Hexylresorcinol_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

195 genes differentially expressed following the Hexylresorcinol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TFRC transferrin receptor 0.139867
SPAG9 sperm associated antigen 9 0.137597
BAIAP2L1 BAI1-associated protein 2-like 1 0.119456
USP34 ubiquitin specific peptidase 34 0.114348
NDRG1 N-myc downstream regulated 1 0.106235
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.09625
TSC22D2 TSC22 domain family, member 2 0.094778
NKD1 naked cuticle homolog 1 (Drosophila) 0.0924608
FAM13A family with sequence similarity 13, member A 0.0914305
RAB7A RAB7A, member RAS oncogene family 0.09016
SLIT2 slit homolog 2 (Drosophila) 0.0877561
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0852113
NAP1L1 nucleosome assembly protein 1-like 1 0.0791154
FNIP1 folliculin interacting protein 1 0.0764481
ASPH aspartate beta-hydroxylase 0.0761598
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0759941
ELL2 elongation factor, RNA polymerase II, 2 0.0737608
ZNF638 zinc finger protein 638 0.0726378
COL5A2 collagen, type V, alpha 2 0.0700079
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0664498
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0654302
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0651112
EHBP1 EH domain binding protein 1 0.0637008
RUNX1 runt-related transcription factor 1 0.0609448
DST dystonin 0.0567091
NAMPT nicotinamide phosphoribosyltransferase 0.0561655
TXNRD1 thioredoxin reductase 1 0.055974
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0552437
TENM3 teneurin transmembrane protein 3 0.0526885
PDIA3 protein disulfide isomerase family A, member 3 0.0524927
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.051276
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0490954
RLF rearranged L-myc fusion 0.0484123
CMIP c-Maf inducing protein 0.0481011
IGF2 insulin-like growth factor 2 0.047714
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0476896
PKM pyruvate kinase, muscle 0.0468048
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0460505
MAML2 mastermind-like 2 (Drosophila) 0.0457053
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0453327
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0441465
PTPRG protein tyrosine phosphatase, receptor type, G 0.0410659
SRRM2 serine/arginine repetitive matrix 2 0.0398514
RAB1A RAB1A, member RAS oncogene family 0.0387958
EXT1 exostosin glycosyltransferase 1 0.0383492
ZBTB20 zinc finger and BTB domain containing 20 0.0371646
FTL ferritin, light polypeptide 0.035983
SLC38A2 solute carrier family 38, member 2 0.0357021
NABP1 nucleic acid binding protein 1 0.0351045
ERRFI1 ERBB receptor feedback inhibitor 1 0.0338408
DOCK5 dedicator of cytokinesis 5 0.0329787
GMDS GDP-mannose 4,6-dehydratase 0.0328656
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0326952
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0312033
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0303891
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0298094
FLNB filamin B, beta 0.0288664
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0258122
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0256723
PRELID2 PRELI domain containing 2 0.0255562
SND1 staphylococcal nuclease and tudor domain containing 1 0.0251778
NONO non-POU domain containing, octamer-binding 0.0240448
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231629
CNKSR3 CNKSR family member 3 0.0226828
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.020713
DLG1 discs, large homolog 1 (Drosophila) 0.0203092
CARD16 caspase recruitment domain family, member 16 0.0188826
ZSWIM6 zinc finger, SWIM-type containing 6 0.0180747
ZNF292 zinc finger protein 292 0.0171759
LMO7 LIM domain 7 0.0168546
HDLBP high density lipoprotein binding protein 0.0166494
ITGA6 integrin, alpha 6 0.0161274
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0160419
ANO6 anoctamin 6 0.0152694
SYT1 synaptotagmin I 0.0145549
COL6A3 collagen, type VI, alpha 3 0.013793
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0136409
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0133139
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0132012
ZFAND3 zinc finger, AN1-type domain 3 0.012946
RPS12 ribosomal protein S12 0.0122936
CAMKMT calmodulin-lysine N-methyltransferase 0.0120134
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0110419
TBC1D22A TBC1 domain family, member 22A 0.0101026
TPT1 tumor protein, translationally-controlled 1 0.00855832
YAP1 Yes-associated protein 1 0.0072604
SLTM SAFB-like, transcription modulator 0.00676796
MACF1 microtubule-actin crosslinking factor 1 0.00652373
ANKRD11 ankyrin repeat domain 11 0.00644768
PSD3 pleckstrin and Sec7 domain containing 3 0.00397886
AKAP13 A kinase (PRKA) anchor protein 13 0.00323577
NAV2 neuron navigator 2 0.00296428
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00257097
FAT1 FAT atypical cadherin 1 0.00253305
INTS6 integrator complex subunit 6 3.9129E-5

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.30436
FN1 fibronectin 1 -0.124698
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.102038
RPS6 ribosomal protein S6 -0.0887765
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0885865
APP amyloid beta (A4) precursor protein -0.0849122
TCF12 transcription factor 12 -0.0841431
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.080226
EGFR epidermal growth factor receptor -0.0791717
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0776877
PDLIM5 PDZ and LIM domain 5 -0.0775557
LPP LIM domain containing preferred translocation partner in lipoma -0.0774178
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0743722
THSD4 thrombospondin, type I, domain containing 4 -0.0743371
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0725374
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0660635
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0652646
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0619483
ANKRD12 ankyrin repeat domain 12 -0.0616346
PTMA prothymosin, alpha -0.0607221
AOPEP aminopeptidase O (putative) -0.0605835
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0604815
PRKD3 protein kinase D3 -0.0594203
ATP9B ATPase, class II, type 9B -0.0592555
PARD3 par-3 family cell polarity regulator -0.0588663
GRB10 growth factor receptor-bound protein 10 -0.0583426
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0582363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0569692
VIM vimentin -0.0564058
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0559521
MCL1 myeloid cell leukemia 1 -0.0552128
ELOVL5 ELOVL fatty acid elongase 5 -0.0533417
MT2A metallothionein 2A -0.0529102
RPLP1 ribosomal protein, large, P1 -0.0504418
SLC38A1 solute carrier family 38, member 1 -0.0503159
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0499214
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0492169
RIGI RNA sensor RIG-I -0.0475038
BBX bobby sox homolog (Drosophila) -0.0473321
TMSB10 thymosin beta 10 -0.0469376
CDH13 cadherin 13 -0.0467753
MARCHF7 membrane associated ring-CH-type finger 7 -0.0467089
TTC3 tetratricopeptide repeat domain 3 -0.0456202
FNDC3A fibronectin type III domain containing 3A -0.045521
JMJD1C jumonji domain containing 1C -0.0452706
KDM2A lysine (K)-specific demethylase 2A -0.0440733
MYO10 myosin X -0.0437746
CTIF CBP80/20-dependent translation initiation factor -0.0434458
SMAD3 SMAD family member 3 -0.0432448
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0423317
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0421418
PTPRM protein tyrosine phosphatase, receptor type, M -0.0421161
FNDC3B fibronectin type III domain containing 3B -0.0413426
SAMD4A sterile alpha motif domain containing 4A -0.0396413
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0384553
AKAP12 A kinase (PRKA) anchor protein 12 -0.0370839
CERS6 ceramide synthase 6 -0.0363631
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0359162
RPL12 ribosomal protein L12 -0.0355748
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0341664
PRKCA protein kinase C, alpha -0.032724
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0320137
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0313694
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0309967
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0281242
SETD5 SET domain containing 5 -0.024379
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0238958
SRPK2 SRSF protein kinase 2 -0.0236721
NHSL1 NHS-like 1 -0.0234157
NALF1 NALCN channel auxiliary factor 1 -0.0231939
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0222009
KTN1 kinectin 1 (kinesin receptor) -0.0208926
TAS2R14 taste receptor, type 2, member 14 -0.0208819
DSCAM Down syndrome cell adhesion molecule -0.0202409
FOXP1 forkhead box P1 -0.0198798
ATXN1 ataxin 1 -0.0195997
TRIO trio Rho guanine nucleotide exchange factor -0.0190982
DOCK4 dedicator of cytokinesis 4 -0.0189494
KMT2C lysine (K)-specific methyltransferase 2C -0.0171746
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0168458
ESYT2 extended synaptotagmin-like protein 2 -0.0156835
NBEAL1 neurobeachin-like 1 -0.0155641
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0153611
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0146275
SBF2 SET binding factor 2 -0.0129701
RNF213 ring finger protein 213 -0.0127697
ALCAM activated leukocyte cell adhesion molecule -0.0125986
RORA RAR-related orphan receptor A -0.0122452
AKAP9 A kinase (PRKA) anchor protein 9 -0.0118677
ANKRD28 ankyrin repeat domain 28 -0.0115812
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0112985
RPLP2 ribosomal protein, large, P2 -0.0106511
PRRC2C proline-rich coiled-coil 2C -0.00999491
EGR1 early growth response 1 -0.00995504
ENO1 enolase 1, (alpha) -0.00903434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0077671
RABGAP1L RAB GTPase activating protein 1-like -0.00676037
JARID2 jumonji, AT rich interactive domain 2 -0.00640582
IQGAP1 IQ motif containing GTPase activating protein 1 -0.00628647
ANKHD1 ankyrin repeat and KH domain containing 1 -0.00522971