Hexylresorcinol_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.114159
EZR ezrin 0.0793063
RPS6 ribosomal protein S6 0.0790058
TM4SF1 transmembrane 4 L six family member 1 0.0741245
FTH1 ferritin, heavy polypeptide 1 0.0740851
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0695586
MT1E metallothionein 1E 0.0682621
MT2A metallothionein 2A 0.066664
MT1X metallothionein 1X 0.0567849
ESYT2 extended synaptotagmin-like protein 2 0.0566128
FOSL1 FOS-like antigen 1 0.052883
TXNRD1 thioredoxin reductase 1 0.05219
POTEF POTE ankyrin domain family, member F 0.052033
RPS19 ribosomal protein S19 0.0500063
SLK STE20-like kinase 0.0493191
RPL36 ribosomal protein L36 0.0488881
AHNAK AHNAK nucleoprotein 0.0464028
VIM vimentin 0.0459883
RTN4 reticulon 4 0.0459733
FTL ferritin, light polypeptide 0.045013
RPS27 ribosomal protein S27 0.0447384
RAI1 retinoic acid induced 1 0.0423785
ADAM17 ADAM metallopeptidase domain 17 0.0420865
S100A6 S100 calcium binding protein A6 0.0416771
RPS12 ribosomal protein S12 0.0415438
RPLP1 ribosomal protein, large, P1 0.0396746
KLF6 Kruppel-like factor 6 0.0390529
RPL35A ribosomal protein L35a 0.0389842
RAB27B RAB27B, member RAS oncogene family 0.0387801
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0379844
UBC ubiquitin C 0.0366937
EREG epiregulin 0.0362238
JUN jun proto-oncogene 0.0361816
RPS8 ribosomal protein S8 0.0360893
TXNIP thioredoxin interacting protein 0.0348054
HILPDA hypoxia inducible lipid droplet-associated 0.0345651
RPL37A ribosomal protein L37a 0.0344647
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0342999
TMSB4X thymosin beta 4, X-linked 0.03421
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0336501
HMGA1 high mobility group AT-hook 1 0.0334539
ZMYND8 zinc finger, MYND-type containing 8 0.033356
ERRFI1 ERBB receptor feedback inhibitor 1 0.0332818
RPS23 ribosomal protein S23 0.032993
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.032633
YEATS2 YEATS domain containing 2 0.0321296
NPEPPS aminopeptidase puromycin sensitive 0.0318638
ANGPTL4 angiopoietin-like 4 0.0318313
HLA-A major histocompatibility complex, class I, A 0.0316946
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315436
RPL37 ribosomal protein L37 0.0310202
RPL36A ribosomal protein L36a 0.0302771
SEC24A SEC24 family member A 0.030001
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0291028
PGK1 phosphoglycerate kinase 1 0.0290184
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0289598
RPL35 ribosomal protein L35 0.0289279
DST dystonin 0.0286413
RPL31 ribosomal protein L31 0.0284312
RPS14 ribosomal protein S14 0.0283889
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0283876
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282456
RPLP2 ribosomal protein, large, P2 0.027971
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0278501
RAB6A RAB6A, member RAS oncogene family 0.0278236
NIBAN2 niban apoptosis regulator 2 0.0273453
CCNL1 cyclin L1 0.0266241
KLHL24 kelch-like family member 24 0.026407
ZFP36L1 ZFP36 ring finger protein-like 1 0.0263873
WARS1 tryptophanyl-tRNA synthetase 1 0.0263804
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.026287
MIDEAS mitotic deacetylase associated SANT domain protein 0.0262729
SET SET nuclear proto-oncogene 0.0260583
HOOK2 hook microtubule-tethering protein 2 0.0259705
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0259138
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0257157
AMPD3 adenosine monophosphate deaminase 3 0.0256148
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0255517
RPL12 ribosomal protein L12 0.0249841
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0249036
PDE8A phosphodiesterase 8A 0.0248278
NPAS2 neuronal PAS domain protein 2 0.0245699
RLF rearranged L-myc fusion 0.0245285
ZNF292 zinc finger protein 292 0.0243583
RPL28 ribosomal protein L28 0.0241472
WSB1 WD repeat and SOCS box containing 1 0.0240078
RPL26 ribosomal protein L26 0.0236876
RPL5 ribosomal protein L5 0.0236748
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0232506
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0232222
SPAG9 sperm associated antigen 9 0.0229235
RPS17 ribosomal protein S17 0.0228015
KMT2E lysine (K)-specific methyltransferase 2E 0.0226003
GOLGA4 golgin A4 0.0224881
ECE1 endothelin converting enzyme 1 0.0223609
BHLHE40 basic helix-loop-helix family, member e40 0.0220354
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220043
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0218086
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0217103
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0215345

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.134041
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0863989
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0803339
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0728819
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.068163
PTMA prothymosin, alpha -0.0669876
CD44 CD44 molecule (Indian blood group) -0.0662051
NEK10 NIMA-related kinase 10 -0.0650895
INTS6 integrator complex subunit 6 -0.0629585
RIGI RNA sensor RIG-I -0.0626732
SP100 SP100 nuclear antigen -0.0621225
EHBP1 EH domain binding protein 1 -0.0618355
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0591353
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0530672
CANX calnexin -0.0504768
CENPF centromere protein F, 350/400kDa -0.0504469
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0490517
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0482535
VCL vinculin -0.0475384
TRIO trio Rho guanine nucleotide exchange factor -0.0469888
DPYD dihydropyrimidine dehydrogenase -0.0468944
EXOC4 exocyst complex component 4 -0.0467881
DENND1A DENN/MADD domain containing 1A -0.0465225
CADM2 cell adhesion molecule 2 -0.0460507
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0454233
ZBTB38 zinc finger and BTB domain containing 38 -0.04458
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0440626
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0432176
NCEH1 neutral cholesterol ester hydrolase 1 -0.0429503
AEBP2 AE binding protein 2 -0.0425714
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0425578
DLG1 discs, large homolog 1 (Drosophila) -0.0413878
FNIP1 folliculin interacting protein 1 -0.041254
MBD5 methyl-CpG binding domain protein 5 -0.0402253
ACTG1 actin gamma 1 -0.0388482
LPP LIM domain containing preferred translocation partner in lipoma -0.037894
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0376579
EGFR epidermal growth factor receptor -0.0376563
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.036129
PLSCR1 phospholipid scramblase 1 -0.0356978
THSD4 thrombospondin, type I, domain containing 4 -0.0354369
RAD51B RAD51 paralog B -0.0353471
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0351259
HDAC9 histone deacetylase 9 -0.0349858
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0345767
RCOR1 REST corepressor 1 -0.0343527
TRIP12 thyroid hormone receptor interactor 12 -0.0332558
EPHA4 EPH receptor A4 -0.0331175
IFI6 interferon, alpha-inducible protein 6 -0.0327974
KDM4B lysine (K)-specific demethylase 4B -0.0326781
STK17A serine/threonine kinase 17a -0.0325746
FMNL2 formin-like 2 -0.0324076
RUNX1 runt-related transcription factor 1 -0.0321633
CFAP299 cilia and flagella associated protein 299 -0.0319061
BICD1 bicaudal D homolog 1 (Drosophila) -0.030814
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0302069
ARB2A ARB2 cotranscriptional regulator A -0.0299365
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0299008
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0298394
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0293291
SDCCAG8 serologically defined colon cancer antigen 8 -0.0292234
HOMER1 homer scaffolding protein 1 -0.0283924
CMIP c-Maf inducing protein -0.0283102
FBXO11 F-box protein 11 -0.0282162
RNF213 ring finger protein 213 -0.0282031
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.02772
PDE10A phosphodiesterase 10A -0.0275904
PMP22 peripheral myelin protein 22 -0.0275802
PRELID2 PRELI domain containing 2 -0.0272579
ZNF644 zinc finger protein 644 -0.0271799
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0268717
KDM4C lysine (K)-specific demethylase 4C -0.0268375
RASAL2 RAS protein activator like 2 -0.0267926
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0265969
APOLD1 apolipoprotein L domain containing 1 -0.0259293
USP34 ubiquitin specific peptidase 34 -0.0258624
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0254406
LDHA lactate dehydrogenase A -0.0253557
FNDC3B fibronectin type III domain containing 3B -0.0251903
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.025166
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0251083
EXT1 exostosin glycosyltransferase 1 -0.0248998
PTK2 protein tyrosine kinase 2 -0.0248845
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0247583
PSD3 pleckstrin and Sec7 domain containing 3 -0.0245102
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0243489
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0242548
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0242096
BCAR3 breast cancer anti-estrogen resistance 3 -0.0240856
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0240341
MCTP1 multiple C2 domains, transmembrane 1 -0.0239482
CCDC91 coiled-coil domain containing 91 -0.0239093
DPH6 diphthamine biosynthesis 6 -0.0238646
SPDYA speedy/RINGO cell cycle regulator family member A -0.0237267
HDLBP high density lipoprotein binding protein -0.0235874
TAS2R14 taste receptor, type 2, member 14 -0.0234721
TNS3 tensin 3 -0.0226736
PLK2 polo-like kinase 2 -0.0223409
PHF3 PHD finger protein 3 -0.022331
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0221176