2A metallothionein 2A -0.101213
GLIS3 GLIS family zinc finger 3 -0.0882772
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0783944
ZMYND8 zinc finger, MYND-type containing 8 -0.0759415
NDRG1 N-myc downstream regulated 1 -0.0642837
FRMD4A FERM domain containing 4A -0.0617366
AKAP12 A kinase (PRKA) anchor protein 12 -0.060967
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0555717
IGFBP3 insulin-like growth factor binding protein 3 -0.0516768
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0507456
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0504723
HMGA2 high mobility group AT-hook 2 -0.0467923
TPT1 tumor protein, translationally-controlled 1 -0.0461331
CD44 CD44 molecule (Indian blood group) -0.0455985
IFI16 interferon, gamma-inducible protein 16 -0.0452848
BICC1 BicC family RNA binding protein 1 -0.0433796
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0416203
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0411019
ATXN1 ataxin 1 -0.0399271
EGR1 early growth response 1 -0.0384265
FTL ferritin, light polypeptide -0.0383747
BASP1 brain abundant, membrane attached signal protein 1 -0.0373737
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0373532
RPS3 ribosomal protein S3 -0.0354087
ENO2 enolase 2 (gamma, neuronal) -0.0351325
EGFR epidermal growth factor receptor -0.0348103
RAI14 retinoic acid induced 14 -0.0344665
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0341937
IFI6 interferon, alpha-inducible protein 6 -0.0323304
RPS19 ribosomal protein S19 -0.0321535
RPL37A ribosomal protein L37a -0.0320726
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0319776
EXT1 exostosin glycosyltransferase 1 -0.031566
RPL35A ribosomal protein L35a -0.0311913
IFITM3 interferon induced transmembrane protein 3 -0.0311486
RPLP2 ribosomal protein, large, P2 -0.0308823
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0307553
RPL36 ribosomal protein L36 -0.0303307
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0285627
RPL9 ribosomal protein L9 -0.0272543
DIAPH2 diaphanous-related formin 2 -0.026798
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0263786
ZBTB38 zinc finger and BTB domain containing 38 -0.0262538
RNF213 ring finger protein 213 -0.0258784
NAV1 neuron navigator 1 -0.0253195
RPS12 ribosomal protein S12 -0.0247928
RPL36A ribosomal protein L36a -0.0246464
PRELID2 PRELI domain containing 2 -0.0246281
HLA-A major histocompatibility complex, class I, A -0.0244869
COL1A1 collagen, type I, alpha 1 -0.0243572
RPL19 ribosomal protein L19 -0.0242845
ZBTB20 zinc finger and BTB domain containing 20 -0.0242264
TNS3 tensin 3 -0.0242167
PTPRF protein tyrosine phosphatase, receptor type, F -0.0240929
AFF3 AF4/FMR2 family, member 3 -0.024086
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0238568
SLC38A2 solute carrier family 38, member 2 -0.0235732
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0235376
RPS21 ribosomal protein S21 -0.0235128
GOLGB1 golgin B1 -0.0233691
TGFBI transforming growth factor, beta-induced, 68kDa -0.0230613
CLMP CXADR-like membrane protein -0.0229916
DST dystonin -0.0229284
VEGFA vascular endothelial growth factor A -0.0229106
TOX2 TOX high mobility group box family member 2 -0.0228425
RPL38 ribosomal protein L38 -0.0226392
RPL26 ribosomal protein L26 -0.0225375
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0221484
SP100 SP100 nuclear antigen -0.0221112
BTG1 B-cell translocation gene 1, anti-proliferative -0.0220635
OSMR oncostatin M receptor -0.0218537
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0217991
RPS13 ribosomal protein S13 -0.0217951
IFITM1 interferon induced transmembrane protein 1 -0.0217379
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0216334
FBXL7 F-box and leucine-rich repeat protein 7 -0.0214388
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0213665
MACF1 microtubule-actin crosslinking factor 1 -0.0213443
GPC6 glypican 6 -0.0213173
AKAP9 A kinase (PRKA) anchor protein 9 -0.0213119
RRBP1 ribosome binding protein 1 -0.0212637
HDAC8 histone deacetylase 8 -0.0210167
MYO9A myosin IXA -0.0209302
LDHA lactate dehydrogenase A -0.0208815
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0206478
RPL35 ribosomal protein L35 -0.0206273
MAML2 mastermind-like 2 (Drosophila) -0.0205444
EFNA5 ephrin-A5 -0.0202514
CEP112 centrosomal protein 112kDa -0.0201507
DPYD dihydropyrimidine dehydrogenase -0.0201458
RPL31 ribosomal protein L31 -0.0197666
PTPRK protein tyrosine phosphatase, receptor type, K -0.0196272
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0195004
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0194464
TMEM132D transmembrane protein 132D -0.0194106
KLF6 Kruppel-like factor 6 -0.0193756
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0193735