Hesperidin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hesperidin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hesperidin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.170146
CXCL8 chemokine (C-X-C motif) ligand 8 0.135925
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.116145
FTH1 ferritin, heavy polypeptide 1 0.105954
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0981333
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0843506
CANX calnexin 0.0807406
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0760663
NAMPT nicotinamide phosphoribosyltransferase 0.0628647
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0596938
SOD2 superoxide dismutase 2, mitochondrial 0.0581636
SUCO SUN domain containing ossification factor 0.0486484
FAM13A family with sequence similarity 13, member A 0.048155
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0472708
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0465966
RAB1A RAB1A, member RAS oncogene family 0.0447129
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0442831
RLF rearranged L-myc fusion 0.0423725
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0419475
CALR calreticulin 0.0411311
ENO1 enolase 1, (alpha) 0.0398225
NUP58 nucleoporin 58 0.0395277
WAC WW domain containing adaptor with coiled-coil 0.0389122
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0386898
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0380202
HELZ helicase with zinc finger 0.0377694
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0373474
FNDC3B fibronectin type III domain containing 3B 0.0366909
INSIG2 insulin induced gene 2 0.0363616
QKI QKI, KH domain containing, RNA binding 0.0357495
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0356983
USP3 ubiquitin specific peptidase 3 0.0355443
ZNF292 zinc finger protein 292 0.0351728
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0347352
HILPDA hypoxia inducible lipid droplet-associated 0.034505
RHEB Ras homolog enriched in brain 0.0341463
PCBP2 poly(rC) binding protein 2 0.0339489
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0335672
UBA6 ubiquitin-like modifier activating enzyme 6 0.033107
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0330866
RAD21 RAD21 homolog (S. pombe) 0.0322428
RNF145 ring finger protein 145 0.031979
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0312922
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0310208
LCORL ligand dependent nuclear receptor corepressor-like 0.0306846
FXR1 fragile X mental retardation, autosomal homolog 1 0.0306771
USP12 ubiquitin specific peptidase 12 0.0302787
PDIA3 protein disulfide isomerase family A, member 3 0.0299288
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0295673
TOP2A topoisomerase (DNA) II alpha 170kDa 0.029006
ARL8B ADP-ribosylation factor-like 8B 0.0289729
WDR45B WD repeat domain 45B 0.0288543
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0286942
PGK1 phosphoglycerate kinase 1 0.0286586
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0280892
RAB7A RAB7A, member RAS oncogene family 0.0276191
SEC23A Sec23 homolog A (S. cerevisiae) 0.0276144
RICTOR RPTOR independent companion of MTOR, complex 2 0.0274685
TXNRD1 thioredoxin reductase 1 0.0273831
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0272771
BHLHE40 basic helix-loop-helix family, member e40 0.0270638
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0269505
YME1L1 YME1-like 1 ATPase 0.0266868
BIRC6 baculoviral IAP repeat containing 6 0.0264071
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0263496
ANKRD11 ankyrin repeat domain 11 0.0261894
TFG TRK-fused gene 0.0260073
SEC31A SEC31 homolog A (S. cerevisiae) 0.0258188
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0255318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0254765
RAB6A RAB6A, member RAS oncogene family 0.0254742
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0253872
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0253053
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0251561
ECT2 epithelial cell transforming 2 0.0251237
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0250515
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0249056
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0247148
CLINT1 clathrin interactor 1 0.0246526
YAP1 Yes-associated protein 1 0.0242195
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0237388
USP15 ubiquitin specific peptidase 15 0.0233107
RYBP RING1 and YY1 binding protein 0.0228593
TPD52 tumor protein D52 0.0228094
MARCHF6 membrane associated ring-CH-type finger 6 0.0225939
CUL3 cullin 3 0.022506
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0224355
PDS5A PDS5 cohesin associated factor A 0.0222857
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0219491
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0219186
TFRC transferrin receptor 0.021713
CALU calumenin 0.0216298
MXI1 MAX interactor 1, dimerization protein 0.0215521
PUM2 pumilio RNA-binding family member 2 0.0214937
DIAPH3 diaphanous-related formin 3 0.0214435
IL6 interleukin 6 0.0212437
CDC27 cell division cycle 27 0.0212303
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0211734
SDCBP syndecan binding protein (syntenin) 0.0211657
SSBP2 single-stranded DNA binding protein 2 0.0211497

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0917543
MT2A metallothionein 2A -0.0879367
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0830598
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.075543
HMGA2 high mobility group AT-hook 2 -0.0642991
FN1 fibronectin 1 -0.0617475
NRG1 neuregulin 1 -0.0609967
ASPH aspartate beta-hydroxylase -0.0577914
GLIS3 GLIS family zinc finger 3 -0.0528437
IFI16 interferon, gamma-inducible protein 16 -0.0460457
TMEM156 transmembrane protein 156 -0.0456982
FTL ferritin, light polypeptide -0.0451243
IFI27 interferon, alpha-inducible protein 27 -0.0444843
ITGA1 integrin, alpha 1 -0.0443289
NDRG1 N-myc downstream regulated 1 -0.0409414
RPS6 ribosomal protein S6 -0.0375354
SMYD3 SET and MYND domain containing 3 -0.0373545
AKAP12 A kinase (PRKA) anchor protein 12 -0.0369152
VCL vinculin -0.0364107
NRP1 neuropilin 1 -0.0349544
TMSB10 thymosin beta 10 -0.0346752
GCC2 GRIP and coiled-coil domain containing 2 -0.0345713
NRIP1 nuclear receptor interacting protein 1 -0.0342305
OSMR oncostatin M receptor -0.033855
PTMA prothymosin, alpha -0.0323878
DST dystonin -0.0319371
LOC102724023 ES1 protein homolog, mitochondrial -0.0313261
RPL9 ribosomal protein L9 -0.0310882
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0307377
TAS2R14 taste receptor, type 2, member 14 -0.0305844
CAB39 calcium binding protein 39 -0.0301357
AKAP9 A kinase (PRKA) anchor protein 9 -0.0298563
MCTP2 multiple C2 domains, transmembrane 2 -0.0291767
RPL37A ribosomal protein L37a -0.02901
SVIL supervillin -0.02812
ETV1 ets variant 1 -0.0279181
TFPI2 tissue factor pathway inhibitor 2 -0.0276135
BASP1 brain abundant, membrane attached signal protein 1 -0.0275546
EFNA5 ephrin-A5 -0.0274576
SQSTM1 sequestosome 1 -0.0268627
SHB Src homology 2 domain containing adaptor protein B -0.0266151
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.026522
SOX4 SRY (sex determining region Y)-box 4 -0.0264381
TMEM165 transmembrane protein 165 -0.0259898
NPC1 Niemann-Pick disease, type C1 -0.0252161
S100A6 S100 calcium binding protein A6 -0.0249727
LOXL2 lysyl oxidase-like 2 -0.0248439
RPL26 ribosomal protein L26 -0.0245943
ZBTB20 zinc finger and BTB domain containing 20 -0.0245065
SEPTIN9 septin 9 -0.0243111
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0242738
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0241176
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0239304
TXNIP thioredoxin interacting protein -0.0235024
RPL34 ribosomal protein L34 -0.023267
PLAUR plasminogen activator, urokinase receptor -0.0230961
TSC22D1 TSC22 domain family, member 1 -0.0230661
VEGFA vascular endothelial growth factor A -0.0230284
UBXN4 UBX domain protein 4 -0.0228536
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0223522
WWTR1 WW domain containing transcription regulator 1 -0.0220084
AHR aryl hydrocarbon receptor -0.0219872
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.021929
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.021807
RASAL2 RAS protein activator like 2 -0.0217169
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0213797
LTBP1 latent transforming growth factor beta binding protein 1 -0.0212524
TM4SF1 transmembrane 4 L six family member 1 -0.0203681
NTN4 netrin 4 -0.0201789
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0201672
RPLP1 ribosomal protein, large, P1 -0.0200641
GNAS GNAS complex locus -0.0200393
RPS21 ribosomal protein S21 -0.0199704
VIM vimentin -0.0197841
ETV6 ets variant 6 -0.0196651
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0193075
RAI14 retinoic acid induced 14 -0.0192153
HMGA1 high mobility group AT-hook 1 -0.018979
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0187913
PTPRD protein tyrosine phosphatase, receptor type, D -0.01865
CAPN2 calpain 2, (m/II) large subunit -0.0185007
DUSP5 dual specificity phosphatase 5 -0.0184587
RAD51B RAD51 paralog B -0.01844
HLA-B major histocompatibility complex, class I, B -0.0183857
DNAH14 dynein, axonemal, heavy chain 14 -0.0183582
ADAM8 ADAM metallopeptidase domain 8 -0.0183417
RPS19 ribosomal protein S19 -0.0180968
CHD9 chromodomain helicase DNA binding protein 9 -0.0177555
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0176465
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0176188
FHIT fragile histidine triad -0.0175806
EXT1 exostosin glycosyltransferase 1 -0.0171082
ARHGAP35 Rho GTPase activating protein 35 -0.0169749
GUK1 guanylate kinase 1 -0.0167444
SH3RF1 SH3 domain containing ring finger 1 -0.0167041
RNF213 ring finger protein 213 -0.0166141
AGO2 argonaute RISC catalytic component 2 -0.016566
HPS3 Hermansky-Pudlak syndrome 3 -0.0163646
SUMF1 sulfatase modifying factor 1 -0.0162904
HIPK2 homeodomain interacting protein kinase 2 -0.0162729