Hexylresorcinol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.198142
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.15216
AKAP12 A kinase (PRKA) anchor protein 12 0.0998728
VIM vimentin 0.0735209
RPL23 ribosomal protein L23 0.0666747
ACTG1 actin gamma 1 0.0602117
PLAT plasminogen activator, tissue 0.0531598
EIF1 eukaryotic translation initiation factor 1 0.0501235
SEPTIN9 septin 9 0.0477349
TMSB10 thymosin beta 10 0.0477187
RPL37A ribosomal protein L37a 0.044853
PTMA prothymosin, alpha 0.0436184
TRIO trio Rho guanine nucleotide exchange factor 0.0406669
ANTXR1 anthrax toxin receptor 1 0.0401383
TLE4 transducin-like enhancer of split 4 0.0358424
RPLP1 ribosomal protein, large, P1 0.0344921
VCL vinculin 0.0333465
NCOR2 nuclear receptor corepressor 2 0.0328347
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0319441
MYH9 myosin, heavy chain 9, non-muscle 0.0317672
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0316803
RPL19 ribosomal protein L19 0.0293525
RNF213 ring finger protein 213 0.0288864
EGR1 early growth response 1 0.0286432
RPL38 ribosomal protein L38 0.0284718
BPTF bromodomain PHD finger transcription factor 0.02841
TIMP3 TIMP metallopeptidase inhibitor 3 0.0282719
BICD1 bicaudal D homolog 1 (Drosophila) 0.0280744
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0274807
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270195
RPS23 ribosomal protein S23 0.0267902
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0260995
NBR1 neighbor of BRCA1 gene 1 0.0258185
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0255116
GOLGA4 golgin A4 0.025349
TBX2 T-box 2 0.0253172
RPS29 ribosomal protein S29 0.0252316
FRMD5 FERM domain containing 5 0.0246631
LPIN1 lipin 1 0.0246248
VMP1 vacuole membrane protein 1 0.0244375
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0243578
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0241807
THSD4 thrombospondin, type I, domain containing 4 0.0234661
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0233708
PDE8A phosphodiesterase 8A 0.0226573
GPC5 glypican 5 0.0226063
BCAS3 breast carcinoma amplified sequence 3 0.0224465
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0219946
ATXN10 ataxin 10 0.0219303
TNRC6B trinucleotide repeat containing 6B 0.0219103
PTPRD protein tyrosine phosphatase, receptor type, D 0.0218063
RBM20 RNA binding motif protein 20 0.0217477
CHD9 chromodomain helicase DNA binding protein 9 0.0217125
FTL ferritin, light polypeptide 0.0214598
RPL5 ribosomal protein L5 0.021387
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0212516
DPH6 diphthamine biosynthesis 6 0.0211975
RIGI RNA sensor RIG-I 0.0211911
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0211894
RPS12 ribosomal protein S12 0.0209443
H3-3B H3.3 histone B 0.0209331
PTPRM protein tyrosine phosphatase, receptor type, M 0.0208187
RPS19 ribosomal protein S19 0.0207982
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0206939
RPL12 ribosomal protein L12 0.0203907
PRPF3 pre-mRNA processing factor 3 0.0203476
MACF1 microtubule-actin crosslinking factor 1 0.0202516
HDAC5 histone deacetylase 5 0.0202373
DNM3 dynamin 3 0.0202128
SMAD3 SMAD family member 3 0.0200626
RPL36 ribosomal protein L36 0.0200288
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0198369
PSD3 pleckstrin and Sec7 domain containing 3 0.0196789
PRKCA protein kinase C, alpha 0.0196438
RPS6 ribosomal protein S6 0.0193804
RPTOR regulatory associated protein of MTOR, complex 1 0.0193587
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0193267
TPI1 triosephosphate isomerase 1 0.019215
RPS27 ribosomal protein S27 0.0191938
KLF6 Kruppel-like factor 6 0.0190987
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0190847
CDK12 cyclin-dependent kinase 12 0.019022
PTPRK protein tyrosine phosphatase, receptor type, K 0.0189008
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0188418
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0186561
SOX4 SRY (sex determining region Y)-box 4 0.0185815
GLG1 golgi glycoprotein 1 0.0185773
S100A6 S100 calcium binding protein A6 0.0184757
S100A9 S100 calcium binding protein A9 0.0183805
RPL34 ribosomal protein L34 0.0183374
COL6A1 collagen, type VI, alpha 1 0.0181828
USP36 ubiquitin specific peptidase 36 0.0181034
RPL26 ribosomal protein L26 0.0179579
IGFBP5 insulin-like growth factor binding protein 5 0.0178818
UNC5B unc-5 homolog B (C. elegans) 0.0178173
NACA nascent polypeptide-associated complex alpha subunit 0.0178152
SSH1 slingshot protein phosphatase 1 0.0176702
TENT5A terminal nucleotidyltransferase 5A 0.0176169
TRIM56 tripartite motif containing 56 0.0175904
MDK midkine (neurite growth-promoting factor 2) 0.0175442

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.162818
LSAMP limbic system-associated membrane protein -0.0687613
FAM13A family with sequence similarity 13, member A -0.0650259
NAMPT nicotinamide phosphoribosyltransferase -0.0583657
SYT1 synaptotagmin I -0.0565288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.048693
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.046905
DTNA dystrobrevin, alpha -0.0442282
PCDH9 protocadherin 9 -0.043915
COL3A1 collagen, type III, alpha 1 -0.0408527
NALF1 NALCN channel auxiliary factor 1 -0.0374027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.037249
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0365724
GPBP1 GC-rich promoter binding protein 1 -0.0360495
KMT2C lysine (K)-specific methyltransferase 2C -0.0346131
HELZ helicase with zinc finger -0.0339711
NREP neuronal regeneration related protein -0.0337686
SOS1 son of sevenless homolog 1 (Drosophila) -0.0335968
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0333834
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0324826
CADM2 cell adhesion molecule 2 -0.0320233
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0319755
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0316193
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0314255
DST dystonin -0.0311392
ZNF804A zinc finger protein 804A -0.0310915
NUP58 nucleoporin 58 -0.0291492
ADGRG6 adhesion G protein-coupled receptor G6 -0.0278374
SETD5 SET domain containing 5 -0.0276581
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0266767
TRIB2 tribbles pseudokinase 2 -0.02662
PTK2 protein tyrosine kinase 2 -0.0265099
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0261203
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0259113
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0256004
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0253863
PDE4D phosphodiesterase 4D, cAMP-specific -0.025219
SCAF11 SR-related CTD-associated factor 11 -0.025143
NCAM2 neural cell adhesion molecule 2 -0.0248791
PDIA3 protein disulfide isomerase family A, member 3 -0.024762
NGLY1 N-glycanase 1 -0.0247458
CENPF centromere protein F, 350/400kDa -0.0247038
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243871
FNDC3B fibronectin type III domain containing 3B -0.0241559
CD36 CD36 molecule (thrombospondin receptor) -0.0241515
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0239327
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0237908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0233928
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0232929
KDM3A lysine (K)-specific demethylase 3A -0.0232552
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0230769
SPAG16 sperm associated antigen 16 -0.0229211
QKI QKI, KH domain containing, RNA binding -0.0224763
RAD21 RAD21 homolog (S. pombe) -0.0223744
FAM162A family with sequence similarity 162, member A -0.0222919
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0218322
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0216868
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0212031
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0208584
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0207405
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0207216
BIRC2 baculoviral IAP repeat containing 2 -0.0204924
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0203596
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0202858
MMP12 matrix metallopeptidase 12 -0.0202263
HAND2 heart and neural crest derivatives expressed 2 -0.0201213
ZNF148 zinc finger protein 148 -0.0200606
SUCO SUN domain containing ossification factor -0.0198867
RBM39 RNA binding motif protein 39 -0.0196324
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0195861
NRG1 neuregulin 1 -0.019258
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0192302
DLC1 DLC1 Rho GTPase activating protein -0.0190449
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0189302
RFX7 regulatory factor X, 7 -0.0189282
RAP1B RAP1B, member of RAS oncogene family -0.0187848
SEC23A Sec23 homolog A (S. cerevisiae) -0.0187487
BIRC6 baculoviral IAP repeat containing 6 -0.0187364
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0187283
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.018709
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.018638
ZMYM2 zinc finger, MYM-type 2 -0.0186072
LUM lumican -0.0185447
IPO7 importin 7 -0.0185042
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.01849
SPAG9 sperm associated antigen 9 -0.0184506
UGCG UDP-glucose ceramide glucosyltransferase -0.0184414
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0183751
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -0.0183664
RNF145 ring finger protein 145 -0.018315
HOOK2 hook microtubule-tethering protein 2 -0.0180496
NF1 neurofibromin 1 -0.0180388
C1ORF21 chromosome 1 open reading frame 21 -0.017976
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0175589
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0170804
AOPEP aminopeptidase O (putative) -0.0167387
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0167085
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0166272
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0165471
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0164979