Hesperidin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.124598
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0588321
FMNL2 formin-like 2 0.0574419
AHNAK AHNAK nucleoprotein 0.0559154
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0516954
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0513222
BIRC3 baculoviral IAP repeat containing 3 0.0511443
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0510544
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0507246
SVIL supervillin 0.0481718
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0465284
WAC WW domain containing adaptor with coiled-coil 0.0458784
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0442691
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0392708
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0369616
IRAK2 interleukin-1 receptor-associated kinase 2 0.036705
ANXA2 annexin A2 0.0355592
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0343063
TPT1 tumor protein, translationally-controlled 1 0.0341145
PALM2AKAP2 PALM2 and AKAP2 fusion 0.033283
BZW1 basic leucine zipper and W2 domains 1 0.0326748
NAV2 neuron navigator 2 0.0324986
HMGA2 high mobility group AT-hook 2 0.0321258
EGFR epidermal growth factor receptor 0.0319745
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0309815
DSCAM Down syndrome cell adhesion molecule 0.0307552
RPLP1 ribosomal protein, large, P1 0.0306254
IER3 immediate early response 3 0.030529
NUP58 nucleoporin 58 0.0305115
BIRC2 baculoviral IAP repeat containing 2 0.0299493
SOD2 superoxide dismutase 2, mitochondrial 0.0298282
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0295052
TRIO trio Rho guanine nucleotide exchange factor 0.029482
SNX14 sorting nexin 14 0.0290929
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0290814
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0286084
MYO9A myosin IXA 0.0282682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.028158
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0281224
ATP13A3 ATPase type 13A3 0.027798
ADAM17 ADAM metallopeptidase domain 17 0.0267978
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0267547
SFTPA2 surfactant protein A2 0.0266275
ZNF292 zinc finger protein 292 0.0264519
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0261236
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0259004
ANXA5 annexin A5 0.0257506
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0256361
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0250931
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.025033
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0249689
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0248927
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0245954
TOP2B topoisomerase (DNA) II beta 180kDa 0.0243906
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0242592
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.024201
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0239672
PDIA6 protein disulfide isomerase family A, member 6 0.0238914
ZBTB20 zinc finger and BTB domain containing 20 0.0236656
COPB1 coatomer protein complex, subunit beta 1 0.0236397
USP3 ubiquitin specific peptidase 3 0.0232281
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0231446
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0228458
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0227831
SAMD4A sterile alpha motif domain containing 4A 0.0227676
CDK17 cyclin-dependent kinase 17 0.0226612
NAP1L1 nucleosome assembly protein 1-like 1 0.0226262
SH3KBP1 SH3-domain kinase binding protein 1 0.0225604
RAI14 retinoic acid induced 14 0.0221973
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0221384
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0218885
PARD3 par-3 family cell polarity regulator 0.0217144
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0216668
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0215597
NT5E 5'-nucleotidase, ecto (CD73) 0.0215234
PGK1 phosphoglycerate kinase 1 0.0212521
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0211926
URI1 URI1, prefoldin-like chaperone 0.0211169
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0207878
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0207704
KLF6 Kruppel-like factor 6 0.0207109
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0206474
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0206372
PNRC1 proline-rich nuclear receptor coactivator 1 0.020452
RBM33 RNA binding motif protein 33 0.0204019
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0201985
SMAD3 SMAD family member 3 0.0201114
ZBTB1 zinc finger and BTB domain containing 1 0.0199164
RPL26 ribosomal protein L26 0.0198389
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0194232
ZFAND6 zinc finger, AN1-type domain 6 0.0193011
PRSS23 protease, serine, 23 0.0192102
SPNS1 spinster homolog 1 (Drosophila) 0.0192051
FOXO3 forkhead box O3 0.0191647
POGLUT3 protein O-glucosyltransferase 3 0.0191279
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0191184
RAD21 RAD21 homolog (S. pombe) 0.0190909
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0188993
EPN2 epsin 2 0.0188343
IFRD1 interferon-related developmental regulator 1 0.0187776

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0989552
TMSB10 thymosin beta 10 -0.0964763
IGFBP3 insulin-like growth factor binding protein 3 -0.0850029
PTMA prothymosin, alpha -0.0649561
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0544924
DERA deoxyribose-phosphate aldolase (putative) -0.0507899
EGR1 early growth response 1 -0.044139
YBX3 Y box binding protein 3 -0.0439051
HILPDA hypoxia inducible lipid droplet-associated -0.0422283
ANKRD28 ankyrin repeat domain 28 -0.0415581
ATM ATM serine/threonine kinase -0.0414814
PHIP pleckstrin homology domain interacting protein -0.0412141
CENPF centromere protein F, 350/400kDa -0.0381892
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0378765
DIAPH3 diaphanous-related formin 3 -0.0359647
SMC4 structural maintenance of chromosomes 4 -0.0354997
MT2A metallothionein 2A -0.0338606
IGF2 insulin-like growth factor 2 -0.0333454
VIM vimentin -0.0332934
NF1 neurofibromin 1 -0.0327411
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.028601
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0285152
TXNIP thioredoxin interacting protein -0.0281786
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281258
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.026119
ZNF609 zinc finger protein 609 -0.0260205
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0258688
H3-3B H3.3 histone B -0.025604
TMF1 TATA element modulatory factor 1 -0.0250323
RBM25 RNA binding motif protein 25 -0.0250247
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0249108
TAOK1 TAO kinase 1 -0.0245936
NKTR natural killer cell triggering receptor -0.0244584
AKAP9 A kinase (PRKA) anchor protein 9 -0.0242512
KIAA1328 KIAA1328 -0.0242069
STK4 serine/threonine kinase 4 -0.0241565
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0240973
SAFB2 scaffold attachment factor B2 -0.0240165
CCDC14 coiled-coil domain containing 14 -0.0239078
NBEAL1 neurobeachin-like 1 -0.0238512
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0238425
CEP290 centrosomal protein 290kDa -0.0238328
MBNL1 muscleblind-like splicing regulator 1 -0.023663
RPL11 ribosomal protein L11 -0.0234323
BASP1 brain abundant, membrane attached signal protein 1 -0.023423
LOC112694756 uncharaterized LOC112694756 -0.023284
H1-0 H1.0 linker histone -0.0232525
RPS6 ribosomal protein S6 -0.0230677
RPL35A ribosomal protein L35a -0.0229716
MKI67 marker of proliferation Ki-67 -0.0227976
GNAS GNAS complex locus -0.022463
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0222596
TM4SF1 transmembrane 4 L six family member 1 -0.0222339
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0221986
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0220639
FTL ferritin, light polypeptide -0.021985
TMEM263 transmembrane protein 263 -0.0216015
EIF4A1 eukaryotic translation initiation factor 4A1 -0.02157
HDAC9 histone deacetylase 9 -0.0213748
PRKCE protein kinase C, epsilon -0.0213269
FLNB filamin B, beta -0.0213255
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0212029
DNER delta/notch-like EGF repeat containing -0.0210411
NXN nucleoredoxin -0.021021
SETD5 SET domain containing 5 -0.0210071
HMGA1 high mobility group AT-hook 1 -0.0209116
TNRC18 trinucleotide repeat containing 18 -0.0208684
SRSF11 serine/arginine-rich splicing factor 11 -0.0207458
GLCCI1 glucocorticoid induced 1 -0.020725
ZMYND8 zinc finger, MYND-type containing 8 -0.0206614
HJURP Holliday junction recognition protein -0.0205028
TPI1 triosephosphate isomerase 1 -0.0204992
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0204263
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0203818
WNK1 WNK lysine deficient protein kinase 1 -0.0201336
KLC1 kinesin light chain 1 -0.0200916
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0200625
BSG basigin (Ok blood group) -0.0200521
RPS23 ribosomal protein S23 -0.0199599
FNDC3A fibronectin type III domain containing 3A -0.0199206
PCNX4 pecanex 4 -0.0196812
ANKRD11 ankyrin repeat domain 11 -0.0196065
RPS3 ribosomal protein S3 -0.0194237
ENO2 enolase 2 (gamma, neuronal) -0.0193672
PTBP2 polypyrimidine tract binding protein 2 -0.0193583
VCL vinculin -0.0193028
GAS2L3 growth arrest-specific 2 like 3 -0.0192407
EXOC5 exocyst complex component 5 -0.0192165
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0189418
FNBP1 formin binding protein 1 -0.018937
SEPTIN7 septin 7 -0.0188499
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0188141
YBX1 Y box binding protein 1 -0.018793
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0185845
SQSTM1 sequestosome 1 -0.0185454
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0184
BHLHE40 basic helix-loop-helix family, member e40 -0.0183838
RPS17 ribosomal protein S17 -0.0183072
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0181768
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0181764