Hexylresorcinol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.122281
LIMCH1 LIM and calponin homology domains 1 0.119754
NDRG1 N-myc downstream regulated 1 0.11513
LPP LIM domain containing preferred translocation partner in lipoma 0.110969
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.108901
FTL ferritin, light polypeptide 0.108344
PTMA prothymosin, alpha 0.107078
ACTG1 actin gamma 1 0.0992553
EFNA5 ephrin-A5 0.0853655
IGFBP3 insulin-like growth factor binding protein 3 0.0790179
POTEF POTE ankyrin domain family, member F 0.0724955
FBXO32 F-box protein 32 0.0718585
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0683971
TMSB10 thymosin beta 10 0.0658303
SOX4 SRY (sex determining region Y)-box 4 0.0630942
AHNAK AHNAK nucleoprotein 0.0577021
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0560281
NAV2 neuron navigator 2 0.0559551
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0554494
TMEM165 transmembrane protein 165 0.0536439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0510293
EXT1 exostosin glycosyltransferase 1 0.0507015
MYH9 myosin, heavy chain 9, non-muscle 0.0499512
VEGFA vascular endothelial growth factor A 0.049356
RBM47 RNA binding motif protein 47 0.0442745
FNDC3B fibronectin type III domain containing 3B 0.0442353
DSPP dentin sialophosphoprotein 0.0437067
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0415095
KMT2C lysine (K)-specific methyltransferase 2C 0.0411623
EIF1 eukaryotic translation initiation factor 1 0.0405454
TMSB4X thymosin beta 4, X-linked 0.0402502
TRIO trio Rho guanine nucleotide exchange factor 0.039602
RPLP1 ribosomal protein, large, P1 0.0393185
FTH1 ferritin, heavy polypeptide 1 0.0387839
ZBTB20 zinc finger and BTB domain containing 20 0.037916
RAI14 retinoic acid induced 14 0.0374987
RPLP2 ribosomal protein, large, P2 0.0364473
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0360875
RPS6 ribosomal protein S6 0.0357687
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0356997
RCOR1 REST corepressor 1 0.0355142
RPS27 ribosomal protein S27 0.0352497
ISG15 ISG15 ubiquitin-like modifier 0.0350738
RPS29 ribosomal protein S29 0.0347076
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0346956
ATXN1 ataxin 1 0.0345134
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0343395
NPEPPS aminopeptidase puromycin sensitive 0.0335727
RAD51B RAD51 paralog B 0.0329046
HLA-B major histocompatibility complex, class I, B 0.0325186
WSB1 WD repeat and SOCS box containing 1 0.0325005
PKM pyruvate kinase, muscle 0.0321123
RPS19 ribosomal protein S19 0.031724
ITCH itchy E3 ubiquitin protein ligase 0.0316452
PTK2 protein tyrosine kinase 2 0.0311271
PRRC2C proline-rich coiled-coil 2C 0.0310418
TPM4 tropomyosin 4 0.0308182
BASP1 brain abundant, membrane attached signal protein 1 0.030433
LAMB3 laminin, beta 3 0.0302889
RAB6A RAB6A, member RAS oncogene family 0.0298933
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0292586
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0287838
SAMD12 sterile alpha motif domain containing 12 0.0284949
IFI27 interferon, alpha-inducible protein 27 0.0281129
GOLGB1 golgin B1 0.0280937
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0280855
BBX bobby sox homolog (Drosophila) 0.0280035
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0279423
MYO1E myosin IE 0.0275944
CSTB cystatin B (stefin B) 0.0273878
APLP2 amyloid beta (A4) precursor-like protein 2 0.0273436
GOLGA4 golgin A4 0.0273293
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0272199
CDCP1 CUB domain containing protein 1 0.0272071
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0272001
RNF213 ring finger protein 213 0.0269929
ESRP1 epithelial splicing regulatory protein 1 0.0269193
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0266583
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0266156
FBXL20 F-box and leucine-rich repeat protein 20 0.0265295
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0264991
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263074
TOP1 topoisomerase (DNA) I 0.0263044
MAP1B microtubule-associated protein 1B 0.0260759
PPARD peroxisome proliferator-activated receptor delta 0.0257588
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0256979
CTBP2 C-terminal binding protein 2 0.0254415
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.025356
RPL8 ribosomal protein L8 0.0252018
ERBIN erbb2 interacting protein 0.025064
SH3KBP1 SH3-domain kinase binding protein 1 0.0250575
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0249863
STRN3 striatin, calmodulin binding protein 3 0.0248029
WASF2 WAS protein family, member 2 0.0248017
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0247641
MX1 MX dynamin-like GTPase 1 0.0245478
TMF1 TATA element modulatory factor 1 0.0245254
FLNB filamin B, beta 0.0244754
MSN moesin 0.0244441
CTNND1 catenin (cadherin-associated protein), delta 1 0.0243527

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11617
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0469323
ALCAM activated leukocyte cell adhesion molecule -0.0351695
TFG TRK-fused gene -0.0313009
ASPH aspartate beta-hydroxylase -0.0297225
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.026668
HMGA1 high mobility group AT-hook 1 -0.0262118
TPT1 tumor protein, translationally-controlled 1 -0.026136
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.023531
MARCHF6 membrane associated ring-CH-type finger 6 -0.0230699
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0209618
NAMPT nicotinamide phosphoribosyltransferase -0.0208903
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0199161
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0194853
KRT7 keratin 7, type II -0.0186493
ANXA2 annexin A2 -0.0174939
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0173518
RYBP RING1 and YY1 binding protein -0.0168755
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0167937
TUBA1B tubulin, alpha 1b -0.0165984
C3ORF52 chromosome 3 open reading frame 52 -0.0156814
PLAU plasminogen activator, urokinase -0.0156636
TMEM263 transmembrane protein 263 -0.0155473
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0154533
NAP1L1 nucleosome assembly protein 1-like 1 -0.0146897
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0142623
LDHA lactate dehydrogenase A -0.0142503
SHROOM3 shroom family member 3 -0.013677
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0134538
USP15 ubiquitin specific peptidase 15 -0.0134119
MSMO1 methylsterol monooxygenase 1 -0.013264
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0131472
RAD21 RAD21 homolog (S. pombe) -0.0130724
CCNL1 cyclin L1 -0.0129849
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -0.0129012
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0127571
TM4SF1 transmembrane 4 L six family member 1 -0.0127189
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0127084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0125579
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.012163
PEG10 paternally expressed 10 -0.0118809
ARHGAP29 Rho GTPase activating protein 29 -0.0116722
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0115763
AREG amphiregulin -0.0115732
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0115248
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0115234
HMGB2 high mobility group box 2 -0.0114378
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0113002
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0112906
CD83 CD83 molecule -0.0112693
EGR1 early growth response 1 -0.0111328
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0111324
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0109673
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.010956
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0109107
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0109021
SGMS2 sphingomyelin synthase 2 -0.0107507
EMP1 epithelial membrane protein 1 -0.0105878
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0105515
IARS1 isoleucyl-tRNA synthetase 1 -0.0105171
RPLP0 ribosomal protein, large, P0 -0.0103793
PRRC1 proline-rich coiled-coil 1 -0.0102299
ARF1 ADP-ribosylation factor 1 -0.0101888
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.010098
BIRC3 baculoviral IAP repeat containing 3 -0.00998275
QKI QKI, KH domain containing, RNA binding -0.00993709
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.00991156
TACSTD2 tumor-associated calcium signal transducer 2 -0.00982519
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.00982022
TCEA1 transcription elongation factor A (SII), 1 -0.00974022
WTAP Wilms tumor 1 associated protein -0.00966573
USP3 ubiquitin specific peptidase 3 -0.00958614
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00955865
TMEM131L transmembrane 131 like -0.00952222
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00950001
NEK7 NIMA-related kinase 7 -0.00944332
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00941589
LOC102724023 ES1 protein homolog, mitochondrial -0.00940584
VGLL3 vestigial-like family member 3 -0.00937566
MB21D2 Mab-21 domain containing 2 -0.00933487
DENND4A DENN/MADD domain containing 4A -0.00933437
CDC73 cell division cycle 73 -0.00932894
CAV1 caveolin 1, caveolae protein, 22kDa -0.00928413
EREG epiregulin -0.00922987
NCEH1 neutral cholesterol ester hydrolase 1 -0.00921148
IRF1 interferon regulatory factor 1 -0.00920918
SMC4 structural maintenance of chromosomes 4 -0.00914574
ANXA5 annexin A5 -0.00910129
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.00908596
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00905292
ZBTB10 zinc finger and BTB domain containing 10 -0.00899198
TXNL1 thioredoxin-like 1 -0.00894179
BLZF1 basic leucine zipper nuclear factor 1 -0.00893453
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00892815
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00890018
FUBP1 far upstream element (FUSE) binding protein 1 -0.00886928
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00886534
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0088614
MAPK8 mitogen-activated protein kinase 8 -0.00859514
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.00857519