Hexylresorcinol_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.19957
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119132
VIM vimentin 0.107509
STC1 stanniocalcin 1 0.101377
LOX lysyl oxidase 0.0826584
GRB10 growth factor receptor-bound protein 10 0.0808531
PDE4D phosphodiesterase 4D, cAMP-specific 0.0787099
IGFBP3 insulin-like growth factor binding protein 3 0.0769125
TIMP1 TIMP metallopeptidase inhibitor 1 0.0745019
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0742353
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0698792
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0696795
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0653539
CDCP1 CUB domain containing protein 1 0.0610241
FTH1 ferritin, heavy polypeptide 1 0.0593184
ZEB2 zinc finger E-box binding homeobox 2 0.0588985
TMSB10 thymosin beta 10 0.0561752
FN1 fibronectin 1 0.0558826
MEF2A myocyte enhancer factor 2A 0.0549641
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0543533
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0495877
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0492013
ELL2 elongation factor, RNA polymerase II, 2 0.0449038
NDRG1 N-myc downstream regulated 1 0.0444973
SNX9 sorting nexin 9 0.0420707
BTG1 B-cell translocation gene 1, anti-proliferative 0.0412745
RAB27B RAB27B, member RAS oncogene family 0.0410567
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0398173
ANGPTL4 angiopoietin-like 4 0.03957
IL1B interleukin 1, beta 0.0392118
CA12 carbonic anhydrase XII 0.0380858
MTSS1 metastasis suppressor 1 0.0375257
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0367014
BHLHE40 basic helix-loop-helix family, member e40 0.0365262
TM4SF1 transmembrane 4 L six family member 1 0.036466
ARHGAP5 Rho GTPase activating protein 5 0.0362346
TFPI2 tissue factor pathway inhibitor 2 0.0360483
RAI14 retinoic acid induced 14 0.0360444
ZMYND8 zinc finger, MYND-type containing 8 0.0355478
CD44 CD44 molecule (Indian blood group) 0.0344406
S100A6 S100 calcium binding protein A6 0.0336768
HAS2 hyaluronan synthase 2 0.0335804
PYGL phosphorylase, glycogen, liver 0.0335157
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0330947
H1-0 H1.0 linker histone 0.0330119
DOCK5 dedicator of cytokinesis 5 0.0326458
LTBP1 latent transforming growth factor beta binding protein 1 0.0325785
AMPD3 adenosine monophosphate deaminase 3 0.0312433
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0307149
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0302224
IFI6 interferon, alpha-inducible protein 6 0.0301371
ESYT2 extended synaptotagmin-like protein 2 0.030002
FAM107B family with sequence similarity 107, member B 0.0299758
ARL4C ADP-ribosylation factor-like 4C 0.0288039
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0282726
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280619
ENO1 enolase 1, (alpha) 0.0278508
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0277955
RND3 Rho family GTPase 3 0.0277731
OSMR oncostatin M receptor 0.0274792
RPS27 ribosomal protein S27 0.0274279
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0271654
TPT1 tumor protein, translationally-controlled 1 0.0268662
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0263228
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0263046
CLMP CXADR-like membrane protein 0.0262217
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0261345
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0260415
FTL ferritin, light polypeptide 0.0259284
MYADM myeloid-associated differentiation marker 0.0255978
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0255336
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0255003
LDHA lactate dehydrogenase A 0.0251552
KMT2E lysine (K)-specific methyltransferase 2E 0.0251037
B2M beta-2-microglobulin 0.025054
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0249418
FOSL1 FOS-like antigen 1 0.0245548
LRRC8C leucine rich repeat containing 8 family, member C 0.0241063
MSRB3 methionine sulfoxide reductase B3 0.0239357
S100A10 S100 calcium binding protein A10 0.0238938
DPYSL3 dihydropyrimidinase-like 3 0.0234698
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0234238
KRT19 keratin 19, type I 0.0229427
BMERB1 bMERB domain containing 1 0.0228917
ADM adrenomedullin 0.0227322
NPAS2 neuronal PAS domain protein 2 0.0223965
TGM2 transglutaminase 2 0.0223546
RPL31 ribosomal protein L31 0.0222765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0222499
RUNX2 runt-related transcription factor 2 0.0219023
EIF1 eukaryotic translation initiation factor 1 0.0217336
TMEM165 transmembrane protein 165 0.0217011
CHD1L chromodomain helicase DNA binding protein 1-like 0.0216896
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0216259
PGK1 phosphoglycerate kinase 1 0.0211713
FAM13A family with sequence similarity 13, member A 0.0210913
ANKRD28 ankyrin repeat domain 28 0.0209249
ZFP36L1 ZFP36 ring finger protein-like 1 0.0207449
PLIN2 perilipin 2 0.0206189
TNS1 tensin 1 0.0206124

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.167173
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10018
HMGA2 high mobility group AT-hook 2 -0.079897
RBM39 RNA binding motif protein 39 -0.0641188
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0514693
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0484943
AADAC arylacetamide deacetylase -0.046985
HDLBP high density lipoprotein binding protein -0.0449103
PRELID2 PRELI domain containing 2 -0.0431296
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0430125
GLCCI1 glucocorticoid induced 1 -0.0429054
PCBP2 poly(rC) binding protein 2 -0.0424791
NCOA7 nuclear receptor coactivator 7 -0.040838
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0399567
USP34 ubiquitin specific peptidase 34 -0.0399499
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0379558
GPC6 glypican 6 -0.0358824
ANKRD17 ankyrin repeat domain 17 -0.0349716
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0338802
FNDC3B fibronectin type III domain containing 3B -0.033424
EXT1 exostosin glycosyltransferase 1 -0.0333892
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0333664
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0331857
INTS6 integrator complex subunit 6 -0.0331641
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0318349
NABP1 nucleic acid binding protein 1 -0.0315857
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0313432
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0306354
OGA O-GlcNAcase -0.0305627
ATXN1 ataxin 1 -0.0304943
GOLGA4 golgin A4 -0.0303132
ERBIN erbb2 interacting protein -0.0291113
LMAN1 lectin, mannose-binding, 1 -0.0289604
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0286267
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.028476
CANX calnexin -0.0270729
GPHN gephyrin -0.0268812
NIPBL Nipped-B homolog (Drosophila) -0.02679
ZNF804A zinc finger protein 804A -0.0266301
COG5 component of oligomeric golgi complex 5 -0.0266022
PDLIM5 PDZ and LIM domain 5 -0.0264213
KMT2C lysine (K)-specific methyltransferase 2C -0.0263148
EGFR epidermal growth factor receptor -0.0261336
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0259675
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0256721
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0256347
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.025475
SAMD4A sterile alpha motif domain containing 4A -0.0252859
COPA coatomer protein complex, subunit alpha -0.0252261
MBD5 methyl-CpG binding domain protein 5 -0.0252004
DSCAM Down syndrome cell adhesion molecule -0.025134
PARD3 par-3 family cell polarity regulator -0.0248129
BIRC6 baculoviral IAP repeat containing 6 -0.0245085
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0243124
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0242546
ZFAND3 zinc finger, AN1-type domain 3 -0.0240983
ZNF638 zinc finger protein 638 -0.0238171
SP100 SP100 nuclear antigen -0.0236711
TAS2R14 taste receptor, type 2, member 14 -0.0234759
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0233226
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0232703
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0231016
MYOF myoferlin -0.0230678
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0228855
EEF2 eukaryotic translation elongation factor 2 -0.0228291
VCL vinculin -0.0228106
USP53 ubiquitin specific peptidase 53 -0.0227497
KDM3A lysine (K)-specific demethylase 3A -0.0226854
CLTC clathrin, heavy chain (Hc) -0.0226725
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.022588
SRP54 signal recognition particle 54kDa -0.0221747
FBXL13 F-box and leucine-rich repeat protein 13 -0.0221175
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0220371
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0220007
TRA2A transformer 2 alpha homolog (Drosophila) -0.0218919
KYNU kynureninase -0.0215858
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0214289
MED13 mediator complex subunit 13 -0.0212231
BLZF1 basic leucine zipper nuclear factor 1 -0.0211345
SYT1 synaptotagmin I -0.021116
MYH9 myosin, heavy chain 9, non-muscle -0.0211026
STRN3 striatin, calmodulin binding protein 3 -0.0210182
MORF4L2 mortality factor 4 like 2 -0.0209667
WDPCP WD repeat containing planar cell polarity effector -0.0207592
NF1 neurofibromin 1 -0.0206888
COL12A1 collagen, type XII, alpha 1 -0.0206108
SPAG9 sperm associated antigen 9 -0.0205865
MYO10 myosin X -0.0205223
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0200683
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0200143
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0197423
PRRC2C proline-rich coiled-coil 2C -0.019719
RAD51B RAD51 paralog B -0.0195198
ALCAM activated leukocyte cell adhesion molecule -0.019389
GLS2 glutaminase 2 (liver, mitochondrial) -0.0193545
USP15 ubiquitin specific peptidase 15 -0.0193437
TMEM263 transmembrane protein 263 -0.0192895
PUM2 pumilio RNA-binding family member 2 -0.0192365
MEIS2 Meis homeobox 2 -0.0187207
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0186672