Hexylresorcinol_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.223361
TM4SF1 transmembrane 4 L six family member 1 0.171871
AKAP12 A kinase (PRKA) anchor protein 12 0.14135
GRAMD1B GRAM domain containing 1B 0.128431
TXNRD1 thioredoxin reductase 1 0.106681
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.08822
AHNAK AHNAK nucleoprotein 0.0865604
RPL4 ribosomal protein L4 0.0733205
SVIL supervillin 0.0726507
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0617192
FTH1 ferritin, heavy polypeptide 1 0.0549293
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0539913
IER3 immediate early response 3 0.0529539
HDAC9 histone deacetylase 9 0.0472677
THSD4 thrombospondin, type I, domain containing 4 0.0439567
CFLAR CASP8 and FADD-like apoptosis regulator 0.0418933
STC1 stanniocalcin 1 0.0396628
BICC1 BicC family RNA binding protein 1 0.0393218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0376022
EIF1 eukaryotic translation initiation factor 1 0.0371466
OSMR oncostatin M receptor 0.0360661
RPLP1 ribosomal protein, large, P1 0.0355307
HLA-B major histocompatibility complex, class I, B 0.0354843
BASP1 brain abundant, membrane attached signal protein 1 0.0351502
TIMP1 TIMP metallopeptidase inhibitor 1 0.0350625
CD99 CD99 molecule 0.0342654
INHBA inhibin, beta A 0.0339135
H1-0 H1.0 linker histone 0.0332397
HSPA8 heat shock 70kDa protein 8 0.0332153
EGR1 early growth response 1 0.0321834
PRDX1 peroxiredoxin 1 0.0319635
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0315265
VMP1 vacuole membrane protein 1 0.0310013
ANGPTL4 angiopoietin-like 4 0.0295219
RPL26 ribosomal protein L26 0.0290005
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0288176
RPS12 ribosomal protein S12 0.02866
BCAR3 breast cancer anti-estrogen resistance 3 0.0283489
PFKP phosphofructokinase, platelet 0.0281818
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0280338
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0273697
CYTH1 cytohesin 1 0.0272351
RPL34 ribosomal protein L34 0.0264977
MKI67 marker of proliferation Ki-67 0.0261424
ASPH aspartate beta-hydroxylase 0.0259832
AFF4 AF4/FMR2 family, member 4 0.0255662
HMOX1 heme oxygenase 1 0.0249192
RPS8 ribosomal protein S8 0.0248127
SPIDR scaffolding protein involved in DNA repair 0.024554
HLA-A major histocompatibility complex, class I, A 0.0243415
SFTPA2 surfactant protein A2 0.0241217
RPTOR regulatory associated protein of MTOR, complex 1 0.0240943
LOC112694756 uncharaterized LOC112694756 0.0236948
PRKN parkin RBR E3 ubiquitin protein ligase 0.0236307
KYNU kynureninase 0.023513
ZMYND8 zinc finger, MYND-type containing 8 0.0234901
FAM107B family with sequence similarity 107, member B 0.0233235
AGO2 argonaute RISC catalytic component 2 0.0232103
CDK12 cyclin-dependent kinase 12 0.0228724
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0228254
HLA-E major histocompatibility complex, class I, E 0.0223492
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0223355
JUN jun proto-oncogene 0.0222129
S100A6 S100 calcium binding protein A6 0.0217674
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.021647
PRRC2A proline-rich coiled-coil 2A 0.0216025
KLF6 Kruppel-like factor 6 0.02154
MAML3 mastermind-like 3 (Drosophila) 0.0214312
ERRFI1 ERBB receptor feedback inhibitor 1 0.0208247
FLNB filamin B, beta 0.0207922
LAMC2 laminin, gamma 2 0.0203722
NNMT nicotinamide N-methyltransferase 0.02036
MYH9 myosin, heavy chain 9, non-muscle 0.0200128
SERF2 small EDRK-rich factor 2 0.0199708
RPS2 ribosomal protein S2 0.0198836
LOC102724023 ES1 protein homolog, mitochondrial 0.0196138
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0194364
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0193701
GPATCH8 G patch domain containing 8 0.0193518
TPT1 tumor protein, translationally-controlled 1 0.0191733
ARL5B ADP-ribosylation factor-like 5B 0.0191114
ETV3 ets variant 3 0.0190746
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019031
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0188059
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0187935
DENND4A DENN/MADD domain containing 4A 0.0185965
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0185047
IQGAP1 IQ motif containing GTPase activating protein 1 0.0184438
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.0181511
CREBBP CREB binding protein 0.0180824
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0180073
HDLBP high density lipoprotein binding protein 0.0179629
BICD1 bicaudal D homolog 1 (Drosophila) 0.017859
HLA-C major histocompatibility complex, class I, C 0.0178473
PTPRF protein tyrosine phosphatase, receptor type, F 0.0178265
BZW1 basic leucine zipper and W2 domains 1 0.017763
FGB fibrinogen beta chain 0.0177112
SDC4 syndecan 4 0.0176211
WWTR1 WW domain containing transcription regulator 1 0.0175827
SH3KBP1 SH3-domain kinase binding protein 1 0.0174247

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.308237
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.135222
VIM vimentin -0.061129
HMGA1 high mobility group AT-hook 1 -0.0542659
ERBIN erbb2 interacting protein -0.0539856
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0538642
PTMA prothymosin, alpha -0.0536112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0522055
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0489099
TFG TRK-fused gene -0.0478422
TPM3 tropomyosin 3 -0.0476913
KTN1 kinectin 1 (kinesin receptor) -0.0471288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0468988
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0465055
RBM25 RNA binding motif protein 25 -0.046354
RPLP0 ribosomal protein, large, P0 -0.0460084
PCBP2 poly(rC) binding protein 2 -0.0454858
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0454675
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0449359
KIF5B kinesin family member 5B -0.0421529
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0416022
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0404424
CCNL1 cyclin L1 -0.0404201
BIRC3 baculoviral IAP repeat containing 3 -0.0392303
FMNL2 formin-like 2 -0.0389244
PDE4D phosphodiesterase 4D, cAMP-specific -0.0388085
ZNF207 zinc finger protein 207 -0.038664
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0383119
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0381898
UBA6 ubiquitin-like modifier activating enzyme 6 -0.038104
COPA coatomer protein complex, subunit alpha -0.0375115
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0368486
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0368286
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0363926
TRA2A transformer 2 alpha homolog (Drosophila) -0.0363446
PDIA3 protein disulfide isomerase family A, member 3 -0.0360781
LDHB lactate dehydrogenase B -0.0357348
ECT2 epithelial cell transforming 2 -0.0355928
PA2G4 proliferation-associated 2G4, 38kDa -0.0353142
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0350579
MIS18BP1 MIS18 binding protein 1 -0.0350442
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0341656
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0340596
FTL ferritin, light polypeptide -0.0335369
PARD3 par-3 family cell polarity regulator -0.0331551
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0324522
VDAC1 voltage-dependent anion channel 1 -0.0322148
PDIA6 protein disulfide isomerase family A, member 6 -0.0320742
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0316568
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0316457
YY1 YY1 transcription factor -0.0316202
USP3 ubiquitin specific peptidase 3 -0.0311889
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0310852
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0306412
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0300905
WAC WW domain containing adaptor with coiled-coil -0.0299459
TRIO trio Rho guanine nucleotide exchange factor -0.0294257
RTN4 reticulon 4 -0.0290868
MBNL1 muscleblind-like splicing regulator 1 -0.0289555
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0288319
RNF145 ring finger protein 145 -0.0284083
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0282449
POTEF POTE ankyrin domain family, member F -0.028239
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0281846
PRR16 proline rich 16 -0.0281553
ENAH enabled homolog (Drosophila) -0.0280069
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0277946
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.02764
PTBP2 polypyrimidine tract binding protein 2 -0.027556
PAWR PRKC, apoptosis, WT1, regulator -0.0273578
NEBL nebulette -0.0268783
FNDC3B fibronectin type III domain containing 3B -0.0268646
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0264023
CBX3 chromobox homolog 3 -0.0259857
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0259775
TMOD3 tropomodulin 3 (ubiquitous) -0.0258356
CDK6 cyclin-dependent kinase 6 -0.0253979
ANKRD28 ankyrin repeat domain 28 -0.0252348
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0252088
NUP58 nucleoporin 58 -0.0243525
HELZ helicase with zinc finger -0.0241315
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.024009
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0239834
PNN pinin, desmosome associated protein -0.0237306
SEPTIN7 septin 7 -0.0237286
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0236508
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.023596
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0233655
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0233588
ELL2 elongation factor, RNA polymerase II, 2 -0.023256
RANBP9 RAN binding protein 9 -0.0231592
BRWD1 bromodomain and WD repeat domain containing 1 -0.0230188
NFIA nuclear factor I/A -0.0230077
TMSB10 thymosin beta 10 -0.022925
LYPLA1 lysophospholipase I -0.022808
SPDYA speedy/RINGO cell cycle regulator family member A -0.0227148
TMEM123 transmembrane protein 123 -0.0227134
PDLIM5 PDZ and LIM domain 5 -0.0223736
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0222936
ITCH itchy E3 ubiquitin protein ligase -0.0221761