Hexylresorcinol_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.207694
MT2A metallothionein 2A 0.175283
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.147732
VIM vimentin 0.123825
AHNAK AHNAK nucleoprotein 0.119721
COL1A1 collagen, type I, alpha 1 0.114424
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.113615
CDH13 cadherin 13 0.109383
FTL ferritin, light polypeptide 0.0844824
IGFBP3 insulin-like growth factor binding protein 3 0.0822136
CADM1 cell adhesion molecule 1 0.0804551
RPL35A ribosomal protein L35a 0.0751828
NDRG1 N-myc downstream regulated 1 0.0732378
JARID2 jumonji, AT rich interactive domain 2 0.0685834
RPS8 ribosomal protein S8 0.0664563
RPS19 ribosomal protein S19 0.0628517
IER3 immediate early response 3 0.0626904
RPLP1 ribosomal protein, large, P1 0.0593307
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.059328
MT1X metallothionein 1X 0.0567057
ACTG1 actin gamma 1 0.0559399
LGALS1 lectin, galactoside-binding, soluble, 1 0.0544387
COL7A1 collagen, type VII, alpha 1 0.053859
HLA-B major histocompatibility complex, class I, B 0.0535281
RPL23 ribosomal protein L23 0.0493415
MARCKS myristoylated alanine-rich protein kinase C substrate 0.048931
RPL19 ribosomal protein L19 0.0481975
RPL36 ribosomal protein L36 0.0469103
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0460559
H1-0 H1.0 linker histone 0.0456503
EXT1 exostosin glycosyltransferase 1 0.0453775
RPS21 ribosomal protein S21 0.0439669
RPL28 ribosomal protein L28 0.043872
COL6A2 collagen, type VI, alpha 2 0.0428428
RPL5 ribosomal protein L5 0.0426052
LOX lysyl oxidase 0.0424113
RRBP1 ribosome binding protein 1 0.0422414
VCL vinculin 0.0421691
S100A9 S100 calcium binding protein A9 0.0421588
ANKRD11 ankyrin repeat domain 11 0.0393688
TUBB tubulin, beta class I 0.0390452
RPL8 ribosomal protein L8 0.0380065
RPLP2 ribosomal protein, large, P2 0.037638
GARS1 glycyl-tRNA synthetase 1 0.0375077
EGR1 early growth response 1 0.0372209
RPL11 ribosomal protein L11 0.0367683
RPS6 ribosomal protein S6 0.0357682
EIF4A1 eukaryotic translation initiation factor 4A1 0.0354084
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0352538
SQSTM1 sequestosome 1 0.0349288
TIMP1 TIMP metallopeptidase inhibitor 1 0.0347076
SLC38A2 solute carrier family 38, member 2 0.0342057
CAVIN1 caveolae associated protein 1 0.0337646
ATXN1 ataxin 1 0.0330833
RPS20 ribosomal protein S20 0.0330703
LOC112694756 uncharaterized LOC112694756 0.0328598
PLEC plectin 0.0322889
HDLBP high density lipoprotein binding protein 0.0322847
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0321846
COL6A1 collagen, type VI, alpha 1 0.0320963
RPL12 ribosomal protein L12 0.032017
RPL26 ribosomal protein L26 0.0316148
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0315059
HDAC9 histone deacetylase 9 0.0314909
RPLP0 ribosomal protein, large, P0 0.0305148
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0304363
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0301544
RPL34 ribosomal protein L34 0.0300473
RPS11 ribosomal protein S11 0.0299195
GNAS GNAS complex locus 0.0285202
RPS14 ribosomal protein S14 0.0283532
RPS23 ribosomal protein S23 0.0277447
RPL31 ribosomal protein L31 0.0274954
RPL35 ribosomal protein L35 0.0274545
SP100 SP100 nuclear antigen 0.0273503
RPS16 ribosomal protein S16 0.0273138
NALF1 NALCN channel auxiliary factor 1 0.0268425
RPL18 ribosomal protein L18 0.0265852
COL6A3 collagen, type VI, alpha 3 0.0264614
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0259825
ASPH aspartate beta-hydroxylase 0.0253998
TPT1 tumor protein, translationally-controlled 1 0.0246341
RPS24 ribosomal protein S24 0.0244976
TPI1 triosephosphate isomerase 1 0.0243625
LMNA lamin A/C 0.0241863
VDAC1 voltage-dependent anion channel 1 0.0237921
LPP LIM domain containing preferred translocation partner in lipoma 0.0237346
ISG15 ISG15 ubiquitin-like modifier 0.0236409
RPS15 ribosomal protein S15 0.0236275
TOP1 topoisomerase (DNA) I 0.023392
PFN1 profilin 1 0.0232879
RPL30 ribosomal protein L30 0.0231834
HLA-A major histocompatibility complex, class I, A 0.0231766
RPS3 ribosomal protein S3 0.023148
RPS4X ribosomal protein S4, X-linked 0.0230825
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0228686
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0223966
CTNND1 catenin (cadherin-associated protein), delta 1 0.022157
RACK1 receptor for activated C kinase 1 0.0221502
NPAS2 neuronal PAS domain protein 2 0.0219744

decreased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 -0.123009
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110395
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0844745
CD44 CD44 molecule (Indian blood group) -0.0798115
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0751964
VEGFA vascular endothelial growth factor A -0.0738169
FN1 fibronectin 1 -0.0703588
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0698241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0669961
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0593672
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0577006
RPS2 ribosomal protein S2 -0.0575664
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0554873
NAMPT nicotinamide phosphoribosyltransferase -0.0518383
ARRDC3 arrestin domain containing 3 -0.0511886
TGFBI transforming growth factor, beta-induced, 68kDa -0.049936
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0465975
VCAN versican -0.0458103
IGFBP7 insulin-like growth factor binding protein 7 -0.0453331
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0443662
POSTN periostin, osteoblast specific factor -0.0433545
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0430555
ELL2 elongation factor, RNA polymerase II, 2 -0.0426028
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0421617
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0414534
ATP13A3 ATPase type 13A3 -0.0403227
ANTXR2 anthrax toxin receptor 2 -0.0398353
INHBA inhibin, beta A -0.0396457
TPM4 tropomyosin 4 -0.0389756
PTK2 protein tyrosine kinase 2 -0.0387617
LOXL2 lysyl oxidase-like 2 -0.0373558
SQLE squalene epoxidase -0.0373306
SMAD3 SMAD family member 3 -0.0372944
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0367413
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0364687
F3 coagulation factor III (thromboplastin, tissue factor) -0.0359175
PDIA3 protein disulfide isomerase family A, member 3 -0.035897
KMT2E lysine (K)-specific methyltransferase 2E -0.0348641
DPYSL3 dihydropyrimidinase-like 3 -0.0335704
ESYT2 extended synaptotagmin-like protein 2 -0.0329703
PDIA6 protein disulfide isomerase family A, member 6 -0.0329333
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0323751
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0322413
IL6 interleukin 6 -0.0320407
POTEF POTE ankyrin domain family, member F -0.0307129
LDHA lactate dehydrogenase A -0.0301835
DSTN destrin (actin depolymerizing factor) -0.0301399
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.029907
MYH9 myosin, heavy chain 9, non-muscle -0.0290043
ABLIM3 actin binding LIM protein family, member 3 -0.0276516
CANX calnexin -0.0274513
KDM7A lysine (K)-specific demethylase 7A -0.0270787
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0269761
TMF1 TATA element modulatory factor 1 -0.0268765
GOLGA4 golgin A4 -0.0266253
TRIO trio Rho guanine nucleotide exchange factor -0.0256682
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0256433
BZW1 basic leucine zipper and W2 domains 1 -0.0253889
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0253148
RTN4 reticulon 4 -0.0249833
DST dystonin -0.0244634
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0243544
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0241239
FCHSD2 FCH and double SH3 domains 2 -0.0241021
APP amyloid beta (A4) precursor protein -0.0239854
MX2 MX dynamin-like GTPase 2 -0.0239292
TNIP1 TNFAIP3 interacting protein 1 -0.0236059
LAMB1 laminin, beta 1 -0.023435
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0229236
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0228593
DOCK5 dedicator of cytokinesis 5 -0.0225658
WWTR1 WW domain containing transcription regulator 1 -0.0225102
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.022356
MSN moesin -0.0215085
ARHGAP29 Rho GTPase activating protein 29 -0.0214296
IFNGR1 interferon gamma receptor 1 -0.0213698
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0211045
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0206175
MAP4 microtubule-associated protein 4 -0.0205663
RLF rearranged L-myc fusion -0.0205371
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0205109
IL6ST interleukin 6 signal transducer -0.0203196
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0203119
RASA2 RAS p21 protein activator 2 -0.0202231
YEATS2 YEATS domain containing 2 -0.0201029
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0200971
PDE10A phosphodiesterase 10A -0.0199907
NKTR natural killer cell triggering receptor -0.0196065
RB1CC1 RB1-inducible coiled-coil 1 -0.0195322
MLF1 myeloid leukemia factor 1 -0.0194894
ARF4 ADP-ribosylation factor 4 -0.0192798
TTC3 tetratricopeptide repeat domain 3 -0.0192524
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0192272
FAM219A family with sequence similarity 219, member A -0.0189925
SOCS5 suppressor of cytokine signaling 5 -0.0189787
RPL3 ribosomal protein L3 -0.0189512
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0187751
ANXA5 annexin A5 -0.0187012
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0185954
PCBP2 poly(rC) binding protein 2 -0.01842