Hexylresorcinol_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.4334
AKAP12 A kinase (PRKA) anchor protein 12 0.12171
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0578148
MT2A metallothionein 2A 0.050102
TIMP1 TIMP metallopeptidase inhibitor 1 0.048526
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0453487
SVIL supervillin 0.0451942
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0430554
NDRG1 N-myc downstream regulated 1 0.0377205
TNS1 tensin 1 0.0354599
RPS12 ribosomal protein S12 0.0324594
RPL37A ribosomal protein L37a 0.0323523
ENO1 enolase 1, (alpha) 0.0295798
FERMT1 fermitin family member 1 0.0235233
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0220997
IGFBP1 insulin-like growth factor binding protein 1 0.021044
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0209515
TGFBI transforming growth factor, beta-induced, 68kDa 0.0209384
RUNX1 runt-related transcription factor 1 0.0205262
RNASET2 ribonuclease T2 0.0201118
ENKUR enkurin, TRPC channel interacting protein 0.019357
ZMYND8 zinc finger, MYND-type containing 8 0.0188683
PDGFB platelet-derived growth factor beta polypeptide 0.0185492
TMSB10 thymosin beta 10 0.0178614
LOC112694756 uncharaterized LOC112694756 0.0168652
RPLP1 ribosomal protein, large, P1 0.0166795
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0160808
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0159651
EGR1 early growth response 1 0.0156134
RPL31 ribosomal protein L31 0.0156104
RPS3 ribosomal protein S3 0.0156028
RPS29 ribosomal protein S29 0.014759
ARFGEF3 ARFGEF family member 3 0.0145848
H1-0 H1.0 linker histone 0.0141458
RPS24 ribosomal protein S24 0.0134676
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0130157
RAI14 retinoic acid induced 14 0.012929
ZFP36L2 ZFP36 ring finger protein-like 2 0.0126957
RPS25 ribosomal protein S25 0.0126429
GRB10 growth factor receptor-bound protein 10 0.012246
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0121344
FLNB filamin B, beta 0.0120706
MCL1 myeloid cell leukemia 1 0.0119473
RPL37 ribosomal protein L37 0.0116199
FTH1 ferritin, heavy polypeptide 1 0.0115897
DUSP6 dual specificity phosphatase 6 0.0114183
PGK1 phosphoglycerate kinase 1 0.0113406
IFI6 interferon, alpha-inducible protein 6 0.0112775
RPS20 ribosomal protein S20 0.0112471
FAM13A family with sequence similarity 13, member A 0.0112336
RACK1 receptor for activated C kinase 1 0.0110286
BHLHE40 basic helix-loop-helix family, member e40 0.0107576
DOCK5 dedicator of cytokinesis 5 0.010404
RPL26 ribosomal protein L26 0.0101649
CRLS1 cardiolipin synthase 1 0.0101264
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00999726
POTEF POTE ankyrin domain family, member F 0.00967568
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00946351
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.00929745
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00926873
DDIT4 DNA-damage-inducible transcript 4 0.00925271
RAB3B RAB3B, member RAS oncogene family 0.00919835
S100A10 S100 calcium binding protein A10 0.0091249
RCAN3 RCAN family member 3 0.00908711
RELL1 RELT-like 1 0.00907999
EIF1 eukaryotic translation initiation factor 1 0.00899772
BMERB1 bMERB domain containing 1 0.00887407
RPL36A ribosomal protein L36a 0.00887349
IGFBP3 insulin-like growth factor binding protein 3 0.00885102
ARHGAP21 Rho GTPase activating protein 21 0.00870586
CLTB clathrin, light chain B 0.00868138
RTN4 reticulon 4 0.00865232
RPS2 ribosomal protein S2 0.008504
KPNA7 karyopherin alpha 7 (importin alpha 8) 0.00848213
RHOB ras homolog family member B 0.00841987
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00841186
DSPP dentin sialophosphoprotein 0.00816384
RPL9 ribosomal protein L9 0.00814032
IFITM1 interferon induced transmembrane protein 1 0.00812467
PTPRF protein tyrosine phosphatase, receptor type, F 0.00806827
ESYT2 extended synaptotagmin-like protein 2 0.00806654
RPS17 ribosomal protein S17 0.00802723
BCAR3 breast cancer anti-estrogen resistance 3 0.00793739
OPTN optineurin 0.00784506
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00783019
SLF2 SMC5-SMC6 complex localization factor 2 0.00782295
CNOT8 CCR4-NOT transcription complex, subunit 8 0.00776088
ANGPTL2 angiopoietin-like 2 0.00774331
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00773954
RPS19 ribosomal protein S19 0.00772591
RPL23 ribosomal protein L23 0.00771939
DNAH5 dynein, axonemal, heavy chain 5 0.00766167
RPS27 ribosomal protein S27 0.00766118
UBC ubiquitin C 0.00762361
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.00757589
RPL7A ribosomal protein L7a 0.00752713
CDHR2 cadherin-related family member 2 0.00751814
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.00740542
MYADM myeloid-associated differentiation marker 0.00739154
RPL36 ribosomal protein L36 0.00737484

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.116514
PDLIM5 PDZ and LIM domain 5 -0.064545
FNDC3B fibronectin type III domain containing 3B -0.0605749
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0555169
FBF1 Fas (TNFRSF6) binding factor 1 -0.0520393
LRMDA leucine rich melanocyte differentiation associated -0.0488287
PTPRM protein tyrosine phosphatase, receptor type, M -0.0457187
GMDS GDP-mannose 4,6-dehydratase -0.0438765
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0419349
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0402801
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0393068
A2M alpha-2-macroglobulin -0.0388458
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0382551
ZFAND3 zinc finger, AN1-type domain 3 -0.0377194
RBM39 RNA binding motif protein 39 -0.0370347
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0362249
TRIM26 tripartite motif containing 26 -0.0348981
EML4 echinoderm microtubule associated protein like 4 -0.0340518
PTPRK protein tyrosine phosphatase, receptor type, K -0.0325008
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031966
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0317811
PTCHD4 patched domain containing 4 -0.0304429
FN1 fibronectin 1 -0.0296364
DSCAM Down syndrome cell adhesion molecule -0.0295787
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0289416
INTS6 integrator complex subunit 6 -0.0288716
FMNL2 formin-like 2 -0.0285213
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0284368
DLC1 DLC1 Rho GTPase activating protein -0.028211
SESTD1 SEC14 and spectrin domains 1 -0.0279814
DENND4A DENN/MADD domain containing 4A -0.0273942
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0272697
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0266321
DST dystonin -0.0265746
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0261212
STAU1 staufen double-stranded RNA binding protein 1 -0.0260747
AHSG alpha-2-HS-glycoprotein -0.0258646
SOD2 superoxide dismutase 2, mitochondrial -0.0251038
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0249577
SAMD4A sterile alpha motif domain containing 4A -0.0248996
LCOR ligand dependent nuclear receptor corepressor -0.0247598
AFDN afadin, adherens junction formation factor -0.024584
TMEM123 transmembrane protein 123 -0.0245008
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0241436
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0240813
VCL vinculin -0.0233571
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0231876
CAMTA1 calmodulin binding transcription activator 1 -0.0220502
AHR aryl hydrocarbon receptor -0.0219176
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0219163
CANX calnexin -0.0218961
PEG3 paternally expressed 3 -0.0218952
ADGRG6 adhesion G protein-coupled receptor G6 -0.0213567
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0211541
ZBTB20 zinc finger and BTB domain containing 20 -0.0210617
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0210443
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0209246
ATXN1 ataxin 1 -0.02047
MBNL2 muscleblind-like splicing regulator 2 -0.0204228
CLIC4 chloride intracellular channel 4 -0.0201974
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0201213
EXT1 exostosin glycosyltransferase 1 -0.0199287
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0198998
NIPBL Nipped-B homolog (Drosophila) -0.0196515
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0196478
SOX5 SRY (sex determining region Y)-box 5 -0.019607
QKI QKI, KH domain containing, RNA binding -0.0196055
ZEB1 zinc finger E-box binding homeobox 1 -0.0195957
ANKRD17 ankyrin repeat domain 17 -0.0195587
CNKSR3 CNKSR family member 3 -0.0195138
KIF21A kinesin family member 21A -0.019479
IGF1R insulin-like growth factor 1 receptor -0.0194411
HDLBP high density lipoprotein binding protein -0.0190238
BIRC6 baculoviral IAP repeat containing 6 -0.0190108
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0190085
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0186509
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0183989
USP34 ubiquitin specific peptidase 34 -0.0183706
ITGAV integrin, alpha V -0.0182631
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.018205
TRIO trio Rho guanine nucleotide exchange factor -0.0181003
LPP LIM domain containing preferred translocation partner in lipoma -0.0180275
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0179665
CAPZB capping protein (actin filament) muscle Z-line, beta -0.017836
TRIP12 thyroid hormone receptor interactor 12 -0.0177179
KMT2E lysine (K)-specific methyltransferase 2E -0.0176459
TCF12 transcription factor 12 -0.0176284
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0174403
PARD3 par-3 family cell polarity regulator -0.0173848
LARP4B La ribonucleoprotein domain family, member 4B -0.0168553
NRIP1 nuclear receptor interacting protein 1 -0.0167314
OLA1 Obg-like ATPase 1 -0.0166782
STK17A serine/threonine kinase 17a -0.0164606
STRN3 striatin, calmodulin binding protein 3 -0.0164146
PUM2 pumilio RNA-binding family member 2 -0.0163808
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0163781
CPE carboxypeptidase E -0.0161767
GNAS GNAS complex locus -0.0160211
PCBP2 poly(rC) binding protein 2 -0.0159472
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0159472