Hexylresorcinol_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
H1-0 H1.0 linker histone 0.133073
TMSB10 thymosin beta 10 0.115945
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.102035
AHNAK AHNAK nucleoprotein 0.0868319
KRT19 keratin 19, type I 0.0751039
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0709538
FTL ferritin, light polypeptide 0.0628241
S100A10 S100 calcium binding protein A10 0.06027
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0553522
MUC1 mucin 1, cell surface associated 0.0532996
NDRG1 N-myc downstream regulated 1 0.0503398
S100A6 S100 calcium binding protein A6 0.0502402
CLDN7 claudin 7 0.0493978
FTH1 ferritin, heavy polypeptide 1 0.0476169
LOC112694756 uncharaterized LOC112694756 0.0432517
AREG amphiregulin 0.0416913
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0412952
CLDN4 claudin 4 0.0384679
AGR3 anterior gradient 3 0.0369627
JUP junction plakoglobin 0.0366215
ACTN4 actinin, alpha 4 0.0363577
HLA-A major histocompatibility complex, class I, A 0.0363454
S100P S100 calcium binding protein P 0.0357489
GSTP1 glutathione S-transferase pi 1 0.0356559
LOC102724023 ES1 protein homolog, mitochondrial 0.0317735
EGR1 early growth response 1 0.0317425
LMNA lamin A/C 0.0300251
POTEF POTE ankyrin domain family, member F 0.0297049
CALR calreticulin 0.02942
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0282394
PKM pyruvate kinase, muscle 0.0282189
ATF5 activating transcription factor 5 0.0277067
GPX2 glutathione peroxidase 2 0.0276049
HLA-B major histocompatibility complex, class I, B 0.0273264
RPLP1 ribosomal protein, large, P1 0.0271996
MUC17 mucin 17, cell surface associated 0.0268756
HMGA1 high mobility group AT-hook 1 0.0264755
PFN1 profilin 1 0.0256949
S100A11 S100 calcium binding protein A11 0.0255896
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0252246
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0248635
SERF2 small EDRK-rich factor 2 0.024366
RPS19 ribosomal protein S19 0.0239422
EMP1 epithelial membrane protein 1 0.023098
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0226778
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.0212454
RPL28 ribosomal protein L28 0.0210088
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.0207245
LAMB3 laminin, beta 3 0.020297
BAIAP2L1 BAI1-associated protein 2-like 1 0.0197628
FLNB filamin B, beta 0.0197521
KRT18 keratin 18, type I 0.0197193
ITGB4 integrin, beta 4 0.0196891
TFF2 trefoil factor 2 0.0195794
NCOR2 nuclear receptor corepressor 2 0.0192772
MDK midkine (neurite growth-promoting factor 2) 0.0186537
MT1X metallothionein 1X 0.0183231
KRT8 keratin 8, type II 0.0179353
PLEC plectin 0.0178532
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.0178495
MKI67 marker of proliferation Ki-67 0.017485
S100A9 S100 calcium binding protein A9 0.0173087
JUN jun proto-oncogene 0.0172663
CST3 cystatin C 0.0170462
CNRIP1 cannabinoid receptor interacting protein 1 0.0166004
RPS21 ribosomal protein S21 0.0164908
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0163956
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0163864
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0162469
WDR45B WD repeat domain 45B 0.0161023
FLNA filamin A, alpha 0.0160712
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0159406
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0158035
KRT7 keratin 7, type II 0.0158016
NXPH4 neurexophilin 4 0.0157144
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0156007
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0154639
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0154562
TTYH3 tweety family member 3 0.0153926
LCN2 lipocalin 2 0.015329
RPL35 ribosomal protein L35 0.0153097
LAMA4 laminin, alpha 4 0.0149106
KLK10 kallikrein-related peptidase 10 0.0148997
CLIC1 chloride intracellular channel 1 0.0147991
CSTB cystatin B (stefin B) 0.0147577
BCL9L B-cell CLL/lymphoma 9-like 0.0146271
RPL18 ribosomal protein L18 0.0145159
LY6E lymphocyte antigen 6 complex, locus E 0.0144624
EZR ezrin 0.0144435
CIB1 calcium and integrin binding 1 (calmyrin) 0.0143802
DPYSL2 dihydropyrimidinase-like 2 0.0143525
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0143195
RPL8 ribosomal protein L8 0.0142634
FASN fatty acid synthase 0.0142231
PTPRF protein tyrosine phosphatase, receptor type, F 0.0140458
ZFP36L2 ZFP36 ring finger protein-like 2 0.0136742
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0135801
SRRM2 serine/arginine repetitive matrix 2 0.0135643
COX7C cytochrome c oxidase subunit VIIc 0.0134785
PER1 period circadian clock 1 0.0134098

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.117455
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112869
GMDS GDP-mannose 4,6-dehydratase -0.108959
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.105399
MAML2 mastermind-like 2 (Drosophila) -0.102909
FGFR2 fibroblast growth factor receptor 2 -0.0952675
LMO7 LIM domain 7 -0.0759577
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0755284
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.074462
AHR aryl hydrocarbon receptor -0.0659665
ATXN1 ataxin 1 -0.0600045
CANX calnexin -0.0578889
MBNL2 muscleblind-like splicing regulator 2 -0.0571764
GOLGB1 golgin B1 -0.0566991
TMEM123 transmembrane protein 123 -0.0553246
FNDC3B fibronectin type III domain containing 3B -0.0540949
EXOC4 exocyst complex component 4 -0.0533689
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0533222
PTPRK protein tyrosine phosphatase, receptor type, K -0.0517579
CDK6 cyclin-dependent kinase 6 -0.0501777
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0498695
FAT1 FAT atypical cadherin 1 -0.0496477
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0494613
EHBP1 EH domain binding protein 1 -0.0488491
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0485518
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0476129
KLF5 Kruppel-like factor 5 (intestinal) -0.0472462
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0469483
DSPP dentin sialophosphoprotein -0.0467416
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0456299
PTMA prothymosin, alpha -0.0449606
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.044048
CDK13 cyclin-dependent kinase 13 -0.0439289
CLTC clathrin, heavy chain (Hc) -0.0433295
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.043002
RAD51B RAD51 paralog B -0.0429086
BTBD9 BTB (POZ) domain containing 9 -0.0427796
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0421232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0420254
DSG2 desmoglein 2 -0.0415593
FNIP1 folliculin interacting protein 1 -0.0411677
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0410929
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0408388
EXT1 exostosin glycosyltransferase 1 -0.0404869
POF1B premature ovarian failure, 1B -0.0404182
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.04004
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0395142
MBNL1 muscleblind-like splicing regulator 1 -0.0395076
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0386609
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0386326
TES testin LIM domain protein -0.0386026
SAMD12 sterile alpha motif domain containing 12 -0.0379512
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.03726
TRPS1 trichorhinophalangeal syndrome I -0.0372561
RPS6 ribosomal protein S6 -0.0371204
ARHGAP32 Rho GTPase activating protein 32 -0.0364503
ARCN1 archain 1 -0.0363658
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0357551
RPS2 ribosomal protein S2 -0.0357087
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0351179
TNRC6B trinucleotide repeat containing 6B -0.0346579
CEMIP cell migration inducing protein, hyaluronan binding -0.0342869
ANKRD11 ankyrin repeat domain 11 -0.0338059
PATJ PATJ crumbs cell polarity complex component -0.0336389
ATM ATM serine/threonine kinase -0.033589
SIK3 SIK family kinase 3 -0.033247
PDIA3 protein disulfide isomerase family A, member 3 -0.0331702
ZBTB20 zinc finger and BTB domain containing 20 -0.033158
CADPS2 Ca++-dependent secretion activator 2 -0.0329661
LPP LIM domain containing preferred translocation partner in lipoma -0.0326887
TCF12 transcription factor 12 -0.0315757
COBL cordon-bleu WH2 repeat protein -0.0313725
YAP1 Yes-associated protein 1 -0.0313295
ZFAND3 zinc finger, AN1-type domain 3 -0.0311525
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0311438
WWOX WW domain containing oxidoreductase -0.0307396
PUM2 pumilio RNA-binding family member 2 -0.0307171
RUNX1 runt-related transcription factor 1 -0.0305617
ABHD2 abhydrolase domain containing 2 -0.0304597
TNIK TRAF2 and NCK interacting kinase -0.0304086
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0302056
USP34 ubiquitin specific peptidase 34 -0.0301327
KLHL29 kelch-like family member 29 -0.0300579
TFRC transferrin receptor -0.0300014
SLC38A2 solute carrier family 38, member 2 -0.0299344
GOLGA4 golgin A4 -0.0299001
EPCAM epithelial cell adhesion molecule -0.0297197
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0295956
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0294568
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0293715
ASPH aspartate beta-hydroxylase -0.0292301
PHF3 PHD finger protein 3 -0.0292135
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0289713
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0286726
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0286266
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0286172
PLSCR1 phospholipid scramblase 1 -0.0282267
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0280997
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0279303
TRAM1 translocation associated membrane protein 1 -0.0278506