Hexylresorcinol_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.209662
MT2A metallothionein 2A 0.111112
FBN1 fibrillin 1 0.110689
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.092554
CD44 CD44 molecule (Indian blood group) 0.0741429
B2M beta-2-microglobulin 0.0568538
FNDC3B fibronectin type III domain containing 3B 0.0505537
STC1 stanniocalcin 1 0.0498706
COL1A2 collagen, type I, alpha 2 0.0490141
FTH1 ferritin, heavy polypeptide 1 0.0439493
DPYSL3 dihydropyrimidinase-like 3 0.0433902
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0399013
PSD3 pleckstrin and Sec7 domain containing 3 0.0385747
MYADM myeloid-associated differentiation marker 0.0376103
SBF2 SET binding factor 2 0.0372679
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0357589
MT1X metallothionein 1X 0.0337517
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330231
UBC ubiquitin C 0.0316858
SOD2 superoxide dismutase 2, mitochondrial 0.0295593
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0288976
GPC6 glypican 6 0.0270997
MB21D2 Mab-21 domain containing 2 0.0269655
TMSB10 thymosin beta 10 0.0261365
CLU clusterin 0.0252966
IFITM3 interferon induced transmembrane protein 3 0.0248141
OGA O-GlcNAcase 0.0243336
COL3A1 collagen, type III, alpha 1 0.0238643
LDHA lactate dehydrogenase A 0.0234921
RNF145 ring finger protein 145 0.0230134
SDC4 syndecan 4 0.0223584
ATP13A3 ATPase type 13A3 0.0223326
WWTR1 WW domain containing transcription regulator 1 0.0222445
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217653
OPTN optineurin 0.0214359
ZBTB20 zinc finger and BTB domain containing 20 0.0213323
KIFAP3 kinesin-associated protein 3 0.0211713
NAP1L1 nucleosome assembly protein 1-like 1 0.0209623
TXNIP thioredoxin interacting protein 0.0208628
RBM25 RNA binding motif protein 25 0.020739
PGK1 phosphoglycerate kinase 1 0.0204081
ARL15 ADP-ribosylation factor-like 15 0.0203367
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0201275
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0201143
CD99 CD99 molecule 0.0199342
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0195073
S100A10 S100 calcium binding protein A10 0.0192908
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0191815
TNIP1 TNFAIP3 interacting protein 1 0.0191206
GLS2 glutaminase 2 (liver, mitochondrial) 0.0190975
RSAD2 radical S-adenosyl methionine domain containing 2 0.0190899
TAGLN2 transgelin 2 0.0190296
RTN4 reticulon 4 0.0190006
IFI6 interferon, alpha-inducible protein 6 0.0186375
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0186169
ARRDC3 arrestin domain containing 3 0.0183899
LY6E lymphocyte antigen 6 complex, locus E 0.0181425
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.0174803
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0173945
NFE2L1 nuclear factor, erythroid 2-like 1 0.0173332
EGR1 early growth response 1 0.0171349
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0170726
TAPBP TAP binding protein (tapasin) 0.0169579
TOP2A topoisomerase (DNA) II alpha 170kDa 0.016782
C1D C1D nuclear receptor corepressor 0.0167731
SLC22A23 solute carrier family 22, member 23 0.0167718
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0166999
PRKD3 protein kinase D3 0.0166818
IQGAP1 IQ motif containing GTPase activating protein 1 0.0163751
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0162461
TMOD1 tropomodulin 1 0.0162141
PFN1 profilin 1 0.0161672
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0161109
SOX9 SRY (sex determining region Y)-box 9 0.0160949
TDRD7 tudor domain containing 7 0.0160391
ADAM19 ADAM metallopeptidase domain 19 0.0158977
SMIM44 small integral membrane protein 44 0.015847
WTAP Wilms tumor 1 associated protein 0.0157362
ARL4C ADP-ribosylation factor-like 4C 0.0157073
ZEB2 zinc finger E-box binding homeobox 2 0.0156615
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0155079
PML promyelocytic leukemia 0.0154931
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0154076
HLA-B major histocompatibility complex, class I, B 0.0153852
FRMD5 FERM domain containing 5 0.0153505
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0152912
PLAUR plasminogen activator, urokinase receptor 0.0152178
ADAM17 ADAM metallopeptidase domain 17 0.0152021
CD46 CD46 molecule, complement regulatory protein 0.0150922
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0149914
PLAT plasminogen activator, tissue 0.0149617
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0148782
ZNF292 zinc finger protein 292 0.0148072
RHOBTB3 Rho-related BTB domain containing 3 0.0147786
EIF1 eukaryotic translation initiation factor 1 0.0146978
LOX lysyl oxidase 0.0145434
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0145213
SNX9 sorting nexin 9 0.0145041
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0143753
TRIM56 tripartite motif containing 56 0.0143737

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.201733
IGFBP3 insulin-like growth factor binding protein 3 -0.166745
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.16218
COL5A1 collagen, type V, alpha 1 -0.152308
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.115843
TRIO trio Rho guanine nucleotide exchange factor -0.115391
SLC39A11 solute carrier family 39, member 11 -0.111027
ABI3BP ABI family, member 3 (NESH) binding protein -0.0965762
AHNAK AHNAK nucleoprotein -0.0956506
EGFR epidermal growth factor receptor -0.087083
PBX3 pre-B-cell leukemia homeobox 3 -0.0632653
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0618693
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0613278
MSI2 musashi RNA-binding protein 2 -0.0608264
FN1 fibronectin 1 -0.0589193
EFNA5 ephrin-A5 -0.0578382
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0542219
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0525324
CCND1 cyclin D1 -0.0522423
MACF1 microtubule-actin crosslinking factor 1 -0.0507124
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0495416
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0479377
CUX1 cut-like homeobox 1 -0.0471131
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0462092
DGKG diacylglycerol kinase, gamma 90kDa -0.045377
CANX calnexin -0.0436062
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0433586
FLT1 fms-related tyrosine kinase 1 -0.0422617
RIGI RNA sensor RIG-I -0.0406647
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0403239
PTMA prothymosin, alpha -0.0401314
ANKRD11 ankyrin repeat domain 11 -0.0399484
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0397117
NAV1 neuron navigator 1 -0.0384472
FSTL1 follistatin-like 1 -0.038039
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0374369
PODXL podocalyxin-like -0.0368703
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0365118
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0363554
INTS6 integrator complex subunit 6 -0.0358252
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0356705
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0350832
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0350819
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0343083
SORBS2 sorbin and SH3 domain containing 2 -0.0336716
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0332982
TENM3 teneurin transmembrane protein 3 -0.0332943
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0330289
PLXNA2 plexin A2 -0.0324245
ASPH aspartate beta-hydroxylase -0.0324147
AUTS2 autism susceptibility candidate 2 -0.032064
TPM4 tropomyosin 4 -0.0312096
CYTH3 cytohesin 3 -0.0301971
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0298816
CAVIN1 caveolae associated protein 1 -0.0297797
TNS3 tensin 3 -0.0296009
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0284816
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0283931
MCL1 myeloid cell leukemia 1 -0.0283756
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0279288
CALR calreticulin -0.0273479
KDM4B lysine (K)-specific demethylase 4B -0.0272355
IL7R interleukin 7 receptor -0.0271315
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269456
LMNA lamin A/C -0.0265169
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0265045
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0262609
IARS1 isoleucyl-tRNA synthetase 1 -0.0262336
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0260989
SDCCAG8 serologically defined colon cancer antigen 8 -0.0259834
FMN2 formin 2 -0.0252783
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0250235
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0247349
RPL35A ribosomal protein L35a -0.0245738
PDE10A phosphodiesterase 10A -0.0245541
ACTG1 actin gamma 1 -0.0245248
ALCAM activated leukocyte cell adhesion molecule -0.0244445
DCLK2 doublecortin-like kinase 2 -0.0243472
PDE4D phosphodiesterase 4D, cAMP-specific -0.0242782
ANKRD30B ankyrin repeat domain 30B -0.0239374
EXT1 exostosin glycosyltransferase 1 -0.0228128
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0227324
ADAM32 ADAM metallopeptidase domain 32 -0.0225931
DENND1A DENN/MADD domain containing 1A -0.0223946
FRMD4A FERM domain containing 4A -0.0223551
MRPS6 mitochondrial ribosomal protein S6 -0.0222344
PCDH7 protocadherin 7 -0.021838
AHNAK2 AHNAK nucleoprotein 2 -0.0218108
KIAA1549L KIAA1549-like -0.0217852
MED13L mediator complex subunit 13-like -0.0217699
TOX thymocyte selection-associated high mobility group box -0.0217094
KRT81 keratin 81, type II -0.0216703
RPTOR regulatory associated protein of MTOR, complex 1 -0.0212692
MTCL1 microtubule crosslinking factor 1 -0.0211638
SRPK2 SRSF protein kinase 2 -0.021021
AEBP2 AE binding protein 2 -0.0209547
SASH1 SAM and SH3 domain containing 1 -0.0208115
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.0205715
TTC3 tetratricopeptide repeat domain 3 -0.0205015
SLC38A1 solute carrier family 38, member 1 -0.0204983