Hexylresorcinol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BMP10 bone morphogenetic protein 10 0.077113
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0697706
PKM pyruvate kinase, muscle 0.0656925
ENO1 enolase 1, (alpha) 0.0557881
SDK1 sidekick cell adhesion molecule 1 0.0479
POTEF POTE ankyrin domain family, member F 0.0443403
PYGB phosphorylase, glycogen; brain 0.0409019
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0395622
MKI67 marker of proliferation Ki-67 0.0393092
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0391785
ADAM10 ADAM metallopeptidase domain 10 0.0385858
LOXL3 lysyl oxidase-like 3 0.0385716
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0382104
TXNRD1 thioredoxin reductase 1 0.0378027
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0370163
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0360138
GLI3 GLI family zinc finger 3 0.033512
PRELID2 PRELI domain containing 2 0.0314009
EEF2 eukaryotic translation elongation factor 2 0.0311601
NPAS2 neuronal PAS domain protein 2 0.0305503
RPS12 ribosomal protein S12 0.028964
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0285906
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0285173
ARL4C ADP-ribosylation factor-like 4C 0.0273534
PDE4D phosphodiesterase 4D, cAMP-specific 0.0268502
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0268215
KLF3 Kruppel-like factor 3 (basic) 0.0260583
MACROD2 MACRO domain containing 2 0.0259982
MYO5C myosin VC 0.0258755
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0257028
ITGA10 integrin, alpha 10 0.0255324
APLP2 amyloid beta (A4) precursor-like protein 2 0.0254524
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0252133
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.025154
GSE1 Gse1 coiled-coil protein 0.0250728
AMOTL2 angiomotin like 2 0.0247982
ASPH aspartate beta-hydroxylase 0.0245274
TTC28 tetratricopeptide repeat domain 28 0.0239802
RPL37A ribosomal protein L37a 0.0236583
EBNA1BP2 EBNA1 binding protein 2 0.0235174
CCND1 cyclin D1 0.0229982
BMP2K BMP2 inducible kinase 0.022887
GCLM glutamate-cysteine ligase, modifier subunit 0.0227717
RPL26 ribosomal protein L26 0.0226971
TSC22D1 TSC22 domain family, member 1 0.0224911
AKAP12 A kinase (PRKA) anchor protein 12 0.0220476
RPS2 ribosomal protein S2 0.0217187
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0213739
TM4SF1 transmembrane 4 L six family member 1 0.0211848
TPM4 tropomyosin 4 0.0211258
FLNB filamin B, beta 0.0210185
GLI2 GLI family zinc finger 2 0.0209218
RPL9 ribosomal protein L9 0.0206685
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0206619
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0206261
RPLP1 ribosomal protein, large, P1 0.0202837
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0194142
ARHGAP25 Rho GTPase activating protein 25 0.0193176
ANKRD12 ankyrin repeat domain 12 0.0189442
TOB1 transducer of ERBB2, 1 0.0189397
PTPRF protein tyrosine phosphatase, receptor type, F 0.0189303
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0183135
RPL31 ribosomal protein L31 0.0182874
TPM3 tropomyosin 3 0.0182626
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0180148
RHOB ras homolog family member B 0.017738
UNC13A unc-13 homolog A (C. elegans) 0.0176766
EMP3 epithelial membrane protein 3 0.0176346
IFI6 interferon, alpha-inducible protein 6 0.0175753
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0172077
RPS27A ribosomal protein S27a 0.0171462
PCBP2 poly(rC) binding protein 2 0.0170628
DUSP4 dual specificity phosphatase 4 0.016726
TMSB10 thymosin beta 10 0.0166238
SEPTIN9 septin 9 0.0164199
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0163285
MYH9 myosin, heavy chain 9, non-muscle 0.0160995
RPL23 ribosomal protein L23 0.0160311
TAS2R14 taste receptor, type 2, member 14 0.0159466
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0159432
CDK19 cyclin-dependent kinase 19 0.0159093
CRYBG3 beta-gamma crystallin domain containing 3 0.0152915
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0152162
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0151733
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0150758
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0149676
RPS8 ribosomal protein S8 0.0149438
SMAD6 SMAD family member 6 0.0148893
LRP10 low density lipoprotein receptor-related protein 10 0.0147966
AHNAK AHNAK nucleoprotein 0.0147781
RPS27 ribosomal protein S27 0.0145955
HDGFL3 HDGF like 3 0.0145138
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0144932
SOX6 SRY (sex determining region Y)-box 6 0.0144039
PACS1 phosphofurin acidic cluster sorting protein 1 0.0143761
ENOSF1 enolase superfamily member 1 0.0141664
CEP250 centrosomal protein 250kDa 0.0141274
NFE2L1 nuclear factor, erythroid 2-like 1 0.0139564
TNRC18 trinucleotide repeat containing 18 0.0139467
MYO1E myosin IE 0.0139289

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.288714
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.160464
SSBP2 single-stranded DNA binding protein 2 -0.123941
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.115519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.10279
GOLGA4 golgin A4 -0.0895008
ZNF292 zinc finger protein 292 -0.0894639
GARS1 glycyl-tRNA synthetase 1 -0.0860801
RBM39 RNA binding motif protein 39 -0.0848994
ECT2 epithelial cell transforming 2 -0.0833009
QKI QKI, KH domain containing, RNA binding -0.0805496
ZFAND3 zinc finger, AN1-type domain 3 -0.0805376
KMT2E lysine (K)-specific methyltransferase 2E -0.0761108
NFIA nuclear factor I/A -0.0752509
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0749344
NAMPT nicotinamide phosphoribosyltransferase -0.0707916
TMSB4X thymosin beta 4, X-linked -0.0695345
KDM3A lysine (K)-specific demethylase 3A -0.0694382
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0690205
PTMA prothymosin, alpha -0.0686476
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0630456
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0624636
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0615658
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0585854
TFG TRK-fused gene -0.0581614
IARS1 isoleucyl-tRNA synthetase 1 -0.0577468
EML4 echinoderm microtubule associated protein like 4 -0.0570886
WAC WW domain containing adaptor with coiled-coil -0.0563141
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0556733
PDE4B phosphodiesterase 4B, cAMP-specific -0.0551326
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0545591
DSCAM Down syndrome cell adhesion molecule -0.0542518
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0532592
CDC73 cell division cycle 73 -0.0531726
DLG1 discs, large homolog 1 (Drosophila) -0.0522818
RTN4 reticulon 4 -0.0507108
NCOR1 nuclear receptor corepressor 1 -0.0497375
RNF145 ring finger protein 145 -0.0480747
EPS8 epidermal growth factor receptor pathway substrate 8 -0.047958
ANKRD11 ankyrin repeat domain 11 -0.0478293
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.04697
SETD5 SET domain containing 5 -0.0465953
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0453505
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0440801
PUM2 pumilio RNA-binding family member 2 -0.0437661
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0437638
JMJD1C jumonji domain containing 1C -0.0434932
ELOVL5 ELOVL fatty acid elongase 5 -0.04302
RAB1A RAB1A, member RAS oncogene family -0.042746
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0427091
RLF rearranged L-myc fusion -0.0423538
NIPBL Nipped-B homolog (Drosophila) -0.0411608
SENP6 SUMO1/sentrin specific peptidase 6 -0.0411438
MARCHF6 membrane associated ring-CH-type finger 6 -0.0410559
ZEB1 zinc finger E-box binding homeobox 1 -0.040437
TTC3 tetratricopeptide repeat domain 3 -0.0403875
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0402045
TMEM41B transmembrane protein 41B -0.040095
NCKAP1 NCK-associated protein 1 -0.0395895
FNDC3B fibronectin type III domain containing 3B -0.0395194
EXT1 exostosin glycosyltransferase 1 -0.0394884
BIRC6 baculoviral IAP repeat containing 6 -0.0394175
EVI5 ecotropic viral integration site 5 -0.0390839
TRA2A transformer 2 alpha homolog (Drosophila) -0.038849
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0375561
NUP58 nucleoporin 58 -0.0375148
STRN3 striatin, calmodulin binding protein 3 -0.0370805
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0368822
RHEB Ras homolog enriched in brain -0.0367584
USP3 ubiquitin specific peptidase 3 -0.0365679
KMT2C lysine (K)-specific methyltransferase 2C -0.0363326
PNISR PNN-interacting serine/arginine-rich protein -0.0361848
LCORL ligand dependent nuclear receptor corepressor-like -0.0360166
ANK2 ankyrin 2, neuronal -0.0360123
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0359988
MON2 MON2 homolog (S. cerevisiae) -0.0359264
COG5 component of oligomeric golgi complex 5 -0.0357916
ASXL1 additional sex combs like transcriptional regulator 1 -0.0357847
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0357582
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0355796
PDGFC platelet derived growth factor C -0.0353171
FBXO11 F-box protein 11 -0.0351194
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0348797
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0345635
WDR43 WD repeat domain 43 -0.0343295
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0342744
AKAP9 A kinase (PRKA) anchor protein 9 -0.0340363
CCNL1 cyclin L1 -0.0339481
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0338239
CALR calreticulin -0.0337664
HDLBP high density lipoprotein binding protein -0.0336204
HDAC9 histone deacetylase 9 -0.0335362
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0334648
MATR3 matrin 3 -0.0326816
COPA coatomer protein complex, subunit alpha -0.0323748
MORF4L2 mortality factor 4 like 2 -0.0322822
MSI2 musashi RNA-binding protein 2 -0.0320261
CHD1 chromodomain helicase DNA binding protein 1 -0.0318368
RAB7A RAB7A, member RAS oncogene family -0.0317178
ZNF644 zinc finger protein 644 -0.0315147