Hesperidin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.138183
CDH13 cadherin 13 0.0722861
ERRFI1 ERBB receptor feedback inhibitor 1 0.0684642
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0591217
MYO1E myosin IE 0.0581982
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0539196
EGFR epidermal growth factor receptor 0.0520737
VCL vinculin 0.0502313
ENO1 enolase 1, (alpha) 0.0498346
WSB1 WD repeat and SOCS box containing 1 0.0486048
NRXN3 neurexin 3 0.0484779
TXNRD1 thioredoxin reductase 1 0.0450438
AHNAK AHNAK nucleoprotein 0.0449661
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0438772
ZNF207 zinc finger protein 207 0.043768
MLEC malectin 0.0435537
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0425311
XRN1 5'-3' exoribonuclease 1 0.0423447
PTBP2 polypyrimidine tract binding protein 2 0.0423445
GOLGA4 golgin A4 0.041977
RPL37A ribosomal protein L37a 0.0412205
MORF4L2 mortality factor 4 like 2 0.0410291
OSBPL9 oxysterol binding protein-like 9 0.0404041
EZR ezrin 0.0398813
RPS12 ribosomal protein S12 0.0395057
GRB10 growth factor receptor-bound protein 10 0.0390452
COL6A3 collagen, type VI, alpha 3 0.0388576
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0386471
NAV2 neuron navigator 2 0.0381883
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0376172
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0373199
JMJD1C jumonji domain containing 1C 0.0373132
TENT2 terminal nucleotidyltransferase 2 0.0371122
IGFBP3 insulin-like growth factor binding protein 3 0.0370777
PGK1 phosphoglycerate kinase 1 0.0367175
FNBP1L formin binding protein 1-like 0.0360259
ANTXR2 anthrax toxin receptor 2 0.0355819
RNF145 ring finger protein 145 0.0353563
NCOR1 nuclear receptor corepressor 1 0.0350635
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0350099
FN1 fibronectin 1 0.034411
ABLIM3 actin binding LIM protein family, member 3 0.034385
NAP1L1 nucleosome assembly protein 1-like 1 0.0339011
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0337583
LMO7 LIM domain 7 0.0336696
SH3KBP1 SH3-domain kinase binding protein 1 0.0334412
ANXA5 annexin A5 0.0332804
FRMD6 FERM domain containing 6 0.0332271
ACTN4 actinin, alpha 4 0.0326168
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0322431
DST dystonin 0.0319469
GARS1 glycyl-tRNA synthetase 1 0.0317276
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0315414
PRMT2 protein arginine methyltransferase 2 0.0315168
MED13L mediator complex subunit 13-like 0.0314975
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0314754
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0312729
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0312057
GPC6 glypican 6 0.0309268
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0307012
MXI1 MAX interactor 1, dimerization protein 0.0306908
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.030408
DNM1L dynamin 1-like 0.0303497
ACTN1 actinin, alpha 1 0.0302717
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0301522
RSRC2 arginine/serine-rich coiled-coil 2 0.0300084
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0299744
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0299499
RIOK3 RIO kinase 3 0.0297545
ZFP36L1 ZFP36 ring finger protein-like 1 0.0297273
ASPH aspartate beta-hydroxylase 0.0297159
RTN4 reticulon 4 0.0297079
FAM13A family with sequence similarity 13, member A 0.029603
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0295953
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0295867
VMP1 vacuole membrane protein 1 0.0295096
MYOF myoferlin 0.0291101
FCHSD2 FCH and double SH3 domains 2 0.0290302
MACF1 microtubule-actin crosslinking factor 1 0.0289902
RPS13 ribosomal protein S13 0.0284834
GPATCH2L G patch domain containing 2-like 0.0283662
QKI QKI, KH domain containing, RNA binding 0.0281156
SQSTM1 sequestosome 1 0.0279804
CSNK1G3 casein kinase 1, gamma 3 0.0278764
CD9 CD9 molecule 0.0278718
KDM3A lysine (K)-specific demethylase 3A 0.0278212
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0277606
RTN3 reticulon 3 0.0277365
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0276508
SND1 staphylococcal nuclease and tudor domain containing 1 0.0275928
IFIH1 interferon induced with helicase C domain 1 0.0274009
USO1 USO1 vesicle transport factor 0.0272602
LIFR leukemia inhibitory factor receptor alpha 0.0272598
HELZ helicase with zinc finger 0.0270668
PRKCSH protein kinase C substrate 80K-H 0.0269349
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0268711
HIPK2 homeodomain interacting protein kinase 2 0.0265562
MYO10 myosin X 0.0263582
MBNL2 muscleblind-like splicing regulator 2 0.0263014
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.026036

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131026
MT2A metallothionein 2A -0.117988
B2M beta-2-microglobulin -0.106294
TGFBI transforming growth factor, beta-induced, 68kDa -0.0881592
HLA-B major histocompatibility complex, class I, B -0.0754447
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0713832
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0657809
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0607518
HDLBP high density lipoprotein binding protein -0.0567851
VEGFA vascular endothelial growth factor A -0.0556834
LDHA lactate dehydrogenase A -0.0530772
SRSF11 serine/arginine-rich splicing factor 11 -0.0523821
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0503577
COL6A1 collagen, type VI, alpha 1 -0.0496954
RNF24 ring finger protein 24 -0.0491348
SDC4 syndecan 4 -0.0482798
NAMPT nicotinamide phosphoribosyltransferase -0.0473283
MAP1B microtubule-associated protein 1B -0.0458366
CALR calreticulin -0.0455105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0444594
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0443559
SMYD3 SET and MYND domain containing 3 -0.0434063
IARS1 isoleucyl-tRNA synthetase 1 -0.0431345
POTEF POTE ankyrin domain family, member F -0.0421857
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0414886
RAB10 RAB10, member RAS oncogene family -0.0407021
MAML2 mastermind-like 2 (Drosophila) -0.0399965
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0390308
EIF1 eukaryotic translation initiation factor 1 -0.0383289
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0381413
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0378154
HMGA2 high mobility group AT-hook 2 -0.0375179
H3-3B H3.3 histone B -0.0371707
UGP2 UDP-glucose pyrophosphorylase 2 -0.0370152
SKIC3 SKI3 subunit of superkiller complex -0.036877
RPS21 ribosomal protein S21 -0.0359121
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0354941
FUS FUS RNA binding protein -0.0344467
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0341878
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0341681
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0337561
RSF1 remodeling and spacing factor 1 -0.0336412
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0335357
CD44 CD44 molecule (Indian blood group) -0.0329426
RRBP1 ribosome binding protein 1 -0.0328824
RPL18 ribosomal protein L18 -0.0327477
GCC2 GRIP and coiled-coil domain containing 2 -0.0324503
MEF2A myocyte enhancer factor 2A -0.0324075
GNAS GNAS complex locus -0.0321552
MTPN myotrophin -0.0317595
ITCH itchy E3 ubiquitin protein ligase -0.0315109
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0314795
KMT2E lysine (K)-specific methyltransferase 2E -0.0314664
NUP58 nucleoporin 58 -0.0313798
CDK13 cyclin-dependent kinase 13 -0.030828
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0306439
PDIA4 protein disulfide isomerase family A, member 4 -0.0304217
THRAP3 thyroid hormone receptor associated protein 3 -0.0303752
SRPK2 SRSF protein kinase 2 -0.0302864
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0298072
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0297742
TRIP12 thyroid hormone receptor interactor 12 -0.0297692
PDE4D phosphodiesterase 4D, cAMP-specific -0.0297301
MMP2 matrix metallopeptidase 2 -0.0289662
CUL3 cullin 3 -0.0288032
PGAP1 post-GPI attachment to proteins 1 -0.0287678
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0286963
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0285904
RUNX1 runt-related transcription factor 1 -0.0284353
HMGB1 high mobility group box 1 -0.0284302
PKM pyruvate kinase, muscle -0.0282344
BSG basigin (Ok blood group) -0.0281115
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0280534
COL5A1 collagen, type V, alpha 1 -0.0280109
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0280036
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0279166
PDIA3 protein disulfide isomerase family A, member 3 -0.0278054
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0274949
SETD5 SET domain containing 5 -0.027458
SEM1 SEM1 26S proteasome subunit -0.0272432
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0269526
IGFBP7 insulin-like growth factor binding protein 7 -0.0269135
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0268532
TMSB4X thymosin beta 4, X-linked -0.0265737
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0265724
S100A10 S100 calcium binding protein A10 -0.0264804
ANKRD33B ankyrin repeat domain 33B -0.0264466
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0263895
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.026155
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0260536
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0259308
CKAP5 cytoskeleton associated protein 5 -0.0256526
CIRSR corepressor of RBPJ and splicing regulator -0.0252843
TPM2 tropomyosin 2 (beta) -0.0252548
GOLGB1 golgin B1 -0.0252291
RPS14 ribosomal protein S14 -0.0250872
GPR107 G protein-coupled receptor 107 -0.0248407
UBE2K ubiquitin-conjugating enzyme E2K -0.0248181
ERP44 endoplasmic reticulum protein 44 -0.0247104
HDAC8 histone deacetylase 8 -0.0246641