Hexylresorcinol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.178421
COL11A1 collagen, type XI, alpha 1 0.127682
CDH10 cadherin 10, type 2 (T2-cadherin) 0.103435
CADM2 cell adhesion molecule 2 0.0949827
AHNAK AHNAK nucleoprotein 0.075069
ADGRV1 adhesion G protein-coupled receptor V1 0.0729625
MKI67 marker of proliferation Ki-67 0.0656798
PARD3B par-3 family cell polarity regulator beta 0.065482
PCLO piccolo presynaptic cytomatrix protein 0.0584604
FOXP2 forkhead box P2 0.0528339
PCDH7 protocadherin 7 0.0521474
TENM3 teneurin transmembrane protein 3 0.0520876
SLIT2 slit homolog 2 (Drosophila) 0.0497336
PGK1 phosphoglycerate kinase 1 0.0476793
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0418101
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0400847
RAD51B RAD51 paralog B 0.0388989
GSE1 Gse1 coiled-coil protein 0.0372465
PCDH9 protocadherin 9 0.0364834
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0364434
BCAS3 breast carcinoma amplified sequence 3 0.034853
IGF2 insulin-like growth factor 2 0.0332383
ARHGAP15 Rho GTPase activating protein 15 0.0324789
RREB1 ras responsive element binding protein 1 0.0312463
H1-0 H1.0 linker histone 0.0310965
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0301549
COL5A2 collagen, type V, alpha 2 0.0298866
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0289887
TJP1 tight junction protein 1 0.0288764
TENM2 teneurin transmembrane protein 2 0.0284335
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.028358
SHROOM3 shroom family member 3 0.0281345
ZMYM2 zinc finger, MYM-type 2 0.0280073
TTC28 tetratricopeptide repeat domain 28 0.0277053
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0276905
ZC3H12B zinc finger CCCH-type containing 12B 0.0275834
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0275388
TBL1X transducin (beta)-like 1X-linked 0.0275023
CSMD3 CUB and Sushi multiple domains 3 0.0274649
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0266953
METAP2 methionyl aminopeptidase 2 0.0265739
SVIL supervillin 0.0259709
SOS1 son of sevenless homolog 1 (Drosophila) 0.0254163
WWOX WW domain containing oxidoreductase 0.0253032
TTC17 tetratricopeptide repeat domain 17 0.0252054
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0248703
TET1 tet methylcytosine dioxygenase 1 0.0248579
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0243584
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0243433
MAML2 mastermind-like 2 (Drosophila) 0.024301
JMJD1C jumonji domain containing 1C 0.0241924
MACROD2 MACRO domain containing 2 0.0240651
CREBBP CREB binding protein 0.023343
BPTF bromodomain PHD finger transcription factor 0.0227667
GPHN gephyrin 0.0226687
LDHA lactate dehydrogenase A 0.0225348
FNDC3B fibronectin type III domain containing 3B 0.0224026
METTL15 methyltransferase like 15 0.0223017
TEX11 testis expressed 11 0.0221444
ITGAV integrin, alpha V 0.0221403
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0220639
EXOC4 exocyst complex component 4 0.0220567
KDM2A lysine (K)-specific demethylase 2A 0.0218696
SPIRE1 spire-type actin nucleation factor 1 0.02182
GPC4 glypican 4 0.0211056
RIMS2 regulating synaptic membrane exocytosis 2 0.0210118
NCAM2 neural cell adhesion molecule 2 0.0209745
MGA MGA, MAX dimerization protein 0.0208157
ADCY9 adenylate cyclase 9 0.0206835
ZNF608 zinc finger protein 608 0.0206724
NFE2L2 nuclear factor, erythroid 2-like 2 0.0203961
ATXN2 ataxin 2 0.020384
NUBPL nucleotide binding protein-like 0.0202881
ABI1 abl-interactor 1 0.0202345
RBM20 RNA binding motif protein 20 0.0200689
CCNG2 cyclin G2 0.0199764
KIAA1328 KIAA1328 0.0199435
BLTP1 bridge-like lipid transfer protein family member 1 0.0197593
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0196928
RNF213 ring finger protein 213 0.0195426
AFAP1 actin filament associated protein 1 0.0194446
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0192598
PEG10 paternally expressed 10 0.0192285
ATM ATM serine/threonine kinase 0.0191315
WDR70 WD repeat domain 70 0.0190997
MBD5 methyl-CpG binding domain protein 5 0.0190685
PCDH18 protocadherin 18 0.0190427
HYOU1 hypoxia up-regulated 1 0.0189927
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0188093
BIRC6 baculoviral IAP repeat containing 6 0.0187566
EXOC2 exocyst complex component 2 0.0187283
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.0184664
WNK1 WNK lysine deficient protein kinase 1 0.0184338
RASAL2 RAS protein activator like 2 0.0183942
PTH2R parathyroid hormone 2 receptor 0.0182545
TTC3 tetratricopeptide repeat domain 3 0.0181583
CKAP2 cytoskeleton associated protein 2 0.0180776
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0180096
SCAPER S-phase cyclin A-associated protein in the ER 0.0179205
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.0177034

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.165095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119809
PTMA prothymosin, alpha -0.104536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0961806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0720048
ANKRD33B ankyrin repeat domain 33B -0.0712909
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0690992
HDAC9 histone deacetylase 9 -0.0687454
CALR calreticulin -0.0633002
RPS8 ribosomal protein S8 -0.060632
ACTG1 actin gamma 1 -0.0568563
VIM vimentin -0.0567386
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0543036
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0526684
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0490943
SFRP4 secreted frizzled-related protein 4 -0.0485226
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0481967
SAMD4A sterile alpha motif domain containing 4A -0.045757
CCN2 cellular communication network factor 2 -0.043819
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0433677
TPT1 tumor protein, translationally-controlled 1 -0.0422982
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0421967
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0420636
EMP1 epithelial membrane protein 1 -0.0419116
SNX6 sorting nexin 6 -0.0408411
RPS12 ribosomal protein S12 -0.0406661
ANXA2 annexin A2 -0.0396117
TSC22D2 TSC22 domain family, member 2 -0.0380499
PHIP pleckstrin homology domain interacting protein -0.0371435
RFPL4B ret finger protein-like 4B -0.0361099
HMGB2 high mobility group box 2 -0.0360965
NRG1 neuregulin 1 -0.0357218
TRA2A transformer 2 alpha homolog (Drosophila) -0.0357021
KDM3A lysine (K)-specific demethylase 3A -0.0353429
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0352697
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0351829
UPP1 uridine phosphorylase 1 -0.0349143
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0344233
FNDC3A fibronectin type III domain containing 3A -0.0344053
SPAG9 sperm associated antigen 9 -0.0341393
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0338367
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0337388
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0336434
CAVIN1 caveolae associated protein 1 -0.0335818
RAD21 RAD21 homolog (S. pombe) -0.033052
RBM39 RNA binding motif protein 39 -0.0329508
TMSB4X thymosin beta 4, X-linked -0.0329381
GNAS GNAS complex locus -0.0321037
HDAC2 histone deacetylase 2 -0.0320012
AKAP12 A kinase (PRKA) anchor protein 12 -0.0318963
PDCD5 programmed cell death 5 -0.0318458
TPR translocated promoter region, nuclear basket protein -0.0317895
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317246
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.030831
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0305877
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0303907
STRN3 striatin, calmodulin binding protein 3 -0.030338
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0300491
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0299631
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0296748
RAB1A RAB1A, member RAS oncogene family -0.0296612
RAI1 retinoic acid induced 1 -0.0293446
RPS16 ribosomal protein S16 -0.0292919
MRPS30 mitochondrial ribosomal protein S30 -0.0291651
QKI QKI, KH domain containing, RNA binding -0.02914
LRRN3 leucine rich repeat neuronal 3 -0.0289432
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0286674
RPL37A ribosomal protein L37a -0.0282947
FBXO11 F-box protein 11 -0.0282689
NOP58 NOP58 ribonucleoprotein -0.0281905
RPS3 ribosomal protein S3 -0.0281437
TFRC transferrin receptor -0.0280929
CAMTA1 calmodulin binding transcription activator 1 -0.0278773
LOC102724023 ES1 protein homolog, mitochondrial -0.027801
B2M beta-2-microglobulin -0.0271355
ISG15 ISG15 ubiquitin-like modifier -0.0268633
URI1 URI1, prefoldin-like chaperone -0.0268477
DSTN destrin (actin depolymerizing factor) -0.026844
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0267137
RPS2 ribosomal protein S2 -0.0264114
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0263932
RPS13 ribosomal protein S13 -0.0263797
LYPLA1 lysophospholipase I -0.0263058
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0262206
KPNB1 karyopherin (importin) beta 1 -0.0256246
PTK2 protein tyrosine kinase 2 -0.0254874
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0251885
THBS1 thrombospondin 1 -0.0251643
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0250079
PALLD palladin, cytoskeletal associated protein -0.0249447
POTEF POTE ankyrin domain family, member F -0.0248072
ENAH enabled homolog (Drosophila) -0.024514
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0244966
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0244526
COL3A1 collagen, type III, alpha 1 -0.0243392
SRP72 signal recognition particle 72kDa -0.0243108
RPS27A ribosomal protein S27a -0.024278
SEC63 SEC63 homolog (S. cerevisiae) -0.0242242
RPL38 ribosomal protein L38 -0.0240627
H1-4 H1.4 linker histone, cluster member -0.0239786