Hexylresorcinol_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.217994
FTH1 ferritin, heavy polypeptide 1 0.0900406
SULF1 sulfatase 1 0.0897011
HSPG2 heparan sulfate proteoglycan 2 0.0788104
MTSS1 metastasis suppressor 1 0.0709719
CALB1 calbindin 1, 28kDa 0.0686893
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0680214
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0679511
MSN moesin 0.0677205
TGM2 transglutaminase 2 0.0659807
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.064062
STC1 stanniocalcin 1 0.0637522
RPS6 ribosomal protein S6 0.0630039
FOXP1 forkhead box P1 0.0628106
PDE4D phosphodiesterase 4D, cAMP-specific 0.0596994
NDRG1 N-myc downstream regulated 1 0.0592187
DOK5 docking protein 5 0.0567926
B2M beta-2-microglobulin 0.0565415
EMP1 epithelial membrane protein 1 0.0531939
HLA-E major histocompatibility complex, class I, E 0.0529633
PCDH1 protocadherin 1 0.0491335
MT1E metallothionein 1E 0.0480281
IGF2 insulin-like growth factor 2 0.0460228
TSC22D1 TSC22 domain family, member 1 0.0454968
KRT17 keratin 17, type I 0.0447865
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0432017
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.042833
MEF2A myocyte enhancer factor 2A 0.0428173
RPL35A ribosomal protein L35a 0.0424248
PTK2 protein tyrosine kinase 2 0.0419063
ABI3BP ABI family, member 3 (NESH) binding protein 0.0415885
POTEF POTE ankyrin domain family, member F 0.0411423
EFHD2 EF-hand domain family, member D2 0.0405264
IFITM1 interferon induced transmembrane protein 1 0.0398335
DIAPH1 diaphanous-related formin 1 0.0381911
ZMYND8 zinc finger, MYND-type containing 8 0.0378976
RPLP0 ribosomal protein, large, P0 0.0375453
FOSL1 FOS-like antigen 1 0.0373036
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0370954
NAMPT nicotinamide phosphoribosyltransferase 0.0352413
KIAA1217 KIAA1217 0.0350177
KCTD12 potassium channel tetramerization domain containing 12 0.0347332
CLU clusterin 0.0344692
RPS13 ribosomal protein S13 0.0343816
BLCAP bladder cancer associated protein 0.0341795
DPYSL2 dihydropyrimidinase-like 2 0.0341118
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0337277
RPL5 ribosomal protein L5 0.0329522
DPYD dihydropyrimidine dehydrogenase 0.0328005
HSPH1 heat shock 105kDa/110kDa protein 1 0.0325746
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.032281
MRPS6 mitochondrial ribosomal protein S6 0.0321005
RPL37 ribosomal protein L37 0.0313935
GNAS GNAS complex locus 0.0313348
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0310535
CLIC4 chloride intracellular channel 4 0.0307607
OSMR oncostatin M receptor 0.0306471
SRRM2 serine/arginine repetitive matrix 2 0.0304785
DOCK9 dedicator of cytokinesis 9 0.0303964
SOX7 SRY (sex determining region Y)-box 7 0.0303008
CDCP1 CUB domain containing protein 1 0.0299954
RPS21 ribosomal protein S21 0.0299714
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0299286
EIF1 eukaryotic translation initiation factor 1 0.0298674
RABGAP1L RAB GTPase activating protein 1-like 0.0298165
HIPK3 homeodomain interacting protein kinase 3 0.029538
DUSP4 dual specificity phosphatase 4 0.0287082
ASTN2 astrotactin 2 0.0286279
ECE1 endothelin converting enzyme 1 0.0284816
HMGA1 high mobility group AT-hook 1 0.028381
LOC112694756 uncharaterized LOC112694756 0.028338
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0280816
RPS14 ribosomal protein S14 0.028075
ANGPTL4 angiopoietin-like 4 0.0280169
KPNB1 karyopherin (importin) beta 1 0.0279611
RPS8 ribosomal protein S8 0.027701
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0275124
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.026935
WARS1 tryptophanyl-tRNA synthetase 1 0.0264532
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0263825
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.026347
CFB complement factor B 0.0262789
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026175
ATF4 activating transcription factor 4 0.0260371
RPL39 ribosomal protein L39 0.0259921
RPL7 ribosomal protein L7 0.0259296
MGST2 microsomal glutathione S-transferase 2 0.0258155
LDLR low density lipoprotein receptor 0.0257885
JMJD1C jumonji domain containing 1C 0.0255964
ISG15 ISG15 ubiquitin-like modifier 0.0255086
KIAA1671 KIAA1671 0.0254282
SQLE squalene epoxidase 0.025419
ATP9A ATPase, class II, type 9A 0.0251197
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0250799
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0249156
PKM pyruvate kinase, muscle 0.0247717
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.024575
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0244673
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0244261
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0243462

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.0867082
PRELID2 PRELI domain containing 2 -0.0724737
S100A10 S100 calcium binding protein A10 -0.0659526
TMSB10 thymosin beta 10 -0.0605746
INTS6 integrator complex subunit 6 -0.05041
SEC31A SEC31 homolog A (S. cerevisiae) -0.049318
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.048241
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0457625
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0452867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0426467
H1-0 H1.0 linker histone -0.0425083
MORF4L2 mortality factor 4 like 2 -0.0422826
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0412862
TRA2A transformer 2 alpha homolog (Drosophila) -0.0391783
HMGA2 high mobility group AT-hook 2 -0.0385188
TOP2A topoisomerase (DNA) II alpha 170kDa -0.037911
TMF1 TATA element modulatory factor 1 -0.0378099
GOLGA4 golgin A4 -0.0375069
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0362937
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0359855
PRSS23 protease, serine, 23 -0.0358995
ASPH aspartate beta-hydroxylase -0.0358918
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0354162
TM4SF1 transmembrane 4 L six family member 1 -0.0351175
MKI67 marker of proliferation Ki-67 -0.0350708
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0340009
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0339283
KDM3A lysine (K)-specific demethylase 3A -0.0335612
ANLN anillin, actin binding protein -0.0330982
SDCBP syndecan binding protein (syntenin) -0.0330702
MYH9 myosin, heavy chain 9, non-muscle -0.0326457
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.032618
TTC3 tetratricopeptide repeat domain 3 -0.032564
COG6 component of oligomeric golgi complex 6 -0.0318799
SEC24D SEC24 family member D -0.0317637
NAP1L1 nucleosome assembly protein 1-like 1 -0.0310165
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0308613
ALCAM activated leukocyte cell adhesion molecule -0.0306759
NRIP1 nuclear receptor interacting protein 1 -0.0305409
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298892
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0296079
NAV2 neuron navigator 2 -0.029526
TM9SF3 transmembrane 9 superfamily member 3 -0.0290633
EXT1 exostosin glycosyltransferase 1 -0.0290584
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0289631
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0286947
TOP1 topoisomerase (DNA) I -0.0281334
RPS3 ribosomal protein S3 -0.0276771
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0275277
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0274219
PSD3 pleckstrin and Sec7 domain containing 3 -0.0271841
PDLIM5 PDZ and LIM domain 5 -0.027031
NF1 neurofibromin 1 -0.0269624
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0262778
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0262368
PMM2 phosphomannomutase 2 -0.0260438
FAM107B family with sequence similarity 107, member B -0.025507
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0254286
TNIK TRAF2 and NCK interacting kinase -0.0253624
TPX2 TPX2, microtubule-associated -0.025
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0249982
FRMD6 FERM domain containing 6 -0.0248444
SMAD3 SMAD family member 3 -0.0248049
ECT2 epithelial cell transforming 2 -0.0247518
ZEB1 zinc finger E-box binding homeobox 1 -0.0246833
USP15 ubiquitin specific peptidase 15 -0.0245216
HDLBP high density lipoprotein binding protein -0.0244346
ANO1 anoctamin 1, calcium activated chloride channel -0.0244236
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.024336
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0241992
YBX3 Y box binding protein 3 -0.0241944
VIM vimentin -0.0241178
QKI QKI, KH domain containing, RNA binding -0.0240308
SUCO SUN domain containing ossification factor -0.0239643
SLC35H1 solute carrier family 35 member H1 -0.0238525
NIPBL Nipped-B homolog (Drosophila) -0.0238283
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0237655
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0236643
DUSP6 dual specificity phosphatase 6 -0.0235868
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0235321
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0235205
JAK1 Janus kinase 1 -0.023453
IFI6 interferon, alpha-inducible protein 6 -0.0233712
RUNX1 runt-related transcription factor 1 -0.0232555
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0232322
YME1L1 YME1-like 1 ATPase -0.0228496
NDE1 nudE neurodevelopment protein 1 -0.0227677
COPA coatomer protein complex, subunit alpha -0.0227403
RPS2 ribosomal protein S2 -0.02274
RPS24 ribosomal protein S24 -0.0227174
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0224739
ACTG1 actin gamma 1 -0.0222498
RND3 Rho family GTPase 3 -0.0221989
ARF4 ADP-ribosylation factor 4 -0.0221524
PNISR PNN-interacting serine/arginine-rich protein -0.022057
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0219809
ARHGAP42 Rho GTPase activating protein 42 -0.0219124
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.021847
PLXNA2 plexin A2 -0.0216792
PLAT plasminogen activator, tissue -0.0216233