Hexylresorcinol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Hexylresorcinol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.174882
AKAP12 A kinase (PRKA) anchor protein 12 0.117336
TFPI2 tissue factor pathway inhibitor 2 0.117008
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0869803
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0845226
ERRFI1 ERBB receptor feedback inhibitor 1 0.0715863
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0653156
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0592136
WNK1 WNK lysine deficient protein kinase 1 0.056554
GRAMD1B GRAM domain containing 1B 0.056478
AHNAK AHNAK nucleoprotein 0.0453483
ADAR adenosine deaminase, RNA-specific 0.0441202
GATAD2B GATA zinc finger domain containing 2B 0.0435502
MARCHF4 membrane associated ring-CH-type finger 4 0.0427115
RTN4 reticulon 4 0.0424811
TM4SF1 transmembrane 4 L six family member 1 0.0424451
EEF2 eukaryotic translation elongation factor 2 0.0421944
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0413237
TMEM41B transmembrane protein 41B 0.0401139
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0396869
CTTNBP2NL CTTNBP2 N-terminal like 0.038991
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0383523
ZFAND3 zinc finger, AN1-type domain 3 0.0362254
CDK17 cyclin-dependent kinase 17 0.0357163
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0353705
RUSC2 RUN and SH3 domain containing 2 0.0347739
EGR1 early growth response 1 0.034732
TPM3 tropomyosin 3 0.0340563
GPHN gephyrin 0.0326912
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0321102
PFDN2 prefoldin subunit 2 0.0320689
ATP11A ATPase, class VI, type 11A 0.0318717
SLC38A2 solute carrier family 38, member 2 0.0316931
ICAM1 intercellular adhesion molecule 1 0.0312812
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0308959
IPO7 importin 7 0.0307
OGA O-GlcNAcase 0.0305505
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0301688
SPRED2 sprouty-related, EVH1 domain containing 2 0.0297939
SRPK2 SRSF protein kinase 2 0.0295823
ADAM17 ADAM metallopeptidase domain 17 0.0290334
EIF4B eukaryotic translation initiation factor 4B 0.028613
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0283741
RNF145 ring finger protein 145 0.0282451
PGK1 phosphoglycerate kinase 1 0.0278941
RASAL2 RAS protein activator like 2 0.0275599
GSE1 Gse1 coiled-coil protein 0.0273635
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0265259
NCAPD2 non-SMC condensin I complex, subunit D2 0.0263743
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0263703
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0263368
LOC112694756 uncharaterized LOC112694756 0.0262584
RUNX1 runt-related transcription factor 1 0.0259702
JMJD1C jumonji domain containing 1C 0.0259597
TJP1 tight junction protein 1 0.0259172
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0259088
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0258471
XPO1 exportin 1 0.0257827
DENR density-regulated protein 0.0255141
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.025418
KDM7A lysine (K)-specific demethylase 7A 0.0253013
ERBIN erbb2 interacting protein 0.0252385
KCMF1 potassium channel modulatory factor 1 0.0251331
SRRM2 serine/arginine repetitive matrix 2 0.0249284
ATXN2L ataxin 2-like 0.0249264
PPME1 protein phosphatase methylesterase 1 0.0248874
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0246095
USP22 ubiquitin specific peptidase 22 0.0245514
PUM1 pumilio RNA-binding family member 1 0.0244366
FLOT1 flotillin 1 0.0243809
UBAP2L ubiquitin associated protein 2-like 0.0240265
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0239463
ARL5B ADP-ribosylation factor-like 5B 0.0237412
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.023697
CMIP c-Maf inducing protein 0.0235583
NAMPT nicotinamide phosphoribosyltransferase 0.0234742
MKI67 marker of proliferation Ki-67 0.0231439
ELL2 elongation factor, RNA polymerase II, 2 0.0231348
BRD2 bromodomain containing 2 0.0230864
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0230207
RB1CC1 RB1-inducible coiled-coil 1 0.0229522
MEF2D myocyte enhancer factor 2D 0.0228615
KDM2A lysine (K)-specific demethylase 2A 0.0226706
PER1 period circadian clock 1 0.0226263
PKM pyruvate kinase, muscle 0.0219206
RPLP1 ribosomal protein, large, P1 0.0219072
PCNX1 pecanex 1 0.0218995
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0217553
CDCP1 CUB domain containing protein 1 0.0216266
ATP5F1B ATP synthase F1 subunit beta 0.0214817
MIDEAS mitotic deacetylase associated SANT domain protein 0.0213785
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0213495
CCNL1 cyclin L1 0.0213443
SINHCAF SIN3-HDAC complex associated factor 0.02126
ATXN2 ataxin 2 0.0211478
EXOC6B exocyst complex component 6B 0.0209873
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0209041
FBXO11 F-box protein 11 0.0207852
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.020762
NFE2L2 nuclear factor, erythroid 2-like 2 0.0207281

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.200757
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0958057
RAD51B RAD51 paralog B -0.0803339
YBX3 Y box binding protein 3 -0.0712894
PTMA prothymosin, alpha -0.0699632
HMGA2 high mobility group AT-hook 2 -0.057395
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0544202
ATXN1 ataxin 1 -0.0537416
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0505395
ACTG1 actin gamma 1 -0.0495052
VIM vimentin -0.0482828
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0466373
AEBP2 AE binding protein 2 -0.0464641
AFF3 AF4/FMR2 family, member 3 -0.0434141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0433804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.04276
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.042602
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0424925
TAS2R14 taste receptor, type 2, member 14 -0.0423354
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.040869
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0405014
VCL vinculin -0.0392201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0390776
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0387477
PRH1 proline-rich protein HaeIII subfamily 1 -0.0381533
TMSB10 thymosin beta 10 -0.0377782
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.037376
EGFR epidermal growth factor receptor -0.0372322
TPT1 tumor protein, translationally-controlled 1 -0.0370101
RYR3 ryanodine receptor 3 -0.0366963
NCOA7 nuclear receptor coactivator 7 -0.0357328
ZBTB20 zinc finger and BTB domain containing 20 -0.0342511
HLA-B major histocompatibility complex, class I, B -0.033571
IFI6 interferon, alpha-inducible protein 6 -0.033146
EXOC4 exocyst complex component 4 -0.0330288
NAP1L1 nucleosome assembly protein 1-like 1 -0.0326477
RPS3 ribosomal protein S3 -0.0316998
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.030571
POTEF POTE ankyrin domain family, member F -0.0304067
IFIH1 interferon induced with helicase C domain 1 -0.029777
RNF213 ring finger protein 213 -0.0291058
WNT2B wingless-type MMTV integration site family, member 2B -0.0277758
PRELID2 PRELI domain containing 2 -0.0275596
S100A10 S100 calcium binding protein A10 -0.0275402
PDLIM5 PDZ and LIM domain 5 -0.0270635
NLGN1 neuroligin 1 -0.0268292
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0267984
PDE10A phosphodiesterase 10A -0.0260119
FMN1 formin 1 -0.0253581
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0250466
TRA2A transformer 2 alpha homolog (Drosophila) -0.0249208
FNDC3B fibronectin type III domain containing 3B -0.0242166
INTS6 integrator complex subunit 6 -0.0239554
LDHA lactate dehydrogenase A -0.0236922
CALD1 caldesmon 1 -0.0222772
RPS21 ribosomal protein S21 -0.0222032
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0217387
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0215805
STYK1 serine/threonine/tyrosine kinase 1 -0.021321
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0211317
GPATCH2L G patch domain containing 2-like -0.0209878
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0209669
PATJ PATJ crumbs cell polarity complex component -0.0209632
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0207985
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0207559
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0207269
USP34 ubiquitin specific peptidase 34 -0.0206818
MYOF myoferlin -0.020445
OSMR oncostatin M receptor -0.0204053
MFSD4B major facilitator superfamily domain containing 4B -0.0202462
HDAC8 histone deacetylase 8 -0.0199819
WSB1 WD repeat and SOCS box containing 1 -0.0199198
RPS8 ribosomal protein S8 -0.019891
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0196519
FMNL2 formin-like 2 -0.0196009
GOLGB1 golgin B1 -0.0195612
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0195588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.019511
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0193777
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0193653
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0192219
ARB2A ARB2 cotranscriptional regulator A -0.0186558
EHBP1 EH domain binding protein 1 -0.0184446
NABP1 nucleic acid binding protein 1 -0.0181682
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0178641
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0178322
SDK1 sidekick cell adhesion molecule 1 -0.0177901
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0177158
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0176576
RIMS2 regulating synaptic membrane exocytosis 2 -0.0175796
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0175608
MBD5 methyl-CpG binding domain protein 5 -0.0173025
MCTP1 multiple C2 domains, transmembrane 1 -0.017294
DNAH14 dynein, axonemal, heavy chain 14 -0.0172305
MT2A metallothionein 2A -0.0171846
DENND1A DENN/MADD domain containing 1A -0.0171688
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0171474
DPH6 diphthamine biosynthesis 6 -0.0170333
PLSCR1 phospholipid scramblase 1 -0.0169185
RSF1 remodeling and spacing factor 1 -0.016844