Hexylresorcinol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 0.142895
TPT1 tumor protein, translationally-controlled 1 0.110653
B2M beta-2-microglobulin 0.0817742
C6ORF132 chromosome 6 open reading frame 132 0.0796681
IFI6 interferon, alpha-inducible protein 6 0.0789274
HLA-B major histocompatibility complex, class I, B 0.0744067
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0714617
EPSTI1 epithelial stromal interaction 1 (breast) 0.0672608
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0618797
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0557154
H1-0 H1.0 linker histone 0.0550072
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0530433
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0529616
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0519371
MX2 MX dynamin-like GTPase 2 0.0498903
MT2A metallothionein 2A 0.0496943
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0484349
IFNGR1 interferon gamma receptor 1 0.0483214
XAF1 XIAP associated factor 1 0.0475223
NCKAP5 NCK-associated protein 5 0.0456646
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.045448
TXNIP thioredoxin interacting protein 0.0448072
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0441447
ETV6 ets variant 6 0.0426304
LIMA1 LIM domain and actin binding 1 0.0420369
RNF43 ring finger protein 43 0.0417717
KLF5 Kruppel-like factor 5 (intestinal) 0.041703
MYO1E myosin IE 0.0404713
STK24 serine/threonine kinase 24 0.0400192
MEIS2 Meis homeobox 2 0.0397254
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0392269
KLF6 Kruppel-like factor 6 0.0389508
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0379271
NRIP1 nuclear receptor interacting protein 1 0.0371014
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0351077
PTBP3 polypyrimidine tract binding protein 3 0.0346502
WSB1 WD repeat and SOCS box containing 1 0.0340646
TMEM62 transmembrane protein 62 0.034009
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0338132
ACTN4 actinin, alpha 4 0.0337454
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0333357
APOL1 apolipoprotein L, 1 0.0332445
FOXP1 forkhead box P1 0.0331508
ZMYND8 zinc finger, MYND-type containing 8 0.0329257
RNF213 ring finger protein 213 0.0328738
PLAUR plasminogen activator, urokinase receptor 0.032562
USP54 ubiquitin specific peptidase 54 0.0318059
TC2N tandem C2 domains, nuclear 0.0317068
TMSB10 thymosin beta 10 0.0313847
RPL7L1 ribosomal protein L7-like 1 0.0311651
EFNB2 ephrin-B2 0.0311611
ATP10B ATPase, class V, type 10B 0.0311108
MUC13 mucin 13, cell surface associated 0.030967
RIGI RNA sensor RIG-I 0.030778
CTNND1 catenin (cadherin-associated protein), delta 1 0.0307101
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0306742
RPL11 ribosomal protein L11 0.0305228
SP100 SP100 nuclear antigen 0.0298045
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0296619
RRBP1 ribosome binding protein 1 0.0296105
TRERF1 transcriptional regulating factor 1 0.0289188
PTPRF protein tyrosine phosphatase, receptor type, F 0.0284077
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0283481
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0276894
IFIH1 interferon induced with helicase C domain 1 0.0274957
ASPH aspartate beta-hydroxylase 0.0273989
MT1X metallothionein 1X 0.0271613
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0271529
VCL vinculin 0.0269617
PGK1 phosphoglycerate kinase 1 0.0268136
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0267047
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.026629
GCC2 GRIP and coiled-coil domain containing 2 0.0264574
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0261724
RABGAP1L RAB GTPase activating protein 1-like 0.0260116
RPS24 ribosomal protein S24 0.0259177
SHB Src homology 2 domain containing adaptor protein B 0.025803
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0254639
RPS19 ribosomal protein S19 0.0253678
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0252797
NT5C2 5'-nucleotidase, cytosolic II 0.0246225
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0242433
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0240557
ZNFX1 zinc finger, NFX1-type containing 1 0.0236983
EPCAM epithelial cell adhesion molecule 0.0232553
RSAD2 radical S-adenosyl methionine domain containing 2 0.0232177
RPL12 ribosomal protein L12 0.0230428
PTGR1 prostaglandin reductase 1 0.0229496
LPP LIM domain containing preferred translocation partner in lipoma 0.0228554
TRIM56 tripartite motif containing 56 0.0227852
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0226336
S100A10 S100 calcium binding protein A10 0.0224511
TM4SF1 transmembrane 4 L six family member 1 0.0223606
MAP2K6 mitogen-activated protein kinase kinase 6 0.0223234
MX1 MX dynamin-like GTPase 1 0.0222127
RPL18 ribosomal protein L18 0.0219807
H3-3B H3.3 histone B 0.0217608
RUNX1 runt-related transcription factor 1 0.0217549
NCOA7 nuclear receptor coactivator 7 0.0216825
MECOM MDS1 and EVI1 complex locus 0.02161

decreased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 -0.0885308
INTS6 integrator complex subunit 6 -0.0866868
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0761481
LYZ lysozyme -0.0696043
PDIA3 protein disulfide isomerase family A, member 3 -0.0627505
RAB7A RAB7A, member RAS oncogene family -0.0608538
FTH1 ferritin, heavy polypeptide 1 -0.0541441
FNDC3B fibronectin type III domain containing 3B -0.0538193
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0520262
IGFBP3 insulin-like growth factor binding protein 3 -0.0476918
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0470213
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0423707
MORF4L2 mortality factor 4 like 2 -0.0411482
FNIP1 folliculin interacting protein 1 -0.0389933
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0387203
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0386526
GOLGB1 golgin B1 -0.0385535
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0371888
ARF4 ADP-ribosylation factor 4 -0.0356661
COG6 component of oligomeric golgi complex 6 -0.0356269
SEC31A SEC31 homolog A (S. cerevisiae) -0.0348907
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0344681
ANXA2 annexin A2 -0.0337104
GMDS GDP-mannose 4,6-dehydratase -0.0330352
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0314734
COPA coatomer protein complex, subunit alpha -0.0313426
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0310572
BCLAF1 BCL2-associated transcription factor 1 -0.0310088
UBC ubiquitin C -0.0301087
SPDYA speedy/RINGO cell cycle regulator family member A -0.0295323
TSC22D2 TSC22 domain family, member 2 -0.0294721
MAGT1 magnesium transporter 1 -0.0292261
NPSR1 neuropeptide S receptor 1 -0.0291942
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0291119
CCNL1 cyclin L1 -0.0291069
N4BP2L2 NEDD4 binding protein 2-like 2 -0.029084
SEC24A SEC24 family member A -0.0290357
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.028926
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0287562
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0286419
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0286329
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0282684
EZR ezrin -0.0281401
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0278522
SRP54 signal recognition particle 54kDa -0.0278029
SREBF2 sterol regulatory element binding transcription factor 2 -0.0271494
VEGFA vascular endothelial growth factor A -0.0267131
IRF1 interferon regulatory factor 1 -0.0265488
HM13 histocompatibility (minor) 13 -0.0262032
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0260758
PKM pyruvate kinase, muscle -0.0259298
NDRG1 N-myc downstream regulated 1 -0.0258203
DDIT3 DNA-damage-inducible transcript 3 -0.0254077
GOLGA4 golgin A4 -0.025344
MCL1 myeloid cell leukemia 1 -0.0247267
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0244176
UFM1 ubiquitin-fold modifier 1 -0.0241518
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240599
PLSCR2 phospholipid scramblase 2 -0.0237543
SCFD1 sec1 family domain containing 1 -0.0236974
LMO7 LIM domain 7 -0.0234918
EGR1 early growth response 1 -0.0231284
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0228488
RAB1A RAB1A, member RAS oncogene family -0.0228083
NUP58 nucleoporin 58 -0.0226835
CLTC clathrin, heavy chain (Hc) -0.0224128
GOSR2 golgi SNAP receptor complex member 2 -0.0223283
MLEC malectin -0.0223125
PADI1 peptidyl arginine deiminase, type I -0.0223074
TTC3 tetratricopeptide repeat domain 3 -0.0221956
VMP1 vacuole membrane protein 1 -0.0219177
SPAG9 sperm associated antigen 9 -0.0217762
UBAP2 ubiquitin associated protein 2 -0.0210438
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0210297
BIRC6 baculoviral IAP repeat containing 6 -0.0209874
RAB10 RAB10, member RAS oncogene family -0.020432
PARD3 par-3 family cell polarity regulator -0.0202004
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0201925
ACBD3 acyl-CoA binding domain containing 3 -0.0196029
SSH2 slingshot protein phosphatase 2 -0.0195522
CANX calnexin -0.0193223
SCARB1 scavenger receptor class B, member 1 -0.0192199
BRD2 bromodomain containing 2 -0.0189817
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0189684
SEC16A SEC16 homolog A (S. cerevisiae) -0.0189499
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0189232
PGM3 phosphoglucomutase 3 -0.0188953
FDPS farnesyl diphosphate synthase -0.0188478
PDLIM5 PDZ and LIM domain 5 -0.0188031
RAB6A RAB6A, member RAS oncogene family -0.0187802
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0187213
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0184609
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0183882
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0183478
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0181661
UGDH UDP-glucose 6-dehydrogenase -0.0181183
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0181016
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0180961
SLC38A2 solute carrier family 38, member 2 -0.0180739
NABP1 nucleic acid binding protein 1 -0.0180477