Hexylresorcinol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0953305
NDRG1 N-myc downstream regulated 1 0.0927307
AKAP12 A kinase (PRKA) anchor protein 12 0.077531
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0753416
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0742063
MYH9 myosin, heavy chain 9, non-muscle 0.0647755
FTH1 ferritin, heavy polypeptide 1 0.0632985
NAV2 neuron navigator 2 0.0613342
VEGFA vascular endothelial growth factor A 0.0610842
EEF2 eukaryotic translation elongation factor 2 0.057515
FNDC3B fibronectin type III domain containing 3B 0.056861
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0518898
SFTPA2 surfactant protein A2 0.0515189
MSN moesin 0.0510525
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0501482
ZNF292 zinc finger protein 292 0.0454345
MT2A metallothionein 2A 0.0413259
COL6A3 collagen, type VI, alpha 3 0.0412168
GPC6 glypican 6 0.0410511
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0398062
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0387303
ICAM1 intercellular adhesion molecule 1 0.0385094
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0364412
SOD2 superoxide dismutase 2, mitochondrial 0.0360686
HDAC9 histone deacetylase 9 0.0348358
PPARD peroxisome proliferator-activated receptor delta 0.0347273
CDCP1 CUB domain containing protein 1 0.0333331
FLNB filamin B, beta 0.0306662
TNS3 tensin 3 0.0286859
DEPP1 DEPP autophagy regulator 1 0.0275255
SMAD3 SMAD family member 3 0.0274961
ELL2 elongation factor, RNA polymerase II, 2 0.0268494
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0267565
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0266356
ZMIZ1 zinc finger, MIZ-type containing 1 0.026501
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0261269
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.026058
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0253673
SEPTIN9 septin 9 0.025124
VMP1 vacuole membrane protein 1 0.0243842
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0242212
NAV1 neuron navigator 1 0.024136
FAM20C family with sequence similarity 20, member C 0.0235152
HLA-B major histocompatibility complex, class I, B 0.0222764
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0221495
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0218648
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0218207
MT1X metallothionein 1X 0.0214124
RPL4 ribosomal protein L4 0.0209467
YEATS2 YEATS domain containing 2 0.0208929
LOC112694756 uncharaterized LOC112694756 0.0205371
HLA-A major histocompatibility complex, class I, A 0.0200438
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0196992
PGK1 phosphoglycerate kinase 1 0.0196278
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0195349
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0192384
NOTCH2 notch 2 0.0191938
RPS12 ribosomal protein S12 0.0191389
EIF1 eukaryotic translation initiation factor 1 0.0188814
CLIC4 chloride intracellular channel 4 0.0186234
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0186222
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0184022
TRAM2 translocation associated membrane protein 2 0.0182825
FNIP1 folliculin interacting protein 1 0.0181262
FOSL1 FOS-like antigen 1 0.0177451
UBA6 ubiquitin-like modifier activating enzyme 6 0.0175734
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.017568
CDK19 cyclin-dependent kinase 19 0.0174879
SEC24A SEC24 family member A 0.0174273
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0172597
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0172437
STC2 stanniocalcin 2 0.0172256
PTH2R parathyroid hormone 2 receptor 0.0171856
FOXO3 forkhead box O3 0.0171723
UBC ubiquitin C 0.0171403
RERE arginine-glutamic acid dipeptide (RE) repeats 0.017123
DOCK5 dedicator of cytokinesis 5 0.0167759
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0167723
ERRFI1 ERBB receptor feedback inhibitor 1 0.0166816
RPS23 ribosomal protein S23 0.0164945
RHOA ras homolog family member A 0.016431
KDM4C lysine (K)-specific demethylase 4C 0.0164139
DENND5A DENN/MADD domain containing 5A 0.0162004
CEP250 centrosomal protein 250kDa 0.0160777
TNIP1 TNFAIP3 interacting protein 1 0.0158876
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0157961
RUNX1 runt-related transcription factor 1 0.0156941
PKM pyruvate kinase, muscle 0.0156035
RNF24 ring finger protein 24 0.0153784
SDC4 syndecan 4 0.0153184
PTK2 protein tyrosine kinase 2 0.0153096
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0152936
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0152893
RPS6 ribosomal protein S6 0.0152617
EFNA5 ephrin-A5 0.0152335
RTN4 reticulon 4 0.015131
TAPBP TAP binding protein (tapasin) 0.015098
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.015028
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0150211
SLC39A11 solute carrier family 39, member 11 0.0149619

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0912127
FRMD4A FERM domain containing 4A -0.0617148
IER3 immediate early response 3 -0.0594798
TPT1 tumor protein, translationally-controlled 1 -0.0572515
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0533478
EXT1 exostosin glycosyltransferase 1 -0.0500814
FN1 fibronectin 1 -0.0407567
CD44 CD44 molecule (Indian blood group) -0.0365615
COL1A1 collagen, type I, alpha 1 -0.0354308
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0342731
CADM1 cell adhesion molecule 1 -0.0342229
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0340341
TMSB10 thymosin beta 10 -0.0337242
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0336796
PTPRK protein tyrosine phosphatase, receptor type, K -0.0293548
VCL vinculin -0.0279606
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277809
LDHA lactate dehydrogenase A -0.0252902
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.025042
SLC38A1 solute carrier family 38, member 1 -0.0250125
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0247232
SFRP1 secreted frizzled-related protein 1 -0.024396
TENM2 teneurin transmembrane protein 2 -0.0241644
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0239422
ACTG1 actin gamma 1 -0.023773
CANX calnexin -0.022907
NIPBL Nipped-B homolog (Drosophila) -0.0228471
WSB1 WD repeat and SOCS box containing 1 -0.0223056
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0218308
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0211921
EGFR epidermal growth factor receptor -0.0210637
PTMA prothymosin, alpha -0.0205126
RIGI RNA sensor RIG-I -0.020301
GNAS GNAS complex locus -0.0198951
CAVIN1 caveolae associated protein 1 -0.0197613
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0188454
CDH13 cadherin 13 -0.0187465
CTSD cathepsin D -0.0186419
TRA2A transformer 2 alpha homolog (Drosophila) -0.0184633
LSAMP limbic system-associated membrane protein -0.0182146
INHBA inhibin, beta A -0.0180898
CDK6 cyclin-dependent kinase 6 -0.01755
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0169747
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0167981
LMNA lamin A/C -0.0160325
KYNU kynureninase -0.0159729
MAML2 mastermind-like 2 (Drosophila) -0.0152919
DEK DEK proto-oncogene -0.0151661
ZFR zinc finger RNA binding protein -0.0150459
RASAL2 RAS protein activator like 2 -0.0148471
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0145643
ZMYND8 zinc finger, MYND-type containing 8 -0.014538
CP ceruloplasmin (ferroxidase) -0.0144166
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0142983
TLE4 transducin-like enhancer of split 4 -0.0141489
ZBTB20 zinc finger and BTB domain containing 20 -0.0141424
PDE4D phosphodiesterase 4D, cAMP-specific -0.0141307
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0140541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0139836
LMAN1 lectin, mannose-binding, 1 -0.0138301
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0137764
DPYD dihydropyrimidine dehydrogenase -0.0137672
MYOF myoferlin -0.0137441
NAP1L1 nucleosome assembly protein 1-like 1 -0.0136268
FNDC3A fibronectin type III domain containing 3A -0.013626
RRBP1 ribosome binding protein 1 -0.0135728
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0135076
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0134399
IFI6 interferon, alpha-inducible protein 6 -0.0134392
ARHGAP29 Rho GTPase activating protein 29 -0.0133923
FTL ferritin, light polypeptide -0.0133364
PRSS23 protease, serine, 23 -0.0133356
IFIH1 interferon induced with helicase C domain 1 -0.0133305
KDM5B lysine (K)-specific demethylase 5B -0.013078
GCC2 GRIP and coiled-coil domain containing 2 -0.0130094
ZEB1 zinc finger E-box binding homeobox 1 -0.0129918
PLCB4 phospholipase C, beta 4 -0.0127893
TRIM55 tripartite motif containing 55 -0.0127847
SYAP1 synapse associated protein 1 -0.0127013
SRSF11 serine/arginine-rich splicing factor 11 -0.0126494
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0126479
INSIG1 insulin induced gene 1 -0.0125845
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0125487
BRWD3 bromodomain and WD repeat domain containing 3 -0.0125155
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0125111
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0124633
SMC3 structural maintenance of chromosomes 3 -0.0124422
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0123329
NCOA7 nuclear receptor coactivator 7 -0.0123007
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0122487
TTC3 tetratricopeptide repeat domain 3 -0.0122236
PALLD palladin, cytoskeletal associated protein -0.0122078
IGF2R insulin-like growth factor 2 receptor -0.0121949
COL4A2 collagen, type IV, alpha 2 -0.0120622
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0119997
SOX4 SRY (sex determining region Y)-box 4 -0.0118872
MARCHF6 membrane associated ring-CH-type finger 6 -0.011865
NALF1 NALCN channel auxiliary factor 1 -0.0118628
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0117339
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0117018